Yurong Feng, Shuai Xu, Haowei Guo, Tian-Bing Ren, Shuang-Yan Huan, Lin Yuan, Xiao-Bing Zhang
Acute kidney injury (AKI) is a common medical condition with high morbidity and mortality. Although urinalysis provides a noninvasive and convenient diagnostic method for AKI at the molecular level, the low sensitivity of current chemical probes used in urinalysis hinders the time diagnosis of AKI. Herein, we achieved the sensitive and early diagnosis of AKI by the development of a chemiluminescent probe CL-Pa suitable for detection of urinary Vanin-1. Vanin-1 is considered as an early and sensitive biomarker for AKI, while few chemical probes have been applied to for its efficient detection...
September 21, 2023: Analytical Chemistry
Kylie M Taylor, Amy Ym Au, Sanjeeva Herath, Lena Succar, Jasmine Wong, Jonathan Erlich, Zoltan H Endre
Significant loss of kidney function is not easily identified by serum creatinine (sCr)-based measurements. In the presence of normal sCr, decreased KFR may identify significant loss of function. We evaluated KFR in experimental subclinical chronic kidney disease (sCKD) before and after brief ischemia-reperfusion injury (IRI). Using fluorescein isothiocyanate (FITC)-labelled sinistrin, GFR was measured transcutaneously before and after adenine induced sCKD, and 1 and 2 weeks after brief IRI, and compared with urinary kidney damage biomarkers...
September 21, 2023: American Journal of Physiology. Renal Physiology
Xiying Hou, Binbin Cui, Andong Qiu, Na Liu, Shougang Zhuang
Mixed lineage leukemia 1 (MLL1) is a methyltransferase that induces histone H3 lysine 4 trimethylation (H3K4me3) and partially exerts its untoward functional effects by interacting with multiple subunits including Menin and WD repeat-containing protein 5 (WDR5). In this study, we investigated the role and mechanisms of MLL1 in murine models of acute kidney injury (AKI) induced by folic acid (FA) and ischemia/reperfusion (I/R). Injury to the kidney elevated expression of MLL1, Menin, WDR5 and H3K4Me3, which was accompanied by increased serum creatinine (Scr) and blood urea nitrogen (BUN), renal tubular injury and apoptosis...
September 21, 2023: American Journal of Physiology. Renal Physiology
Marta Kelava, Adam J Milam, Junhui Mi, Andrej Alfirevic, Patrick Grady, Shinya Unai, Haytham Elgharably, Kenneth McCurry, Marijan Koprivanac, Andra Duncan
BACKGROUND: Arterial hyperoxemia may cause end-organ damage secondary to the increased formation of free oxygen radicals. The clinical evidence on postoperative lung toxicity from arterial hyperoxemia during cardiopulmonary bypass (CPB) is scarce, and the effect of arterial partial pressure of oxygen (Pao2) during cardiac surgery on lung injury has been underinvestigated. Thus, we aimed to examine the relationship between Pao2 during CPB and postoperative lung injury. Secondarily, we examined the relationship between Pao2 and global (lactate), and regional tissue malperfusion (acute kidney injury)...
September 21, 2023: Anesthesia and Analgesia
Sundar Jagannath, Mark A Anderson, Andrew J Yee, Robert P Hasserjian
New England Journal of Medicine, Volume 389, Issue 12, Page 1133-1143, September 2023.
September 21, 2023: New England Journal of Medicine
Rebecca E Hay, Simon J Parsons, Andrew W Wade
BACKGROUND: Acute kidney injury (AKI) is a recognized comorbidity in pediatric diabetic ketoacidosis (DKA), although the exact etiology is unclear. The unique physiology of DKA makes dehydration assessments challenging, and these patients potentially receive excessive amounts of intravenous fluids (IVF). We hypothesized that dehydration is over-estimated in pediatric DKA, leading to over-administration of IVF and hyperchloremia that worsens AKI. METHODS: Retrospective cohort of all DKA inpatients at a tertiary pediatric hospital from 2014 to 2019...
September 21, 2023: Pediatric Nephrology
Li Zhang, Chong-Sen Zang, Bin Chen, Yu Wang, Shuai Xue, Mei-Yan Wu
Diabetic nephropathy (DN) is an important complication of diabetes and the leading cause of end-stage renal disease globally. Renal tubular damage occurs to varying degrees in the early stages of DN prior to glomerular damage. Renalase (RNLS) is an amine oxidase, which is produced and secreted by the renal tubular epithelial cells. RNLS is reportedly closely related to renal tubular injury in acute and chronic kidney diseases. Herein, we aimed to evaluate the changes in tubular RNLS expression in DN and its correlation with DN-associated renal tubular injury...
