Guangxi Zhou, Fengqin Zhu, Hairong Zhang, Yan Wang, Yonghong Yang, Guiyuan Jin, Yibo Wang, Guanjun Dong, Huabao Xiong
Neutrophils participate in the pathogenesis of ulcerative colitis (UC) through regulating the intestinal homeostasis. Several inflammatory diseases are reported to be regulated by proline-rich tyrosine kinase 2B (PTK2B). However, the role of PTK2B in regulating the function of neutrophils and the pathogenesis of UC remains unknown. In this study, the mRNA and protein levels of PTK2B in the colonic tissues from UC patients were measured by using quantitative real-time polymerase chain reaction (qRT-PCR), western blotting, and immunohistochemistry...
July 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Chung Sang Tse, Hang P Nguyen, Siddharth Singh, Parambir S Dulai, Jennifer Neill, Helen Le, Mark Valasek, Thierry Dervieux, Angelina E Collins, Brigid Sweeney Boland
INTRODUCTION: Discordance between gastrointestinal (GI) symptoms and endoscopic inflammation in patients with ulcerative colitis (UC) is known. However, the correlations between symptoms and endoscopic and histologic (endo-histologic) mucosal healing and remains unknown. METHODS: We performed a secondary analysis of prospectively collected clinical, endoscopic, and histologic data on 254 colonoscopies from 179 unique adults at a tertiary referral center from 2014 to 2021...
June 3, 2023: Digestive Diseases and Sciences
Priyanka Raju Chougule, Rajendra Sangaraju, Pradeep B Patil, S S Y H Qadri, Virendra V Panpatil, Sudip Ghosh, Sathish Kumar Mungamuri, Manjula Bhanoori, Sukesh Narayan Sinha
OBJECTIVE AND DESIGN: Inflammatory bowel disease (IBD) is an idiopathic inflammatory condition of the digestive system marked by oxidative stress, leukocyte infiltration, and elevation of inflammatory mediators. In this study, we demonstrate the protective effect of ethyl gallate (EG), a phytochemical, and propyl gallate (PG), an anti-oxidant, given through normal drinking water (DW) and copper water (CW) in various combinations, which had a positive effect on the amelioration of DSS-induced ulcerative colitis in C57BL/6 J mice...
June 2, 2023: Inflammopharmacology
Sudheer K Vuyyuru, Lisa M Shackelton, Jurij Hanzel, Christopher Ma, Vipul Jairath, Brian G Feagan
Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, comprises multiple complex immune-mediated disorders. Early diagnosis and prompt disease control may prevent long-term complications and hospitalization. The therapeutic options have expanded in the last two decades, with the development of biologics and small molecules targeting specific pathways implicated in inflammatory bowel disease pathogenesis. The interleukin (IL)-23/Th-17 axis is one such example. Targeting IL-12/23 is effective for the treatment of both moderate-to-severe Crohn's disease and ulcerative colitis, and ustekinumab (an IL-12/23p40 antagonist) is approved for both indications...
June 2, 2023: Drugs
Hélène Sarter, Guillaume Savoye, Guillemette Marot, Delphine Ley, Dominique Turck, Jean-Pierre Hugot, Francis Vasseur, Alain Duhamel, Pauline Wils, Fred Princen, Jean-Frédéric Colombel, Corinne Gower-Rousseau, Mathurin Fumery
BACKGROUND: The identification of patients at high risk of a disabling disease course would be invaluable in guiding initial therapy in Crohn's disease (CD). Our objective was to evaluate a combination of clinical, serological, and genetic factors to predict complicated disease course in pediatric-onset CD. METHODS: Data for pediatric-onset CD patients, diagnosed before 17 years of age between 1988 and 2004 and followed more than 5 years, were extracted from the population-based EPIMAD registry...
June 2, 2023: Inflammatory Bowel Diseases
Paige E Jamieson, Franck Carbonero, Jan F Stevens
Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, are a rapidly growing public health concern worldwide. These diseases are heterogeneous at the clinical, immunological, molecular, genetic, and microbial level, but characteristically involve a disrupted immune-microbiome axis. Shortcomings in conventional treatment options warrant the need for novel therapeutic strategies to mitigate these life-long and relapsing disorders of the gastrointestinal tract. Polyphenols, a diverse group of phytochemicals, have gained attention as candidate treatments due to their array of biological effects...
2023: Current research in food science
Yifei Yang, Yi Wang, Long Zhao, Fang Wang, Mingxing Li, Qin Wang, Haoming Luo, Qianyun Zhao, Jiuping Zeng, Yueshui Zhao, Fukuan Du, Yu Chen, Jing Shen, Shulin Wei, Zhangang Xiao, Xu Wu
Ulcerative colitis (UC) is one of types of inflammatory bowel disease with high recurrence. Recent studies have highlighted that microbial dysbiosis as well as abnormal gut immunity are crucial factors that initiate a series of inflammatory responses in the UC. Modulating the gut microbiota-intestinal immunity loop has been suggested as one of key strategies for relieving UC. Many Chinese herbal medicines including some of single herb, herbal formulas and the derived constituents have been reported with protective effect against UC through modulating gut microbiome and intestinal immunity...
