Kori Asante, Patrick Racsa, Andrea Bloomfield, Daniel Cornett, Phil Schwab
BACKGROUND: Patients with rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, or ulcerative colitis may require treatment with a biologic or targeted synthetic disease-modifying antirheumatic drug (b/tsDMARD). Often, a tumor necrosis factor inhibitor (TNFi) is the initial b/tsDMARD. The TNFi may not be effective or may not be well tolerated, so patients will opt for a different TNFi or switch to a non-TNFi b/tsDMARD. No preference for a TNFi or non-TNFi has been established and guidelines are unclear...
October 2023: Journal of Managed Care & Specialty Pharmacy
Zixuan He, Tian Fu, Shiyuan Lu, Yuhao Sun, Yao Zhang, Wenming Shi, Zhaoshen Li, Minzi Deng, Jie Chen, Yu Bai
BACKGROUND: To examine whether general and abdominal adiposity was a risk factor for the new-onset of inflammatory bowel disease (IBD) and the potential mediating effect of metabolic and inflammation status. METHODS: A total of 492,998 individuals free of IBD recruited from 2006 to 2010 in the UK Biobank were included in our study, with ongoing follow-up linking to the health-related outcome. Multivariable Cox regression models were used to evaluate the associations between general adiposity (body mass index) and abdominal adiposity (waist circumference) and the subsequent risk of IBD and its subtype...
September 30, 2023: United European Gastroenterology Journal
Chensijin Sun, Luyun Zhang, Mengting Zhang, Jianxin Wang, Shaoya Rong, Wei Lu, Hui Dong
BACKGROUND: Although Zinc pyrithione (ZPT) could lower blood pressure by inducing vasorelaxation, it is unclear if it is able to induce vasorelaxation of mesenteric arterioles in health and ulcerative colitis (UC) to exert anti-colitic action. METHODS: The vasorelaxation of the second-order branch of the mesenteric artery from wide type (WT) mice, TRPV1-/- (KO) mice, and TRPV4-/- (KO) mice was determined using a Mulvany-style wire myograph. Calcium imaging and patch clamp were applied to analyze the actions of ZPT in human vascular endothelial cells...
September 27, 2023: Biochemical Pharmacology
Lingyan Ma, Chenyang Hou, Hua Yang, Qu Chen, Wentao Lyu, Zhen Wang, Jianfeng Wang, Yingping Xiao
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract that co-occurs with gut microbiota dysbiosis; however, its etiology remains unclear. MicroRNA (miRNA)-microbiome interactions play an essential role in host health and disease. METHODS: To investigate the gut microbiome and host miRNA profiles in colitis, we used a Dextran Sulfate Sodium (DSS)-induced ulcerative colitis (UC) model. Metagenomic sequencing and metabolome profiling were performed to explore typical microbiota and metabolite signatures in colitis, whereas mRNA and miRNA sequencing were used to determine differentially expressed miRNAs and their target genes in the inflamed colon...
2023: Annals of Medicine
Yoo Jin Lee, Dalin Li, Angela Mujukian, Philip Debbas, Melissa Hampton, Emebet Mengesha, Susan Cheng, Joseph E Ebinger, Michael Chiorean, Donald Lum, Oriana M Damas, Jonathan Braun, Dermot P B McGovern, Gil Y Melmed
No abstract text is available yet for this article.
September 29, 2023: Inflammatory Bowel Diseases
Blake Rosenthal, Sabreen Aulakh, Perseus V Patel, Jason T Wong, Sabina Ali
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: Biosimilar tumor necrosis factor inhibitors (b-TNFi) reduce healthcare costs and maintain equal efficacy when compared to their originator counterparts (o-TNFi)...
September 29, 2023: American Journal of Health-system Pharmacy: AJHP
Congxin Li, Kaixin Peng, Siqi Xiao, Yuanyuan Long, Qin Yu
Inflammatory Bowel Disease (IBD), a chronic nonspecific intestinal inflammatory disease, is comprised of Ulcerative Colitis (UC) and Crohn's Disease (CD). IBD is closely related to a systemic inflammatory reaction and affects the progression of many intestinal and extraintestinal diseases. As one of the representative bacteria for probiotic-assisted therapy in IBD, multiple strains of Lactobacillus have been proven to alleviate intestinal damage and strengthen the intestinal immunological barrier, epithelial cell barrier, and mucus barrier...
