Danyu Li, Bing Liu, Yumei Fan, Ming Liu, Bihui Han, Yanxiu Meng, Xiao Xu, Zhiyuan Song, Xiaopeng Liu, Qiang Hao, Xianglin Duan, Akira Nakai, Yanzhong Chang, Pengxiu Cao, Ke Tan
BACKGROUND AND PURPOSE: Acute kidney injury (AKI) is a common clinical problem with no definitive or specific treatment. Therefore, the molecular mechanisms of AKI must be elicited to develop novel treatments. Nuciferine, a major bioactive compound isolated from the lotus leaf, possesses extensive pharmacological activities. Its effect on folic acid (FA)-induced AKI, however, remains unknown. Here we aimed to clarify the pharmacological effects of nuciferine and underlying mechanisms in AKI...
January 15, 2021: British Journal of Pharmacology