Difan Lu, Wenchao Mao
BACKGROUND: This study explored the efficacy of hydrocortisone combined with vitamin C and thiamine (HVT) in the treatment of sepsis/septic shock. METHODS: PubMed, EMBASE and Web of Science were searched (establishment of the database to October 31, 2022). The meta-analysis included randomized controlled trials (RCTs); comparing the efficacy of HVT regimen and placebo in the treatment of sepsis/septic shock. The Cochrane Handbook for Systematic Reviews of Interventions was used to assess the risk of bias...
March 26, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
Sandor Szabo, Oksana Zayachkivska, Alamdar Hussain, Veronika Muller
The previous acute respiratory diseases caused by viruses originating from China or the middle east (e.g., SARS, MERS) remained fast developing short diseases without major sequalae or any long-lasting complications. The new COVID-19, on the other hand, not only that it rapidly spread over the world, but some patients never fully recovered or even if they did, a few weeks later started to complain not only of shortness of breath, if any, but general weakness, muscle pains and 'brain fog', i.e., fuzzy memories...
March 25, 2023: Inflammopharmacology
Yang-Tian Yan, Hua-Min Liu, Yi-Fan Kong, Jia-Ming Liu, Cai Li, Bing-Cheng Zhao, Ke-Xuan Liu
PURPOSE: To examine the relationship between Neutrophil-Lymphocyte Ratio (NLR) and Acute Kidney Injury (AKI) in patients undergoing noncardiac surgery, and subgroup analysis was performed for different types of non-cardiac surgery. METHODS: The present retrospective cohort study included 10,159 adult patients who underwent major noncardiac surgery at Nanfang Hospital, Southern Medical University, between 2008 and 2018. Postoperative AKI was defined as an increase in serum creatinine level of at least 0...
March 25, 2023: International Urology and Nephrology
Qiang Wang, Shifang Li, Meifeng Sun, Junwei Ma, Jian Sun, Mingchao Fan
BACKGROUND: The systemic immune-inflammation index (SII) is an emerging prognostic marker of cancer. We aimed to explore the predictive ability of the SII on acute kidney injury (AKI) and prognosis in patients with spontaneous cerebral hemorrhage (SCH) who underwent craniotomy. METHODS: Patients with SCH who underwent craniotomy between 2014 and 2021 were enrolled in this study. The epidemiology and predictive factors for AKI after SCH were analyzed. The prognostic factors for clinical outcomes in patients with SCH and AKI were further investigated...
March 25, 2023: BMC Nephrology
Hyang-Yun Lee, Jungho Shin, Su-Hyun Kim, Jin Ho Hwang
BACKGROUND: Idiopathic systemic capillary leak syndrome (ISCLS) is a rare disease characterized by recurrent episodes of acute life-threatening attacks of shock, hemoconcentration, and hypoalbuminemia. Increase in capillary permeability results in reversible plasma movement into the interstitial spaces followed by appearance of related symptoms or complications, including renal failure. This condition can be potentially life-threatening; however, it is easily misdiagnosed. CASE PRESENTATION: A 47-year-old man with no previous medical history presented to the emergency department after experiencing general weakness and abdominal pain...
March 25, 2023: BMC Nephrology
Lingbo Zhang, Isaac Kumi Adu, Haifeng Zhang, Jiancheng Wang
BACKGROUND: The WNT/β-catenin system is an evolutionarily conserved signaling pathway that plays a crucial role in morphogenesis and cell tissue formation during embryogenesis. Although usually suppressed in adulthood, it can be reactivated during organ damage and regeneration. Transient activation of the WNT/β-catenin pathway stimulates tissue regeneration after acute kidney injury, while persistent (uncontrolled) activation can promote the development of chronic kidney disease (CKD)...
March 24, 2023: International Urology and Nephrology
Xiaotong Li, Liyuan Zhou, Martina Gaggl, Alan C Kinlaw, Zhuoyue Gou, Yang Xu, Jingkai Wei, Tiansheng Wang
BACKGROUND: Evidence about remdesivir-associated acute kidney injury (AKI) among patients with novel coronavirus disease 2019 (COVID-19) was controversial. AIM: To investigate the signal of disproportionate reporting of remdesivir-related AKI in COVID-19 patients over time with data from US Food and Drug Administration Adverse Event Reporting System. METHOD: Adverse events in COVID-19 patients reported between April 2020 and September 2022 were included...
