Yang Chen, Jiayi Zhu, Xin Guo, Chenghui Cao, Xuan Xiao, Botao Zhu, Shuwei Weng, Die Hu, Yonghong Luo, Shuai Wang, Sha Wu, Jia He, Yang Yang, Daoquan Peng
BACKGROUND: Recent studies have revealed a significant decrease in serum fetuin-A levels in atherosclerotic aneurysms, indicating that fetuin-A may play a protective role in the progression of arterial calcification. However, the specific mechanism behind this phenomenon remains unclear. We aimed to examine the association between fetuin-A levels in thoracic aortic aneurysms (TAAs) and risk of TAAs and to evaluate whether this association was causal. METHODS: A total of 26 SNPs were selected as instrumental variables for fetuin-A in 9,055 participants of European ancestry from the CHARGE consortium, and their effects on thoracic aortic aneurysm and decreased descending thoracic aortic diameter were separately estimated in 353,049 and 39,688 individuals from FinnGen consortium...
2024: Frontiers in Endocrinology