Aziz Belkadi, Gaurav Thareja, Darshana Dadhania, John R Lee, Thangamani Muthukumar, Catherine Snopkowski, Carol Li, Anna Halama, Sara Abdelkader, Silvana Abdulla, Yasmin Mahmoud, Joel Malek, Manikkam Suthanthiran, Karsten Suhre
Kidney transplantation is the treatment of choice for patients with end-stage kidney failure, but transplanted allograft could be affected by viral and bacterial infections and by immune rejection. The standard test for the diagnosis of acute pathologies in kidney transplants is kidney biopsy. However, noninvasive tests would be desirable. Various methods using different techniques have been developed by the transplantation community. But these methods require improvements. We present here a cost-effective method for kidney rejection diagnosis that estimates donor/recipient-specific DNA fraction in recipient urine by sequencing urinary cell DNA...
2021: PloS One
Raghad Buqaileh, Hannah Saternos, Sidney Ley, Arianna Aranda, Kathleen Forero, Wissam A AbouAlaiwi
A world-wide coronavirus pandemic is in full swing and, at the time of writing, there are only few treatments that have been successful in clinical trials, but no effective anti-viral treatment has been approved. Because of its lethality, it is important to understand the current strain's effects and mechanisms not only in the respiratory system, but in other affected organ systems as well. Past coronavirus outbreaks caused by SARS-CoV and MERS-CoV inflicted life-threatening acute kidney injuries (AKI) on their hosts leading to significant mortality rates, which went somewhat overlooked in the face of the severe respiratory effects...
April 15, 2021: Physiological Genomics
Sandra L Kane-Gill, Erin F Barreto, Azra Bihorac, John A Kellum
BACKGROUND: Goals of managing patients with acute kidney injury (AKI) are mitigating disease progression and ensuring safety while providing supportive care because no effective treatment exists. One strategy recommended in guidelines to meet these goals is optimizing medication management. Unfortunately, guideline implementation appears to be lacking as observed by the frequent occurrence of medication errors and adverse drug events. OBJECTIVE: To address this performance gap in the care of hospitalized patients receiving nephrotoxins and renally eliminated drugs, we sought to provide a potential intervention based on theory-informed behavior change...
April 15, 2021: Annals of Pharmacotherapy
Chelsey Chenxi Song, Andrew Brown, Ryan Winstead, Idris Yakubu, Moses Demehin, Dhiren Kumar, Gaurav Gupta
There is a paucity of data on the use of SGLT2 inhibitors on outcomes in kidney transplant recipients. There may be concern in initiating these agents, especially within the first year post-transplant when renal function is more labile and immunosuppression more intense, due to a presumed high risk of urinary infections and acute kidney injury. This is a retrospective study on 50 kidney transplant recipients, half of whom were started on therapy within the first year of transplant. Over a follow-up period of 6 months, overall patients had a statistically significant improvement in weight by -2...
April 2021: Endocrinology, Diabetes & Metabolism
Alexander H Flannery, Katie L Wallace, Christian N Rhudy, Allison S Olmsted, Rachel C Minrath, Stuart M Pope, Aaron M Cook, David S Burgess, Peter E Morris
Background: While vancomycin loading doses may facilitate earlier pharmacokinetic-pharmacodynamic target attainment, the impact of loading doses on clinical outcomes remains understudied. Critically ill patients are at highest risk of morbidity and mortality from methicillin resistant Staphylococcus aureus (MRSA) infection and hypothesized to most likely benefit from a loading dose. We sought to determine the association between receipt of a vancomycin loading dose and clinical outcomes in a cohort of critically ill adults...
January 2021: Therapeutic Advances in Infectious Disease
Patrick M Honore, Sebastien Redant, Keitiane Kaefer, Leonel Barreto Gutierrez, Luc Kugener, Rachid Attou, Andrea Gallerani, David De Bels
No abstract text is available yet for this article.
May 1, 2021: Critical Care Medicine
Maria Teresa Sciarrone Alibrandi, Marta Vespa, Giancarlo Joli, Romina Bucci, Elena Brioni, Rodolfo F Rivera
The SARS-CoV-2 (Covid-19) has infected about 124 million people worldwide and the total amount of casualties now sits at a staggering 2.7 million. One enigmatic aspect of this disease is the protean nature of the clinical manifestations, ranging from total absence of symptoms to extremely severe cases with multiorgan failure and death. Chronic Kidney Disease (CKD) has emerged as the primary risk factor in the most severe patients, apart from age. Kidney disease and acute kidney injury have been correlated with a higher risk of death...
