Jijia Hu, Zijing Zhu, Zongwei Zhang, Hongtu Hu, Qian Yang
AIMS: Steroidogenic acute regulatory (StAR)-related lipid transfer domain-3 (STARD3) is a sterol-binding protein that facilitates cholesterol transport between cellular organelles. Cholesterol accumulation in podocytes directly contributes to the pathogenesis of albuminuria and renal injury under the condition of diabetic kidney disease (DKD). The aim of this study is to determine the role of STARD3 on the intracellular distribution of cholesterol within podocytes. METHODS: In vivo and in vitro models of diabetes were performed...
May 14, 2024: Life Sciences
Rakesh B Daude, Rajendra Bhadane, Jigna S Shah
Chronic diabetes mellitus is reported to be associated with acute kidney injury. The enzyme histone deacetylase-2 (HDAC-2) was found to be upregulated in diabetes-related kidney damage. Alpha-cyperone (α-CYP) is one of the active ingredients of Cyperus rotundus that possesses antioxidant and anti-inflammatory effects. We evaluated the effect of α-CYP on improving oxidative stress and tissue inflammation following renal ischemia/reperfusion (I/R) injury in diabetic rats. The effect of α-CYP on HDAC-2 expression in renal homogenates and in the NRK-52E cell line was evaluated following renal I/R injury and high glucose conditions, respectively...
May 14, 2024: European Journal of Pharmacology
Salem Kaawele, Ahmed Fathy Elkeraie, Eman Youssef, Mohamed Elrggal, Mahmoud Elrggal, Rowan Zyada, Wessam Esmail
INTRODUCTION: Diabetic kidney disease (DKD) affects 30-40% of diabetic patients. The prevalence of non-diabetic kidney disease (NDKD) in patients with type 2 DM (T2D) in Egypt is unknown. This study aimed to assess the prevalence of NDKD in patients with T2D in Egypt. METHODS: In this cross-sectional study, we searched the data of patients with T2D who underwent a native kidney biopsy between January 2010 and December 2020 in a kidney pathology laboratory in Egypt...
May 16, 2024: Kidney & Blood Pressure Research
Jiaxin Li, Yi Yao, Xiaobao Lei, Jingna Bao, Sheng An, Hongbin Hu, Tong Sha, Qiaobing Huang, Tao Li, Zhenhua Zeng, Xiang Wang, Shumin Cai
Sepsis-induced acute kidney injury (SAKI) poses a significant clinical challenge with high morbidity and mortality. Excessive mitochondrial fission has been identified as the central pathogenesis of sepsis-associated organ damage, which is also implicated in the early stages of SAKI. Sirtuin 5 (SIRT5) has emerged as a central regulator of cellular mitochondrial function; however, its role in the regulation of sepsis-induced excessive mitochondrial fission in kidney and the underlying mechanism remains unclear...
May 15, 2024: Shock
Maria Siemionow, Krzysztof Bieda, Katarzyna Stawarz, Malgorzata Cyran, Lucile Chambily, Krzysztof Kusza
In recent years, cell-based therapies have emerged as a promising approach for mitigating radiation-induced injury. Acute radiation syndrome (ARS) results from exposure to high doses of radiation over a short time period. This study aimed to compare the efficacy of donor-recipient chimeric cell (DRCC) therapy in mitigating ARS induced by a total body irradiation (TBI) dose of 10 gray (Gy). Thirty irradiated Lewis rats were employed as ARS models to assess the efficacy of systemic-intraosseous transplantation of different cellular therapies in five experimental groups (n=6/group): saline control, isogeneic bone marrow transplantation (isoBMT), allogeneic BMT (alloBMT), DRCC, and alloBMT+DRCC...
May 16, 2024: Stem Cells and Development
Yulin Wang, Ziyan Shen, Shaocong Mo, Han Zhang, Jing Chen, Cheng Zhu, Shiqi Lv, Di Zhang, Xinhui Huang, Yulu Gu, Xixi Yu, Xiaoqiang Ding, Xiaoyan Zhang
The link between ferroptosis, a form of cell death mediated by iron and acute kidney injury (AKI) is recently gaining widespread attention. However, the mechanism of the crosstalk between cells in the pathogenesis and progression of acute kidney injury remains unexplored. In our research, we performed a non-negative matrix decomposition (NMF) algorithm on acute kidney injury single-cell RNA sequencing data based specifically focusing in ferroptosis-associated genes. Through a combination with pseudo-time analysis, cell-cell interaction analysis and SCENIC analysis, we discovered that proximal tubular cells, macrophages, and fibroblasts all showed associations with ferroptosis in different pathways and at various time...
