Judit Erdei, Andrea Tóth, Andrea Nagy, Benard Bogonko Nyakundi, Zsolt Fejes, Béla Nagy, László Novák, László Bognár, Enikö Balogh, György Paragh, János Kappelmayer, Attila Bácsi, Viktória Jeney
Intraventricular hemorrhage (IVH) is a frequent complication of prematurity that is associated with high neonatal mortality and morbidity. IVH is accompanied by red blood cell (RBC) lysis, hemoglobin (Hb) oxidation, and sterile inflammation. Here we investigated whether extracellular Hb, metHb, ferrylHb, and heme contribute to the inflammatory response after IVH. We collected cerebrospinal fluid (CSF) ( n = 20) from premature infants with grade III IVH at different time points after the onset of IVH. Levels of Hb, metHb, total heme, and free heme were the highest in CSF samples obtained between days 0 and 20 after the onset of IVH and were mostly non-detectable in CSF collected between days 41 and 60 of post-IVH...
2020: Frontiers in Immunology
Chan-Hyuk Park, Hyeong Ryu, Chang-Hwan Kim, Kyung-Lim Joa, Myeong-Ok Kim, Han-Young Jung
We report diffusion tensor tractography (DTT) of the corticospinal tract (CST) in a patient with paresis of all four limbs following subarachnoid hemorrhage (SAH) with intraventricular hemorrhage (IVH) after the rupture of an anterior communicating artery (ACoA) aneurysm rupture. The 73-year-old female was admitted to our emergency room in a semi-comatose mental state. After coil embolization-an acute SAH treatment-she was transferred to our rehabilitation department with motor weakness development, two weeks after SAH...
March 19, 2020: Brain Sciences
Frederick Adam Zeiler, Francois Mathieu, Miguel Aires Barros Monteiro, Ben Glocker, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Nino Stocchetti, Peter Smieleweski, Marek Czosnyka, Virginia Newcombe, David Menon
Recent single center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intra-cranial (IC) injury and worse cerebrovascular reactivity. The goal of this study is to further explore these associations using the prospective multi-center Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) high resolution data set (HR ICU). Using the CENTER-TBI HR ICU sub-study cohort, we evaluated those patients with both archived high-frequency digital physiology (100 Hz or higher), and the presence of a digital admission CT scan...
March 13, 2020: Journal of Neurotrauma
J Wu, Z H Wen, D D Liu, C F Wu, Y Zhang, L Zhang, Y L Xu, G Yang, C X Jing
Objective: To evaluate the relative safety of different ventilation methods regarding mortality and rates of complication, on neonatal respiratory distress syndrome (NRDS). Methods: Network Meta-analysis was used to collect data on randomized controlled trials of pulmonary ventilation strategies in preterm infants with a mean gestational age of less than 32 weeks. Diagnostic criteria on NRDS were published in the PubMed, Cochrane, Web of Science, EBSCO, and Springer Link databases from January 1986 to June 2018...
February 10, 2020: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Kefeng Luo, Guoqiang Jiang, Jinjin Zhu, Bin Lu, Jiye Lu, Kai Zhang, Xiumei Wang, Fu-Zhai Cui
To examine the clinical effects of a new bone cement composed of poly(methyl methacrylate) (PMMA) and mineralized collagen (MC) compared with pure PMMA bone cement in treating osteoporotic vertebral compression fractures (OVCFs) in patients aged over 80. In all, 32 cases using pure PMMA bone cement and 31 cases using MC-modified PMMA (MC-PMMA) bone cement for OVCFs between June 2014 and March 2016 were screened as PMMA group and MC-PMMA group, respectively, with an average age of over 80. The operation duration, intraoperative blood loss, hospital stay, oswestry disability index (ODI), visual analogue scale (VAS), anterior vertebral height (AVH), intermediate vertebral height (IVH) and posterior vertebral height (PVH) of injured vertebrae, vertebral computed tomography value, re-fracture rate of adjacent vertebrae, correction rate of spinal kyphotic angle and wedge-shaped vertebra angle and surgical complications were compared between the two groups...