April 14, 2021: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Divya A Ail, Arjun Prakash, Aditi Damle, Swathi Karottue, Roopa R Paulose
Introduction: Kayexalate (Sodium Polystyrene Sulfonate/SPS) and K-bind (Calcium Polystyrene Sulfonate/CPS) are cation exchange resins, commonly used for treatment of hyperkalaemia. SPS/CPS induced injury of the gastrointestinal tract(GIT) is rare, can be potentially life threatening but is under-recognized. This study aims to increase awareness of pathologists and clinicians of this under-reported complication of a drug commonly used to treat hyperkalaemia. Materials: Study population comprised patients with SPS/CPS (Kayexalate or its analogues) crystals identified in gastrointestinal specimens from 2017-2019 at a tertiary care centre...
April 2021: Indian Journal of Pathology & Microbiology
Olivier Mat, Lidia Ghisdal, Annick Massart, Selda Aydin, Ahmed Goubella, Niko Blankoff, Fabrice Gankam, Frédéric Debelle, Quentin Mat
No abstract text is available yet for this article.
April 8, 2021: KI Reports
Reham Z Hamza, Abdel Aziz A Diab, Mansour H Zahra, Ali K Asalah, Mai S Attia, Suzan Mm Moursi
Pre-eclampsia (PE) accompanying acute liver and kidney injury has remained a master cause of both fetal and maternal mortality and morbidity. Vasoactive mediators, oxidative stress and inflammatory imbalanceshave an important role in PE pathogenesis. Apelin is an adipokine that improves endothelial dysfunction; has anti-inflammatory and antioxidant effects; moreover, its level reduced during PE. This study aimed to explore the effects of apelin-13 administration on preeclampsia-associated renal dysfunction and proteinuria...
2021: PeerJ
Maurits Roorda, Jan Lj Miljkovic, Harry van Goor, Robert H Henning, Hjalmar R Bouma
Hydrogen sulfide (H2 S) has long been recognized as a putrid, toxic gas. However, as a result of intensive biochemical research in the past two decades, H2 S is now considered to be the third gasotransmitter alongside nitric oxide (NO) and carbon monoxide (CO) in mammalian systems. H2 S-producing enzymes are expressed in all organs, playing an important role in their physiology. In the kidney, H2 S is a critical regulator of vascular and cellular function, although the mechanisms that affect (sub)cellular levels of H2 S are not precisely understood...
April 2, 2021: Redox Biology
Hemindermeet Singh, Rajendra H Mehta, William O'Neill, Navin K Kapur, Thomas Lalonde, Magnus Ohman, Ioana Ghiu, Yen Chen-Hsing, Karey Dutcheshen, Theodore Schreiber, Howard Rosman, Amir Kaki
OBJECTIVES: To compare clinical features and outcomes in patients with acute myocardial infarction complicated by cardiogenic shock (AMICS) treated in the early experience with Impella percutaneous ventricular assist device and patients treated recently. BACKGROUND: Since pre-market approval (PMA) of Impella device as treatment for AMICS, use of the device has grown considerably. METHODS: We retrospectively analyzed 649 AMICS patients treated with perioperative Impella, with 291 patients treated from 2008 to 2014 comprising the early experience cohort and 358 patients treated from 2017 to 2019 comprising the recent experience cohort...
April 10, 2021: American Heart Journal
Steven L Flamm, Kimberly Brown, Hani M Wadei, Robert S Brown, Marcelo Kugelmas, Milagros Samaniego-Picota, Patrizia Burra, Fred Poordad, Sammy Saab
Acute kidney injury in the setting of cirrhosis (hepatorenal syndrome-acute kidney injury [HRS-AKI]) is a severe and often fatal complication of end-stage liver disease. The goals of treatment are to reverse renal failure and prolong survival in critically ill patients. However, interventions have limited efficacy, and mortality rates remain high. In the US, the mainstay of pharmacologic therapy consists of the off-label use of vasoconstrictive agents in combination with plasma expanders, a strategy that produces modest effects...
April 13, 2021: Liver Transplantation
Matthieu Jamme, Leopold Oliver, Julien Ternacle, Raphael Lepeule, Amina Moussafeur, Jean-Philippe Haymann, Sovannarith San, Antonio Fiore, Nicolas Mongardon, Michel Daudon, Pascal Lim, Emmanuel Letavernier
No abstract text is available yet for this article.
