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REVIEW
Narges Norouzkhani, Mahbobeh Faramarzi, Ali Bahari, Javad Shokri Shirvani, Saeid Eslami, Hamed Tabesh
BACKGROUND: Inflammatory bowel disease (IBD) imposes a huge burden on the healthcare systems and greatly declines the patient's quality of life. However, there is a paucity of detailed data regarding information and supportive needs as well as sources and methods of obtaining information to control different aspects of the disease from the perspectives of the patients themselves. This study aimed to establish the IBD patients' preferences of informational and supportive needs through Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA)...
April 13, 2024: BMC Gastroenterology
#2
REVIEW
Abhishek Gairola, Aaron Wetten, Jessica Dyson
INTRODUCTION: Pruritus is common and often undertreated in patients with primary biliary cholangitis (PBC). Existing treatments largely have an aging and low-quality evidence base, and studies included only small numbers of patients. More recent data that has added to our understanding of pruritus treatments has often come from clinical trials where itch was a secondary outcome measure in a trial designed primarily to assess disease modifying agents. This area represents an unmet clinical need in the management of PBC...
April 13, 2024: Expert Opinion on Investigational Drugs
#3
REVIEW
Ioana Ruxandra Mihai, Ciprian Rezus, Maria Alexandra Burlui, Anca Cardoneanu, Luana Andreea Macovei, Patricia Richter, Ioana Bratoiu, Elena Rezus
Rheumatoid arthritis (RA) is a systemic immune-mediated disease that, in addition to the articular involvement, can have extra-articular manifestations. Even though liver damage in RA is not very common, associated autoimmune liver diseases (AILDs) may occur. The most common AILD associated with RA is primary biliary cirrhosis (PBC), followed by autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC). There are common underlying mechanisms that play a role in the emergence of autoimmunity and inflammation in both rheumatic and autoimmune liver diseases...
March 29, 2024: International Journal of Molecular Sciences
#4
REVIEW
Ahmad Abu-Omar, Nicolas Murray, Ismail T Ali, Faisal Khosa, Sarah Barrett, Adnan Sheikh, Savvas Nicolaou, Stefania Tamburrini, Francesca Iacobellis, Giacomo Sica, Vincenza Granata, Luca Saba, Salvatore Masala, Mariano Scaglione
Advancing medical technology revolutionizes our ability to diagnose various disease processes. Conventional Single-Energy Computed Tomography (SECT) has multiple inherent limitations for providing definite diagnoses in certain clinical contexts. Dual-Energy Computed Tomography (DECT) has been in use since 2006 and has constantly evolved providing various applications to assist radiologists in reaching certain diagnoses SECT is rather unable to identify. DECT may also complement the role of SECT by supporting radiologists to confidently make diagnoses in certain clinically challenging scenarios...
April 7, 2024: Diagnostics
#5
REVIEW
Alberto Maringhini, Margherita Rossi, Rosalia Patti, Marco Maringhini, Valerio Vassallo
During pregnancy and in the post-partum period, several diseases may arise or become exacerbated. Acute pancreatitis is an inflammatory disease with an increasing incidence in Western countries. The incidence of acute pancreatitis during pregnancy is not different with respect to the general population, but this incidence increases in the first 2 years after delivery. Biliary sludge and stones are the most frequent aetiologies, followed by hypertriglyceridemia. Taking care of the mother and foetus through a potentially severe disease requires a team consisting of an obstetrician, a gastroenterologist, an anaesthesiologist, and a surgeon...
March 30, 2024: Journal of Clinical Medicine
#6
JOURNAL ARTICLE
Jawad Abou Zeid, Souheil Hallit, Bassem Akiki, Zeina Abou Zeid, Charbel Yazbeck
BACKGROUND: Different split regimens of polyethylene glycol are routinely used and no guidelines are available to select an optimal protocol of ingestion. This study aims to compare the efficacy and side effect profile of two different regimens of polyethylene glycol bowel preparation solution: PEG (3 + 1) vs. PEG (2 + 2). METHODS: 240 patients above the age of 18 years were included in the study between June 1st and November 31st, 2023...
April 12, 2024: BMC Gastroenterology
#7
JOURNAL ARTICLE
Chen Chen, Daya Zhang, Shimei Huang, Fan Zeng, Da Li, Xiaodong Zhang, Runxiang Chen, Shiju Chen, Jun Wang, Feihu Bai
OBJECTIVE: To compare the potential efficacy and safety of dual therapy and quadruple therapy with vonoprazan (VPZ) as well as the standard quadruple therapy of proton pump inhibitor (PPI) for the eradication of Helicobacter pylori (Hp) infection in Hainan province. METHODS: A single-centre, non-blinded, non-inferiority randomized controlled trial was conducted at the outpatient department of gastroenterology at the Second Affiliated Hospital of Hainan Medical University from June 2022 to February 2023...
