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Fluid administration in preterm baby

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https://read.qxmd.com/read/29218481/concepts-for-a-therapeutic-prolongation-of-nephrogenesis-in-preterm-and-low-birth-weight-babies-must-correspond-to-structural-functional-properties-in-the-nephrogenic-zone
#1
REVIEW
Will W Minuth
Numerous investigations are dealing with anlage of the mammalian kidney and primary development of nephrons. However, only few information is available about the last steps in kidney development leading at birth to a downregulation of morphogen activity in the nephrogenic zone and to a loss of stem cell niches aligned beyond the organ capsule. Surprisingly, these natural changes in the developmental program display similarities to processes occurring in the kidneys of preterm and low-birth-weight babies. Although those babies are born at a time with a principally intact nephrogenic zone and active niches, a high proportion of them suffers on impairment of nephrogenesis resulting in oligonephropathy, formation of atypical glomeruli, and immaturity of parenchyma...
December 7, 2017: Molecular and Cellular Pediatrics
https://read.qxmd.com/read/28701011/action-plan-for-prolongation-of-nephrogenesis-in-preterm-and-growth-restricted-babies-explore-ultrastructure-of-the-nephrogenic-zone-identify-a-molecular-target-select-a-viable-drug-and-find-a-path-for-administration
#2
REVIEW
Will W Minuth
A large amount of investigations informs about primary steps of mammalian kidney development such as anlage of the organ and initial nephron formation, while only few data exists about the late phase of human kidney development. In particular, little attention was up to date addressed to the decrease of morphogenic activity in the nephrogenic zone short before birth and the vanishing of all stem cell niches aligned beyond the organ capsule. There is evidence that molecular controlling of this normal but degenerative developmental process also plays a decisive role in the kidneys of preterm and growth restricted babies...
January 2018: Drug Research
https://read.qxmd.com/read/27810158/clinical-outcomes-associated-with-a-failed-infant-car-seat-challenge
#3
Malika D Shah, Keith A Dookeran, Janine Y Khan
OBJECTIVE: To assess comorbid conditions and clinical outcomes among late preterm and low birth weight term infants (<2.5 kg) who failed the Infant Car Seat Challenge (ICSC) on the Mother-Baby Unit. STUDY DESIGN: This was a retrospective chart review of consecutive infants who failed ICSC on the Mother-Baby Unit and were subsequently admitted to the neonatal intensive care unit at Prentice Women's Hospital between January 1, 2009, and December 31, 2015. Regression models were used to estimate risk differences (RDs) with 95% CIs for factors related to length of stay...
January 2017: Journal of Pediatrics
https://read.qxmd.com/read/27649091/european-consensus-guidelines-on-the-management-of-respiratory-distress-syndrome-2016-update
#4
David G Sweet, Virgilio Carnielli, Gorm Greisen, Mikko Hallman, Eren Ozek, Richard Plavka, Ola Didrik Saugstad, Umberto Simeoni, Christian P Speer, Máximo Vento, Gerard H A Visser, Henry L Halliday
Advances in the management of respiratory distress syndrome (RDS) ensure that clinicians must continue to revise current practice. We report the third update of the European Guidelines for the Management of RDS by a European panel of expert neonatologists including input from an expert perinatal obstetrician based on available literature up to the beginning of 2016. Optimizing the outcome for babies with RDS includes consideration of when to use antenatal steroids, and good obstetric practice includes methods of predicting the risk of preterm delivery and also consideration of whether transfer to a perinatal centre is necessary and safe...
2017: Neonatology
https://read.qxmd.com/read/24140977/calcium-signaling-related-proteins-are-associated-with-broncho-pulmonary-dysplasia-progression
#5
Cinzia Magagnotti, Piero Giuseppe Matassa, Angela Bachi, Valentina Vendettuoli, Isabella Fermo, Maria Rosa Colnaghi, Rose Mary Carletti, Domenica Mercadante, Elena Fattore, Fabio Mosca, Annapaola Andolfo
UNLABELLED: Broncho-pulmonary dysplasia (BPD) is a chronic pulmonary disorder that follows premature birth. It is preceded by respiratory distress syndrome (RDS), characterized by acute respiratory failure due to deficiency of surfactant at birth. Clinical characteristics of infants affected by BPD have widely changed in the last decades: they are extraordinarly immature, with impaired alveolar and vascular lung development. To build up new therapeutic strategies for BPD babies, it is necessary to understand the pathogenic mechanisms, which are complicated by environmental risk factors and genetic predisposition...
