Shehriyar Mehershahi, Asim Haider, Danial Shaikh, Hafsa Abbas, Ariyo Ihimoyan
The list of drugs associated with acute pancreatitis is increasing with each passing year. Nevertheless, knowledge of drug-induced pancreatitis (DIP) are often curtailed by the limited availability of evidence needed to implicate given agents, especially for non-prescription medications. Indeed, the majority of available data are derived from case reports, case series, or case-control studies. We present a case chemically and radiologically proven pancreatitis in a 43-year-old female who was on sulfasalazine as a maintenance therapy for ulcerative colitis...
September 14, 2020: Curēus
Rola Husain, Ameen Alawadhi, Etan Dayan, Mingqian Huang, Idoia Corcuera-Solano
Pyoderma gangrenosum (PG) is a rare noninfectious skin condition which clinical picture can overlap with that of the diabetic foot. Meticulous physical examination along with biopsy and magnetic resonance imaging (MRI) can make the distinction easier, saving the patients from undergoing a debilitating intervention. We report a case of pathologically proven PG in the right ankle region of a 55-year old male with known uncontrolled diabetes mellitus and inflammatory bowel disease. Radiographs revealed increased soft tissue density overlying the lateral melleolus of the right ankle...
December 2020: Radiology Case Reports
Marta Vuerich, Samiran Mukherjee, Simon C Robson, Maria Serena Longhi
Inflammatory bowel disease (IBD) is a serious inflammatory condition of the gastrointestinal tract. Crohn's disease (CD) and ulcerative colitis (UC) are two of the most common IBD manifestations and are both associated with unfettered inflammation, often refractory to conventional immunosuppressive treatment. In both conditions, imbalance between effector and regulatory cell immune responses has been documented and is thought to contribute to disease pathogenesis. Purinergic signaling is a known modulator of systemic and local inflammation and growing evidences point to extracellular ATP/adenosine imbalance as a key determinant factor in IBD-associated immune dysregulation...
2020: Frontiers in Immunology
Chiara Lasconi, Matthew C Pahl, Diana L Cousminer, Claudia A Doege, Alessandra Chesi, Kenyaita M Hodge, Michelle E Leonard, Sumei Lu, Matthew E Johnson, Chun Su, Reza K Hammond, James A Pippin, Natalie A Terry, Louis R Ghanem, Rudolph L Leibel, Andrew D Wells, Struan F A Grant
BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is a polygenic disorder principally characterized by dysregulated inflammation impacting the gastrointestinal tract. However, there is also increasing evidence for a clinical association with stress and depression. Given the role of the hypothalamus in stress responses and in the pathogenesis of depression, useful insights could be gleaned from understanding its genetic role in IBD. METHODS: We conducted genetic correlation analyses on publicly available GWAS summary statistics for depression and IBD traits to identify genetic commonalities...
October 15, 2020: Cellular and Molecular Gastroenterology and Hepatology
Dan Jia, Yonghui Dou, Ziwen Li, Xinxin Zhou, Ying Gao, Keji Chen, Weihong Cong, Min Ma, Zhengzhi Wu, Weimin Li
Structural modification of active natural compoundswhichwereoriginated fromTraditional Chinese Medicine (TCM) have showedgreat advantagesin thedevelopmentof new drugs. In TCM, "Huangqin-Huanglian" is a classic "medicine couple"thathas been used to treat intestinal diseases for thousands ofyears, while baicalinand berberine are the major active compoundsof Huangqin and Huanglianrespectively. Based onthis"medicine couple",wedesignedand synthesizeda newbaicalin and berberine hybrid compound (BBH)...
August 6, 2020: Bioorganic & Medicinal Chemistry
Kourosh Masnadi Shirazi, Simin Sotoudeh, Arman Masnadi Shirazi, Seyyed-Yaghoub Moaddab, Zahra Nourpanah, Zeinab Nikniaz
BACKGROUND: The use of antioxidant agents is suggested as a complementary therapy in UC patients for the prevention of flares. Considering the potent antioxidant activity of N-acetylcysteine (NAC), in the present study we aimed to assess the effect of this supplement on remission maintenance in patients with ulcerative colitis (UC). METHODS: In the present double-blind randomized controlled clinical trial, 168 volunteer UC patients who were on high dose corticosteroid and Mesalamine for flare-up management, were recruited...
