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JOURNAL ARTICLE
Erik Hansson, Kristina Jakobsson, Jason R Glaser, Catharina Wesseling, Denis Chavarría, Rebekah A I Lucas, David H Wegman
BACKGROUND: Mesoamerican sugarcane cutters are at a high risk of chronic kidney disease of non-traditional origin, a disease likely linked to heat-related acute kidney injury (AKI). Studies in general populations have described a positive association between high environmental temperatures and clinically assessed kidney outcomes, but there are no studies in occupational settings. METHOD: We accessed routine records of clinically diagnosed AKI (AKI-CD) and wet bulb globe temperatures (WBGT) at a large Nicaraguan sugarcane plantation and modeled the relationship between these using negative binomial regression...
April 9, 2024: Workplace Health & Safety
#22
JOURNAL ARTICLE
Yuan Ren, Zuoyuan Wang, Li You, Jie Zhou, Haowen Huang, Sansi Chang, Yuanhao Wu, Jun Xue
BACKGROUND: Inflammation is crucial in the development of AKI and subsequent CKD following renal ischemia-reperfusion (IR) injury. Gut microbiota metabolites trigger inflammation and affect IR-induced renal damage. Yet, the driving factors and mechanisms are unclear. Trimethylamine N-oxide (TMAO), a gut-derived choline metabolite, is a strong pro-inflammatory factor that increases in patients with AKI and CKD. We hypothesized that TMAO can promote renal injury caused by IR. METHODS: Mice subjected to unilateral renal IR to induce AKI and CKD were fed a high-choline diet to observe the effects of TMAO on kidney inflammation, fibrosis, and macrophage dynamics...
April 8, 2024: Nephrology, Dialysis, Transplantation
#23
JOURNAL ARTICLE
Debora M Hofer, Livio Ruzzante, Jan Waskowski, Anna S Messmer, Carmen A Pfortmueller
BACKGROUND: Fluid accumulation (FA) is known to be associated with acute kidney injury (AKI) during intensive care unit (ICU) stay but data on mid-term renal outcome is scarce. The aim of this study was to investigate the association between FA at ICU day 3 and major adverse kidney events in the first 30 days after ICU admission (MAKE30). METHODS: Retrospective, single-center cohort study including adult ICU patients with sufficient data to compute FA and MAKE30...
April 8, 2024: Annals of Intensive Care
#24
REVIEW
Fatemeh Jahanshahi, Seyed Behnam Jazayeri, Mohammad Mirahmadi Eraghi, Leonardo Oliveira Reis, Mahtab Hamidikia, Shayan Amiri, Seyed Mohammad Kazem Aghamir
Studies showed that the respiratory is not the only system affected by coronavirus 2, while cardiovascular, digestive, and nervous systems, as well as essential organs such as the kidneys, can be affected by this virus. In this review, we have studied the epidemiology, clinical, and laboratory findings on COVID-19 infection renal involvement, mortality, physiopathology, remaining renal sequels after recovery, underlying renal disease, and renal injury due to its treatment. Also, protective measures for kidney injury are explained in three levels...
2024: Open Medicine (Warsaw, Poland)
#25
JOURNAL ARTICLE
S H Ooi, K P Ng, Pavai Sthaneshwar, S K Lim, P Y Khor, J Y Lim, W S Siow, K W Lim, Muhummad Azlan
BACKGROUND: The commonest indication for hospitalization in COVID-19 patients is hypoxemia or severe respiratory symptoms. However, COVID-19 disease may result in extrapulmonary complications including kidney-related pathology. The reported incidence of renal involvement related to COVID infection varies based on geographical location. OBJECTIVE: This study aimed to assess the incidence rate of AKI in hospitalized COVID-19 patients and identify risk factors and prognostic predictors...