December 6, 2013: Journal of Proteomics
https://read.qxmd.com/read/23736015/european-consensus-guidelines-on-the-management-of-neonatal-respiratory-distress-syndrome-in-preterm-infants-2013-update
#6
David G Sweet, Virgilio Carnielli, Gorm Greisen, Mikko Hallman, Eren Ozek, Richard Plavka, Ola D Saugstad, Umberto Simeoni, Christian P Speer, Maximo Vento, Henry L Halliday
Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report updated recommendations of a European Panel of expert neonatologists who developed consensus guidelines after critical examination of the most up-to-date evidence in 2007 and 2010. This second update of the guidelines is based upon published evidence up to the end of 2012. Strong evidence exists for the role of antenatal steroids in RDS prevention, but it is still not clear if the benefit of repeated courses on respiratory outcomes outweighs the risk of adverse outcomes in the short and long term...
2013: Neonatology
https://read.qxmd.com/read/23029875/effectiveness-of-treatment-with-surfactant-in-premature-infants-with-respiratory-failure-and-pulmonary-infection
#7
Giovanni Vento, M Tana, C Tirone, C Aurilia, A Lio, S Perelli, C Ricci, C Romagnoli
INTRODUCTION: Surfactant inactivation is present in neonatal pneumonia. MATERIALS AND METHODS: One hundred thirty-nine preterm babies with Birth Weight (BW) < or = 1250 grams were studied and subdivided in two groups: RDS Group, with a diagnosis of "simple" RDS (N 80) and RDS with Pneumonia Group, consisting of babies with a diagnosis of RDS and a positive BALF culture in the first 24-48 h of life (N 59). OUTCOMES: Surfactant administration seems less effective in the latter group, because a significantly higher number of infants needed a second dose of surfactant, compared to the patients suffering from RDS alone...
2012: Acta Bio-medica: Atenei Parmensis
https://read.qxmd.com/read/22564298/transient-tachypnea-of-the-newborn-the-treatment-strategies
#8
Murat Yurdakok, Eren Ozek
Transient tachypnea of the newborn results from delayed clearance of lung fluid and is a common cause of admission of full term and late preterm infants to neonatal intensive care units. The condition is particularly common after elective cesarean section. Conventional treatment involves supplemental oxygen, withholding enteral feeds and administration of intravenous fluids and antibiotics. Rarely, infants require CPAP and mechanical ventilation. Occasionally some babies develop severe hypoxemia and may require high concentrations of oxygen...
2012: Current Pharmaceutical Design
https://read.qxmd.com/read/22385056/transient-tachypnea-of-the-newborn-the-treatment-strategies
#9
Murat Yurdakok, Eren Ozek
Transient tachypnea of the newborn results from delayed clearance of lung fluid and is a common cause of admission of full term and late preterm infants to neonatal intensive care units. The condition is particularly common after elective cesarean section. Conventional treatment involves supplemental oxygen, withholding enteral feeds and administration of intravenous fluids and antibiotics. Rarely, infants require CPAP and mechanical ventilation. Occasionally some babies develop severe hypoxemia and may require high concentrations of oxygen...
February 27, 2012: Current Pharmaceutical Design
https://read.qxmd.com/read/22036228/congenital-chylothorax-in-a-late-preterm-infant-and-successful-treatment-with-octreotide
#10
Ning-Hui Foo, Yea-Shwu Hwang, Chin-Chuan Lin, Wen-Hui Tsai
Chylothorax is defined as abnormal accumulation of lymphatic fluid in the pleural space and is a rare condition in neonates. Chylothorax causes respiratory and nutritional problems and a significant mortality rate. Octreotide is a long-acting somatostatin analog that can reduce lymphatic fluid production and has been used as a new strategy in the treatment of chylothorax. Here, we report a premature baby with severe bilateral pleural effusion diagnosed by prenatal ultrasound and subsequently confirmed to be congenital chylothorax after birth...