May 16, 2024: Human Cell
Kashish Garg, Anand Kumar Jain, Ganesh Ramaji Nimje, Kamal Kajal
Acute liver failure (ALF) is a life-threatening condition characterized by rapid liver function deterioration, necessitating a multidisciplinary approach for optimal perioperative care. This comprehensive review focuses on the critical role of the anaesthesiologist throughout the preoperative, intraoperative, and postoperative phases, addressing the unique challenges posed by ALF. The article begins with an exploration of ALF, underlining the urgency of timely referral to specialized hepatology centres. Liver transplantation emerges as a life-saving intervention, and the complex decision-making process is discussed, emphasizing the need for a multidisciplinary team to assess transplantation candidacy based on established prognostic criteria...
May 16, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
Maryam Safari Samangani, Soghra Mehri, Tahereh Aminifard, Amirhossein Jafarian, Pooneh Fallah Yazdani, Hossein Hosseinzadeh
Rhabdomyolysis is a pathological condition caused by muscle tissue degradation. In this condition, intracellular contents enter the bloodstream, and acute kidney injury (AKI) develops. Verbascoside (VB) is one of the most common phenylethanoid glycosides and has antioxidant and anti-inflammatory effects. This study investigated the effects of VB on AKI induced by rhabdomyolysis in rats. Male Wistar rats were divided into six groups (n = 6): (1) control group (normal saline), (2) 50% glycerol (10 ml/kg, IM, single injection, only on the first day), (3)-(5) 50% glycerol (same as group 2) + VB (30, 60, and 100 mg/kg, IP, 4 days), and (6) VB (100 mg/kg)...
May 16, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
Ben J Lee, Tessa R Flood, Sophie L Russell, James J McCormick, Naoto Fujii, Glen P Kenny
PURPOSE: Prolonged work in the heat increases the risk of acute kidney injury (AKI) in young men. Whether aging and age-associated chronic disease may exacerbate the risk of AKI remains unclear. METHODS: We evaluated plasma neutrophil gelatinase-associated lipocalin (NGAL) and serum kidney injury molecule-1 (KIM1) before and after 180 min of moderate-intensity work (200 W/m2 ) in temperate (wet-bulb globe temperature [WBGT] 16 °C) and hot (32 °C) environments in healthy young (n = 13, 22 years) and older men (n = 12, 59 years), and older men with type 2 diabetes (T2D; n = 9, 60 years) or hypertension (HTN; n = 9, 60 years)...
May 16, 2024: European Journal of Applied Physiology
Bangchen Wang, Micah Schub, Derrick L Robinson, David N Howell
Glomerular deposition of monoclonal IgM, frequently in the form of intracapillary pseudothrombi, can be seen in Waldenström macroglobulinemia (WM) and type I cryoglobulinemia (CG). They are typically associated with plasma cell or B-lymphoid neoplasms, particularly lymphoplasmacytic lymphoma (LPL). While infection is a frequent trigger of mixed (type II and III) CG, its association with type I CG is uncommon. We report two cases in which striking lambda-chain-restricted IgM deposits and acute kidney injury (AKI) occurred in the setting of known or suspected systemic infections, with prompt resolution on treatment of the infection...
May 16, 2024: Ultrastructural Pathology
Jamie S Penk, Katja M Gist, Matthew Barhight, Karl Migally, Santiago Borasino, Wendy F Torres, Siyuan Dong, Bradley S Marino, Catherine D Krawczeski
INTRODUCTION: Acute kidney injury is associated with worse outcomes after cardiac surgery. The haemodynamic goals to ameliorate kidney injury are not clear. Low post-operative renal perfusion pressure has been associated with acute kidney injury in adults. Inadequate oxygen delivery may also cause kidney injury. This study evaluates pressure and oximetric haemodynamics after paediatric cardiac surgery and their association with acute kidney injury. MATERIALS AND METHODS: Retrospective case-control study at a children's hospital...
May 16, 2024: Cardiology in the Young
Faris Qaqish, Reem Dimachkie, Roula Sasso, Jeffrey Loeffler, Mohammed Hasan, Shabnam Deghani, Ahmad Abou Yassine, Liliane Deeb
Background Nonselective beta-blockers (NSBBs) have been used in the management of portal hypertension and the prevention of initial and recurrent variceal bleeding in patients with liver cirrhosis. However, there is controversy regarding the use of NSBBs in patients with decompensated cirrhosis (DC) due to concerns over potential adverse effects, such as worsening of hepatic function and risk of hepatorenal syndrome (HRS). HRS is a serious complication of DC characterized by acute kidney injury (AKI) and progressive renal failure, and its development can lead to significant morbidity and mortality in this setting...