February 2020: Regenerative Biomaterials
Giovana Figueira Rodrigues Vieira, José Fernando Guedes Correa
PURPOSE: Diffuse axonal injury (DAI) is the rupture of multiple axons due to acceleration and deceleration forces during a closed head injury. Most traumatic brain injuries (TBI) have some degree of DAI, especially severe TBI. Computed tomography (CT) remains the first imaging test performed in the acute phase of TBI, but has low sensitivity for detecting DAI, since DAI is a cellular lesion. The aim of this study is to search in the literature for CT signs, in the first 24 h after TBI, that may help to differentiate patients in groups with a better versus worst prognosis...
March 4, 2020: Neuroradiology
Awfa Aktham, Mohammed Maan AbdulAzeez, Samer S Hoz
Background: The incidence of intracerebral hematoma among patients with aneurysmal subarachnoid hemorrhage is up to third of the cases (12%-35%). The presence of an aneurysm with ICH negatively influences the patient's presentation, course, and outcome, and may be associated with an increased re-hemorrhage rate, vasospasm, cerebral edema, and hydrocephalus. Aneurysm obliteration and hematoma evacuation have been associated with a favourable outcome. Aim of Study: To explore the effectiveness and the prognostic factors for patients with middle cerebral artery aneurysm associated with intracerebral hematoma treated by early surgical clipping of the aneurysm with hematoma evacuation...
January 2020: Neurology India
Jonathan J Lee, Meng Huang, Jaime Guerrero, Virendra R Desai, Amanda Jenson, Ryan Austerman, Orlando Diaz, Gavin W Britz
BACKGROUND AND IMPORTANCE: Superior cerebellar artery (SCA) perforator aneurysms are extremely rare, with only one other case published in the literature. There is no conclusive management strategy for these aneurysms, although endovascular treatment, open surgical treatment with clipping, and antifibrinolytic administration with spontaneous thrombosis have all been discussed. CLINICAL PRESENTATION: A 61-yr-old male presented with intraventricular hemorrhage (IVH) primarily in the posterior fossa...
March 3, 2020: Operative Neurosurgery (Hagerstown, Md.)
Vaibhav Vagal, Simone U Venema, Tyler P Behymer, Eva A Mistry, Padmini Sekar, Russell P Sawyer, Lee Gilkerson, Charles J Moomaw, Mary Haverbusch, Elisheva R Coleman, Matthew L Flaherty, Carson Van Sanford, Robert J Stanton, Christopher Anderson, Jonathan Rosand, Daniel Woo
BACKGROUND: Intraventricular hemorrhage (IVH) and white matter lesion (WML) severity are associated with higher rates of death and disability in intracerebral hemorrhage (ICH). A prior report identified an increased risk of IVH with greater WML burden but did not control for location of ICH. We sought to determine whether a higher degree of WML is associated with a higher risk of IVH after controlling for ICH location. METHODS: Utilizing the patient population from 2 large ICH studies; the Genetic and Environmental Risk Factors for Hemorrhagic Stroke (GERFHS III) Study and the Ethnic/Racial Variations of Intracerebral Hemorrhage study, we graded WML using the Van Swieten Scale (0-1 for mild, 2 for moderate, and 3-4 for severe WML) and presence or absence of IVH in baseline CT scans...
February 28, 2020: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Yingfeng Wan, Feng Gao, Fenghui Ye, Weiming Yang, Ya Hua, Richard F Keep, Guohua Xi
BACKGROUND: Hydrocephalus is a common and major complication that affects outcome after intraventricular hemorrhage (IVH). While aging impacts the occurrence of hydrocephalus in patients with IVH this and the underlying mechanisms have received little attention. The present investigation, therefore, studied the impact of aging on hydrocephalus after IVH in a rat model. METHODS: Young and aged (3 and 18 months old, respectively) male Fischer 344 rats had an intraventricular injection of 200 μl autologous blood or saline...
