Yupeng Zhang, Li Zhang, Xuejin Gao, Cong Dai, Yuhong Huang, Yan Wu, Wei Zhou, Qian Cao, Xue Jing, Haitao Jiang, Yong Zhong, Weiming Zhu, Xinying Wang
BACKGROUND: Malnutrition and subsequent alterations in body composition (BC), particularly sarcopenia, are common but not yet elucidated in patients with inflammatory bowel disease (IBD); we aimed to detail the changes in BC and the characteristics of co-occurrence of malnutrition and sarcopenia in IBD patients and to investigate its effect on quality of life. METHODS: This study was a multicentre, prospective, observational study involving four tertiary referral hospitals in China...
October 1, 2023: Journal of Cachexia, Sarcopenia and Muscle
Chunxia Li, Dongna Huo, Xiuxue Liu, Hongxia Yang, Yuqing Pang, Qian Tang, Hong Xing, Yumeng Shi, Xiaopeng Chen
INTRODUCTION: Coptidis Rhizoma (CR) is one of the most frequently used herbs to treat ulcerative colitis (UC) and is often processed before usage. However, the composition changes and therapeutic effects of CR before and after processing in the treatment of UC are still unclear. OBJECTIVE: The purpose of the study is to explore the chemical components and therapeutic effects of crude and processed CR. MATERIAL AND METHODS: CR was processed according to the 2020 version of the Chinese Pharmacopoeia...
October 1, 2023: Phytochemical Analysis: PCA
Yuichiro Yoshida, Shin Fujioka, Tomohiko Moriyama, Junji Umeno, Keisuke Kawasaki, Yuta Fuyuno, Yuichi Matsuno, Yutaro Ihara, Takehiro Torisu, Takanari Kitazono
Objective Flares of inflammatory bowel disease (IBD) can occur infrequently after vaccination for coronavirus disease 2019 (COVID-19), although the details of this phenomenon are poorly understood. To clarify the possibility of an unfavorable response in patients with IBD, we investigated IBD-related symptoms during the COVID-19 vaccination. Methods Between October 2021 and February 2022, we obtained the COVID-19 vaccination status of 411 IBD patients who were being treated at our institution. The disease course of IBD after vaccination was investigated in 188 patients with ulcerative colitis (UC) and 119 patients with Crohn's disease (CD) who had received at least one dose of the vaccine during the clinical remission phase...
September 29, 2023: Internal Medicine
Leonard Barasa, Paul R Thompson
Protein citrullination is a post-translational modification (PTM) that is catalysed by the protein arginine deiminase (PAD) family of enzymes. This PTM involves the transformation of an arginine residue into citrulline. Protein citrullination is associated with several physiological processes, including the epigenetic regulation of gene expression, neutrophil extracellular trap formation and DNA damage-induced apoptosis. Aberrant protein citrullination is relevant to several autoimmune and neurodegenerative diseases and certain forms of cancer...
November 20, 2023: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Raja Atreya, Tanja Kühbacher, Maximilian J Waldner, Simon Hirschmann, Oliver Drvarov, Raed Abu Hashem, Christian Maaser, Torsten Kucharzik, Johanna Dinter, Jessica Mertens, Christoph Schramm, Babett Holler, Joachim Mössner, Kenji Suzuki, Junji Yokoyama, Shuji Terai, Wolfgang Uter, Hiroyuki Yoneyama, Hitoshi Asakura, Toshifumi Hibi, Markus F Neurath
BACKGROUND AND AIMS: Carbohydrate sulfotransferase 15 (CHST15) biosynthesizes sulfated matrix glycosaminoglycans and is implicated in intestinal inflammation and fibrosis. Here, we evaluate efficacy and safety of the double-stranded RNA oligonucleotide GUT-1, a specific blocker of CHST15, as induction therapy in patients with ulcerative colitis (UC). METHODS: In this randomized, double-blind, placebo-controlled, phase 2a study, we enrolled endoscopic active UC patients, refractory to conventional therapy, in 5 hospital centers across Germany...
September 30, 2023: Journal of Crohn's & Colitis
Feng Shi, Mengzhe Du, Qin Wang, Michael Adu-Frimpong, Chenlu Li, Xinyue Zhang, Hao Ji, Elmurat Toreniyazov, Xia Cao, Qilong Wang, Ximing Xu
Isoliquiritigenin (ISL) is known to have a variety of pharmacological activities, but its poor water solubility limits its application. In order to improve the bioavailability of ISL and its anti-colitis activity, this study aims to develop an effective drug delivery system loaded with ISL. In this study, ISL pH-sensitive micelles (ISL-M) were prepared by thin film hydration method. The micellar size (PS), polydispersity index (PDI), electrokinetic potential (ζ-potential), drug loading (DL), encapsulation rate (EE) and other physical parameters were characterized...
