Abdulmajed Almutairi, Farhan Alenezi, Hani Tamim, Musharaf Sadat, Felwa Bin Humaid, Amal AlMatrood, Yadullah Syed, Yaseen Arabi
BACKGROUND: Community-acquired pneumonia (CAP) is a common reason for intensive care unit (ICU) admission and sepsis. Acute kidney injury (AKI) is a frequent complication of community-acquired pneumonia and is associated with increased short- and long-term morbidity and mortality and healthcare costs. OBJECTIVE: Describe the prevalence of AKI in patients with CAP requiring mechanical ventilation and evaluate its association with inhospital mortality. DESIGN: Retrospective cohort...
2024: Annals of Saudi Medicine
Boby Varkey Maramattom
A 28-year-old man was brought to the emergency department with quadriparesis of acute onset after a bout of binge drinking. Evaluation revealed a mid-cervical myelopathy and magnetic resonance imaging (MRI) showed an acute compressive cervical myelopathy. He also developed rhabdomyolysis, and cervical paraspinal muscles showed MRI hyperintensities. After resolution of rhabdomyolysis and acute kidney injury, he underwent cervical spine fixation. He was found to have acute dropped head syndrome with secondary compressive myelopathy...
September 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
Khin Kay Kay Kyaw
No abstract text is available yet for this article.
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
Lauren E Lee, Tomohito Doke, Dhanunjay Mukhi, Katalin Susztak
Kidney epithelial cells have very high energy requirements, which are largely met by fatty acid oxidation. Complex changes in lipid metabolism are observed in patients with kidney disease. Defects in fatty acid oxidation and increased lipid uptake, especially in the context of hyperlipidemia and proteinuria, contribute to this excess lipid build-up and exacerbate kidney disease development. Recent studies have also highlighted the role of increased de novo lipogenesis in kidney fibrosis. The defect in fatty acid oxidation will cause energy starvation...
April 11, 2024: Kidney International
Lara Fabiana Luz Malheiro, Mariana Masimessi Fernandes, Caroline Assunção Oliveira, Isadora de Souza Barcelos, Ana Jullie Veiga Fernandes, Bruna Santos Silva, Júlia Spínola Ávila, Telma de Jesus Soares, Liliany Souza de Brito Amaral
Regular exercise training can lead to several health benefits, reduce mortality risk, and increase life expectancy. On the other hand, a sedentary lifestyle is a known risk factor for chronic diseases and increased mortality. Acute kidney injury (AKI) and chronic kidney disease (CKD) represent a significant global health problem, affecting millions of people worldwide. The progression from AKI to CKD is well-recognized in the literature, and exercise training has emerged as a potential renoprotective strategy...
April 11, 2024: Life Sciences
Zengyu Xun, Tianqi Li, Xue Xue
Liposomes-microscopic phospholipid bubbles with bilayered membrane structure-have been a focal point in drug delivery research for the past 30 years. Current liposomes possess a blend of biocompatibility, drug loading efficiency, prolonged circulation and targeted delivery. Tailored liposomes, varying in size, charge, lipid composition, and ratio, have been developed to address diseases in specific organs, thereby enhancing drug circulation, accumulation at lesion sites, intracellular delivery, and treatment efficacy for various organ-specific diseases...
2024: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Anastasios Apostolos, Nikolaos Ktenopoulos, Dimitrios-David Chlorogiannis, Odysseas Katsaros, Konstantinos Konstantinou, Maria Drakopoulou, Sotirios Tsalamandris, Antonios Karanasos, Andreas Synetos, Georgios Latsios, Constantina Aggeli, Vasileios Panoulas, Costas Tsioufis, Konstantinos Toutouzas
Patients with severe aortic stenosis (AoS) often present with acute heart failure and compensation, frequently leading to cardiogenic shock. Transcatheter Aortic Valve Replacement (TAVR) has been recently performed as a bailout treatment in such patients. The aim of our meta-analysis is to compare urgent TAVR with elective procedures. We systematically screened three databases searching for studies comparing urgent vs elective TAVR. Primary endpoint is the 30-days mortality. Secondary endpoints included in-hospital mortality, device success, periprocedural vascular complications, 30-days stroke, 30-days acute kidney injury (AKI), permanent pacemaker implantation (PPM), moderate or severe paravalvular leakage, and 30-days bleeding...