April 5, 2024: BMC Nephrology
#26
EDITORIAL
Rakhi Maiwall, Satender Pal Singh, Paolo Angeli, Richard Moreau, Aleksander Krag, Virender Singh, Ashwani K Singal, S S Tan, Puneet Puri, Mamun Mahtab, George Lau, Qin Ning, Manoj Kumar Sharma, P N Rao, Dharmesh Kapoor, Subhash Gupta, Ajay Duseja, Manav Wadhawan, Dinesh Jothimani, Sanjiv Saigal, Sunil Taneja, Akash Shukla, Pankaj Puri, Deepak Govil, Gaurav Pandey, Kaushal Madan, C E Eapen, Jaya Benjamin, Ashok Chowdhury, Shweta Singh, Vaishali Salao, Jin Mo Yang, Saeed Hamid, Shalimar, Sanjiv Jasuja, Anand V Kulkarni, Madund A Niriella, Harsh Vardhan Tevethia, Vinod Arora, R P Mathur, Akash Roy, Ankur Jindal, Neeraj Saraf, Nipun Verma, Arka De, Narendra S Choudhary, Rohit Mehtani, Phool Chand, Omkar Rudra, Shiv Kumar Sarin
Acute-on-chronic liver failure (ACLF) is a syndrome that is characterized by the rapid development of organ failures predisposing these patients to a high risk of short-term early death. The main causes of organ failure in these patients are bacterial infections and systemic inflammation, both of which can be severe. For the majority of these patients, a prompt liver transplant is still the only effective course of treatment. Kidneys are one of the most frequent extrahepatic organs that are affected in patients with ACLF, since acute kidney injury (AKI) is reported in 22...
April 5, 2024: Hepatology International
#27
REVIEW
Zheng Li, Jihong Xing
Acute kidney injury (AKI) is a common clinical syndrome characterized by a rapid deterioration in renal function, manifested by a significant increase in creatinine and a sharp decrease in urine output. The incidence of morbidity and mortality associated with AKI is on the rise, with most patients progressing to chronic kidney disease or end-stage renal disease. Treatment options for patients with AKI remain limited. Circular RNA (circRNA) is a wide and diverse class of non-coding RNAs that are present in a variety of organisms and are involved in gene expression regulation...
April 2, 2024: Biomedicine & Pharmacotherapy
#28
JOURNAL ARTICLE
Lynda K Cameron, Lesedi Ledwaba-Chapman, Kieran Voong, Geeta Hampson, Lui G Forni, Nina Seylanova, Dominic J Harrington, Rosario Lim, Aneta Bociek, Wang Yanzhong, Marlies Ostermann
BACKGROUND: Vitamin D deficiency in critically ill patients is associated with poor outcomes, and vitamin D supplementation is recommended for patients with chronic kidney disease. Whether acute kidney injury (AKI) is associated with altered Vitamin D metabolism is unknown. We aimed to compare the longitudinal profiles of serum 25(OH)D and 1,25(OH)2 D concentrations in critically ill patients with and without moderate to severe AKI and explore the impact of renal recovery and parathyroid hormone (PTH)...
April 2, 2024: Critical Care: the Official Journal of the Critical Care Forum
#29
JOURNAL ARTICLE
Gianluca DE Rubeis, Simone Zilahi DE Gyurgyokai, Sebastiano Fabiano, Luca Bertaccini, Andrea Wlderk, Francesca R Pezzella, Sabrina Anticoli, Giuseppe Biondi-Zoccai, Francesco Versaci, Luca Saba, Enrico Pampana
BACKGROUND: Contrast media used in mechanical therapies for stroke and myocardial infarction represent a significant cause of acute kidney injury (AKI) in acute medical scenarios. Although the continuous saline infusion line (CSIL) is a standard procedure to prevent thrombus formation within the catheter during neurovascular interventions of mechanical thrombectomy (MT), it is not utilized in percutaneous coronary interventions (PCI). METHODS: A systematic review of the incidence of AKI after MT for stroke treatment was performed...
