keyword
https://read.qxmd.com/read/38528127/3d-bioprinting-based-dopamine-coupled-flexible-material-for-nasal-cartilage-repair
#1
JOURNAL ARTICLE
Wendan Jia, Zixian Liu, Zhuwei Ma, Peiyi Hou, Yanyan Cao, Zhizhong Shen, Meng Li, Hulin Zhang, Xing Guo, Shengbo Sang
INTRODUCTION: Since 3D printing can be used to design implants according to the specific conditions of patients, it has become an emerging technology in tissue engineering and regenerative medicine. How to improve the mechanical, elastic and adhesion properties of 3D-printed photocrosslinked hydrogels is the focus of cartilage tissue repair and reconstruction research. MATERIALS AND METHODS: We established a strategy for toughening hydrogels by mixing GelMA-DOPA (GD), which is prepared by coupling dopamine (DA) with GelMA, with HAMA, bacterial cellulose (BC) to produce composite hydrogels (HB-GD)...
March 25, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38454966/3d-printing-sequentially-strengthening-high-strength-natural-polymer-hydrogel-bilayer-scaffold-for-cornea-regeneration
#2
JOURNAL ARTICLE
Xiongfeng Nie, Yong Tang, Tengling Wu, Xinrui Zhao, Ziyang Xu, Rong Yang, Yage Sun, Bin Wu, Quanhong Han, Jingwen Hui, Wenguang Liu
3D printing of high-strength natural polymer biodegradable hydrogel scaffolds simultaneously resembling the biomechanics of corneal tissue and facilitating tissue regeneration remains a huge challenge due to the inherent brittleness of natural polymer hydrogels and the demanding requirements of printing. Herein, concentrated aqueous solutions of gelatin and carbohydrazide-modified alginate (Gel/Alg-CDH) are blended to form a natural polymer hydrogel ink, where the hydrazides in Alg-CDH are found to form strong hydrogen bonds with the gelatin...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38389497/structuring-and-shaping-of-mechanically-robust-and-functional-hydrogels-toward-wearable-and-implantable-applications
#3
REVIEW
Xiao-Qiao Wang, An-Quan Xie, Pengle Cao, Jian Yang, Wei Li Ong, Ke-Qin Zhang, Ghim Wei Ho
Hydrogels possess unique features such as softness, wetness, responsiveness, and biocompatibility, making them highly suitable for biointegrated applications that have close interactions with living organisms. However, conventional man-made hydrogels are usually soft and brittle, making them inferior to the mechanically robust biological hydrogels. To ensure reliable and durable operation of biointegrated wearable and implantable devices, mechanical matching and shape adaptivity of hydrogels to tissues and organs are essential...
February 23, 2024: Advanced Materials
https://read.qxmd.com/read/38381141/growth-of-double-network-tough-hydrogel-coatings-by-surface-initiated-polymerization
#4
JOURNAL ARTICLE
Yuhong Li, Junjie Liu, Qifang Zhang, Nan Hu, Zhouhu Jiang, Qianhua Kan, Guozheng Kang
Hydrogel coatings exhibit versatile applications in biomedicine, flexible electronics, and environmental science. However, current coating methods encounter challenges in simultaneously achieving strong interfacial bonding, robust hydrogel coatings, and the ability to coat substrates with controlled thickness. This paper introduces a novel approach to grow a double-network (DN) tough hydrogel coating on various substrates. The process involves initial substrate modification using a silane coupling agent, followed by the deposition of an initiator layer on its surface...