April 13, 2024: Angiology
Taro Yasuma, Esteban C Gabazza
Tissue fibrosis is characterized by the excessive accumulation of extracellular matrix in various organs, including the lungs, liver, skin, kidneys, pancreas, and heart, ultimately leading to organ failure [...].
April 1, 2024: International Journal of Molecular Sciences
Jelena Nesovic Ostojic, Sanjin Kovacevic, Milan Ivanov, Predrag Brkic, Maja Zivotic, Nevena Mihailovic-Stanojevic, Danijela Karanovic, Una Jovana Vajic, Rada Jeremic, Djurdjica Jovovic, Zoran Miloradovic
The central exacerbating factor in the pathophysiology of ischemic-reperfusion acute kidney injury (AKI) is oxidative stress. Lipid peroxidation and DNA damage in ischemia are accompanied by the formation of 3-nitrotyrosine, a biomarker for oxidative damage. DNA double-strand breaks (DSBs) may also be a result of postischemic AKI. γH2AX(S139) histone has been identified as a potentially useful biomarker of DNA DSBs. On the other hand, hypoxia-inducible factor (HIF) is the "master switch" for hypoxic adaptation in cells and tissues...
March 30, 2024: International Journal of Molecular Sciences
Rajesh Nachiappa Ganesh, Gabriela Garcia, Luan Truong
The monocyte-macrophage lineage of inflammatory cells is characterized by significant morphologic and functional plasticity. Macrophages have broad M1 and M2 phenotype subgroups with distinctive functions and dual reno-toxic and reno-protective effects. Macrophages are a major contributor to injury in immune-complex-mediated, as well as pauci-immune, glomerulonephritis. Macrophages are also implicated in tubulointerstitial and vascular disease, though there have not been many human studies. Patrolling monocytes in the intravascular compartment have been reported in auto-immune injury in the renal parenchyma, manifesting as acute kidney injury...
March 28, 2024: International Journal of Molecular Sciences
Suhail Al-Salam, Govindan S Jagadeesh, Manjusha Sudhadevi, Javed Yasin
Acute kidney injury (AKI) is a public health burden with increasing morbidity and mortality rates and health care costs. Acute tubular necrosis (ATN) is the most common cause of AKI. Cisplatin (CIS) is a platinum-based chemotherapeutic agent used in the treatment of a wide variety of malignancies such as lung, breast, ovary, testis, bladder, cervix, and head and neck cancers. Autophagy plays an important role in AKI. Galectin-3 (Gal-3) is significantly increased in renal tubules in AKI; however, its role in autophagy is not well understood...
March 22, 2024: International Journal of Molecular Sciences
Dae Yong Park, Yasser Jamil, Yousif Ahmad, Theresa Coles, Hayden Barry Bosworth, Nikhil Sikand, Carlos Davila, Golsa Babapour, Abdulla A Damluji, Sunil V Rao, Michael G Nanna, Marc D Samsky
(1) Background : Cardiogenic shock (CS) is associated with high morbidity and mortality. Frailty and cardiovascular diseases are intertwined, commonly sharing risk factors and exhibiting bidirectional relationships. The relationship of frailty and non-acute myocardial infarction with cardiogenic shock (non-AMI-CS) is poorly described. (2) Methods : We retrospectively analyzed the National Inpatient Sample from 2016 to 2020 and identified all hospitalizations for non-AMI-CS. We classified them into frail and non-frail groups according to the hospital frailty risk score cut-off of 5 and compared in-hospital outcomes...
April 3, 2024: Journal of Clinical Medicine
Giulia Nardi, Enrico Marchi, Marco Allinovi, Gianmarco Lugli, Lucrezia Biagiotti, Francesca Maria Di Muro, Renato Valenti, Iacopo Muraca, Benedetta Tomberli, Niccolò Ciardetti, Brunetto Alterini, Francesco Meucci, Carlo Di Mario, Alessio Mattesini
(1) Background : This single-center retrospective study aimed to evaluate whether sodium-glucose cotransporter-2 inhibitors (SGLT2-i) therapy may have a nephroprotective effect to prevent contrast-induced acute kidney injury (CI-AKI) in patients with heart failure (HF) undergoing iodinated contrast medium (ICM) invasive procedures. (2) Methods : The population was stratified into SGLT2-i users and SGLT2-i non-users according to the chronic treatment with gliflozins. The primary endpoint was CI-AKI incidence during hospitalization...
