Jessica C Petrov, Aakash A Desai, Gursimran S Kochhar, Sheena K Crosby, Jami A Kinnucan, Michael F Picco, Jana G Hashash, Francis A Farraye
BACKGROUND: Metformin exerts anti-inflammatory properties through a positive effect on oxidative stress, gut barrier integrity, and the gut microbiota. Our aim was to evaluate the influence of metformin on inflammatory bowel disease (IBD) outcomes in patients with type 2 diabetes mellitus (T2DM). METHODS: We conducted a retrospective cohort study using the TriNetX database in patients with IBD and T2DM who initiated metformin vs oral hypoglycemics or insulin (control cohort) between August 31, 2002, and August 31, 2022...
July 12, 2024: Inflammatory Bowel Diseases
Seung Min Hong, Dong Hoon Baek
Diagnosing inflammatory bowel disease (IBD) can often be challenging, and differentiating between Crohn's disease and ulcerative colitis can be particularly difficult. Diagnostic procedures for IBD include laboratory tests, endoscopy, pathological tests, and imaging tests. Serological and stool tests can be easily performed in an outpatient setting and provide critical diagnostic clues. Although endoscopy is an invasive procedure, it offers essential diagnostic information and allows for tissue biopsy and therapeutic procedures...
June 28, 2024: Diagnostics
Philippe Pinton
Machine learning (ML) has been applied to predict the efficacy of biologic agents in ulcerative colitis (UC). ML can offer precision, personalization, efficiency, and automation. Moreover, it can improve decision support in predicting clinical outcomes. However, it faces challenges related to data quality and quantity, overfitting, generalization, and interpretability. This paper comments on two recent ML models that predict the efficacy of vedolizumab and ustekinumab in UC. Models that consider multiple pathways, multiple ethnicities, and combinations of real-world and clinical trial data are required for optimal shared decision-making and precision medicine...
June 21, 2024: Diagnostics
Eguzkiñe Diez-Martin, Leidi Hernandez-Suarez, Carmen Muñoz-Villafranca, Leire Martin-Souto, Egoitz Astigarraga, Andoni Ramirez-Garcia, Gabriel Barreda-Gómez
In inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and ulcerative colitis (UC), the immune system relentlessly attacks intestinal cells, causing recurrent tissue damage over the lifetime of patients. The etiology of IBD is complex and multifactorial, involving environmental, microbiota, genetic, and immunological factors that alter the molecular basis of the organism. Among these, the microbiota and immune cells play pivotal roles; the microbiota generates antigens recognized by immune cells and antibodies, while autoantibodies target and attack the intestinal membrane, exacerbating inflammation and tissue damage...
June 27, 2024: International Journal of Molecular Sciences
Takamitsu Sasaki, Rina Fujiwara-Tani, Yi Luo, Ruiko Ogata, Rika Sasaki, Ayaka Ikemoto, Yukiko Nishiguchi, Chie Nakashima, Shingo Kishi, Kiyomu Fujii, Hitoshi Ohmori, Naohide Oue, Hiroki Kuniyasu
Abnormalities in mucosal immunity are involved in the onset and progression of ulcerative colitis (UC), resulting in a high incidence of colorectal cancer (CRC). While high-mobility group box-1 (HMGB1) is overexpressed during colorectal carcinogenesis, its role in UC-related carcinogenesis remains unclear. In the present study, we investigated the role of HMGB1 in UC-related carcinogenesis and sporadic CRC. Both the azoxymethane colon carcinogenesis and dextran sulfate sodium colitis carcinogenesis models demonstrated temporal increases in mucosal HMGB1 levels...
June 21, 2024: International Journal of Molecular Sciences
Natalia Ekstedt, Dominika Jamioł-Milc, Joanna Pieczyńska
Inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and ulcerative colitis (UC), are chronic diseases of the digestive system with a multifactorial and not fully understood etiology. There is research suggesting that they may be initiated by genetic, immunological, and lifestyle factors. In turn, all of these factors play an important role in the modulation of intestinal microflora, and a significant proportion of IBD patients struggle with intestinal dysbiosis, which leads to the conclusion that intestinal microflora disorders may significantly increase the risk of developing IBD...
June 30, 2024: Nutrients
Yoshihiro Tatsumi, Kazuki Kakimoto, Azusa Hara, Noboru Mizuta, Keijiro Numa, Naohiko Kinoshita, Kei Nakazawa, Ryoji Koshiba, Yuki Hirata, Kazuhiro Ota, Takako Miyazaki, Shiro Nakamura, Kayoko Sakagami, Shoko Arimitsu, Hiroaki Ito, Hiroki Nishikawa
Text Correction [...].
July 4, 2024: Journal of Clinical Medicine
Maria Ling Lundström, Christer Peterson, Charlotte R H Hedin, Daniel Bergemalm, Maria Lampinen, Maria K Magnusson, Åsa V Keita, Robert Kruse, Carl Mårten Lindqvist, Dirk Repsilber, Mauro D'Amato, Henrik Hjortswang, Hans Strid, Johan D Söderholm, Lena Öhman, Per Venge, Jonas Halfvarson, Marie Carlson
BACKGROUND: Faecal biomarkers can be used to assess inflammatory bowel disease (IBD). AIM: To explore the performance of some promising biomarkers in diagnosing and predicting disease course in IBD. METHODS: We included 65 patients with treatment-naïve, new-onset Crohn's disease (CD), 90 with ulcerative colitis (UC), 67 symptomatic controls (SC) and 41 healthy controls (HC) in this prospective observational study. We analysed faecal samples for calprotectin (FC), myeloperoxidase (MPO), human neutrophil lipocalin (HNL), eosinophil cationic protein ECP and eosinophil-derived neurotoxin (EDN) and compared markers among groups...
