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JOURNAL ARTICLE
Priyanka Koshy, Lucrezia Furian, Peter Nickerson, Gianluigi Zaza, Maria Haller, Aiko P J de Vries, Maarten Naesens
The KDIGO guideline for acute rejection treatment recommends use of corticosteroids and suggests using lymphocyte-depleting agents as second line treatment. Aim of the study was to determine the current practices of detection and treatment of TCMR of kidney allografts amongst European kidney transplant centres. An invitation was sent through ESOT/EKITA newsletters and through social media to transplant professionals in Europe for taking part in the survey. A total of 129 transplant professionals responded to the survey...
2024: Transplant International
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JOURNAL ARTICLE
Wendy Pringle, Devon Greyson, Janice E Graham, Ève Dubé, Hana Mitchell, Margaret L Russell, Shannon E MacDonald, Julie A Bettinger
OBJECTIVE: Successful clinical conversations about vaccination in pregnancy (pertussis, COVID-19, and influenza) are key to improving low uptake rates of both vaccination in pregnancy and infancy. The purpose of this study was to understand Canadian perinatal care providers' knowledge, attitudes, and practices around vaccination in pregnancy. METHODS: Qualitative interviews with 49 perinatal care providers (nurse practitioner, general practitioner, registered nurse, registered midwife, obstetrician-gynecologist, and family physicians) in 6 of 13 provinces and territories were deductively coded using directed content analysis [1] and analyzed according to key themes...
June 2024: Vaccine: X
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JOURNAL ARTICLE
Gyula Kasza, Tekla Izsó, Atilla Kunszabó, Dávid Szakos, István Lénárt, Emese Bozánné Békefi, Khamphouth Vongxay, József Popp, Judit Oláh, Zoltán Lakner, Widya Satya Nugraha, Lajos Bognár, Miklós Süth
Primary research data on food chain safety at consumer level is needed to help policymakers to decrease the risk of foodborne infections in the Lao People's Democratic Republic. Therefore, the objectives of this study are to 1) determine Lao people's food safety knowledge, attitudes, and intentions and identify the most influential factors that shape their food safety behaviour, and 2) to support the government in the development of more efficient risk communication programmes. A paper-based consumer survey was implemented to collect quantitative data on the selected topics about Laotian consumers, as well as on the equipment of households regarding the conditions and tools necessary for safe food preparation and storage...
May 15, 2024: Heliyon
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JOURNAL ARTICLE
Valerie K Bürger, Julia Amann, Cathrine K T Bui, Jana Fehr, Vince I Madai
Artificial intelligence (AI) has the potential to revolutionize healthcare, for example via decision support systems, computer vision approaches, or AI-based prevention tools. Initial results from AI applications in healthcare show promise but are rarely translated into clinical practice successfully and ethically. This occurs despite an abundance of "Trustworthy AI" guidelines. How can we explain the translational gaps of AI in healthcare? This paper offers a fresh perspective on this problem, showing that failing translation of healthcare AI markedly arises from a lack of an operational definition of "trust" and "trustworthiness"...
2024: Frontiers in digital health
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JOURNAL ARTICLE
Riccardo Antonio Ricciuti, Fabrizio Mancini, Giusy Guzzi, Daniele Marruzzo, Alessandro Dario, Alessandro Della Puppa, Alessandro Ricci, Andrea Barbanera, Andrea Talacchi, Andreas Schwarz, Antonino Germanò, Antonino Raco, Antonio Colamaria, Antonio Santoro, Riccardo Boccaletti, Carlo Conti, Carlo Conti, Nunzia Cenci, Christian Cossandi, Claudio Bernucci, Corrado Lucantoni, Giovanni Battista Costella, Diego Garbossa, Donato Carlo Zotta, Federico De Gonda, Felice Esposito, Flavio Giordano, Giancarlo D'Andrea, Gianluca Piatelli, Gianluigi Zona, Giannantonio Spena, Giovanni Tringali, Giuseppe Barbagallo, Carlo Giussani, Maurizio Gladi, Andrea Landi, Angelo Lavano, Letterio Morabito, Luciano Mastronardi, Marco Locatelli, Michele D'Agruma, Michele Maria Lanotte, Nicola Montano, Orazio Santo Santonocito, Angelo Pompucci, Raffaele de Falco, Franco Randi, Sara Bruscella, Ivana Sartori, Francesco Signorelli, Luigino Tosatto, Roberto Trignani, Vincenzo Esposito, Gualtiero Innocenzi, Sergio Paolini, Vincenzo Vitiello, Michele Alessandro Cavallo, Francesco Sala
INTRODUCTION: Intraoperative Neurophysiological Monitoring (IOM) is widely used in neurosurgery but specific guidelines are lacking. Therefore, we can assume differences in IOM application between Neurosurgical centers. RESEARCH QUESTION: The section of Functional Neurosurgery of the Italian Society of Neurosurgery realized a survey aiming to obtain general data on the current practice of IOM in Italy. MATERIALS AND METHODS: A 22-item questionnaire was designed focusing on: volume procedures, indications, awake surgery, experience, organization and equipe...