September 28, 2023: Journal of Pharmaceutical Sciences
Liwei Xue, Xiaosheng Jin, Tingting Ji, Rongzhou Li, Xiaoju Zhuge, Fang Xu, Zijiao Quan, Haibin Tong, Weilai Yu
OBJECTIVES: Luteolin, known for its multifaceted therapeutic properties against inflammatory diseases, holds potential for addressing the unmet need for effective treatments in ulcerative colitis (UC), a prevalent subtype of inflammatory bowel disease (IBD). This study aimed to comprehensively assess luteolin's therapeutic efficacy in a dextran sulfate sodium (DSS)-induced colitis mouse model, shedding light on its anti-UC mechanisms. METHODS: Our investigation encompassed in vivo assessments of luteolin's therapeutic potential against DSS-induced colitis through rigorous histopathological examination and biochemical analyses...
September 28, 2023: International Immunopharmacology
Wei Ding, Olivia M Marx, Marc M Mankarious, Walter A Koltun, Gregory S Yochum
INTRODUCTION: Chronic inflammation of the intestinal epithelium is an underlying cause of the two main types of inflammatory bowel disease (IBD), ulcerative colitis (UC), and Crohn's disease (CD). Ex vivo organoids derived from the intestinal epithelium are a useful model to study IBD. Whether such cultures can be established from surgically resected diseased IBD intestinal tissues has not been fully explored. In this study, we tested our ability to establish organoids from nondiseased and diseased IBD intestinal tissues...
September 28, 2023: Journal of Surgical Research
Gaëlle Tyrode, Zaher Lakkis, Dewi Vernerey, Antoine Falcoz, Valentine Clairet, Line Alibert, Stéphane Koch, Lucine Vuitton
BACKGROUND: Surgical resection rates remain high in Crohn's disease (CD). Reducing postoperative recurrence (POR) is challenging. Besides drug therapy, the surgical anastomosis technique may reduce POR. We aimed to compare the endoscopic POR rate after Kono-S vs standard ileocolic anastomosis. METHODS: The study included all consecutive CD patients operated on for ileocolic resection with a Kono-S anastomosis between February 2020 and March 2022. These patients were prospectively followed, and colonoscopy was performed 6 to 12 months after surgery...
September 30, 2023: Inflammatory Bowel Diseases
Kori Asante, Patrick Racsa, Andrea Bloomfield, Daniel Cornett, Phil Schwab
BACKGROUND: Patients with rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, or ulcerative colitis may require treatment with a biologic or targeted synthetic disease-modifying antirheumatic drug (b/tsDMARD). Often, a tumor necrosis factor inhibitor (TNFi) is the initial b/tsDMARD. The TNFi may not be effective or may not be well tolerated, so patients will opt for a different TNFi or switch to a non-TNFi b/tsDMARD. No preference for a TNFi or non-TNFi has been established and guidelines are unclear...
October 2023: Journal of Managed Care & Specialty Pharmacy
Zixuan He, Tian Fu, Shiyuan Lu, Yuhao Sun, Yao Zhang, Wenming Shi, Zhaoshen Li, Minzi Deng, Jie Chen, Yu Bai
BACKGROUND: To examine whether general and abdominal adiposity was a risk factor for the new-onset of inflammatory bowel disease (IBD) and the potential mediating effect of metabolic and inflammation status. METHODS: A total of 492,998 individuals free of IBD recruited from 2006 to 2010 in the UK Biobank were included in our study, with ongoing follow-up linking to the health-related outcome. Multivariable Cox regression models were used to evaluate the associations between general adiposity (body mass index) and abdominal adiposity (waist circumference) and the subsequent risk of IBD and its subtype...
September 30, 2023: United European Gastroenterology Journal
Chensijin Sun, Luyun Zhang, Mengting Zhang, Jianxin Wang, Shaoya Rong, Wei Lu, Hui Dong
BACKGROUND: Although Zinc pyrithione (ZPT) could lower blood pressure by inducing vasorelaxation, it is unclear if it is able to induce vasorelaxation of mesenteric arterioles in health and ulcerative colitis (UC) to exert anti-colitic action. METHODS: The vasorelaxation of the second-order branch of the mesenteric artery from wide type (WT) mice, TRPV1-/- (KO) mice, and TRPV4-/- (KO) mice was determined using a Mulvany-style wire myograph. Calcium imaging and patch clamp were applied to analyze the actions of ZPT in human vascular endothelial cells...