September 29, 2023: Cell Death Discovery
Fang Li, Hua Huang, Ping Zhao, Jie Jiang, Xufeng Ding, Donxgue Lu, Lijiang Ji
Curculigoside (CUR), a primary active ingredient of Curculigo orchioides Gaertn , serves an important role in the intervention of numerous diseases, including ulcerative colitis, rheumatoid arthritis, myocardial ischemia, etc. However its specific mechanisms of therapy have not been fully elucidated. The aim of the present study was to elucidate the mechanisms underlying the anti‑oxidative stress and anti‑ulcerative colitis (UC) effects of CUR. Mouse model of dextran sulfate sodium (DSS)‑induced colitis, along with Caco2 and mouse intestine organoid in vitro models were used...
November 2023: International Journal of Molecular Medicine
Lei Liu, Xing Chen, Chengyi Zhang, Jia Deng, Hang Xiao, Yu Rao
Since ulcerative colitis (UC) has become a global concern, Lactiplantibacillus is considered an effective, safe strategy for alleviating intestinal inflammation in UC patients. The most advanced fourth-generation probiotics involve beneficial bacteria enclosed in biofilms with multiple advantages. However, the difference between the effect of probiotic biofilm and planktonic cells on UC remains unclear. This study indicated that the biofilm cells of Lactiplantibacillus LR-1 were more successful in increasing the colon length, relieving intestinal inflammation, and repairing colon damage, regulating the host immunity than the planktonic cells...
September 29, 2023: Food & Function
Nouf Turki, Jacob Newman, Leen Raddaoui, Taylor Brewer, Bedoor Alabbas, Sarah Turki, Mamoun Younes, Marie L Borum, Samuel A Schueler
Gastrointestinal (GI) cytomegalovirus (CMV) infections are far more common in immunocompromised as opposed to immunocompetent patients. Immunocompetent patients who develop GI tract CMV infections are typically older with medical comorbidities. As such, descriptions of GI CMV infections in younger immunocompetent patients are lacking. Here, we present a case of a GI CMV infection in a young and healthy immunocompetent patient. A 41-year-old male with hyperlipidemia and hypothyroidism presented with painless, intermittent hematochezia...
August 2023: Curēus
Michael T Dolinger, Emma Calabrese, Fabrizio Pizzolante, Maria T Abreu
Intestinal ultrasound (IUS) is a patient-centric, noninvasive, real-time, point-of-care tool with the capability to aid in diagnosis and monitoring of disease activity in both Crohn's disease and ulcerative colitis without the need for bowel preparation. IUS can be used as a tool for precision monitoring of inflammatory bowel disease (IBD) treatment response. IUS as a cross-sectional imaging tool is as accurate as magnetic resonance enterography (MRE) for assessing the ileum and is more accurate than MRE for colonic assessment proximal to the rectum...
August 2023: Gastroenterology & Hepatology
Gary R Lichtenstein
No abstract text is available yet for this article.
August 2023: Gastroenterology & Hepatology
David Hudesman
No abstract text is available yet for this article.
August 2023: Gastroenterology & Hepatology
Antonietta Gerarda Gravina, Raffaele Pellegrino, Tommaso Durante, Giovanna Palladino, Rossella D'Onofrio, Simone Mammone, Giusi Arboretto, Salvatore Auletta, Giuseppe Imperio, Andrea Ventura, Mario Romeo, Alessandro Federico
Inflammatory bowel disease (IBD) is a chronic digestive disease that requires continuous monitoring by healthcare professionals to determine the appropriate therapy and monitor short-term and long-term complications. The progressive development of information technology has enabled healthcare personnel to deliver care services to patients remotely. Therefore, various applications of telemedicine in IBD management have evolved, including telemonitoring, teleconsulting, teleducation, telenursing, telenutrition, and telepathology...