2024: Brain Spine
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JOURNAL ARTICLE
Fatemeh Ghani Dehkordi, Camellia Torabizadeh, Mahnaz Rakhshan, Fatemeh Vizeshfar
BACKGROUND AND AIM: It is essential that healthcare providers display ethical behavior toward their patients. Despite development of codes of ethics for clinical practice, the occurrence of unethical behaviors toward patients is alarmingly high. The present study was conducted to identify the barriers to ethical treatment of patients in clinical environments. METHODS: Through systematic narrative review, the present study investigated the barriers to ethical treatment of patients...
May 2024: Health Science Reports
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JOURNAL ARTICLE
Eric Moughames, Maaza Abdi, Bridget Morris, Sandy Fang, Joyce Jones, Christine M Durand, Willa Cochran, Eduardo F Ribas, Charlee McLean-Powell, Ahmet Gurakar, Ulrike K Buchwald
BACKGROUND: Solid organ transplant recipients are at an increased risk for anogenital Human Papillomavirus (HPV)-related disease, including anal high-grade squamous intraepithelial lesions (HSIL) and anal squamous cell cancer (ASCC). Guidelines for ASCC screening in transplant recipients are limited. Our aim was to understand current practice of ASCC screening in adult liver transplant (LT) candidates and recipients at transplant centers across the United States. METHODS: We surveyed medical directors of 113 LT centers across the United States which had publicly available contact information...
May 2, 2024: Transplant Infectious Disease: An Official Journal of the Transplantation Society
#28
JOURNAL ARTICLE
Mohit Kehar, Samar H Ibrahim, Charina M Ramirez, Saista Asif Amin, Tamir Diamond, Saeed Mohammad
Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing globally in pediatric populations. Currently, MASLD management primarily relies on lifestyle interventions, which pose challenges in sustaining long-term weight loss. This study investigated the use of weight loss medications in MASLD care through an international survey of 166 pediatric gastroenterologists and hepatologists. The results indicated a notable interest in weight loss medications, with 38% of practitioners considering or using them, particularly glucagon-like peptide-1 receptor agonists...
May 2, 2024: Journal of Pediatric Gastroenterology and Nutrition
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JOURNAL ARTICLE
Heledd Lewis, Mark Taubert, Annmarie Nelson
OBJECTIVES: To maintain continuity of care during the Covid-19 pandemic, virtual consultations (VC) became the mainstay of patient-healthcare practitioner interactions. The aim of this study was to explore the views of oncology and palliative care healthcare professionals (HCPs) regarding the medium of VC. METHOD: A cross sectional mixed methodology observational study of oncology and palliative care HCPs, analysed via an inductive thematic approach. This was undertaken in accordance with relevant guidelines and regulations...
May 2, 2024: BMC Palliative Care
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JOURNAL ARTICLE
Lucy M Wilson, Clara Tam, Veronica Ka Wai Lai, Motunrayo Ajayi, Mê-Linh Lê, Banke Oketola, Terry P Klassen, Alex Aregbesola
BACKGROUND: Urinary tract infections (UTIs) are a common cause of acute illness among infants and young children. There are numerous methods for collecting urine in children who are not toilet trained. This review examined practice variation in the urine collection methods for diagnosing UTI in non-toilet-trained children. METHODS: A systematic review was completed by searching MEDLINE (Ovid), Embase (Ovid), CENTRAL (Ovid), PsycInfo (Ovid), CINAHL (EBSCO), and JBI (Ovid) from January 1, 2000 until October 9, 2021 and updated on May 24, 2023...
May 3, 2024: BMC Pediatrics
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JOURNAL ARTICLE
Caroline Gibson, Dianne Goeman, Dimity Pond, Mark Yates, Alison Hutchinson
INTRODUCTION: With an aging population and a growing prevalence of people living with dementia, the demand for best-practice dementia care in general practice increases. There is an opportunity to better utilise the nurse role within the primary care team to meet this increasing demand in the provision of care for people living with dementia. However, general practice nurses have limited knowledge in the provision of best-practice care for people living with dementia and their carer(s)...