March 24, 2023: International Journal of Clinical Pharmacy
Clarissa J Diamantidis, Lindsay Zepel, Valerie A Smith, M Alan Brookhart, Erin Burks, C Barrett Bowling, Matthew L Maciejewski, Virginia Wang
RATIONALE & OBJECTIVE: Community-acquired acute kidney injury (CA-AKI) develops outside of the hospital and is the most common form of AKI globally. National estimates of CA-AKI in the US are absent due to limited availability of lab data. This study leverages national data from the Veterans Health Administration (VA) to estimate incidence and risk factors of CA-AKI. STUDY DESIGN: Retrospective cohort study using national VA administrative and lab data to assess cumulative CA-AKI incidence...
March 22, 2023: American Journal of Kidney Diseases
Jialin Wang, Xiyang Liu, Yulu Gu, Yingying Gao, Vera Jankowski, Nina Was, Anna Leitz, Lucy K Reiss, Yiqin Shi, Jieru Cai, Yi Fang, Nana Song, Shuan Zhao, Jürgen Floege, Tammo Ostendorf, Xiaoqiang Ding, Ute Raffetseder
Open-heart surgery is associated with high morbidity, with acute kidney injury (AKI) being one of the most commonly observed postoperative complications. Following open-heart surgery, in an observational study we found significantly higher numbers of blood neutrophils in a group of 13 patients with AKI compared to 25 patients without AKI (AKI: 12.9±5.4 x109 cells/L; non-AKI: 10.1±2. 9 x109 cells/L). Elevated serum levels of neutrophil extracellular trap (NETs) components, such as dsDNA, histone 3, and DNA binding protein Y-box protein (YB)-1, were found within the first 24 hours in patients who later developed AKI...
March 22, 2023: Kidney International
Ha Ngoc Nguyen, Atsushi Yamada, Shigeyuki Naka, Ken-Ichi Mukaisho, Tohru Tani
OBJECTIVES: To assess the feasibility of off-clamp laparoscopic partial nephrectomy using microwave scissors. METHODS: We performed transperitoneal laparoscopic partial nephrectomy, without hilar clamping or renorrhaphy, using only microwave scissors for renal resection in a porcine model. For each kidney, 2 types of procedures were performed: a middle pole resection excising an area of 2-cm diameter and approximately 1-cm depth and a lower pole resection at the level of the lower polar line...
March 24, 2023: Surgical Innovation
Cyriac Abby Philips, Arif Hussain Theruvath, Resmi Raveendran, Rizwan Ahamed, Sasidharan Rajesh, Jinsha K Abduljaleel, Ajit Tharakan, Philip Augustine
During the coronavirus disease 2019 pandemic, Ayurvedic herbal supplements and homeopathic immune boosters (IBs) were promoted as disease-preventive agents. The present study examined the clinical outcomes among patients with chronic liver disease who presented with complications of portal hypertension or liver dysfunction temporally associated with the use of IBs in the absence of other competing causes. This single-center retrospective observational cohort study included patients with chronic liver disease admitted for the evaluation and management of jaundice, ascites, or hepatic encephalopathy temporally associated with the consumption of IBs and followed up for 180 days...
March 24, 2023: Medicine (Baltimore)
Dulce Maria Calvo, Luis Carlos Saiz, Leire Leache, Maria Concepción Celaya, Marta Gutiérrez-Valencia, Alvaro Alonso, Juan Erviti, Natalia Alzueta, Amaya Echeverría, Javier Garjón, Carmen Fontela, Lorea Sanz, Maria Teresa Acín, Maria Loreto Fernández, Nerea Gómez
PURPOSE: Concomitant use of diuretics, renin-angiotensin-aldosterone system (RAAS) inhibitors, and non-steroidal anti-inflammatory drugs (NSAIDs) or metamizole, known as "triple whammy" (TW), has been associated with an increased risk of acute kidney injury (AKI). Nevertheless, there is still uncertainty on its impact in hospitalisation and mortality. The aim of the study was to analyse the association between exposure to TW and the risk of hospitalisation for AKI, all-cause mortality and the need for renal replacement therapy (RRT)...
March 23, 2023: Pharmacoepidemiology and Drug Safety
Yun Yan, Hairong Gong, Jie Hu, Di Wu, Ziyu Zheng, Lini Wang, Chong Lei
BACKGROUND: Acute kidney injury (AKI) is a relevant complication after cardiac surgery and is associated with significant morbidity and mortality. Existing risk prediction tools have certain limitations and perform poorly in the Chinese population. We aimed to develop prediction models for AKI after valvular cardiac surgery in the Chinese population. METHODS: Models were developed from a retrospective cohort of patients undergoing valve surgery from December 2013 to November 2018...