February 28, 2020: Fluids and Barriers of the CNS
Evrim Kıray Baş, Ali Bülbül, Hülya Şirzai, Selda Arslan, Sinan Uslu, Vedat Baş, Umut Zubarioglu, Muhittin Celik, Mesut Dursun, Ömer Güran, Banu Kuran
Objective: To evaluate the impact of preterm birth on bone health in preschool children. Methods: A total of 166 preschool children (aged 7-8 years) born preterm ( n  = 86, <37-week gestation) and at term ( n  = 80, ≥37 weeks of gestation) in our hospital were included in this prospective cross-sectional study. Data on antenatal, perinatal, and early postnatal characteristics and maternal obstetric history were obtained from medical records. Bone densitometry data including total bone mineral content (BMC), bone mineral density (BMD; total, lumbar, and femoral), z-scores, and bone loss were collected for each participant...
February 26, 2020: Journal of Maternal-fetal & Neonatal Medicine
Dorothee Mielke, Kim Bleuel, Christine Stadelmann, Veit Rohde, Vesna Malinova
OBJECTIVE: The amount of extravasated blood is an established surrogate marker for subarachnoid hemorrhage (SAH) severity, which varies in different experimental SAH (eSAH) models. A comprehensive eSAH grading system would allow a more reliable correlation of outcome parameters with SAH severity. The aim of this study was to define a severity score for eSAH related to the Fisher-Score in humans. MATERIAL AND METHODS: SAH was induced in 135 male rats using the modified double hemorrhage model...
2020: PloS One
Mehmet Sinan Beksac, Ayse Korkmaz, Taner Kasapoglu, Pinar Ozdemir, Erdal Cosgun, Atakan Tanacan
Objective: To introduce the effect of a single course of betamethasone for pregnant women at risk of preterm delivery (PTD). Materials and methods: In this study, a single course of 12 mg Bethamethasone was administered twice in 24 h (between 24-34 gestational weeks) for antenatal corticosteroid prophylaxis. Four hundred ninety-three neonates fulfilled the inclusion criteria and they were categorized (259 singletons, 192 twins and 42 triplets who met the inclusion criteria) into two groups according to the utilization of antenatal corticosteroid as control ( n  = 202) and study ( n  = 291) groups...
February 24, 2020: Journal of Maternal-fetal & Neonatal Medicine
Vignan Yogendrakumar, Tim Ramsay, Dean A Fergusson, Andrew M Demchuk, Richard I Aviv, David Rodriguez-Luna, Carlos A Molina, Yolanda Silva, Imanuel Dzialowski, Adam Kobayashi, Jean-Martin Boulanger, Gord Gubitz, Padma Srivastava, Jayanta Roy, Carlos S Kase, Rohit Bhatia, Michael D Hill, Joshua N Goldstein, Dar Dowlatshahi
Background and Purpose- Definitions of significant hematoma expansion traditionally focus on changes in intraparenchymal volume. The presence of intraventricular hemorrhage (IVH) is a predictor of poor outcome, but current definitions of hematoma expansion do not include IVH expansion. We evaluated whether including IVH expansion to current definitions of hematoma expansion improves the ability to predict 90-day outcome. Methods- Using data from the PREDICT-ICH study (Predicting Hematoma Growth and Outcome in Intracerebral Hemorrhage Using Contrast Bolus CT), we compared a standard definition of hematoma expansion (≥6 mL or ≥33%) to revised definitions that includes new IVH development or expansion (≥6 mL or ≥33% or any IVH; ≥6 mL or ≥33% or IVH expansion ≥1 mL)...
February 6, 2020: Stroke; a Journal of Cerebral Circulation
Avadhesh Joshi, Manish Kumar, Grace Rebekah, Sridhar Santhanam
Background: Pneumothorax is a medical emergency and is associated with a significant increase in morbidity and mortality in newborns. It may lead to acute respiratory failure, systemic hypoperfusion, intraventricular hemorrhage (IVH), and death. There is a paucity of data from developing countries about the epidemiology of pneumothorax. Objective: This descriptive study was planned to study the clinical and epidemiological profile of hospitalized neonates with pneumothorax. Material and methods: In this retrospactive study neonates admitted to Neonatal Intensive Care Unit (NICU) from 1 January 2004 to 31 December 2016 were reviewed...
