Rasmus Offersen, Wen-Han Yu, Eileen P Scully, Boris Julg, Zelda Euler, Saheli Sadanand, Dario Garcia-Dominguez, Lu Zheng, Thomas A Rasmussen, Madeleine F Jennewein, Caitlyn Linde, Jessica Sassic, Giuseppe Lofano, Selena Vigano, Kathryn E Stephenson, Stephanie Fischinger, Todd J Suscovich, Mathias Lichterfeld, Douglas Lauffenburger, Erik S Rosenberg, Todd Allen, Marcus Altfeld, Richelle C Charles, Lars Østergaard, Martin Tolstrup, Dan H Barouch, Ole S Søgaard, Galit Alter
Changes in antibody glycosylation are linked to inflammation across several diseases. Alterations in bulk antibody galactosylation can predict rheumatic flares, act as a sensor for immune activation, predict gastric cancer relapse, track with biological age, shift with vaccination, change with HIV reservoir size on therapy, and decrease in HIV and HCV infections. However, whether changes in antibody Fc biology also track with reservoir rebound time remains unclear. The identification of a biomarker that could forecast viral rebound time could significantly accelerate the downselection and iterative improvement of promising HIV viral eradication strategies...
December 15, 2020: Cell Reports