February 21, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38376773/photo-steered-rapid-and-multimodal-locomotion-of-3d-printed-tough-hydrogel-robots
#5
JOURNAL ARTICLE
Min Dong, Weixuan Liu, Chen Fei Dai, Dejin Jiao, Qing Li Zhu, Wei Hong, Jun Yin, Qiang Zheng, Zi Liang Wu
Hydrogels are an ideal material to develop soft robots. However, it remains a grand challenge to develop miniaturized hydrogel robots with mechanical robustness, rapid actuation, and multi-gait motions. Reported here is a facile strategy to fabricate hydrogel-based soft robots by three-dimensional (3D) printing of responsive and nonresponsive tough gels for programmed morphing and locomotion upon stimulations. Highly viscoelastic poly(acrylic acid- co -acrylamide) and poly(acrylic acid- co-N -isopropyl acrylamide) aqueous solutions, as well as their mixtures, are printed with multiple nozzles into 3D constructs followed by incubation in a solution of zirconium ions to form robust carboxyl-Zr4+ coordination complexes, to produce tough metallo-supramolecular hydrogel fibers...
February 20, 2024: Materials Horizons
https://read.qxmd.com/read/38360290/toughening-3d-printed-biomimetic-hydroxyapatite-scaffolds-polycaprolactone-based-self-hardening-inks
#6
JOURNAL ARTICLE
Laura Del-Mazo-Barbara, Linh Johansson, Francesco Tampieri, Maria-Pau Ginebra
The application of 3D printing to calcium phosphates has opened unprecedented possibilities for the fabrication of personalized bone grafts. However, their biocompatibility and bioactivity are counterbalanced by their high brittleness. In this work we aim at overcoming this problem by developing a self-hardening ink containing reactive ceramic particles in a polycaprolactone solution instead of the traditional approach that use hydrogels as binders. The presence of polycaprolactone preserved the printability of the ink and was compatible with the hydrolysis-based hardening process, despite the absence of water in the ink and its hydrophobicity...
February 13, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38105580/engineered-living-material-bioreactors-with-tunable-mechanical-properties-using-vat-photopolymerization
#7
JOURNAL ARTICLE
Gokce Altin-Yavuzarslan, Naroa Sadaba, Sierra M Brooks, Hal S Alper, Alshakim Nelson
3D-printed engineered living materials (ELM) are promising bioproduction platforms for agriculture, biotechnology, sustainable energy, and green technology applications. However, the design of these platforms faces several challenges, such as the processability of these materials into complex form factors and control over their mechanical properties. Herein, ELM are presented as 3D-printed bioreactors with arbitrary shape geometries and tunable mechanical properties (moduli and toughness). Poly(ethylene glycol) diacrylate (PEGDA) is used as the precursor to create polymer networks that encapsulate the microorganisms during the vat photopolymerization process...
December 17, 2023: Small
https://read.qxmd.com/read/38063822/3d-printing-of-robust-high-performance-conducting-polymer-hydrogel-based-electrical-bioadhesive-interface-for-soft-bioelectronics
#8
JOURNAL ARTICLE
Jiawen Yu, Rongtai Wan, Fajuan Tian, Jie Cao, Wen Wang, Qi Liu, Hanjun Yang, Jingcheng Liu, Ximei Liu, Tao Lin, Jingkun Xu, Baoyang Lu
Electrical bioadhesive interface (EBI), especially conducting polymer hydrogel (CPH)-based EBI, exhibits promising potential applications in various fields, including biomedical devices, neural interfaces, and wearable devices. However, current fabrication techniques of CPH-based EBI mostly focus on conventional methods such as direct casting, injection, and molding, which remains a lingering challenge for further pushing them toward customized practical bioelectronic applications and commercialization. Herein, 3D printable high-performance CPH-based EBI precursor inks are developed through composite engineering of PEDOT:PSS and adhesive ionic macromolecular dopants within tough hydrogel matrices (PVA)...