September 20, 2023: World Journal of Methodology
Nojoud Faqerah, Daniel Walker, Konstantinos Gerasimidis
BACKGROUND: Although no causative microbe has been yet identified or successfully targeted in the treatment of inflammatory bowel disease (IBD), the role of Escherichia coli in the pathogenesis of Crohn's disease has attracted considerable interest. AIM: In this review, we present a literature overview of the interactions between diet and E. coli and other Proteobacteria in the aetiology, outcomes and management of IBD and suggest future research directions. METHODS: An extensive literature search was performed to identify in vitro studies and research in animal models that explored mechanisms by which dietary components can interact with E...
September 28, 2023: Alimentary Pharmacology & Therapeutics
Vishavdeep Singh Rana, Gaurav Mahajan, Amol N Patil, Anupam K Singh, Vaneet Jearth, Aravind Sekar, Harjeet Singh, Atul Saroch, Usha Dutta, Vishal Sharma
BACKGROUND: Ulcerative colitis is a relapsing and remitting disease that may be associated with flares. The causes of flares in the Indian setting are not well recognized. METHODS: The present prospective case-control study was conducted at a single center in North India. Cases were defined as patients admitted for flare of ulcerative colitis, while controls were patients in remission enrolled from the outpatient department. The basis of the diagnosis of flare was a simple clinical colitis activity index (SCCAI) of ≥ 5 and endoscopic activity, while remission was based on SCCAI < 4 and a normal fecal calprotectin...
September 28, 2023: BMC Gastroenterology
Xingyao Chen, Beatriz G Mendes, Bruno Secchi Alves, Yi Duan
Phage therapy, the use of bacteriophage viruses for bacterial infection treatment, has been around for almost a century, but with the increase in antibiotic use, its importance has declined rapidly. There has been renewed interest in revisiting this practice due to the general decline in the effectiveness of antibiotics, combined with improved understanding of human microbiota and advances in sequencing technologies. Phage therapy has been proposed as a clinical alternative to restore the gut microbiota in the absence of an effective treatment...
2023: Progress in Molecular Biology and Translational Science
Laura Rossier, Christoph Matter, Emanuel Burri, Tatiana Galperine, Petr Hrúz, Pascal Juillerat, Alain Schoepfer, Stephan R Vavricka, Nadine Zahnd, Natalie Décosterd, Frank Seibold
INTRODUCTION: Faecal microbiota transplantation (FMT) is an established therapy for recurrent C. difficile infection, and recent studies have reported encouraging results of FMT in patients with ulcerative colitis. Few international consensus guidelines exist for this therapy, and thus FMT policies and practices differ among European countries. As of 2019, stool transplants are considered a non-standardised medicinal product in Switzerland, and a standardised production process requires authorisation by the Swiss Agency for Therapeutic Products...
August 25, 2023: Swiss Medical Weekly
Olga A Lavryk, Sherief Shawki, Tracy L Hull, Stefan D Holubar, Arielle Kanters, Scott R Steele
BACKGROUND: Ulcerative colitis (UC) can be diagnosed at a variety of different ages. We evaluated if age of ulcerative colitis (UC) diagnosis impacts outcomes of restorative proctocolectomy (RP) with ileal pouch-anal anastomosis (IPAA). METHODS: A prospectively maintained pouch database (1983-2020) was queried to identify patients undergoing an RP for UC. The cohort was stratified based on bimodal disease presentation into 2 groups: the early adulthood group (19-30 years old) and the mid/late adulthood group (40-70 years old)...
September 28, 2023: International Journal of Colorectal Disease
Lei Guo, Xiuze Chen, Haifeng Zeng, Na Tian, Weijie Lu, Jizhou Zhang, Yechen Xiao
Interleukin-18 binding protein (IL-18BP) is a natural IL-18 inhibitor in vivo, which can effectively neutralize IL-18 and inhibit the inflammatory signaling pathway induced by IL-18, thus playing an anti-inflammatory role. Traditional production methods primarily rely on eukaryotic animal cell expression systems, which often entail complex processes, lower yields, and increase production costs. In this study, we present a novel approach for expressing IL-18BP fusion protein using the Escherichia coli (E. coli) system...
September 28, 2023: Applied Microbiology and Biotechnology
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