October 2011: Pediatrics and Neonatology
https://read.qxmd.com/read/21125214/-comments-on-the-2010-guidelines-on-cardiopulmonary-resuscitation-of-the-european-resuscitation-council
#11
V Wenzel, S G Russo, H R Arntz, J Bahr, M A Baubin, B W Böttiger, B Dirks, U Kreimeier, M Fries, C Eich
ADULTS: Administer chest compressions (minimum 100/min, minimum 5 cm depth) at a ratio of 30:2 with ventilation (tidal volume 500-600 ml, inspiration time 1 s, F(I)O₂ if possible 1.0). Avoid any interruptions in chest compressions. After every single defibrillation attempt (initially biphasic 120-200 J, monophasic 360 J, subsequently with the respective highest energy), chest compressions are initiated again immediately for 2 min independent of the ECG rhythm. Tracheal intubation is the optimal method for securing the airway during resuscitation but should be performed only by experienced airway management providers...
December 2010: Der Anaesthesist
https://read.qxmd.com/read/20629494/surfactant-administration-for-neonatal-respiratory-distress-does-not-improve-lung-interstitial-fluid-clearance-echographic-and-experimental-evidence
#12
Luigi Cattarossi, Roberto Copetti, Besa Poskurica, Giuseppe Miserocchi
OBJECTIVE: Recent ultrasonographic studies suggest that the administration of surfactant to preterm infants with respiratory distress syndrome (RDS) does not affect lung water clearance. The purpose of the study was also to look at clearance of lung water in preterm rabbits receiving surfactant. METHODS: Lung ultrasound was performed in 73 neonates at different gestational ages (range 23-34 weeks) with radiological and clinical signs of RDS, before and after surfactant administration...
September 2010: Journal of Perinatal Medicine
https://read.qxmd.com/read/20551710/european-consensus-guidelines-on-the-management-of-neonatal-respiratory-distress-syndrome-in-preterm-infants-2010-update
#13
David G Sweet, Virgilio Carnielli, Gorm Greisen, Mikko Hallman, Eren Ozek, Richard Plavka, Ola D Saugstad, Umberto Simeoni, Christian P Speer, Henry L Halliday
Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report the updated recommendations of a European panel of expert neonatologists who had developed consensus guidelines after critical examination of the most up-to-date evidence in 2007. These updated guidelines are based upon published evidence up to the end of 2009. Strong evidence exists for the role of a single course of antenatal steroids in RDS prevention, but the potential benefit and long-term safety of repeated courses are unclear...
June 2010: Neonatology
https://read.qxmd.com/read/19685409/-gentamicin-intoxication-in-a-preterm-infant
#14
R Haase, U Lieser, S Butenhoff, N Merkel
Gentamicin is an aminoglycoside that is widely used in neonatology in spite of its known nephrotoxicity and ototoxicity. Because there are only few cases reported in the literature experience with gentamicin overdosage is limited. We report the case of a preterm (gestational age 32+2 weeks) infant with an accidental administration of a ten-fold dose of gentamicin. The baby was treated with a slight increase of fluid intake and monitoring of renal function and gentamicin levels, respectively. A rapid decrease of the gentamicin level (peak level 44...
August 2009: Zeitschrift Für Geburtshilfe und Neonatologie
https://read.qxmd.com/read/17480144/european-consensus-guidelines-on-the-management-of-neonatal-respiratory-distress-syndrome
#15
David Sweet, Giulio Bevilacqua, Virgilio Carnielli, Gorm Greisen, Richard Plavka, Ola Didrik Saugstad, Umberto Simeoni, Christian P Speer, Adolf Valls-I-Soler, Henry Halliday
Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report the recommendations of a European panel of expert neonatologists who developed consensus guidelines after critical examination of the most up-to-date evidence in 2007. Strong evidence exists for the role of antenatal steroids in RDS prevention, but it is not clear if repeated courses are safe. Many practices involved in preterm neonatal stabilization at birth are not evidence based, including oxygen administration and positive pressure lung inflation, and they may at times be harmful...