October 14, 2020: Clinics and Research in Hepatology and Gastroenterology
Harrison Bell, Natasha Kamal, Uni Wong
Patients with inflammatory bowel disease, especially those on immunosuppressive therapy, are at higher risk of acquiring infectious diseases (Reich et al., 2016). For this reason, immunizations are routinely recommended in comprehensive inflammatory bowel disease care. SHINGRIX, a non-live recombinant herpes zoster vaccine, was approved by the Food and Drug Administration in 2017. Adults aged 50 and over are recommended to receive two doses of SHINGRIX. Unlike ZOSTAVAX® which is a live zoster vaccine that has been in use since 2006, SHINGRIX is safe for those on immunosuppression (Reich et al...
October 13, 2020: Vaccine
Dagmar Schierová, Jan Březina, Jakub Mrázek, Kateřina Olša Fliegerová, Simona Kvasnová, Lukáš Bajer, Pavel Drastich
Ulcerative colitis (UC) is an inflammatory bowel disease, and intestinal bacteria are implicated in the pathogenesis of this disorder. The administration of aminosalicylates (5-ASA) is a conventional treatment that targets the mucosa, while fecal microbial transplantation (FMT) is a novel treatment that directly targets the gut microbiota. The aim of this study was to identify changes in fecal bacterial composition after both types of treatments and evaluate clinical responses. Sixteen patients with active left-sided UC underwent enema treatment using 5-ASA ( n = 8) or FMT ( n = 8) with a stool from a single donor...
October 13, 2020: Cells
Amar Vedamurthy, Nikitha Gangasani, Ashwin N Ananthakrishnan
BACKGROUND: Treatment of patients with inflammatory bowel diseases (IBD; Crohn's disease (CD), ulcerative colitis (UC) who have a prior history of cancer pose a unique challenge. The impact of Vedolizumab (VDZ) on the risk of new or recurrent cancers in patients with a previous malignancy is unknown. METHODS: This was a retrospective study of patients with IBD with a history of current or prior cancer who were subsequently initiated on VDZ, tumor necrosis factor α antagonists (anti-TNF), or had no immunosuppressive therapy after the index cancer diagnosis...
October 13, 2020: Clinical Gastroenterology and Hepatology
George Khoudari, Emad Mansoor, Benjamin Click, Motasem Alkhayyat, Mohannad Abou Saleh, Preetika Sinh, Jeffry Katz, Gregory S Cooper, Miguel Regueiro
BACKGROUND AND AIMS: 50% to 80% Crohn's disease (CD) and 10% to 30% ulcerative colitis (UC) patients require surgery over their lifetime. Biologic therapies may alter this natural history, but data on the effect of biologics on surgery rates in this patient population are mixed. We sought to investigate the influence of biologics on surgery prevalence in CD and UC. METHODS: We used a commercial database (Explorys Inc, Cleveland, OH), which includes electronic health record data from 26 major integrated US healthcare systems...
October 13, 2020: Clinical Gastroenterology and Hepatology
Dominik Naessens, Chris Cameron, David C Hoaglin
No abstract text is available yet for this article.
October 13, 2020: Clinical Gastroenterology and Hepatology
Liu Jialing, Gao Yangyang, Zhou Jing, Tang Xiaoyi, Wang Ping, Shen Liwei, Chen Simin
AIMS: Whether dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) animal models undergo self-healing remains unclear. Therefore, the study aim was to determine if these models have self-healing ability. MAIN METHODS: UC was induced using 4% DSS in male KM mice. Histopathological and inflammatory cytokine were evaluated. Fecal samples were analyzed by 16S rDNA gene sequencing. KEY FINDINGS: Physiological and inflammatory cytokine changed obviously on days 4-14 of establishment and returned to normal levels by day 21...
October 13, 2020: Life Sciences
Bin Cai, Min-Hong Zhou, Hua-Li Huang, A-Cheng Zhou, Zheng-da Chu, Xiao-Dong Huang, Chun-Wei Li
It has been reported that supplementing certain amino acids has therapeutic effects on ulcerative colitis (UC). We intend to explore whether citrulline (Cit) supplementation has protective effects on UC. Fifteen male Wistar rats were divided into normal control group (NC group), UC group and UC+Cit group, with five rats in each group. The UC model was established by TNBS/ethanol method. Rats in UC+Cit group were intragastrically administered with Cit for 7 consecutive days after modeling. All rats were sacrificed after 7 days...
2020: PloS One
Ting Zhang, Pan Li, Xia Wu, Gaochen Lu, Cicilia Marcella, Xinghui Ji, Guozhong Ji, Faming Zhang
Akkermansia muciniphila is a promising probiotic in the gut. This study aimed to determine the presence and abundance of Akkermansia in patients with inflammatory bowel disease (IBD) who underwent washed microbiota transplantation (WMT) in order to elucidate the relationship between its level and patients' clinical data and outcomes. A cohort of Chinese volunteers including 80 healthy controls (HC), 43 patients with ulcerative colitis (UC), and 57 patients with Crohn's disease (CD) were recruited. Akkermansia presented a low colonization rate of 48...
