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JOURNAL ARTICLE
R De Vitis, M Passiatore, G Barchetti, I Ceravolo, L Larocca, M Starnoni, F Federico, F Castri, G Taccardo
Primary lymphomas of peripheral nerves (PLPNs) are extremely rare and most commonly reported in lumbar nerves and have been found in only five cases in the upper extremities. We describe two patterns of presentation focusing on clinical, radiological, and pathological findings of two patients affected by primary multifocal lymphoma of the ulnar nerve without systemic involvement or other medical conditions. We report a case of extraneural lymphoma in a 72-years-old (patient #1) and a case of intraneural lymphoma in a 45-years old woman (Patient #2)...
February 2023: Georgian Medical News
#42
JOURNAL ARTICLE
H A Wonink, W J Kruithof, H S Goedee, A Beelen
BACKGROUND: Chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) are inflammatory neuropathies that can lead to considerable limitations in daily activities and in social participation. However, systematic evaluation of these self-reported limitations is lacking in the currently available studies. Understanding the impact of these diagnoses on patients' life is important to optimize management strategies. AIM: To systematically assess the self-reported limitations in activities and participation and determine associated factors...
April 10, 2023: European Journal of Neurology
#43
Pannathat Soontrapa, Christopher J Klein, P James B Dyck, Sarah E Berini, Ellen D McPhail, Moritz Binder, Pitcha Chompoopong, JaNean Engelstad, Kamal Shouman
Amyloid-like IgM deposition neuropathy is a distinct entity in the setting of IgM monoclonal gammopathy in which endoneurial perivascular entire IgM-particle accumulation leads to a painful sensory followed by motor peripheral neuropathy. We report a 77-year-old man presenting with progressive multiple mononeuropathies starting with painless right foot drop. Electrodiagnostic studies showed severe axonal sensory-motor neuropathy superimposed by multiple mononeuropathies. Laboratory investigations were remarkable for biclonal gammopathy of IgM kappa, IgA lambda and severe sudomotor and mild cardiovagal autonomic dysfunction...
May 2023: Neuromuscular Disorders: NMD
#44
JOURNAL ARTICLE
Pietro Emiliano Doneddu, Chiara Briani, Dario Cocito, Fiore Manganelli, Gian Maria Fabrizi, Sabrina Matà, Anna Mazzeo, Raffaella Fazio, Luana Benedetti, Marco Luigetti, Maurizio Inghilleri, Elisa Ruiu, Gabriele Siciliano, Giuseppe Cosentino, Girolama Alessandra Marfia, Marinella Carpo, Massimiliano Filosto, Giovanni Antonini, Francesca Notturno, Stefano Sotgiu, Laura Cucurachi, Claudia Dell'Aquila, Elisa Bianchi, Tiziana Rosso, Andrea Giordano, Marco Fernandes, Marta Campagnolo, Erdita Peci, Emanuele Spina, Matteo Tagliapietra, Martina Sperti, Luca Gentile, Camilla Strano, Francesco Germano, Marina Romozzi, Federica Moret, Ignazio Roberto Zarbo, Divina Valeria Viola, Elisa Vegezzi, Giorgia Mataluni, Stefano Cotti-Piccinelli, Luca Leonardi, Alessandra Carta, Eduardo Nobile-Orazio
BACKGROUND AND PURPOSE: The aim was to evaluate the risk of relapse after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, and its safety and tolerability, in patients with chronic inflammatory neuropathies. METHODS: In this multicenter, cohort and case-crossover study, the risk of relapse associated with SARS-CoV-2 vaccination was assessed by comparing the frequency of relapse in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) patients who underwent or did not undergo vaccination...
March 31, 2023: European Journal of Neurology
#45
JOURNAL ARTICLE
Joe Nemoto, Fumitaka Shimizu, Toshihiko Maeda, Hideaki Nishihara, Michiaki Koga, Takashi Kanda
OBJECTIVE: To clarify the clinical and long-term characteristics of multifocal motor neuropathy (MMN). METHODS: We retrospectively evaluated data from 8 consecutive MMN patients in Yamaguchi University Hospital from 2005 to 2020. Clinical information including dominant hand, occupations, hobbies, nerve conduction data, protein level in cerebrospinal fluid (CSF), responsiveness to intravenous immunoglobulin (IVIg) therapy as initial therapy as well as maintenance therapy were collected...
March 29, 2023: Rinshō Shinkeigaku, Clinical Neurology
#46
M Saucedo, L León-Cejas, C Marchesoni, A Pardal, R Reisin
INTRODUCTION: Multifocal motor neuropathy (MMN) is a chronic progressive immune-mediated neuropathy, predominantly involving upper limbs asymmetrically with electrophysiologic evidence of motor conduction block. The treatment of choice is immunoglobulin (Ig). Nevertheless, some patients may become resistant to treatment. We describe a patient with history of MMN who became resistant to gammaglobulin treatment but markedly improved using ultra-high doses of intravenous immunoglobulin. CASE REPORT: A 36-year-old woman with diagnosis of MMN...