2007: Journal of Perinatal Medicine
https://read.qxmd.com/read/12802597/effects-of-the-plasticiser-dehp-on-lung-of-newborn-rats-catalase-immunocytochemistry-and-morphometric-analysis
#16
Roberta Magliozzi, Roberta Nardacci, Gianfranco Scarsella, Valeria Di Carlo, Stefania Stefanini
Experimental administration of di-(2-ethylexyl)-phthalate (DEHP), a plasticiser employed in the fabrication of polyvinyl chloride (PVC), causes increases in lipid metabolising enzymes along with marked peroxisomal proliferation. The effects are found in several mammalian tissues, of which the rodent liver is the most responsive target. Leakage of DEHP from PVC devices is favoured by high temperature and contact with lipid-containing biological fluids. Since preterm babies are currently ventilated through endotracheal PVC tubes, it seemed worthwhile to investigate DEHP effects on immature mammalian lung...
July 2003: Histochemistry and Cell Biology
https://read.qxmd.com/read/11253732/-treatment-of-posthemorrhagic-hydrocephalus-with-intraventricular-administration-of-recombinant-plasminogen-activator-rt-pa-and-dexamethasone-possible-prevention-of-permanent-shunt-implantation
#17
T Erler, H G Kläber
BACKGROUND: In spite of substantial advances in intensive care for extremely preterm babies, including continuous monitoring and minimal handling, prevention of intracerebral hemorrhage is not successful in some cases. Unless treated adequately, a progressive posthemorrhagical hydrocephalus leads to considerable impairment of neurological outcome. Several conservative treatment strategies have been published, but often fail to avoid a permanent ventriculoperitoneal shunt implantation with its possible complications...
January 2001: Zeitschrift Für Geburtshilfe und Neonatologie
https://read.qxmd.com/read/10868194/a-retrospective-study-on-16-collodion-babies
#18
A Oztürk, H Caksen, N Cetin, S Kurtoğlu
Sixteen collodion babies followed in the Neonatal Care Unit between January 1982 and December 1994 were evaluated retrospectively. The preterm/term ratio was 1.6, and complete shedding of the collodion membrane took an average of 21.9 days (range 18-46 days). Problems noted were marked temperature instability, defective barrier function, increased insensible water loss predisposing to hypernatremic dehydration, cutaneous infections and septicemia. Hypernatremia was observed in 11 (68.7%) and septic infection in seven patients (43...
January 1997: Turkish Journal of Pediatrics
https://read.qxmd.com/read/10771900/clinical-profile-and-management-of-pda-in-neonates
#19
C C Shanthala, P P Maiya, D Vishwanath, N Banakappa, P M Swamy, N Desai, Ravikishore, K H Srinivas
Patent ductus arteriosus (PDA) is recognised more often with increasing survival of preterm babies. The pharmacological closure of ductus by indomethacin has changed the management of PDA. Twenty neonates admitted over a period of 21 months to Neonatal Intensive Care Unit (NICU) of M.S. Ramaiah Medical College hospital, Bangalore, who were diagnosed to have PDA, were analyzed. The objectives of this retrospective analysis were to study the clinical profile, the efficacy of oral indomethacin and the outcome of PDA...
September 1997: Indian Journal of Pediatrics
https://read.qxmd.com/read/10596413/-superoxide-dismutase-and-catalase-activity-in-tracheobronchial-secretions-after-surfactant-treatment-of-newborn-infants-with-respiratory-distress-syndrome
#20
RANDOMIZED CONTROLLED TRIAL
A Schröder, E Herting, C P Speer
Oxygen toxicity and mechanical ventilation are main factors in the development of chronic lung disease in preterm infants. We examined two antioxidant enzymes, superoxide dismutase (SOD) and catalase, in tracheal fluid of preterm infants with severe respiratory distress syndrome (RDS) treated with surfactant. SOD and catalase catalyse the transformation of oxygen radicals and hydrogen peroxide to less toxic metabolites. 31 preterm infants were randomised to either single or multiple dose treatment with surfactant (Curosurf)...
September 1999: Zeitschrift Für Geburtshilfe und Neonatologie
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