December 8, 2023: Small
https://read.qxmd.com/read/37878837/multifunctional-organohydrogels-for-ph-responsive-fluorescent-and-electrostimulus-writing
#9
JOURNAL ARTICLE
Siyu Yang, Qiuyan Luo, Chuanluan Guo, Jia Jiang, Xiaohong Wang, Juguo Dai, Dongxu Li, Kaibin He, Yiting Xu, Conghui Yuan, Weiang Luo, Lizong Dai
Hydrogels have attracted widespread attention in anticounterfeiting due to their unique physical/chemical properties and designability. However, hydrogels' poor mechanical properties and sluggish response to chemical stimuli pose challenges for their wide application. A fluorescent tough organohydrogel capable of freeform writing of information is reported in this work. By incorporation of the fluorescent monomer 7-methylacryloxy-4-methylcoumarin into the polyacrylamide network in a covalently cross-linked manner while intertwining with the carboxymethyl cellulose sodium network, a fluorescent tough organohydrogel with a dual-network structure is prepared...
October 25, 2023: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/37844272/dynamics-of-nanocomposite-hydrogel-alignment-during-3d-printing-to-develop-tissue-engineering-technology
#10
JOURNAL ARTICLE
Hao-Cheng Yu, Kun-Liang Hsieh, Tomoyasu Hirai, Ming-Chia Li
Taking inspiration from spider silk protein spinning, we developed a method to produce tough filaments using extrusion-based 3D bioprinting and salting-out of the protein. To enhance both stiffness and ductility, we have designed a blend of partially crystalline, thermally sensitive natural polymer gelatin and viscoelastic G-polymer networks, mimicking the components of spider silk. Additionally, we have incorporated inorganic nanoparticles as a rheological modifier to fine-tune the 3D printing properties. This self-healing nanocomposite hydrogel exhibits exceptional mechanical properties, biocompatibility, shear thinning behavior, and a well-controlled gelation mechanism for 3D printing...
October 16, 2023: Biomacromolecules
https://read.qxmd.com/read/37822915/collagen-fibril-like-injectable-hydrogels-from-self-assembled-nanoparticles-for-promoting-wound-healing
#11
JOURNAL ARTICLE
Shanshan Li, Xiaoyun Li, Yidi Xu, Chaoran Fan, Zhong Alan Li, Lu Zheng, Bichong Luo, Zhi-Peng Li, Baofeng Lin, Zhen-Gang Zha, Huan-Tian Zhang, Xiaoying Wang
Soft hydrogels are excellent candidate materials for repairing various tissue defects, yet the mechanical strength, anti-swelling properties, and biocompatibility of many soft hydrogels need to be improved. Herein, inspired by the nanostructure of collagen fibrils, we developed a strategy toward achieving a soft but tough, anti-swelling nanofibrillar hydrogel by combining the self-assembly and chemical crosslinking of nanoparticles. Specifically, the collagen fibril-like injectable hydrogel was subtly designed and fabricated by self-assembling methylacrylyl hydroxypropyl chitosan (HM) with laponite (LAP) to form nanoparticles, followed by the inter-nanoparticle bonding through photo-crosslinking...
February 2024: Bioactive Materials
https://read.qxmd.com/read/37810281/additive-manufacturing-of-engineered-living-materials-with-bio-augmented-mechanical-properties-and-resistance-to-degradation
#12
JOURNAL ARTICLE
Gokce Altin-Yavuzarslan, Sierra M Brooks, Shuo-Fu Yuan, James O Park, Hal S Alper, Alshakim Nelson
Engineered living materials (ELMs) combine living cells with polymeric matrices to yield unique materials with programmable functions. While the cellular platform and the polymer network determine the material properties and applications, there are still gaps in our ability to seamlessly integrate the biotic (cellular) and abiotic (polymer) components into singular material, then assemble them into devices and machines. Herein, we demonstrated the additive-manufacturing of ELMs wherein bioproduction of metabolites from the encapsulated cells enhanced the properties of the surrounding matrix...