May 2, 2024: BMC Prim Care
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REVIEW
Christina Baik, Michael L Cheng, Martin Dietrich, Jhanelle E Gray, Nagla A Karim
According to current guidelines, targeted therapy with a combination of BRAF plus MEK inhibitors is the preferred first-line treatment for patients with BRAF V600E-mutant metastatic non-small cell lung cancer (NSCLC). In the open-label, single-arm, phase 2 PHAROS trial (NCT03915951), the combination of encorafenib, a potent BRAF inhibitor, and binimetinib, a potent MEK inhibitor, demonstrated durable antitumor activity with a manageable safety profile in this patient population. On the basis of the results of this study, the combination of encorafenib plus binimetinib was approved by the US Food and Drug Administration on October 11, 2023, for patients with BRAF V600E-mutant metastatic NSCLC...
May 2, 2024: Advances in Therapy
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MULTICENTER STUDY
Masashi Kuwabara, Fusao Ikawa, Shinji Nakazawa, Saori Koshino, Daizo Ishii, Hiroshi Kondo, Takeshi Hara, Yuyo Maeda, Ryo Sato, Taiki Kaneko, Shiyuki Maeyama, Yuki Shimahara, Nobutaka Horie
We aimed to develop a new artificial intelligence software that can automatically extract and measure the volume of white matter hyperintensities (WMHs) in head magnetic resonance imaging (MRI) using only thick-slice fluid-attenuated inversion recovery (FLAIR) sequences from multiple centers. We enrolled 1092 participants in Japan, comprising the thick-slice Private Dataset. Based on 207 randomly selected participants, neuroradiologists annotated WMHs using predefined guidelines. The annotated images of participants were divided into training (n = 138) and test (n = 69) datasets...
May 2, 2024: Scientific Reports
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JOURNAL ARTICLE
Fiaz Alam, Omar Alsaed, Nabeel Abdulla, Ibrahim Abdulmomen, Abdo Lutf, Samar Al Emadi
UNLABELLED: We present comprehensive guidelines for osteoporosis management in Qatar. Formulated by the Qatar Osteoporosis Association, the guidelines recommend the age-dependent Qatar fracture risk assessment tool for screening, emphasizing risk-based treatment strategies and discouraging routine dual-energy X-ray scans. They offer a vital resource for physicians managing osteoporosis and fragility fractures nationwide. PURPOSE: Osteoporosis and related fragility fractures are a growing public health issue with an impact on individuals and the healthcare system...
May 2, 2024: Archives of Osteoporosis
#35
JOURNAL ARTICLE
Helen E Rollison, Pallabi Mitra, Hugues Chanteux, Zhizhou Fang, Xiaomin Liang, Seong Hee Park, Chester Costales, Imad Hanna, Nilay Thakkar, James M Vergis, Daniel A J Bow, Kathleen M Hillgren, Jochen Brumm, Xiaoyan Chu, Cornelis E C A Hop, Yurong Lai, Cindy Yanfei Li, Kelly M Mahar, Laurent Salphati, Rucha Sane, Hong Shen, Kunal Taskar, Mitchell E Taub, Kimio Tohyama, Christine Xu, Katherine S Fenner
The IQ Transporter Working Group had a rare opportunity to analyse a cross-pharma collation of in vitro data and assay methods for the evaluation of drug transporter substrate and inhibitor potential. Experiments were generally performed in accordance with regulatory guidelines. Discrepancies, such as not considering the impact of pre-incubation for inhibition and free or measured in vitro drug concentrations, may be due to the retrospective nature of the dataset and analysis. Lipophilicity was a frequent indicator of cross-transport inhibition (P-gp, BCRP, OATP1B and OCT1) with high molecular weight ({greater than or equal to}500 Da) also common for OATP1B and BCRP inhibitors...