April 2, 2024: Minerva Medica
#30
REVIEW
Melanie M Manis, Jessica W Skelley, J Braden Read, Rebecca Maxson, Emma O'Hagan, Jessica L Wallace, Edward D Siew, Erin F Barreto, Samuel A Silver, Sandra L Kane-Gill, Javier A Neyra
OBJECTIVE: The objective was to explore and describe the role of pharmacists in providing postdischarge care to patients with kidney disease. DATA SOURCES: PubMed, Embase (Elsevier), CINAHL (Ebscohost), Web of Science Core Collection, and Scopus were searched on January 30, 2023. Publication date limits were not included. Search terms were identified based on 3 concepts: kidney disease, pharmacy services, and patient discharge. Experimental, quasi-experimental, observational, and qualitative studies, or study protocols, describing the pharmacist's role in providing postdischarge care for patients with kidney disease, excluding kidney transplant recipients, were eligible...
April 2, 2024: Annals of Pharmacotherapy
#31
JOURNAL ARTICLE
Danni Wang, Yue Niu, Dinghua Chen, Chaofan Li, Fei Liu, Zhe Feng, Xueying Cao, Li Zhang, Guangyan Cai, Xiangmei Chen, Ping Li
BACKGROUND: Nonmalignant pleural effusion (NMPE) is common and remains a definite health care problem. Pleural effusion was supposed to be a risk factor for acute kidney injury (AKI). Incidence of AKI in NMPE patients and whether there is correlation between the size of effusions and AKI is unknown. OBJECTIVE: To assess the incidence of AKI in NMPE inpatients and its association with effusion size. STUDY DESIGN AND METHOD: We conducted a retrospective cohort study of inpatients admitted to the Chinese PLA General Hospital with pleural effusion from 2018-2021...
April 1, 2024: BMC Nephrology
#32
JOURNAL ARTICLE
Yukihiro Hitaka, Naohito Isoyama, Shunya Tsuji, Takeshi Honda, Yuki Nakayama, Mitsuhiro Yamaguchi, Kimihiko Nakamura, Hiroshi Hirata, Koji Shiraishi, Masataka Asagiri
Ischemia-reperfusion (I/R) leads to tissue damage in transplanted kidneys, resulting in acute kidney injury (AKI) and chronic graft dysfunction, which critically compromises transplant outcomes, such as graft loss. Linaclotide, a guanylate cyclase C agonist clinically approved as a laxative, has recently been identified to exhibit renoprotective effects in a chronic kidney disease (CKD) model. This study evaluates the therapeutic effects of linaclotide on AKI triggered by I/R in a rat model with an initial comparison with other laxatives...
February 22, 2024: Biochemical and Biophysical Research Communications
#33
JOURNAL ARTICLE
Kubilay Karaboyun, Yakup İriağaç, Eyyüp Çavdar, Okan Avci, Erdoğan S Şeber
OBJECTIVE: Cisplatin-associated acute kidney injury is a common clinical event that causes increased morbidity and mortality in cancer patients even if they are categorized as having normal functioning kidneys. We aimed to determine predictive factors that can predict acute kidney injury associated with cisplatin therapy in patients with normal renal function by comparison of pre-chemotherapy estimated glomerular filtration rates calculated separately by Cockcroft and Gault (CG), the Modification of Diet in Renal Disease (MDRD), and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPİ) equations and accompanying patient-associated factors...
January 1, 2024: Journal of Cancer Research and Therapeutics
#34
REVIEW
Liangjuan Yuan, Arshad Mehmood, Lei Meng
INTRODUCTION: The spread of coronavirus disease 2019 (COVID-19) worldwide since November 2019 is of interest to understand its impact on various organs. COVID-19 patients experience a higher incidence of acute kidney injury (AKI) compared with non-COVID-19 patients. METHODS: A systematic literature search was conducted that covered the period from November 1, 2019 to February 28, 2021. RESULTS: The analysis incorporated a comprehensive review of 19 studies of 21 362 patients...
March 28, 2024: Therapeutic Apheresis and Dialysis
#35
REVIEW
María Ángeles González-Nicolás, Cristian González-Guerrero, Marian Goicoechea, Lisardo Boscá, Lara Valiño-Rivas, Alberto Lázaro
Contrast-Induced Acute Kidney Injury (CI-AKI) remains a frequent iatrogenic condition since radiological procedures using intra-vascular iodinated contrast media (CM) are being widely administered for diagnostic and therapeutic purposes. Despite the improvement of the medical healthcare system worldwide, CI-AKI is still associated with direct short-term and indirect long-term outcomes including increased morbidity and mortality, especially in patients with underlying pre-existing renal function impairment, cardiovascular disease, or diabetes that could rapidly progress into Chronic Kidney Disease...