June 12, 2023: Advanced Functional Materials
https://read.qxmd.com/read/37713590/incorporation-of-cell-adhesive-proteins-in-3d-printed-lipoic-acid-maleic-acid-poly-propylene-glycol-based-tough-gel-ink-for-cell-supportive-microenvironment
#13
JOURNAL ARTICLE
Hao Nguyen Tran, In Gul Kim, Jong Heon Kim, Amitava Bhattacharyya, Eun-Jae Chung, Insup Noh
In extrusion-based 3D printing, the use of synthetic polymeric hydrogels can facilitate fabrication of cellularized and implanted scaffolds with sufficient mechanical properties to maintain the structural integrity and physical stress within the in vivo conditions. However, synthetic hydrogels face challenges due to their poor properties of cellular adhesion, bioactivity, and bio-functionality. In the past few years, new compositions of hydrogel inks have been designed to address this limitation. We recently developed viscous MPLE hydrogel (poly(maleate-propylene oxide)-lipoate-poly(ethylene oxide)) that shows high-resolution printability, drug-controlled release, excellent mechanical properties with adhesiveness, and biocompatibility...
September 15, 2023: Macromolecular Bioscience
https://read.qxmd.com/read/37615397/3d-printing-of-interpenetrating-network-flexible-hydrogels-with-enhancement-of-adhesiveness
#14
JOURNAL ARTICLE
Lei Zhang, Huifeng Du, Xin Sun, Feng Cheng, Wenhan Lee, Jiahe Li, Guohao Dai, Nicholas Xuanlai Fang, Yongmin Liu
3D printing of hydrogels has been widely explored for the rapid fabrication of complex soft structures and devices. However, using 3D printing to customize hydrogels with both adequate adhesiveness and toughness remains a fundamental challenge. Here, we demonstrate mussel-inspired (polydopamine) PDA hydrogel through the incorporation of a classical double network (2-acrylamido-2-methylpropanesulfonic acid) PAMPS/(polyacrylamide) PAAm to achieve simultaneously tailored adhesiveness, toughness, and biocompatibility and validate the 3D printability of such a hydrogel into customized architectures...
August 24, 2023: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/37604908/rapid-fabrication-of-physically-robust-hydrogels
#15
JOURNAL ARTICLE
Bingkun Bao, Qingmei Zeng, Kai Li, Jianfeng Wen, Yiqing Zhang, Yongjun Zheng, Renjie Zhou, Chutong Shi, Ting Chen, Chaonan Xiao, Baihang Chen, Tao Wang, Kang Yu, Yuan Sun, Qiuning Lin, Yong He, Shantung Tu, Linyong Zhu
Hydrogel materials show promise for diverse applications, particular as biocompatible materials due to their high water content. Despite advances in hydrogel technology in recent years, their application is often severely limited by inadequate mechanical properties and time-consuming fabrication processes. Here we report a rapid hydrogel preparation strategy that achieves the simultaneous photo-crosslinking and establishment of biomimetic soft-hard material interface microstructures. These biomimetic interfacial-bonding nanocomposite hydrogels are prepared within seconds and feature clearly separated phases but have a strongly bonded interface...
August 21, 2023: Nature Materials
https://read.qxmd.com/read/37584171/3d-printable-thermo-responsive-self-healing-graphene-oxide-containing-self-assembled-hydrogels-formed-from-block-copolymer-wormlike-micelles
#16
JOURNAL ARTICLE
Qi Yue, Zhidong Luo, Xueyuan Li, Lee A Fielding
Graphene oxide (GO) containing block copolymer nanocomposite hydrogels formed from poly(glycerol monomethacrylate- block -hydroxypropyl methacrylate) (PGMA-PHPMA) wormlike micelles were prepared by either mixing GO and copolymer at low temperature or via in situ reversible addition-fragmentation chain-transfer (RAFT) polymerisation-induced self-assembly (PISA) of HPMA in the presence of a PGMA macromolecular chain-transfer agent and GO flakes. Hydrogels containing 15-25% w/w copolymer and 0 and 8% w/w GO, based on copolymer, were investigated and the maximum gel strength measured was ∼33 kPa for a 25% w/w copolymer gel prepared by in situ polymerisation and containing 2% w/w GO based on copolymer...