April 2023: Chinese Herbal Medicines
Jessica K Bernard, Edie B Bucar, Cambrian Y Liu, Kay Katada, Mary K Washington, Michael A Schumacher, Mark R Frey
BACKGROUND: Growth factors are essential for maintenance of intestinal health. We previously showed that exogenous neuregulin-4 (NRG4) promotes colonocyte survival during cytokine challenge and is protective against acute models of intestinal inflammation. However, the function(s) of endogenous NRG4 are not well understood. Using NRG4-/- mice, we tested the role of endogenous NRG4 in models of colitis skewed toward either adaptive (interleukin-10 receptor [IL-10R] neutralization) or innate (dextran sulfate sodium [DSS]) immune responses...
June 2, 2023: Inflammatory Bowel Diseases
Tamara Alhobayb, Matthew A Ciorba
PURPOSE OF REVIEW: The chronic inflammatory bowel diseases (IBD), Crohn's disease, and ulcerative colitis, are associated with an increased risk of symptomatic Clostridium difficile infection (CDI). CDI may also masquerade as an IBD flare and complicate IBD management. This review provides a comprehensive overview of the epidemiology, diagnosis, and treatment of CDI in IBD patients. RECENT FINDINGS: CDI remains common in IBD with complications including flares in disease activity, recurrent CDI episodes, and prolonged hospital stays...
May 16, 2023: Current Opinion in Gastroenterology
Jeffrey A Berinstein, Daniel Aintabi, Peter D R Higgins
PURPOSE OF REVIEW: The management of hospitalized patients with inflammatory bowel disease (IBD) is complex. Despite considerable therapeutic advancements in outpatient ulcerative colitis and Crohn's disease management, the in-hospital management continues to lag with suboptimal outcomes. The purpose of this review is to provide a brief overview of our approach to managing patients hospitalized with acute severe ulcerative colitis (ASUC) and Crohn's disease-related complications, followed by a summary of emerging evidence for new management approaches...
May 29, 2023: Current Opinion in Gastroenterology
Harpreet Kaur, Gursimran Singh Kochhar, Parambir S Dulai
PURPOSE OF REVIEW: Hypoxia is a known contributor to inflammation in inflammatory bowel diseases (IBD), and a growing interest has emerged in pharmacologically targeting hypoxia response pathways to treat IBD. The most basic form of treatment for hypoxia is delivering higher amounts of oxygen to the intestinal mucosa. In this review, we summarize the evidence in support of hyperbaric oxygen therapy (HBOT), a mechanism to deliver high amounts of oxygen to tissue, for treating IBD. RECENT FINDINGS: Two phase 2 clinical trials in hospitalized ulcerative colitis patients suffering from moderate-to-severe flares have demonstrated that HBOT improves responsiveness to steroids and avoidance of rescue medical and surgical therapy...
May 31, 2023: Current Opinion in Gastroenterology
Antonius T Otten, Hedwig H van der Meulen, Maurice Steenhuis, Floris C Loeff, Daan J Touw, Jos G W Kosterink, Henderik W Frijlink, Theo Rispens, Gerard Dijkstra, Marijn C Visschedijk, Arno R Bourgonje
BACKGROUND: Therapeutic drug monitoring provides important guidance for treatment of patients with inflammatory bowel disease (IBD) and could help to early identify treatment failure. This study aimed to validate a finger prick-based capillary blood sampling technique to measure biological trough levels and C-reactive protein (CRP) and evaluate patient performance and -support. METHODS: In this prospective cohort study, patients with IBD receiving infliximab (IFX) or vedolizumab (VEDO) therapy performed finger prick-based capillary blood sampling at home...
June 2, 2023: Inflammatory Bowel Diseases
Andreas Wallhuss, Johan Ottosson, Yang Cao, Ellen Andersson, Daniel Bergemalm, Carl Eriksson, Ola Olén, Eva Szabo, Erik Stenberg
BACKGROUND: Obesity is becoming more prevalent in patients with inflammatory bowel disease. Although bariatric surgery is an effective treatment for obesity, questions remain regarding its safety and effectiveness for patients with inflammatory bowel disease. The aim of this study was to evaluate the safety and effectiveness of bariatric surgery in patients with inflammatory bowel disease. METHOD: This registry-based, propensity-matched cohort study included all patients who had primary Roux-en-Y gastric bypass or sleeve gastrectomy in Sweden from January 2007 to June 2020 who had an inflammatory bowel disease diagnosis and matched control patients without an inflammatory bowel disease diagnosis...
