Kannan Sridharan, Shamik Shah, Ola Al Segai, Eman Mansoor, Mustafa Hamad, Eman Farid
BACKGROUND: Renal transplant patients receive several drugs concomitantly. OBJECTIVE: Limited literature exists evaluating the drug use in this population that is at high risk for drug-induced acute kidney injury and complications due to under-or over-dosage of immunosuppressant drugs due to drug-drug interactions. METHODS: A retrospective observational study was carried out in 269 renal transplant patients in whom either oral or parenteral drugs were evaluated...
November 15, 2022: International Journal of Risk & Safety in Medicine
Sophia Heinrich, Thomas Austgen, Darko Castven, Moritz Hess, Christian Labenz, Martha Kirstein, Carolin Zimpel, Lena Stockhoff, Benjamin Maasoumy, Bernd Heinrich, Hans Heinrich Wedemeyer, Peter Robert Galle, Harald Binder, Marc Nguyen-Tat, Jens Uwe Marquardt
BACKGROUND AND AIMS: Hepatorenal syndrome is a major complication in patients with cirrhosis and associated with high mortality. Predictive biomarkers for therapy response are largely missing. Cytokeratin18-based cell death markers are significantly elevated in patients with complications of chronic liver disease, but the role of these markers in patients with HRS treated with vasoconstrictors and albumin is unknown. METHODS: We prospectively analyzed a total of 138 patients with HRS, liver cirrhosis without HRS and acute kidney injury treated at the University Medical Center Mainz between April 2013 and July 2018...
November 28, 2022: United European Gastroenterology Journal
Subodha Waiddyanatha, Anjana Silva, Kosala Weerakoon, Sisira Siribaddana, Geoffrey K Isbister
BACKGROUND: There is limited information on the risk of chronic kidney disease (CKD) following snakebite and its relationship with chronic interstitial nephritis in agricultural communities (CINAC). We aimed to investigate CKD in patients with a confirmed snakebite in rural Sri Lanka. METHODS: Patients prospectively recruited to the Anuradhapura snakebite cohort with authenticated bites were followed up. Two groups of patients were followed up: 199 patients in group I with a snakebite (August 2013-October 2014), reviewed after 4 years, and 168 patients in group II with a snakebite (May 2017-August 2018), reviewed after one year, with serum creatinine (estimated glomerular filtration rate [eGFR]) and urinary albumin to creatinine ratio (ACR)...
November 28, 2022: Clinical Toxicology
Greta Codoni, Theresa Kirchner, Bastian Engel, Alejandra Maria Villamil, Cumali Efe, Albert Friedrich Stättermayer, Jan Philipp Weltzsch, Marcial Sebode, Christine Bernsmeier, Ana Lleo, Tom Jg Gevers, Limas Kupčinskas, Agustin Castiella, Jose Pinazo, Eleonora De Martin, Ingrid Bobis, Thomas Damgaard Sandahl, Federica Pedica, Federica Invernizzi, Paolo Del Poggio, Tony Bruns, Mirjam Kolev, Nasser Semmo, Fernando Bessone, Baptiste Giguet, Guido Poggi, Masayuki Ueno, Helena Jang, Gülsüm Özlem Elpek, Neşe Karadağ Soylu, Andreas Cerny, Heiner Wedemeyer, Diego Vergani, Giorgina Mieli-Vergani, M Isabel Lucena, Raul J Andrade, Yoh Zen, Richard Taubert, Benedetta Terziroli Beretta-Piccoli
BACKGROUND & AIMS: Liver injury with autoimmune features after vaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is increasingly reported. We investigated a large international cohort of individuals with acute hepatitis arising after SARS-CoV-2 vaccination, focusing on histological and serological features. METHODS: Individuals without known pre-existing liver diseases and transaminase levels ≥5x the upper limit of normal within 3 months after any anti-SARS-CoV-2 vaccine, and available liver biopsy were included...
January 2023: JHEP reports: innovation in hepatology
Fang Yan, Li Yuan, Fan Yang, Guicheng Wu, Xiaobo Jiang
In spite of the great progress in the management of critical diseases in recent years, its associated prevalence and mortality of multiple organ failure still remain high. As an endocrine hormone, fibroblast growth factor 21 (FGF21) functions to maintain homeostasis in the whole body. Recent studies have proved that FGF21 has promising potential effects in critical diseases. FGF21 has also been found to have a close relationship with the progression of critical diseases and has a great predictive function for organ failure...
2022: Frontiers in Cardiovascular Medicine
Erik M Anderson, Kyoungrae Kim, Brian J Fazzone, Kenneth C Harland, Qiongyao Hu, Zach Salyers, Victoria R Palzkill, Tomas A Cort, Eric M Kunz, Andrew J Martin, Dan Neal, Kerri A O'Malley, Scott A Berceli, Terence E Ryan, Salvatore T Scali
OBJECTIVE: Hand disability after hemodialysis access surgery has been common yet has remained poorly understood. Arteriovenous fistula (AVF) hemodynamic perturbations have not reliably correlated with the observed measures of hand function. Chronic kidney disease (CKD) is known to precipitate myopathy; however, the interactive influences of renal insufficiency and ischemia on limb outcomes have remained unknown. We hypothesized that CKD would contribute to access-related hand dysfunction via altered mitochondrial bioenergetics...