August 16, 2023: Soft Matter
https://read.qxmd.com/read/37555082/3d-printing-of-mechanically-tough-and-self-healing-hydrogels-with-carbon-nanotube-fillers
#17
JOURNAL ARTICLE
Soo A Kim, Yeontaek Lee, Kijun Park, Jae Park, Soohwan An, Jinseok Oh, Minkyong Kang, Yurim Lee, Yejin Jo, Seung-Woo Cho, Jungmok Seo
Hydrogels have the potential to play a crucial role in bioelectronics, as they share many properties with human tissues. However, to effectively bridge the gap between electronics and biological systems, hydrogels must possess multiple functionalities, including toughness, stretchability, self-healing ability, three-dimensional (3D) printability, and electrical conductivity. Fabricating such tough and self-healing materials has been reported, but it still remains a challenge to fulfill all of those features, and in particular, 3D printing of hydrogel is in the early stage of the research...
2023: International journal of bioprinting
https://read.qxmd.com/read/37530138/3d-printed-microstructured-ultra-sensitive-pressure-sensors-based-on-microgel-reinforced-double-network-hydrogels-for-biomechanical-applications
#18
JOURNAL ARTICLE
Jingxia Zheng, Guoqi Chen, Hailong Yang, Canjie Zhu, Shengnan Li, Wenquan Wang, Jiayuan Ren, Yang Cong, Xun Xu, Xinwei Wang, Jun Fu
Hydrogel-based wearable flexible pressure sensors have great promise in human health and motion monitoring. However, it remains a great challenge to significantly improve the toughness, sensitivity and stability of hydrogel sensors. Here, we demonstrate the fabrication of hierarchically structured hydrogel sensors by 3D printing microgel-reinforced double network (MRDN) hydrogels to achieve both very high sensitivity and mechanical toughness. Polyelectrolyte microgels are used as building blocks, which are interpenetrated with a second network, to construct super tough hydrogels...
August 2, 2023: Materials Horizons
https://read.qxmd.com/read/37457948/the-application-and-prospects-of-3d-printable-microgel-in-biomedical-science-and-engineering
#19
REVIEW
Chengcheng Du, Wei Huang, Yiting Lei
Three-dimensional (3D) bioprinting technology is one of the most advanced techniques currently applied in tissue engineering and regenerative medicine and has developed rapidly in the past few years. Despite many breakthroughs, there are still several challenges of 3D bioprinting technology awaiting to be addressed, and one of them is the urgency of optimizing bioinks (natural or synthetic hydrogel), which are critical elements in 3D bioprinting, for specific properties. Different from traditional hydrogels, microgels, which are a new type of bioink, are micron-sized gels with excellent mechanical and biological properties, which make them great candidates for applications in 3D bioprinting...
2023: International journal of bioprinting
https://read.qxmd.com/read/37417340/ultra-robust-high-adhesive-self-healing-and-photothermal-zwitterionic-hydrogels-for-multi-sensory-applications-and-solar-driven-evaporation
#20
JOURNAL ARTICLE
Youyou Chen, Chen Zhang, Rui Yin, Minghan Yu, Yijie Liu, Yaming Liu, Haoran Wang, Feihua Liu, Feng Cao, Guoqing Chen, Weiwei Zhao
Zwitterionic hydrogels have received considerable attention owing to their characteristic structures and integrating multifunctionality. However, the superhydrophilicity-induced poor mechanical properties severely hinder their potential applications. Besides, from the perspective of wide applications, zwitterionic hydrogels with integrated high mechanical properties, conductivity and multifunctionalities including self-adhesive, self-healing, and photothermal properties are highly desirable yet challenging...
July 7, 2023: Materials Horizons
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