March 16, 2023: Revista de Neurologia
#47
REVIEW
R Collet, M Caballero-Ávila, L Querol
Autoimmune neuropathies are a heterogeneous group of rare and disabling diseases in which the immune system targets peripheral nervous system antigens and that respond to immune therapies. This review focuses on Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, polyneuropathy associated with IgM monoclonal gammopathy, and autoimmune nodopathies. Autoantibodies targeting gangliosides, proteins in the node of Ranvier, and myelin-associated glycoprotein have been described in these disorders, defining subgroups of patients with similar clinical features and response to therapy...
March 10, 2023: Revue Neurologique
#48
JOURNAL ARTICLE
Buse Rahime Hasırcı Bayır, Miraç Ayşen Ünsal, Cansu Ağırcan, Tuba Cerrahoğlu Şirin, Onur Akan, Gizem Gürsoy, Tuğba Eyigürbüz, Dilara Mermi Dibek, Gönül Akdağ, Ayşe Deniz Elmalı, Ezgi Nazlı, Fatma Akkoyun Arıkan, Sezin Alpaydın Baslo, Dilek Ağırcan, Emel Oguz-Akarsu, Özdem Ertürk Çetin, Tülin Gesoğlu Demir, Esra Acıman Demirel, Doğa Vurallı, Şule Deveci, Tuba Tanyel, Füsun Mayda Domaç, Necdet Karlı, Sibel Velioğlu, Betül Baykan
BACKGROUND: Intravenous immune globulin (IVIg) is frequently used in some neurological diseases and is also the first-line therapy in Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy. We aimed to evaluate the frequency and characteristics of headaches, which is one of the most common side effects of IVIg treatment. METHODS: Patients who received IVIg treatment for neurological diseases were prospectively enrolled in 23 centers...
March 11, 2023: Neurological Sciences
#49
JOURNAL ARTICLE
Christian Schneider, Meike K Wassermann, Martin K R Svačina, Gilbert Wunderlich, Gereon R Fink, Helmar C Lehmann
INTRODUCTION/ AIMS: Non-systemic vasculitic neuropathy (NSVN) is characterized by a predominant lower-limb involvement in many patients. Motor unit changes in upper extremity muscles have not been investigated in this subgroup, but might be of interest to improve the understanding of the multifocal nature of the disease and counseling of patients on potential future symptoms. We aimed to investigate subclinical motor involvement in upper extremity muscles of patients with lower-limb predominant NSVN using the new motor unit number estimation (MUNE) method MScanFit...
March 11, 2023: Muscle & Nerve
#50
JOURNAL ARTICLE
Yuki Setoguchi, Akiko Hayashi, Ayami Kawada, Ayako Ibusuki, Daigo Yanaoka, Ryota Saito, Tomoko Ishibashi, Hiroaki Takimoto, Yoshihide Yamaguchi, Hirokazu Ohtaki, Hiroko Baba
Intravenous immunoglobulin (IVIg) has been used to treat inflammatory demyelinating diseases such as chronic inflammatory demyelinating polyneuropathy, Guillain-Barré syndrome, and multifocal motor neuropathy. Despite studies demonstrating the clinical effectiveness of IVIg, the mechanisms underlying its effects remain to be elucidated in detail. Herein, we examined the effects of IVIg on lysolecithin-induced demyelination of the sciatic nerve in a mouse model. Mice -administered with IVIg 1 and 3 days post-injection (dpi) of lysolecithin -exhibited a significantly decreased demyelination area at 7 dpi...
2023: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
#51
Xin Chu, Jie Dai, Hengxiang Cui, Hailin Shen, Qi Wu, Xiangyang Zhu, Baofeng Zhu
We discuss the involvement of nuclear genetic variants correlating to observed phenotype in this case study. In January 2020, the 19-year-old boy from Nantong, Jiangsu Province, China with epilepsy symptom was identified to have myelin loss in the motor and sensory nerves in the electromyogram examination. Brain magnetic resonance imaging (MRI) demonstrated high-intensity areas of small multifocal gray matter regions in the bilateral temporal, parietal, and occipital lobes. In the serum of the patient, the levels of lactate dehydrogenase (LDH) and lactic acid were higher than the normal range values in multiple tests...
December 2022: Iranian Journal of Public Health
#52
Kumar Saurabh, Reyaz Ahmad
Hereditary neuropathy with liability to pressure palsy (HNPP) is a genetic condition in which individuals develop recurrent nerve palsies due to nerve injury at susceptible anatomic sites. Because of its rarity, other diseases usually appear high in the differential list when the clinical presentation is suggestive. Here, we describe a case of HNPP initially thought of as radiculopathy and focal chronic inflammatory demyelinating polyneuropathy (CIDP). Only on close clinical examination, supportive electrodiagnostic tests, and recurrence with typical history, a diagnosis of HNPP was suspected and later confirmed by a genetic test...