May 30, 2023: Surgery
Raghda N El Mahdy, Manar A Nader, Manar G Helal, Sally E Abu-Risha, Marwa E Abdelmageed
BACKGROUND: Ulcerative colitis (UC) is a chronic mucosal inflammation of the large intestine that mostly affects the rectum and colon. The absence of safe and effective therapeutic agents encourages the discovery of novel therapeutic agents to effectively treat UC and its complications. The purpose of this research was to examine the protective impact of Eicosapentaenoic acid (EPA) in rats with UC induced by acetic acid (AA). METHOD: AA (2 ml, 3 % v/v) was injected intrarectally to cause UC...
May 30, 2023: Life Sciences
Minami Hirai, Shunichi Yanai, Reiko Kunisaki, Masafumi Nishio, Kenji Watanabe, Toshiyuki Sato, Soichiro Ishihara, Hiroyuki Anzai, Takashi Hisabe, Shigeyoshi Yasukawa, Yasuharu Maeda, Kazumi Takishima, Akiko Ohno, Hisashi Shiga, Toshio Uraoka, Yuki Itoi, Haruhiko Ogata, Kaoru Takabayashi, Naohisa Yoshida, Yutaka Saito, Hiroyuki Takamaru, Keisuke Kawasaki, Motohiro Esaki, Nanae Tsuruoka, Tadakazu Hisamatsu, Takayuki Matsumoto
BACKGROUND AND AIMS: Patients with ulcerative colitis (UC) are at risk of developing colorectal cancer (CRC). The feasibility of endoscopic resection (ER) for UC-associated neoplasia (UCAN) has been suggested, but its efficacy and safety remain unclear. We aimed to assess the efficacy and safety of ER for colorectal neoplasms in patients with UC. METHODS: This was a retrospective, multicenter cohort study of patients with UC who initially underwent ER or surgery for colorectal neoplasms between April 2015 and March 2021...
May 30, 2023: Gastrointestinal Endoscopy
Ying Gao, Li-Juan Lu, Zhao-Zheng Zhang, Xiao Yang, Jun Du, Ke Wen, Hua Huang, Xiao-Peng Wang, Xue-Liang Sun
ETHNOPHARMACOLOGICAL RELEVANCE: Xue-Jie-San (XJS), as a traditional Chinese herb prescription, has satisfactory effects on improving clinical symptoms and facilitating the healing of intestinal ulcers in patients with Crohn's disease (CD). This motivates the application of XJS on CD-associated complications. AIM OF THE STUDY: Intestinal fibrosis is a debilitating complication of CD. Currently, there is no effective medication available for preventing or reversing CD-related intestinal fibrosis...
May 30, 2023: Journal of Ethnopharmacology
Botong Li, Yixuan Wang, Xiaolin Jiang, Hongwei Du, Yan Shi, Minghui Xiu, Yongqi Liu, Jianzheng He
Inflammatory bowel disease (IBD) is a special chronic intestinal inflammatory disease, which is mainly divided into Crohn's disease (CD) and ulcerative colitis (UC). Its occurrence is a complex process that regulated by multiple signaling pathways, including nuclear factor erythroid 2-related factor (Nrf2)/ antioxidant response element (ARE) signaling pathway. Nrf2/ARE pathway as the central defense mechanism against oxidative stress controls the expression of many antioxidant and anti-inflammatory genes in the nucleus, and plays a crucial role in the treatment of IBD...
May 30, 2023: Biomedicine & Pharmacotherapy
Amy L Lightner, Ana Otero-Pineiro, Jane Reese, Justin Ream, Douglas Nachand, Ashley C Adams, Alexandra VanDenBossche, Jacob A Kurowski
BACKGROUND: Perianal fistulizing Crohn's disease is notoriously difficult to treat. Recent studies of mesenchymal stem cells have demonstrated safety and efficacy of this novel treatment approach. However, no studies to date have included pediatric patients. We sought to determine safety and efficacy of mesenchymal stem cells for pediatric perianal fistulizing Crohn's disease. METHODS: This was a phase I clinical trial to evaluate safety and feasibility of mesenchymal stem cells in pediatric perianal Crohn's patients 13 to 17 years of age...
June 1, 2023: Inflammatory Bowel Diseases
Claudia Carpineti, Cristina Mugheddu, Marta Cadoni, Jasmine Anedda, Laura Atzori, Massimo C Fantini, Sara Onali
No abstract text is available yet for this article.
June 1, 2023: Inflammatory Bowel Diseases
Kwanwoo Lee, Motofumi Kumazoe, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
INTRODUCTION: Epidemiological studies indicated that inflammatory bowel disease (IBD), with Crohn's disease and ulcerative colitis as its two main types, is associated with dementia. However, little is known about how adolescents with IBD will affect their cognitive ability as adults. The hippocampus, which is crucial for memory and adult neurogenesis, is closely associated with modulation of cognitive processes. Using a low kDa dextran sulfate sodium (DSS, 5 kDa)-induced chronic colitis (mild chronic colitis) mice model in adolescent mice, we investigated the effects of mild chronic colitis on cognitive functions and hippocampal neurogenesis from adolescent mice to adult mice...
May 26, 2023: Biochemical and Biophysical Research Communications
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