2022: Journal of vascular surgery. Vascular science
David R Hallan
Background There is debate over optimal systolic blood pressure (SBP) after traumatic subdural hematoma. Increased SBP has the benefit of increasing cerebral perfusion pressure and limiting the detrimental secondary effects of traumatic brain injury but poses a risk of hematoma expansion. While prior studies have shown that SBP<90mmHg is associated with worsened morbidity and mortality in subdural hematoma patients, clinical guidelines and expert opinion have differing initial SBP goals. The aim of this study is to leverage a large database to determine the effects of two such goals, namely SBP 100-150mmHg versus SBP<180mmHg in this patient population...
October 2022: Curēus
Young Rong Kim, Ha-Jin Chun, Jung Yeon Heo, Jin Sae Yoo, Young Hwa Choi, Eun Jin Kim
BACKGROUND: Current guidelines for the therapeutic monitoring of vancomycin recommend dosing based on the area under the concentration-time curve (AUC) to achieve clinical efficacy while reducing nephrotoxicity. Although a wide range of nephrotoxicity thresholds have been reported, few studies have documented clinical outcomes based on AUC-guided vancomycin dosing in Korea. OBJECTIVE: The aim of the study was to evaluate whether a relationship exists between AUC and treatment outcomes in vancomycin treated patients in methicillin-resistant Staphylococcus aureus bacteremia...
2022: Current Therapeutic Research, Clinical and Experimental
Allen Chung-Cheng Huang, Shu-Min Lin, Tzu-Hsuan Chiu, Ko-Wei Chang, Tse-Hung Huang, Tsung-Hsien Yang, Yi-Hsien Shiao, Chung-Shu Lee, Fu-Tsai Chung, Cheng-Hsun Chiu
Objective: Direct comparison of the clinical traits of coronavirus disease 2019 (COVID-19) in strain D614G, which originated from Wuhan, China, and the Alpha variant, which contains 17 mutations, infected patients could help physicians distinguish between strains and make clinical decisions accordingly. This study sought to compare the clinical characteristics and outcomes of the D614G strain and Alpha variant of SARS-COV-2 and identify the predictors for viral RNA clearance and in-hospital mortality in patients with COVID-19...
2022: International Journal of Medical Sciences
Zahra Sahraei, Ali Saffaei, Ilad Alavi Darazam, Jamshid Salamzadeh, Minoosh Shabani, Shervin Shokouhi, Najmeh Sarvmeili, Mohammadreza Hajiesmaeili, Masood Zangi
Purpose: Vancomycin is a narrow therapeutic window glycopeptide antibiotic that acts against Gram-positive bacteria. As it is renally eliminated, therapeutic drug monitoring is recommended for vancomycin, especially in case of kidney function alteration. Augmented renal clearance (ARC), defined as a creatinine clearance of more than 130 ml/min, is a risk factor for sub-therapeutic concentrations of vancomycin. This study aimed to evaluate the vancomycin pharmacokinetics following the administration of two different regimens in ARC patients...
2022: Frontiers in Pharmacology
Wen-Fang Chiang, Jenq-Shyong Chan, Po-Jen Hsiao, Shih-Hua Lin
Statin treatment for hypercholesterolemia may cause reversible rhabdomyolysis and acute kidney injury in susceptible patients. However, persistent rhabdomyolysis and acute kidney injury following discontinuation of statins require careful evaluation of the underlying causes to avoid missing a curable disease. We describe a 50-year-old woman with hypercholesterolemia [total cholesterol 345 mg/dl, low-density lipoprotein cholesterol (LDL-C) 266 mg/dL] on atorvastatin therapy (40 mg daily) for 1 month that presented with myalgia and muscle weakness...
2022: Frontiers in Medicine
Huanran Zhang, Yan Jiang, Nan Shi, Yuan-Qiang Lu
Numerous researches have evaluated the prevalence and clinical outcome of vitamin D deficiency in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). But the quantitative vitamin D status in acute kidney injury (AKI) patients and its relationship with prognosis remains controversial. We conducted this systemic review and meta-analysis to assess the quantitative difference of vitamin D status, including serum 25(OH) D and 1,25(OH)2D levels, between AKI patients and non-AKI controls, and further explore whether vitamin D status can be clearly correlated with the mortality of AKI...
November 27, 2022: Scientific Reports
Tao Wen, Zhi Mao, Chao Liu, Xiaoli Wang, Shufen Tian, Feihu Zhou
BACKGROUND: The incidence of acute kidney injury (AKI) is high in critically ill patients with rhabdomyolysis. Limited evidence was proved of the association between serum phosphate levels at intensive care unit (ICU) admission and the subsequent risk of AKI. Our study aims to assess if serum phosphate levels at admission were independently associated with AKI risk in these patients. METHODS: This study extracted and analyzed data from Medical Information Mart for Intensive Care-Ⅲ (MIMIC-Ⅲ, version1...