April 12, 2024: BMC Gastroenterology
#8
JOURNAL ARTICLE
Hariklia Kranidioti, Konstantinos Zisimopoulos, Theodora Oikonomou, Theodoros Voulgaris, Spyros Siakavellas, Polixeni Agorastou, Melanie Deutsch, Christos Triantos, Ioannis Goulis, George Papatheodoridis, Spilios Manolakopoulos
BACKGROUND: Preventing disease progression and viral suppression are the main goals of antiviral therapy in chronic hepatitis B (CHB). Liver stiffness measurement (LSM) by transient elastography is a reliable non-invasive method to assess liver fibrosis in patients with CHB. Our aim was to explore factors that may affect changes in LSMs during long term tenofovir (TDF) monotherapy in a well characterized cohort of patients with compensated CHB. METHODS: We analyzed serial LSMs in 103 adult patients with CHB who were on TDF monotherapy and had at least three LSMs over a period of 90 months...
April 12, 2024: BMC Gastroenterology
#9
Anh The Pham, Quoc Hoang Dang, Khue Kim Dang, An Thi My Nguyen, Cuong Manh Truong, Khuyen Thi Nguyen
INTRODUCTION: Tuberculosis is a chronic infectious disease that often has a latent period after the initial infection. Tuberculosis most often affects the lungs but it can also affect other parts of the body. Vietnam is in pandemic area of tuberculosis. CASE REPORT: We present a rare case of a 42-year-old male patient admitted to the hospital with a history of progressive jaundice. Magnetic resonance imaging (MRI) revealed a 26 × 33 mm tuberculous mass located at the intersection between the cystic duct and the common hepatic duct, leading to dilation of the intrahepatic biliary ducts on both sides...
April 3, 2024: International Journal of Surgery Case Reports
#10
REVIEW
Ze Xiang, Jiarui Li, Huixuan Zeng, Xiaonan Xiang, Fengqiang Gao, Kai Wang, Xuyong Wei, Shusen Zheng, Xiao Xu
End-stage liver disease (ESLD), stemming from a spectrum of chronic liver pathologies including chronic liver failure, acute cirrhosis decompensation and hepatocellular carcinoma, imposes a significant global healthcare burden. Liver transplantation (LT) remains the only treatment for ESLD. However, the escalating mortality on transplant waitlists has prompted the utilization of marginal liver grafts in LT procedures. These grafts primarily encompass elderly livers, steatotic livers, livers from donation after circulatory death, split livers and those infected with the hepatitis virus...
April 7, 2024: Aging and Disease
#11
JOURNAL ARTICLE
Naohiro Hirano, Masahiro Iseki, Kei Nakagawa, Masamichi Mizuma, Takashi Kamei, Ryotaro Matsumoto, Shin Miura, Kiyoshi Kume, Atsushi Masamune, Michiaki Unno
Situs inversus totalis is a rare congenital malformation in which organs are positioned in a mirror-image relationship to normal conditions. It often presents with vascular and biliary malformations. Only a few reports have pointed out the surgical difficulties in patients with situs inversus totalis, especially in those with perihilar cholangiocarcinoma. This report describes a 66-year-old male patient who underwent left hemihepatectomy (S5, 6, 7, and 8) with combined resection of the caudate lobe (S1), extrahepatic bile duct, and regional lymph nodes for perihilar cholangiocarcinoma with situs inversus totalis...
April 12, 2024: Clinical Journal of Gastroenterology
#12
JOURNAL ARTICLE
Tomoyuki Niwa, Moeka Watahiki, Toshikatsu Kosugi, Daisuke Kusama, Hiroki Tamakoshi, Masaki Takinami, Junichi Kaneko, Yurimi Takahashi, Masafumi Nishino, Takanori Yamada
A 61-year-old man present to us with continued abdominal pain without abdominal tenderness for 1 month. Blood testing showed elevated biliary enzymes and inflammation. Contrast-enhanced computed tomography (CT) revealed thickening of the transverse colon with relatively strong enhancement but no bile duct dilatation. Colonoscopy revealed localized edema and granular mucosa in the transverse colon. Fluoroscopic endoscopy exhibited the absence of haustra. Multiple biopsies were performed, but differentiation between mild inflammation and mucosa-associated lymphoid tissue (MALT) lymphoma was inconclusive...