March 19, 2024: International Journal of Molecular Sciences
#36
JOURNAL ARTICLE
Hye-Mee Kwon, Sa-Jin Kang, Sang-Bin Han, Jae Hwan Kim, Sung-Hoon Kim, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang
BACKGROUND: Acute kidney injury (AKI) is one of the most common complications after living-donor liver transplantation (LDLT) that has great impact on recipient and graft outcomes. Dexmedetomidine is reported to decrease the incidence of AKI. In the current study, we investigated whether intraoperative dexmedetomidine infusion would reduce the AKI following LDLT. MATERIAL AND METHODS: In total, 205 adult patients undergoing elective LDLT were randomly assigned to the dexmedetomidine group (n=103) or the control group (n=102)...
March 28, 2024: International Journal of Surgery
#37
REVIEW
Soulandi Djorwé, Amale Bousfiha, Néhémie Nzoyikorera, Joseph Nyandwi, Bellamine Kawthar, Abderrahim Malki
BACKGROUND: COVID-19 patients usually present multiple comorbidities and complications associated with severe forms of SARS-CoV-2 infection. This study aimed to assess the risk factors and prevalence of comorbidities and complications contributing to the severity of COVID-19. METHODS: This meta-analysis was performed according to PRISMA guidelines. We searched various databases, including PubMed, Google Scholar, and Scopus (between 2020 and 2023), for eligible studies for this meta-analysis...
2024: BioMedicine
#38
JOURNAL ARTICLE
Sevag Demirjian, Faisal Bakaeen, W H Wilson Tang, Chase Donaldson, Jon Taliercio, Anne Huml, Crystal A Gadegbeku, A Marc Gillinov, Steven Insler
OBJECTIVES: Examine the: 1) relative role of hemodynamic determinants of acute kidney injury (AKI) obtained in the immediate postcardiac surgery setting compared with established risk factors, 2) their predictive value, and 3) extent mediation via central venous pressure (CVP) and mean arterial pressure (MAP). DESIGN: Retrospective observational study. The main outcome of the study was moderate to severe AKI, per kidney disease: improving global outcomes, within 14 days of surgery...
April 2024: Critical care explorations
#39
JOURNAL ARTICLE
Jiajia Liu, Rui Wang, Jianxing Qiu, Tao Su
INTRODUCTION: Acute kidney injury (AKI) is a critical condition with a complex aetiology and different outcomes, where haemodynamic dysfunction, renal hypoperfusion and inflammation serve as key contributors to its development and progression. Early and accurate diagnosis is vital for initiating targeted treatments like fluid resuscitation, vasoactive agents or steroid therapy, which are essential for improving patient outcomes. Intravoxel incoherent motion (IVIM) MRI assesses both capillary perfusion and tissue water diffusion, while arterial spin labelling (ASL) MRI measures renal blood flow without the need for contrast...
March 25, 2024: BMJ Open
#40
JOURNAL ARTICLE
Yaru Wang, Changcheng Li, Jingyi Chen, Xiaoli Cui, Binghuan Wang, Yuezeng Wang, Dayu Wang, Jinping Liu, Jing Li
Acute kidney injury (AKI) is a common, multicause clinical condition that, if ignored, often progresses to chronic kidney disease (CKD) and end-stage kidney disease, with a mortality rate of 40-50%. However, there is a lack of universal treatment for AKI. Inflammation is the basic pathological change of early kidney injury, and inflammation can exacerbate AKI. Macrophages are the primary immune cells involved in the inflammatory microenvironment of kidney disease. Therefore, regulating the function of macrophages is a crucial breakthrough for the AKI intervention...
March 25, 2024: Journal of Agricultural and Food Chemistry
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