April 12, 2021: Nephrology, Dialysis, Transplantation
Rakesh Kumar Pilania, G V Venkatesh, Ritambhra Nada, Pandiarajan Vignesh, Ankur Kumar Jindal, Deepti Suri, Karalanglin Tiewsoh
Renal biopsy is an important diagnostic tool, though invasive and carries risks involved with sedation. The authors wanted to compare suspect histopathological diagnosis with final diagnosis and find out impact of biopsy findings on treatment. They retrospectively analyzed 108 patients. Details of patients, diagnosis, treatment and complications due to kidney biopsy were documented. Statistical analysis was done using SPSS version 20.0 (IBM, NY). Indications of 108 children (69 boys, 39 girls) undergoing renal biopsy were steroid-resistant nephrotic syndrome (35...
April 13, 2021: Indian Journal of Pediatrics
Craig S Brown, John R Montgomery, Pooja U Neiman, Glenn K Wakam, Thomas C Tsai, Justin B Dimick, John W Scott
Importance: Rehospitalization after major surgery is common and represents a significant cost to the health care system. Little is known regarding the causes of these readmissions and the degree to which they may be preventable. Objective: To evaluate the degree to which readmissions after major surgery are potentially preventable. Design, Setting, and Participants: This retrospective cohort study used a weighted sample of 1 937 354 patients from the 2017 National Readmissions Database to evaluate all adult inpatient hospitalizations for 1 of 7 common major surgical procedures...
April 1, 2021: JAMA Network Open
Chuanwen Shen, Shuying Tan, Jun Yang
BACKGROUND: To our knowledge, no meta-analyses or reviews have investigated the efficacy and safety of metformin on cardiovascular outcomes after acute myocardial infarction (AMI) in patients with type 2 diabetes mellitus (T2DM). We thus conduct a high-quality systematic review and meta-analysis to assess the efficacy and safety of metformin on cardiovascular outcomes after AMI in patients with T2DM. METHODS: In this systematic review and meta-analysis, we will search PUBMED, Scopus, EMBASE, and Cochrane Library databases through April, 2021...
April 16, 2021: Medicine (Baltimore)
Hongbin Hu, Lulan Li, Yuan Zhang, Tong Sha, Qiaobing Huang, Xiaohua Guo, Shengli An, Zhongqing Chen, Zhenhua Zeng
BACKGROUND: Sepsis-associated acute kidney injury (SA-AKI) is a common problem in critically ill patients and is associated with high morbidity and mortality. Early prediction of the survival of hospitalized patients with SA-AKI is necessary, but a reliable and valid prediction model is still lacking. METHODS: We conducted a retrospective cohort analysis based on a training cohort of 2066 patients enrolled from the Multiparameter Intelligent Monitoring in Intensive Care Database III (MIMIC III) and a validation cohort of 102 patients treated at Nanfang Hospital of Southern Medical University...
March 3, 2021: Shock
Giuliano Costa, Paola D'Errigo, Stefano Rosato, Roberto Valvo, Fausto Biancari, Corrado Tamburino, Francesco Cerza, Stefano Domenico Cicala, Fulvia Seccareccia, Marco Barbanti
OBJECTIVES: To compare clinical outcomes of balloon-expandable (BE) and self-expanding (SE) transcatheter aortic valves (TAVs) up to 5 years. BACKGROUND: To date, no robust, comparative data of BE and SE TAVs at long-term are available. METHODS: We considered a total of 1,440 patients enrolled in the multicenter OBSERVANT study and undergoing transfemoral transcatheter aortic valve implantation (TF-TAVI) with either supra-annular SE (n = 830, 57...
April 13, 2021: Catheterization and Cardiovascular Interventions
Ilkay Gulturk, Mesut Yilmaz, Aykut Ozmen, Seher Yıldız Tacar, Gülçin Sahingoz Erdal, Deniz Tural
INTRODUCTION: Among females, breast cancer is the most common type of cancer. Hormon receptor positive (HR+) subtype constitutes 75% of the diagnosed breast cancers. Combination of the cyclin D-cyclin-dependent kinase 4/6 (CDK4/6) inhibitor and endocrine therapy significantly improves overall survival and progression-free survival. Ribociclib is an oral CDK 4/6 inhibitor and some adverse effects are identified. According to MONALEESA 2-3-7 studies, no adverse effect (AE) were reported due to grade 3 or 4 acute kidney injury (AKI) that caused treatment discontinuation...
April 13, 2021: Journal of Oncology Pharmacy Practice
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