2023: Frontiers in Cardiovascular Medicine
Peter R Corridon
The rising global incidence of acute and chronic kidney diseases has increased the demand for renal replacement therapy. This issue, compounded with the limited availability of viable kidneys for transplantation, has propelled the search for alternative strategies to address the growing health and economic burdens associated with these conditions. In the search for such alternatives, significant efforts have been devised to augment the current and primarily supportive management of renal injury with novel regenerative strategies...
2023: Frontiers in Medicine
Fortune O Alabi, Christopher O Alabi, Brent Waldon, Fred C Umeh, George Palmer
Hyperbilirubinemia is a common gastrointestinal complication seen post-cardiac surgery. Here, we describe a case of a 72-year-old male with a past medical history of chronic obstructive pulmonary disease, chronic kidney disease (CKD), pulmonary hypertension, and valvular heart disease with severe aortic stenosis, severe mitral and tricuspid regurgitations who underwent elective aortic valve replacement (AVR), mitral valve replacement (MVR), and tricuspid valve (TV) repair; in addition, he required left thoracotomy for the repair of pulmonary artery perforation from a Swan-Ganz catheter that resulted in a large left pleural bleed...
February 2023: Curēus
Kyu Kyu, Tin Ko Ko, Zin Mar Lwin, May Kyi Soe, Kyaw Win Maw, Aung Myo Thant, Kyi Shin, Moe Kyaw Myint
Introduction During the coronavirus disease 2019 (COVID-19) pandemic, private hospitals in Mandalay started to manage COVID-19 infections according to national treatment guidelines since February 2021. Variations of clinical characteristics and their outcomes in different surges could be evaluated in the private hospital. This study aimed to assess the clinical profile and outcomes of COVID-19 patients admitted at a private hospital during three surges in Mandalay. Methods This study is a retrospective record review of the case series of COVID-19 patients admitted at City Hospital, Mandalay...
February 2023: Curēus
Mariam Thalji, Hanan Qunibi, Loai Muhtasib, Hasan Hroob, Ashraf Al-Zughayyar, Rafiq Salhab, Yousef Abu Asbeh
Leptospirosis is a common zoonotic disease with a wide range of clinical manifestations, specifically in tropical regions. Weil's disease is considered a severe form of leptospirosis seen in a minority of leptospirosis cases with considerable mortality. These patients typically developed the triad of acute renal injury, jaundice, and hemorrhages. Herein, we reported a case of a 28-year-old male transferred to our intensive care unit due to severe leptospirosis with diffuse alveolar hemorrhage, cholestatic jaundice, acute respiratory distress, and renal injury...
2023: Frontiers in Surgery
Jia Hou, Jin-Feng Li, Xiu-Juan Yan, Yong-Liang Zhang, Meng-Yu Zhang, Yuan Zhang
OBJECTIVE: The purpose of this study was to analyze the improvement effect of clinical pharmacist intervention on renal function impairment in patients with antimicrobial-induced acute kidney injury (AKI). METHODS: A total of 145 patients with AKI caused by antibiotics admitted to the ICU department were selected as the research subjects. The patients were divided into the control group (n=57) and the intervention group (n=88) according to whether there were ICU specialist clinical pharmacists involved in clinical treatment...
2023: Patient Preference and Adherence
Pruthvi Prabhudev, Kusugodlu Ramamoorthi, Raviraja V Acharya
BACKGROUND: The elderly population in India is expected to increase to 319 million by 2050. Managing critically ill elderly patients in intensive care units (ICUs) is a difficult task. Proper planning and development of healthcare infrastructure are of prime importance to face this challenge. OBJECTIVES: To study the clinical profile and outcomes of elderly patients admitted to the medical ICUs. MATERIALS AND METHODS: A time-bound, prospective observational study on elderly patients admitted to medical ICUs for more than 48 hours was conducted from March 2019 to September 2020...
March 2023: Indian Journal of Critical Care Medicine
Bo Wang, Jun Xu, Ping Fu, Liang Ma
Sepsis is a potentially fatal complication of burns and trauma that can cause acute kidney injury (AKI) with substantial morbidity and mortality, but this disease is poorly understood. Despite medical advances, effective therapeutic regimens for septic AKI remain uncommon. MicroRNAs (miRNAs) are endogenous non-coding RNAs that influence the translation of target messenger RNAs in a variety of biological processes. Emerging evidence has shown that miRNAs are intimately associated with septic AKI. The goal of this review was to summarize recent advances in the profound understanding of the functional role of miRNAs in septic AKI, as well as to provide new insights into miRNAs as feasible biomarkers and therapeutic targets for septic AKI...
2023: Burns and Trauma
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