October 30, 2022: Injury
Yannick Hourmant, Donatien Huard, Dominique Demeure Dit Latte, Marwan Bouras, Karim Asehnoune, Romain Pirrachio, Antoine Roquilly
BACKGROUND: The objective was to determine the effects of continuous infusion of hypertonic saline solutions on patients with brain injury outcomes. METHODS: Preferred Reported Items for Systemic Reviews and Meta-Analysis guidelines were followed. We searched the MEDLINE and COCHRANE clinical trials register (through December 2021) and reference lists of articles. We included all clinical trials conducted in brain-injured patients hospitalized in intensive care units evaluating continuous infusion of hypertonic saline solution (osmolarity above 308 mmol/L)...
November 24, 2022: Anaesthesia, Critical Care & Pain Medicine
Sihong Zhang, Minke He, Yaohui Li, Peirong Xu, Jiaqi Huang, Jianming Guo, Hang Wang
OBJECTIVES: To find factors related to postoperative acute kidney injury (AKI) and long-term significant renal function (RF) loss after partial nephrectomy (PN) in Chinese population. METHODS: The main outcome was significant RF loss during the last follow-up, which was defined as >25% decrease in estimated glomerular filtration rate (eGFR). RESULTS: A total of 416 patients were included with median age as 57 (IQR 49.8-65.0) yr with body mass index (BMI) as 24...
November 24, 2022: Urology
Yipu Fan, Yihan Zhang, Kunyu Shi, Shan Cheng, Duanqing Pei, Xiaodong Shu
Ferroptosis induced by detrimental accumulation of lipid peroxides has been recently linked to a variety of pathological conditions ranging from acute tissue injuries to chronic degenerative diseases and suppression of ferroptosis by small chemical inhibitors is beneficial to the prevention and treatment of these diseases. However, in vivo applicable small chemical ferroptosis inhibitors are limited currently. In this study, we screened an alkaloid natural compound library for compounds that can inhibit RSL3-induced ferroptosis in HT1080 cells and identified a group of bisbenzylisoquinoline (BBIQ) compounds as novel ferroptosis-specific inhibitors...
November 26, 2022: Cell Death & Disease
Todd Leckie, Daniel Fitzpatrick, Alan J Richardson, Alex Hunter, Sonia Bains, Rachael Grimaldi, Rob Galloway, Lui G Forni, Luke E Hodgson
OBJECTIVES: Endurance exercise is known to cause a rise in serum creatinine. It is not known to what extent this rise reflects renal stress and a potential acute kidney injury (AKI). Increases in Insulin Like Growth Factor Binding Protein 7 (IGFBP7) and Tissue Inhibitor of Metalloprotinases-2 (TIMP-2), urinary biomarkers of cell cycle arrest and renal stress, are associated with the development of AKI in clinical populations. DESIGN: Repeated measures study. METHODS: Runners were recruited at the 2019 Brighton Marathon (UK) and provided urine and blood samples at baseline, immediately post-race and 24 h post-race...
October 24, 2022: Journal of Science and Medicine in Sport
Han E Eckenrode, J Caroline Carwie, Lisa M Curtis
Kidney health and manifestation of disease in transgender men, women, and nonbinary individuals are not well understood. Transgender individuals commonly receive gender-affirming hormone therapy (GAHT) to align their outward appearance with their gender. Recent attention to the differences in fundamental kidney parameters has identified that transgender individuals may manifest levels of these biomarkers differently than their cisgender counterparts. Improving understanding of the differences in biomarkers and in the development of kidney disease is essential to providing appropriate kidney care to this vulnerable population...
November 23, 2022: Seminars in Nephrology
Matthew D Cheung, Anupam Agarwal, James F George
Kidney resident macrophages (KRMs) are involved in homeostasis, phagocytosis, defense against infectious agents, response to insults, inflammation, and tissue repair. They also play critical roles in the pathogenesis and recovery from many kidney diseases such as acute kidney injury. KRMs historically have been studied as one homogenous population, but the wide-ranging roles and phenotypes observed suggest that there is greater heterogeneity than previously understood. Advancements in RNA sequencing technologies (single-cell RNA sequencing and spatial transcriptomics) have identified specific subsets of KRMs that are molecularly, functionally, and spatially distinct with dynamic changes after kidney injury...
November 23, 2022: Seminars in Nephrology
Steven Menez, Chirag R Parikh
Kidney involvement is common in coronavirus disease-2019 (COVID-19), and our understanding of the effects of COVID-19 on short- and long-term kidney outcomes has evolved over the course of the pandemic. Initial key questions centered on the spectrum and degree of acute kidney injury (AKI) in patients hospitalized with severe COVID-19. Investigators worldwide have explored the association between COVID-19-associated AKI and short-term outcomes, including inpatient mortality and disease severity. Even as treatments evolved, vaccinations were developed, and newer viral variants arose, subsets of patients were identified as at continued high risk for major adverse kidney outcomes...
October 19, 2022: Seminars in Nephrology
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