September 27, 2023: Biochemical Pharmacology
Lingyan Ma, Chenyang Hou, Hua Yang, Qu Chen, Wentao Lyu, Zhen Wang, Jianfeng Wang, Yingping Xiao
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract that co-occurs with gut microbiota dysbiosis; however, its etiology remains unclear. MicroRNA (miRNA)-microbiome interactions play an essential role in host health and disease. METHODS: To investigate the gut microbiome and host miRNA profiles in colitis, we used a Dextran Sulfate Sodium (DSS)-induced ulcerative colitis (UC) model. Metagenomic sequencing and metabolome profiling were performed to explore typical microbiota and metabolite signatures in colitis, whereas mRNA and miRNA sequencing were used to determine differentially expressed miRNAs and their target genes in the inflamed colon...
2023: Annals of Medicine
Yoo Jin Lee, Dalin Li, Angela Mujukian, Philip Debbas, Melissa Hampton, Emebet Mengesha, Susan Cheng, Joseph E Ebinger, Michael Chiorean, Donald Lum, Oriana M Damas, Jonathan Braun, Dermot P B McGovern, Gil Y Melmed
No abstract text is available yet for this article.
September 29, 2023: Inflammatory Bowel Diseases
Blake Rosenthal, Sabreen Aulakh, Perseus V Patel, Jason T Wong, Sabina Ali
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: Biosimilar tumor necrosis factor inhibitors (b-TNFi) reduce healthcare costs and maintain equal efficacy when compared to their originator counterparts (o-TNFi)...
September 29, 2023: American Journal of Health-system Pharmacy: AJHP
Congxin Li, Kaixin Peng, Siqi Xiao, Yuanyuan Long, Qin Yu
Inflammatory Bowel Disease (IBD), a chronic nonspecific intestinal inflammatory disease, is comprised of Ulcerative Colitis (UC) and Crohn's Disease (CD). IBD is closely related to a systemic inflammatory reaction and affects the progression of many intestinal and extraintestinal diseases. As one of the representative bacteria for probiotic-assisted therapy in IBD, multiple strains of Lactobacillus have been proven to alleviate intestinal damage and strengthen the intestinal immunological barrier, epithelial cell barrier, and mucus barrier...
September 29, 2023: Cell Death Discovery
Fang Li, Hua Huang, Ping Zhao, Jie Jiang, Xufeng Ding, Donxgue Lu, Lijiang Ji
Curculigoside (CUR), a primary active ingredient of Curculigo orchioides Gaertn , serves an important role in the intervention of numerous diseases, including ulcerative colitis, rheumatoid arthritis, myocardial ischemia, etc. However its specific mechanisms of therapy have not been fully elucidated. The aim of the present study was to elucidate the mechanisms underlying the anti‑oxidative stress and anti‑ulcerative colitis (UC) effects of CUR. Mouse model of dextran sulfate sodium (DSS)‑induced colitis, along with Caco2 and mouse intestine organoid in vitro models were used...
November 2023: International Journal of Molecular Medicine
Lei Liu, Xing Chen, Chengyi Zhang, Jia Deng, Hang Xiao, Yu Rao
Since ulcerative colitis (UC) has become a global concern, Lactiplantibacillus is considered an effective, safe strategy for alleviating intestinal inflammation in UC patients. The most advanced fourth-generation probiotics involve beneficial bacteria enclosed in biofilms with multiple advantages. However, the difference between the effect of probiotic biofilm and planktonic cells on UC remains unclear. This study indicated that the biofilm cells of Lactiplantibacillus LR-1 were more successful in increasing the colon length, relieving intestinal inflammation, and repairing colon damage, regulating the host immunity than the planktonic cells...
September 29, 2023: Food & Function
Nouf Turki, Jacob Newman, Leen Raddaoui, Taylor Brewer, Bedoor Alabbas, Sarah Turki, Mamoun Younes, Marie L Borum, Samuel A Schueler
Gastrointestinal (GI) cytomegalovirus (CMV) infections are far more common in immunocompromised as opposed to immunocompetent patients. Immunocompetent patients who develop GI tract CMV infections are typically older with medical comorbidities. As such, descriptions of GI CMV infections in younger immunocompetent patients are lacking. Here, we present a case of a GI CMV infection in a young and healthy immunocompetent patient. A 41-year-old male with hyperlipidemia and hypothyroidism presented with painless, intermittent hematochezia...
August 2023: Curēus
Michael T Dolinger, Emma Calabrese, Fabrizio Pizzolante, Maria T Abreu
Intestinal ultrasound (IUS) is a patient-centric, noninvasive, real-time, point-of-care tool with the capability to aid in diagnosis and monitoring of disease activity in both Crohn's disease and ulcerative colitis without the need for bowel preparation. IUS can be used as a tool for precision monitoring of inflammatory bowel disease (IBD) treatment response. IUS as a cross-sectional imaging tool is as accurate as magnetic resonance enterography (MRE) for assessing the ileum and is more accurate than MRE for colonic assessment proximal to the rectum...
August 2023: Gastroenterology & Hepatology
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