October 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Jingjing Min, Qi Chen, Mengxiong Pan, Tan Liu, Qun Gu, Dongwei Zhang, Ru Sun
Renal ischemia-reperfusion (I/R) injury leads to irreversible brain damage with serious consequences. Activation of oxidative stress and release of inflammatory mediators are considered potential pathological mechanisms. Butylphthalide (NBP) has anti-inflammatory and antioxidant effects on I/R injuries. However, it is unclear whether NBP can effectively mitigate renal I/R secondary to brain injury as well as its mechanism, which are the aims of this study. Both renal I/R injury rats and oxygen and glucose deprivation cell models were established and pre-intervened NBP...
2023: Renal Failure
Jiacheng He, Lijie Gao, Lifeng Mai
Research on the relationship between the weight-adjusted skeletal muscle mass index and all-cause mortality is rare, and even rarer is the relationship between the creatinine/body weight (Cre/BW) ratio and all-cause mortality. Therefore, this study aimed to investigate the relationship between the Cre/BW ratio and mortality in individuals with normal renal function. This prospective study used data from the National Health and Nutrition Examination Survey (NHANES) database. A Cox hazard model was used to analyze the relationship between the Cre/BW ratio and mortality risk...
2023: Renal Failure
Wenwu Tang, Ying Zhang, Zhixin Wang, Xinzhu Yuan, Xiaoxia Chen, Xiaohua Yang, Zhirui Qi, Ju Zhang, Jie Li, Xisheng Xie
BACKGROUND: Heart failure (HF) in patients undergoing maintenance hemodialysis (MHD) increases their hospitalization rates, mortality, and economic burden significantly. We aimed to develop and validate a predictive model utilizing contemporary deep phenotyping for individual risk assessment of all-cause mortality or HF hospitalization in patients on MHD. MATERIALS AND METHODS: A retrospective review was conducted from January 2017 to October 2022, including 348 patients receiving MHD from four centers...
2023: Renal Failure
Jinlan Liao, Qijie Wei, Yingying He, Yumei Liao, Zibo Xiong, Qing Wang, Dayong Ding, Xiaoyan Huang, Zuying Xiong, Yonggui Wu
Objective: Previous studies have shown a relationship between retinopathy and cognition including population with and without chronic kidney disease (CKD) but data regarding peritoneal dialysis (PD) are limited. This study aims to investigate the relationship between retinopathy and cognitive impairment in patients undergoing peritoneal dialysis (PD). Methods: In this observational study, we recruited a total of 107 participants undergoing PD, consisting of 48 men and 59 women, ages ranging from 21 to 78 years...
2023: Renal Failure
Ákos Géza Pethő, Péter Kevei, Márk Juha, Ágnes Kóczy, Nóra Ledó, András Tislér, István Takács, Ádám G Tabák
Due to effective vaccinations, the COVID-19 (coronavirus disease 2019) infection that caused the pandemic has a milder clinical course. We aimed to assess the mortality of hospitalized COVID-19 patients before the vaccination era. We investigated the mortality in those patients between 1 October 2020 and 31 May 2021 who received hemodialysis treatment [patients with previously normal renal function (nCKD), patients with chronic kidney disease previously not requiring hemodialysis (CKDnonHD), chronic kidney disease (CKD), and patients on regular hemodialysis (pHD)]...
2023: Renal Failure
Xueyan Zhang, Jianfang Ni, Hongwei Zhang, Mengyuan Diao
BACKGROUND: Gastrointestinal bleeding (GIB) is a common condition in clinical practice, and predictive models for patients with GIB have been developed. However, assessments of in-hospital mortality due to GIB in the intensive care unit (ICU), especially in critically ill patients, are still lacking. This study was designed to screen out independent predictive factors affecting in-hospital mortality and thus establish a predictive model for clinical use. METHODS: This retrospective study included 1,442 patients with GIB who had been admitted to the ICU...
2023: Frontiers in Medicine
Larsen H Welsh, Jeremy T Bose, Hanna S Sahhar
Calcium channel blockers (CCBs) are among the most commonly prescribed cardiovascular medications in the adult population. Approximately 20% of adults with hypertension in the United States are prescribed dihydropyridine calcium channel blockers. Similarly, in the pediatric population, CCBs such as nifedipine and amlodipine are frequently prescribed in the non-emergent management of hypertension in children and adolescents. Despite the prevalence of CCB usage, the available literature on the management of calcium channel blocker toxicity in the pediatric population remains scarce...