April 12, 2024: Clinical Journal of Gastroenterology
#13
JOURNAL ARTICLE
Yansheng Liu, Yinan Hu, Bo Li, Rui Su, Zheyi Han, Boquan Jin, Ting Li, Xiaohong Zheng, Ying Han
BACKGROUND AND AIM: Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by destructive lymphocytic cholangitis and specific anti-mitochondrial antibodies. Innate lymphoid cells (ILCs) have been reported to play a role in liver homeostasis and autoimmunity. METHODS: We evaluated the features of peripheral ILC1s and ILC3 in patients with PBC and hepatic ILC1 and ILC3 in two different PBC mouse models (dominant-negative transforming growth factor-beta receptor II [dnTGFβRII] and 2-octynoic acid-bovine serum albumin [2OA-BSA])...
April 12, 2024: Journal of Gastroenterology and Hepatology
#14
JOURNAL ARTICLE
Byoung Kuk Jang
No abstract text is available yet for this article.
April 2024: Clinical and Molecular Hepatology
#15
JOURNAL ARTICLE
Hideki Fujii, Michihiro Iwaki, Yoshihiro Kamada
No abstract text is available yet for this article.
April 2024: Clinical and Molecular Hepatology
#16
JOURNAL ARTICLE
Ying-Nan Tsai, Jia-Ling Wu, Yao-Chun Hsu
No abstract text is available yet for this article.
April 2024: Clinical and Molecular Hepatology
#17
Seung Bae Yoon, Sang Myung Woo, Jung Won Chun, Dong Uk Kim, Jaihwan Kim, Joo Kyung Park, Hoonsub So, Moon Jae Chung, In Rae Cho, Jun Heo
BACKGROUND: Recently, anti-programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) immunotherapy offers promising results for advanced biliary tract cancer (BTC). However, patients show highly heterogeneous responses to treatment, and predictive biomarkers are lacking. We performed a systematic review and meta-analysis to assess the potential of PD-L1 expression as a biomarker for treatment response and survival in patients with BTC undergoing anti-PD-1/PD-L1 therapy...
2024: Frontiers in Immunology
#18
JOURNAL ARTICLE
Wills F Filipe, Florian E Buisman, Stijn Franssen, Myrtle F Krul, Dirk J Grünhagen, Roel J Bennink, Karen Bolhuis, Rutger C G Bruijnen, Tineke E Buffart, Mark C Burgmans, Otto M van Delden, Pascal G Doornebosch, Paul D Gobardhan, Laura Graven, Jan Willem B de Groot, Cecile Grootscholten, Jeroen Hagendoorn, Paul Harmsen, Marjolein Y V Homs, Elizabeth G Klompenhouwer, Niels F M Kok, Marnix G E H Lam, Olaf J L Loosveld, Mark A J Meier, J Sven D Mieog, Ad H J Oostdijk, Loubna Outmani, Gijs A Patijn, Stefan Pool, Daphne D D Rietbergen, Jeanine M L Roodhart, Frank M Speetjens, Rutger Jan Swijnenburg, Michelle W J Versleijen, Cornelis Verhoef, Koert F D Kuhlmann, Adriaan Moelker, Bas Groot Koerkamp
INTRODUCTION: This study investigates the incidence of extrahepatic perfusion and incomplete hepatic perfusion at intraoperative methylene blue testing and on postoperative nuclear imaging in patients undergoing hepatic arterial infusion pump (HAIP) chemotherapy. METHODS: The first 150 consecutive patients who underwent pump implantation in the Netherlands were included. All patients underwent surgical pump implantation with the catheter in the gastroduodenal artery...
March 20, 2024: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
#19
JOURNAL ARTICLE
Adham H El-Sherbini, Stefania Coroneos, Ali Zidan, Maha Othman
Khorana score (KS) is an established risk assessment model for predicting cancer-associated thrombosis. However, it ignores several risk factors and has poor predictability in some cancer types. Machine learning (ML) is a novel technique used for the diagnosis and prognosis of several diseases, including cancer-associated thrombosis, when trained on specific diagnostic modalities. Consolidating the literature on the use of ML for the prediction of cancer-associated thrombosis is necessary to understand its diagnostic and prognostic abilities relative to KS...
April 11, 2024: Seminars in Thrombosis and Hemostasis
#20
JOURNAL ARTICLE
Dino Bekric, Tobias Kiesslich, Matthias Ocker, Martina Winklmayr, Markus Ritter, Heidemarie Dobias, Marlena Beyreis, Daniel Neureiter, Christian Mayr
INTRODUCTION: Biliary tract cancer (BTC) is a lethal disease with a bad overall survivability, partly arising from inadequate therapeutic alternatives, detection at a belated stage, and a resistance to common therapeutic approaches. Ferroptosis is a form of programmed cell death that depends on reactive oxygen species (ROS) and iron, causing excessive peroxidation of polyunsaturated fatty acids (PUFAs). Therefore, the objective of this investigation is, whether ferroptosis can be induced in BTC in vitro and whether this induction is dependent on specific molecular markers...
2024: PloS One
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