Jialin Wang, Xiyang Liu, Yulu Gu, Yingying Gao, Vera Jankowski, Nina Was, Anna Leitz, Lucy K Reiss, Yiqin Shi, Jieru Cai, Yi Fang, Nana Song, Shuan Zhao, Jürgen Floege, Tammo Ostendorf, Xiaoqiang Ding, Ute Raffetseder
Open-heart surgery is associated with high morbidity, with acute kidney injury (AKI) being one of the most commonly observed postoperative complications. Following open-heart surgery, in an observational study we found significantly higher numbers of blood neutrophils in a group of 13 patients with AKI compared to 25 patients without AKI (AKI: 12.9±5.4 x109 cells/L; non-AKI: 10.1±2. 9 x109 cells/L). Elevated serum levels of neutrophil extracellular trap (NETs) components, such as dsDNA, histone 3, and DNA binding protein Y-box protein (YB)-1, were found within the first 24 hours in patients who later developed AKI...
March 22, 2023: Kidney International