Natalia Zeber-Lubecka, Maria Kulecka, Michalina Dabrowska, Katarzyna Baginska-Drabiuk, Maria Glowienka-Stodolak, Andrzej Nowakowski, Aneta Slabuszewska-Jozwiak, Bożena Bednorz, Ilona Jędrzejewska, Magdalena Piasecka, Jolanta Pawelec, Elzbieta Wojciechowska-Lampka, Jerzy Ostrowski
High-risk Human Papillomavirus (HR-HPV) genotypes, specifically HPV16 and HPV18, pose a significant risk for the development of cervical intraepithelial neoplasia and cervical cancer. In the multifaceted cervical microenvironment, consisting of immune cells and diverse microbiota, Lactobacillus emerges as a pivotal factor, wielding significant influence in both stabilizing and disrupting the microbiome of the reproductive tract. To analyze the distinction between the cervical microbiota and Lactobacillus-dominant/non-dominant status of HR-HPV and non-infected healthy women, sixty-nine cervical swab samples were analyzed, included 44 with HR-HPV infection and healthy controls...
2024: PloS One