February 19, 2020: Journal of Maternal-fetal & Neonatal Medicine
Mihai Puia-Dumitrescu, Noelle Younge, Daniel K Benjamin, Katie Lawson, Cordelia Hume, Kennedy Hill, Jonathan Mengistu, Aryeona Wilson, Kanecia O Zimmerman, Kaashif Ahmad, Rachel G Greenberg
OBJECTIVE: To evaluate the most commonly used medications and in-hospital morbidities and mortality in infants born 22-24 weeks of gestation. STUDY DESIGN: Multicenter retrospective cohort study of infants born 22-24 weeks of gestation (2006-2016), without major congenital anomalies and with available medication data obtained from neonatal intensive care units managed by the Pediatrix Medical Group. RESULTS: This study included 7578 infants from 195 sites...
February 17, 2020: Journal of Perinatology: Official Journal of the California Perinatal Association
Brittnea Adcock, Sean Carpenter, John Bauer, Peter Giannone, Aric Schadler, Aftab Chishti, Mina Hanna
OBJECTIVE: Evaluate association between fluid balance and intraventricular hemorrhage (IVH). STUDY DESIGN: Retrospective review of infants <30 weeks gestation admitted to Kentucky Children's Hospital Neonatal Intensive Care Unit. RESULTS: Infants with acute kidney injury (AKI) had a 2.4-fold increased risk of IVH (OR 2.38, 95% CI 1.46-3.87) and a 3.5-fold increased risk of severe IVH (OR 3.45, 95% CI 1.98-6.04). Infants above birthweight on day 4 had a 1...
February 17, 2020: Journal of Perinatology: Official Journal of the California Perinatal Association
Samuel G McClugage, Nicholas M B Laskay, Brian N Donahue, Anastasia Arynchyna, Kathrin Zimmerman, Inmaculada B Aban, Elizabeth N Alford, Myriam Peralta-Carcelen, Jeffrey P Blount, Curtis J Rozzelle, James M Johnston, Brandon G Rocque
OBJECTIVE: Posthemorrhagic hydrocephalus of prematurity remains a significant problem in preterm infants. In the literature, there is a scarcity of data on the early disease process, when neurosurgeons are typically consulted for recommendations on treatment. Here, the authors sought to evaluate functional outcomes in premature infants at 2 years of age following treatment for posthemorrhagic hydrocephalus. Their goal was to determine the relationship between factors identifiable at the time of the initial neurosurgical consult and outcomes of patients when they are 2 years of age...
February 14, 2020: Journal of Neurosurgery. Pediatrics
Yukitomo Ishi, Shigeru Yamaguchi, Kanako C Hatanaka, Michinari Okamoto, Hiroaki Motegi, Hiroyuki Kobayashi, Shunsuke Terasaka, Kiyohiro Houkin
OBJECTIVE: The authors aimed to investigate genetic alterations in low-grade gliomas (LGGs) in pediatric and young adult patients presenting with spontaneous hemorrhage. METHODS: Patients younger than 30 years of age with a pathological diagnosis of World Health Organization (WHO) grade I or II glioma and who had undergone treatment at the authors' institution were retrospectively examined. BRAF V600E, FGFR1 N546/K656, IDH1 R132, IDH2 R172, and KIAA1549-BRAF (K-B) fusion genetic alterations were identified, and the presence of spontaneous tumoral hemorrhage was recorded...
February 14, 2020: Journal of Neurosurgery
Niké Posta, Éva Csősz, Melinda Oros, Dávid Pethő, László Potor, Gergő Kalló, Zoltán Hendrik, Katalin Éva Sikura, Gábor Méhes, Csaba Tóth, József Posta, György Balla, József Balla
The lysis of red blood cells was shown to occur in human ruptured atherosclerotic lesions and intraventricular hemorrhage (IVH) of the brain. Liberated cell-free hemoglobin was found to undergo oxidation in both pathologies. We hypothesize that hemoglobin-derived peptides are generated during hemoglobin oxidation both in complicated atherosclerotic lesions and IVH of the brain, triggering endothelial cell dysfunction. Oxidized hemoglobin and its products were followed with spectrophotometry, LC-MS/MS analysis and detection of the cross-linking of globin chains in complicated atherosclerotic lesions of the human carotid artery and the hemorrhaged cerebrospinal liquid of preterm infants...
February 13, 2020: Laboratory Investigation; a Journal of Technical Methods and Pathology
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