January 2023: Curēus
#53
REVIEW
Stefano Tozza, Emanuele Spina, Aniello Iovino, Rosa Iodice, Raffaele Dubbioso, Lucia Ruggiero, Maria Nolano, Fiore Manganelli
Chronic dysimmune neuropathies encompass a group of neuropathies that share immune-mediated pathomechanism. Chronic dysimmune antibody-related neuropathies include anti-MAG neuropathy, multifocal motor neuropathy, and neuropathies related to immune attack against paranodal antigens. Such neuropathies exhibit distinguishing pathomechanism, clinical and response to therapy features with respect to chronic inflammatory demyelinating polyradiculoneuropathy and its variants, which represent the most frequent form of chronic dysimmune neuropathy...
December 23, 2022: Brain Sciences
#54
JOURNAL ARTICLE
Masateru Tajiri, Minori Kodaira, Katsuya Nakamura, Yoshiki Sekijima
No abstract text is available yet for this article.
January 15, 2023: Internal Medicine
#55
Alanood E Elterefi, Mahfoud Y Elbashari, Amani Alzaabi, Mohamed E Abouelnaga, Hesham Eissa
Myelin oligodendrocyte glycoprotein (MOG) antibodies have been identified in central nervous system inflammatory demyelinating disorders (MOG antibody disease), inclusive of optic neuritis, transverse myelitis, or acute disseminated encephalomyelitis. The association of MOG antibodies with combined central and peripheral demyelination (CCPD) is not clear. It has been reported in a few cases where MOG antibodies were detected in the serum of patients with chronic inflammatory demyelinating polyneuropathy. However, multifocal motor neuropathy with MOG antibodies is extremely rare...
December 2022: Curēus
#56
JOURNAL ARTICLE
Ágnes Patzkó, Gabriella Deli, Tamás Cseh, Zsuzsanna Beleznay, Lajos Nagy, Sándor Kéki, Andrea Mike, Endre Pál, Sámuel Komoly, Zsolt Illes, Alexandra Csongor, Zoltán Pfund
BACKGROUND AND PURPOSE: Multifocal motor neuropathy (MMN) is a rare, immune-mediated illness attacking ex-clusively motor nerves. It is known that oxidative stress is present in peripheral neuropathies, but it has not been investigated MMN. METHODS: We measured in our prospective study the L-arginine, symmetric and asymmetric dimethylarginine (SDMA, ADMA) serum concentrations of 10 patients and 10 controls before and after intravenous immunoglobulin treatment (IVIG), as markers of the L-arginine/NO pathway involved in chronic inflammation and oxidative stress...
November 30, 2022: Ideggyógyászati Szemle
#57
JOURNAL ARTICLE
Clare I Campbell, Rhona McGonigal, Jennifer A Barrie, Jolien Delaere, Laura Bracke, Madeleine E Cunningham, Denggao Yao, Tim Delahaye, Inge Van de Walle, Hugh J Willison
The involvement of the complement pathway in Guillain-Barré syndrome pathogenesis has been demonstrated in both patient biosamples and animal models. One proposed mechanism is that anti-ganglioside antibodies mediate neural membrane injury through the activation of complement and the formation of membrane attack complex pores, thereby allowing the uncontrolled influx of ions, including calcium, intracellularly. Calcium influx activates the calcium-dependent protease calpain, leading to the cleavage of neural cytoskeletal and transmembrane proteins and contributing to subsequent functional failure...
2022: Brain communications
#58
JOURNAL ARTICLE
Yeow-Hoay Koh, Yee-Hau Pang, Ee-Wei Lim
PURPOSE: We illustrate three patients with regional amyotrophic lateral sclerosis (ALS) variants and hope to improve accuracy in diagnosis for this scarce group of diseases. CASE REPORT: Amyotrophic lateral sclerosis (ALS) represents a broad spectrum of acquired and inherited neurodegenerative conditions involving the upper and motor neurons. Typical ALS remains a clinical diagnosis that is not hard to diagnose. Still, when it comes to atypical forms of ALS, the physicians may face some difficulties differentiating between atypical forms of ALS and other neurological diseases, such as multifocal motor neuropathy, chronic inflammatory demyelinating polyneuropathy, and spinal muscular atrophy...
March 30, 2023: Acta Neurologica Taiwanica
#59
JOURNAL ARTICLE
Almond Leung, Brendan John Arnold, Timothy Oliver Hodgson, Nicholas John Cutfield
Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae complex, causing skin and nerve lesions with potential for permanent disability. Leprosy can be overlooked in Western settings, as it is more prevalent in low-income and middle-income countries. We describe a 38-year-old woman with a 4-year history of progressive numbness of the left hand incorrectly diagnosed as multifocal acquired demyelinating sensory and motor neuropathy on the basis of clinical and neurophysiological findings. Treatment with empirical weekly corticosteroid followed by intravenous immunoglobulin resulted in the sudden development of a widespread rash; we then diagnosed borderline lepromatous leprosy on skin biopsy...
November 25, 2022: Practical Neurology
#60
LETTER
Soumya Sundaram, Vaibhav Tandon, Sruthi S Nair
No abstract text is available yet for this article.
December 1, 2022: Journal of Clinical Neuromuscular Disease
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