August 2023: Curēus
Dongju Zhu, Xiang Wu
Resveratrol has a protective effect on sepsis-induced acute kidney injury (AKI). Circ_0074371 has been confirmed to inhibit sepsis-induced AKI process, but whether resveratrol inhibits sepsis-induced AKI by regulating circ_0074371-related pathway remains unclear. In this study, lipopolysaccharide (LPS)-induced renal tubular epithelial cells (HK2) were used to mimic AKI cell models. Quantitative real-time PCR was used to detect relative expression of circ_0074371, microRNA (miR)-145-5p and inositol polyphosphate multikinase (IPMK)...
September 20, 2023: Biochemical Genetics
Hei Jin Yoon, Tae-Hoon Kim, Da Eun Ko, Jong-Wook Song, Narhyun Min, Sung Yeon Ham
BACKGROUND: Perioperative hypoalbuminemia has a prognostic effect on mortality and morbidity in various cohorts. Patients undergoing open repair of ruptured abdominal aortic aneurysms (rAAA) are at a high risk of hypoalbuminemia due to bleeding and underlying diseases. Hence, this study aimed to investigate the predictive value of immediate postoperative hypoalbuminemia for the risk for acute kidney injury (AKI) in patients undergoing open rAAA repair. METHODS: We retrospectively reviewed 143 patients who underwent open rAAA repair between January 2008 and May 2022...
September 20, 2023: World Journal of Surgery
Bruno Caldin da Silva, Ricardo Luiz Cordioli, Bento Fortunato Cardoso Dos Santos, João Carlos de Campos Guerra, Roseny Dos Reis Rodrigues, Guilherme Martins de Souza, Carolina Ashihara, Thais Dias Midega, Niklas Söderberg Campos, Bárbara Vieira Carneiro, Flávia Nunes Dias Campos, Hélio Penna Guimarães, Gustavo Faissol Janot de Matos, Valdir Fernandes de Aranda, Leonardo José Rolim Ferraz, Thiago Domingos Corrêa
OBJECTIVE: The incidence of thrombotic events and acute kidney injury is high in critically ill patients with COVID-19. We aimed to evaluate and compare the coagulation profiles of patients with COVID-19 developing acute kidney injury versus those who did not, during their intensive care unit stay. METHODS: Conventional coagulation and platelet function tests, fibrinolysis, endogenous inhibitors of coagulation tests, and rotational thromboelastometry were conducted on days 0, 1, 3, 7, and 14 following intensive care unit admission...
2023: Einstein
Stefano Tambuzzi, Laura Vacchiano, Guendalina Gentile, Michele Boracchi, Riccardo Zoja, Arnaldo Stanislao Migliorini
Paraquat (PQ) is one of the most widely used herbicides in the world, and poisoning is generally associated with accidental, suicidal, or homicidal events. Therefore, in the forensic context, PQ could be in various ways involved as a possible cause of death of a subject. However, even though its systemic toxicity is known, the biological effects exerted on individual viscera have been explored only to some extent, especially in case of victim's survival. Therefore, a case concerning a suicidal ingestion of PQ with survival of 3 days was deemed of interest...
September 20, 2023: American Journal of Forensic Medicine and Pathology
Pari Singh, Arjun Verma, Nandini Malshe, Aditya Kallimath, Gauri Oak, Manoj Malviya, Nitin Chouthai, Pradeep Suryawanshi
OBJECTIVES: To measure the Doppler velocimetry parameters in the anterior cerebral artery (ACA), superior mesenteric artery (SMA), and main renal artery (RA) in neonates with late-onset sepsis and correlate it with associated clinical morbidities. METHODOLOGY: Prospective observational study carried out at a tertiary-level neonatal intensive care unit in India in 2022, enrolling 20 neonates with late-onset neonatal sepsis (LONS). Baseline characteristics and sepsis parameters obtained...
September 20, 2023: Journal of Ultrasound
Kinita A Chotkan, Luuk B Hilbrands, Hein Putter, Cynthia Konjin, Brigitte Schaefer, Ludo F M Beenen, Robert A Pol, Andries E Braat
BACKGROUND: The administration of contrast medium is associated with acute kidney injury; however, the effect of exposure of a deceased organ donor to contrast medium on kidney transplant outcomes has been poorly studied. METHODS: A retrospective analysis of all deceased kidney donors between 2011 and 2021 and their corresponding recipients in the Netherlands was conducted. Multivariable analyses were performed to assess the associations between contrast medium exposure and delayed graft function (DGF)/graft survival...
September 6, 2023: Transplantation
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