October 16, 2020: Applied Microbiology and Biotechnology
Estefania Flores, Chimezie Mbachi, Ikechukwu Achebe, Jennifer Asotibe, Emmanuel Palomera-Tejeda, Ishaan Vohra, Victor Udechukwu, Vikram Kotwal
BACKGROUND: Early detection and advancement in therapy have successfully achieved a steady decrease in colorectal cancer (CRC) mortality over the last two decades. On the other hand, studies investigating mortality trends in inflammatory bowel disease-associated CRC (IBD-CRC) are scarce and inconclusive. We conducted a retrospective analysis aiming to identify differences between inpatient mortality trends in IBD-CRC vs non-IBD-CRC and possible contributing factors. METHODS: The National Inpatient Sample (NIS) database from 2006-2014 was queried to identify all patients admitted with a diagnosis of CRC...
October 15, 2020: International Journal of Colorectal Disease
Sara van Gennep, Nanne K H de Boer, Marieke E Gielen, Svend T Rietdijk, Krisztina B Gecse, Cyriel Y Ponsioen, Marjolijn Duijvestein, Geert R D'Haens, Mark Löwenberg, Angela G E M de Boer
BACKGROUND: Work-related aspects are important determinants of health for inflammatory bowel disease (IBD) patients. AIMS: We aimed to describe quality of working life (QWL) in IBD patients and to assess variables that are associated with QWL. METHODS: Employed IBD patients of two tertiary and two secondary referral hospitals were included. QWL (range 0-100) was measured using the Quality of Working Life Questionnaire (QWLQ). Work productivity (WP), fatigue, and health-related quality of life (HRQL) were assessed using the Work Productivity and Activity Impairment questionnaire, Multidimensional Fatigue Inventory, and Short Inflammatory Bowel Disease Questionnaire, respectively...
October 16, 2020: Digestive Diseases and Sciences
Yasi Xiao, Peter L Lakatos, Talat Bessissow
Pseudopolyps are benign lesions without malignant potential and typically do not require biopsy or excision. We describe a 68-year-old man with ulcerative colitis found to have multiple large bridging pseudopolyps. Repeated colonoscopies and extensive biopsies revealed a large ulcerated lesion previously hidden within the pseudopolyps. The pathology of the lesion was consistent with a low-grade adenocarcinoma with invasion into the muscularis propria. This demonstrates that large pseudopolyps, although benign, can obscure other lesions with malignant potential...
June 2020: ACG Case Reports Journal
Asli Semiz, Ozden Ozgun Acar, Hulya Cetin, Gurkan Semiz, Alaattin Sen
Background and Objective: This study was aimed to elucidate the molecular mechanism of Momordica charantia (MCh) , along with a standard drug prednisolone, in a rat model of colitis induced by trinitrobenzene sulfonic acid (TNBS). Methods: After the induction of the experimental colitis, the animals were treated with MCh (4 g/kg/day) for 14 consecutive days by intragastric gavage. The colonic tissue expression levels of C-C motif chemokine ligand 17 (CCL-17), interleukin (IL)-1β, IL-6, IL-23, interferon-γ (IFN-γ), nuclear factor kappa B (NF-kB), and tumor necrosis factor-α (TNF-α), were determined at both mRNA and protein levels to estimate the effect of MCh ...
September 2020: Journal of Translational Internal Medicine
Kaushik Kondubhatla, Ayush Kaushal, Ali Daoud, Hassan Shabbir, Jihan A Mostafa
Inflammatory bowel disease (IBD), comprising ulcerative colitis and Crohn's disease, is characterized by widespread inflammation of the gastrointestinal tract with systemic manifestations. Inflammation is one of the driving forces for the pathogenesis of atherosclerosis and its dreaded complications like myocardial infarction (MI). Yet, the association between IBD and myocardial infarction has not been thoroughly established. Myocardial infarction in IBD patients was predominantly seen in young women during the active disease process...
September 19, 2020: Curēus
Sanaz Soleymani, Azadeh Moradkhani, Masoumeh Eftekhari, Fatemeh Rahmanian, Seyed Hamid Moosavy
BACKGROUND The Crohn's Disease Endoscopic Index of Severity (CDEIS) and the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) are two validated endoscopic scoring system to evaluate patients with inflammatory bowel diseases (IBD). We conducted this study to evaluate the correlation between clinical symptoms and lab tests with these indexes in patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS In this analytical study, 373 consecutive patients referred to Shahid Mohammadi Hospital with IBD were enrolled...
July 2020: Middle East Journal of Digestive Diseases
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