May 2, 2024: Drug Metabolism and Disposition: the Biological Fate of Chemicals
#36
REVIEW
Marcin W Wlodarski, Adrianna Vlachos, Jason E Farrar, Lydie M Da Costa, Antonis Kattamis, Irma Dianzani, Cristina Belendez, Sule Unal, Hannah Tamary, Ramune Pasauliene, Dagmar Pospisilova, Josu de la Fuente, Deena Iskander, Lawrence Wolfe, Johnson M Liu, Akiko Shimamura, Katarzyna Albrecht, Birgitte Lausen, Anne Grete Bechensteen, Ulf Tedgard, Alexander Puzik, Paola Quarello, Ugo Ramenghi, Marije Bartels, Heinz Hengartner, Roula A Farah, Mahasen Al Saleh, Amir Ali Hamidieh, Wan Yang, Etsuro Ito, Hoon Kook, Galina Ovsyannikova, Leo Kager, Pierre-Emmanuel Gleizes, Jean-Hugues Dalle, Brigitte Strahm, Charlotte M Niemeyer, Jeffrey M Lipton, Thierry M Leblanc
Diamond-Blackfan anaemia (DBA), first described over 80 years ago, is a congenital disorder of erythropoiesis with a predilection for birth defects and cancer. Despite scientific advances, this chronic, debilitating, and life-limiting disorder continues to cause a substantial physical, psychological, and financial toll on patients and their families. The highly complex medical needs of affected patients require specialised expertise and multidisciplinary care. However, gaps remain in effectively bridging scientific discoveries to clinical practice and disseminating the latest knowledge and best practices to providers...
May 2024: Lancet Haematology
#37
REVIEW
Nicola West, Iain Chapple, Shauna Culshaw, Nikos Donos, Ian Needleman, Jeanie Suvan, Luigi Nibali, Amit Patel, Philip M Preshaw, Moritz Kebschull
OBJECTIVES: to adapt the supranational European Federation of Periodontology (EFP) Prevention and Treatment of Peri-implant Diseases - The EFP S3 Level Clinical Practice Guideline for UK healthcare environment, taking into account a broad range of views from stakeholders and patients. SOURCES: This UK version, based on the supranational EFP guideline [1] published in the Journal of Clinical Periodontology, was developed using S3-level methodology, combining assessment of formal evidence from 13 systematic reviews with a moderated consensus process of a representative group of stakeholders, and accounts for health equality, environmental factors and clinical effectiveness...
April 30, 2024: Journal of Dentistry
#38
REVIEW
Yilin Yang, Ning Wang, Fei Yan, Zhan Shi, Shouhua Feng
Sonodynamic therapy (SDT), utilizing ultrasound (US) as the trigger, has gained popularity recently as a therapeutic approach with significant potential for treating various diseases. Metal-organic frameworks (MOFs), characterized by structural flexibility, are prominently emerging in the SDT realm as an innovative type of sonosensitizer, offering functional tunability and biocompatibility. However, due to the inherent limitations of MOFs, such as low reactivity to reactive oxygen species and challenges posed by the complex tumor microenvironment, MOF-based sonosensitizers with singular functions are unable to demonstrate the desired therapeutic efficacy and may pose risks of toxicity, limiting their biological applications to superficial tissues...
April 30, 2024: Acta Biomaterialia
#39
REVIEW
Elham Rahmanipour, Emran Askari, Mohammad Ghorbani, Mohammad Mirzaei, Behrooz Rahimi, Mahyar Daskareh, Seyed Ali Mirshahvalad
OBJECTIVE: Although I-131 is relatively safe, there is limited focus on probable eye-related side effects after radioactive iodine (RAI) therapy. Thus, we aimed to provide evidence for the adverse outcomes of I-131, exclusively in thyroid cancer patients. METHODS: A systematic review based on the PRISMA guidelines was designed to examine the ocular complications of RAI therapy. Databases including PubMed, Scopus and Web of Science were searched until October 2023 with specific MeSH terms...
April 30, 2024: Endocrine Practice
#40
JOURNAL ARTICLE
Tamaki Kakuwa, Tomone Watanabe, Mariko Niino, Akira Kawata, Toyomi Satoh, Noriomi Matsumura, Yoshihito Yokoyama, Kei Kawana, Yasuyuki Hirashima, Satoru Kyo, Masanori Yasuda, Kenichi Harano, Hiroko Machida, Hideki Tokunaga, Masanori Kaneuchi, Tsutomu Tabata, Yoichi Kobayashi, Satoru Nagase, Hidetaka Katabuchi, Mikio Mikami, Yoko Yamamoto, Ryoko Rikitake, Yuichi Ichinose, Takahiro Higashi
AIM: Quality of care is important to reduce disease progression, and improve both survival and quality of life. The Japan Society of Gynecologic Oncology has published treatment guidelines to promote standardized high-quality care for ovarian cancer in Japan. We developed quality indicators based on the guideline recommendations and used them on large datasets of health service use to examine the quality of ovarian cancer care. METHODS: A panel of experts developed the indicators using a modified Delphi method...
May 2, 2024: Journal of Obstetrics and Gynaecology Research
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