April 1, 2024: Journal of Clinical Medicine
Claudia Brusasco, Giada Cucciolini, Andrea Barberis, Carlo Introini, Fabio Campodonico, Francesco Corradi
Post-operative acute kidney injury (PO-AKI) is a frequent complication described in 15% of non-cardiac surgeries, 30% of cardiac surgeries, and 52% of patients requiring intensive post-operative care [...].
March 29, 2024: Journal of Clinical Medicine
Nicoletta Mancianti, Sergio Antonio Tripodi, Alessandra Pascucci, Marta Calatroni, Edoardo La Porta, Andrea Guarnieri, Guido Garosi
Introduction : The combination therapy of platinum and pembrolizumab looks like a promising treatment in advanced non-small-cell lung cancer. However, both platinum-based chemotherapy and pembrolizumab can lead to AKI. AKI can occur due to acute tubular necrosis or interstitial nephritis. It is essential to identify the drug responsible for renal damage. For this purpose, we used new immunohistochemistry markers (p53 and anti-PD1 analysis). Case Description : A 77-year-old female patient with advanced non-small-cell lung cancer received the PD-1 inhibitor pembrolizumab and platinum-based chemotherapy carboplatin...
March 22, 2024: Journal of Clinical Medicine
Jacqueline Hui Fen Goh, Nian Chih Hwang
No abstract text is available yet for this article.
March 15, 2024: Journal of Cardiothoracic and Vascular Anesthesia
Kyle C White, Ary Serpa-Neto, Rod Hurford, Pierre Clement, Kevin B Laupland, Marlies Ostermann, Barnaby Sanderson, Michelle Gatton, Rinaldo Bellomo
PURPOSE: A positive fluid balance (FB) is associated with harm in intensive care unit (ICU) patients with acute kidney injury (AKI). We aimed to understand how a positive balance develops in such patients. METHODS: Multinational, retrospective cohort study of critically ill patients with AKI not requiring renal replacement therapy. RESULTS: AKI occurred at a median of two days after admission in 7894 (17.3%) patients. Cumulative FB became progressively positive, peaking on day three despite only 848 (10...
April 11, 2024: Journal of Critical Care
Fabian Jordan, Sven Knecht, Corinne Isenegger, Rebecca Arnet, Philipp Krisai, Gian Völlmin, Jeanne du Fay de Lavallaz, David Spreen, Stefan Osswald, Christian Sticherling, Michael Kühne, Patrick Badertscher
No abstract text is available yet for this article.
April 10, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Huailiang Wu, Liyan Wang, Peng Kang, Xiangjun Zhou, Wei Li, Zhongyuan Xia
BACKGROUND: Renal ischemia-reperfusion is the primary cause of acute kidney injury (AKI). Clinically, most patients who experience ischemia-reperfusion injury eventually progress gradually to renal fibrosis and chronic kidney disease (CKD). However, the underlying mechanism for AKI to CKD transition remain absent. Our study demonstrated that the downregulation of sirtuin 1 (Sirt1)-mediated fatty acid oxidation (FAO) facilitates IRI-induced renal fibrosis. METHODS: The IRI animal model was established, and ribonucleic acid (RNA) sequencing was used to explore potential differentially expressed genes (DEGs) and pathways...
April 11, 2024: International Immunopharmacology
Jiong Zhang, Qian Wei, Shu-Kun Wu, Fang Wang, Tong-Ling Yuan, Jia Wang
Acute kidney injury (AKI) is a critical complication known for their extremely high mortality rate and lack of effective clinical therapy. Disorders in mitochondrial dynamics possess a pivotal role in the occurrence and progression of contrast-induced nephropathy (CIN) by activating NLRP3 inflammasome. The activation of dynamin-related protein-1 (Drp1) can trigger mitochondrial dynamic disorders by regulating excessive mitochondrial fission. However, the precise role of Drp1 during CIN has not been clarified...
April 11, 2024: International Immunopharmacology
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