April 2024: Curēus
Jiachuan Xiong, Jinghong Zhao
BACKGROUND: Acute kidney injury (AKI) is kidney damage that leads to a rapid decline in function. AKI primarily occurs when the tubular epithelium is damaged, causing swelling, loss of brush margin, and eventual apoptosis. Research has shown that tubular epithelial cell damage in AKI is linked to cell cycle arrest, autophagy, and regulation of cell death. SUMMARY: Pyroptosis, a type of programmed cell death triggered by inflammation, is believed to play a role in the pathophysiology of AKI...
April 2024: Kidney Diseases
Jiaying Li, Fangxing Hou, Ning Lv, Ruohuan Zhao, Lei Zhang, Cai Yue, Min Nie, Limeng Chen
BACKGROUND: Acute kidney injury (AKI) is a severe condition marked by rapid renal function deterioration and elevated mortality, with traditional biomarkers lacking sensitivity and specificity. Rare tubulointerstitial diseases encompass a spectrum of disorders, primarily including monogenic diseases, immune-related conditions, and drug-induced tubulointerstitial diseases. The clinical manifestations vary from electrolyte and acid-base imbalances to kidney function insufficiency, which is associated with AKI in up to 20% of cases...
April 2024: Kidney Diseases
Shai Ring, Alexander Llop, Harris Khawaja, Usman Khan, Muhammad Usman Khan
We present the case of an elderly female who presented to the emergency department with dizziness. She was found to have an acute chronic kidney injury complicated by a complete heart block (CHB). She received a transvenous pacemaker and was taken for hemodialysis (HD) with complete resolution of her heart block. The following day, she was noted to be symptomatic and bradycardic. A repeat electrocardiogram showed a recurrence of the CHB. She was taken again for HD which led to the resolution of her conduction abnormalities...
May 2024: Curēus
Igor Oliveira da Silva, Nicole K de Menezes, Heloisa D Jacobina, Antonio Carlos Parra, Felipe Lima Souza, Leticia Cardoso Castro, Joris J T H Roelofs, Alessandra Tammaro, Samirah Abreu Gomes, Talita Rojas Sanches, Lucia Andrade
No abstract text is available yet for this article.
May 15, 2024: Scientific Reports
Qiang Zhang, Yanxu Chen, Haiyue Yu, Jun Li, Chenglin Wu, Sizhe Long, Pengan Li, Qian Fu, Huanxi Zhang, Xiaojun Su, Bowen Xu, Longshan Liu, Changxi Wang
No abstract text is available yet for this article.
May 15, 2024: Chinese Medical Journal
Elisa Alba Schmidt, Silvia De Rosa, Jakob Müller, Paul Hüsing, Rikus Daniels, Pauline Theile, Nils Schweingruber, Stefan Kluge, Tobias B Huber, Kevin Roedl, Christian Schmidt-Lauber
BACKGROUND: The increasing admissions of very elderly patients to intensive care units (ICUs) over recent decades highlight a growing need for understanding acute kidney injury (AKI) in this population. Although these individuals are potentially at high risk for AKI and adverse outcomes, data on AKI in this population is scarce. This study investigates the AKI incidence and outcomes of critically-ill patients aging at least 90 years. METHODS: This retrospective cohort study conducted at the Department of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Germany (2008-2020), investigates AKI incidence and outcomes between 2008 and 2020 in critically-ill patients aged ≥ 90 years...
May 14, 2024: European Journal of Internal Medicine
Guanshi Zhang, Kumar Sharma
No abstract text is available yet for this article.
May 15, 2024: Journal of the American Society of Nephrology: JASN
Yong Kwon Han, Hui Jae Lim, GiBong Jang, Se Young Jang, Kwon Moo Park
BACKGROUND: Acute kidney injury (AKI) causes distant liver injury, to date, which causes poor outcomes of patients with AKI. Many studies have been performed to overcome AKI-associated liver injury. However, those studies have mainly focused on hepatocytes, and AKI-induced liver injury still remains a clinical problem. Here, we investigated the implication of cholangiocytes and their primary cilia which are critical in final bile secretion. Cholangiocyte, a lining cell of bile ducts, are the only liver epithelial cell containing primary cilium (a microtubule-based cell surface signal-sensing organelle)...
May 14, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
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