July 12, 2024: Alimentary Pharmacology & Therapeutics
Haixiang Cheng, Yuan Yang, Junjie Hu, Liang Chen, Ming Yuan, Hongzhi Du, Ziqiang Xu, Zhenpeng Qiu
The pathogenesis of ulcerative colitis (UC), a chronic intestine inflammatory disease primarily affecting adolescents, remains uncertain. Contemporary studies suggest that a confluence of elements, including genetic predispositions, environmental catalysts, dysregulated immune responses, and disturbances in the gut microbiome, are instrumental in the initiation and advancement of UC. Among them, inflammatory activation and mucosal barrier damage caused by abnormal immune regulation are essential links in the development of UC...
July 10, 2024: Life Sciences
Hany S Rasmy, Noha A Elnakeeb, Mohamed F Mohamed, Hossam S Elbaz
Inflammatory bowel disease is a chronic immune-mediated disorder with a relapsing and remitting course. It leads to disabling gastrointestinal symptoms, low quality of life, and a significant burden for healthcare utilization and associated costs. Therefore, non-invasive biomarkers are needed for early diagnosis and follow up to avoid the complications of invasive diagnostic procedures. Calgranulin C is a calcium binding protein with proinflammatory properties. The aim of this study was to evaluate the role of serum calgranulin C as a non-invasive biomarker for diagnosis and prediction of activity in comparison to different biomarkers and endoscopic activity scores in inflammatory bowel disease...
July 2024: Egyptian Journal of Immunology
Jing Pan, Yanwei Lv, Lingyan Wang, Xiaodan Chang, Kaiping Zhao, Xiao Liu
OBJECTIVE: This study is designed to explore the potential causal relationship between psoriasis and psoriatic arthritis (PsA) while investigating the genetic basis shared by these inflammatory diseases. METHODS: Significant single nucleotide polymorphisms (SNPs) associated with UC, psoriasis, and PsA were selected as genetic instrumental variables using Genome-Wide Association Study (GWAS) datasets. Additionally, Mendelian randomization (MR) methods, including inverse-variance weighting (IVW), MR-Egger regression, and Weighted Median (WME), were utilized to evaluate the causal relationships between these diseases...
July 2024: Skin Research and Technology
Teagan S Edwards, Andrew S Day
INTRODUCTION: Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and Ulcerative Colitis (UC), is a relapsing and remitting condition. Noninvasive biomarkers have an increasingly important role in the diagnosis of IBD and in the prediction of future disease course in individuals with IBD. Strategies for the management of IBD increasingly rely upon close monitoring of gastrointestinal inflammation. AREAS COVERED: This review provides an update on the current understanding of established and novel stool-based biomarkers in the diagnosis and management of IBD...
July 12, 2024: Expert Review of Molecular Diagnostics
Francesco Palestra, Gina Memoli, Annagioia Ventrici, Marialuisa Trocchia, Mariarosaria Galdiero, Gilda Varricchi, Stefania Loffredo
IBD is an uncontrolled inflammatory condition of the gastrointestinal tract, which mainly manifests in two forms: ulcerative colitis (UC) and Crohn's disease (CD). The pathogenesis of IBD appears to be associated with an abnormal response of innate and adaptive immune cells. Innate immunity cells, such as macrophages, mast cells, and granulocytes, can produce proinflammatory (e.g., TNF-α) and oxidative stress (ROS) mediators promoting intestinal damage, and their abnormal responses can induce an imbalance in adaptive immunity, leading to the production of inflammatory cytokines that increase innate immune damage, abate intestinal barrier functions, and aggravate inflammation...
June 21, 2024: Cells
Sara Karlqvist, Michael C Sachs, Carl Eriksson, Yang Cao, Scott Montgomery, Jonas F Ludvigsson, Ola Olén, Jonas Halfvarson
OBJECTIVES: We aimed to assess the risk of serious infection in inflammatory bowel disease (IBD) patients treated with vedolizumab, compared to those treated with anti-tumor necrosis factors (TNF) and the general population. METHODS: In this Swedish cohort study, treatment episodes were identified from nationwide health registers. We used Cox regression with propensity score-matched cohorts to estimate hazard ratios (HRs) for incident serious infections, defined as infections requiring hospital admission...
July 12, 2024: American Journal of Gastroenterology
Maximo E Lange, Danisa M Bescucci, Valerie F Boras, Tony Montina, G Douglas Inglis
BACKGROUND: A multitude of mouse models are utilized to emulate and study intestinal inflammation. T-cell receptor alpha chain (TCRα)-deficient mice are used as a model of spontaneous colitis that has similarities with human ulcerative colitis. However, colitis is triggered late in the life of the mouse (age: 4-5 months), and inflammation does not develop at the same time in different mice. A previously conducted study reported that the administration of the drug piroxicam triggered predictable and early colitis in TCRα-deficient mice at the age of 6-8 weeks...
July 11, 2024: Animal Models and Experimental Medicine
Hao Fu, Xiao Zheng, Ke Xu, Yuge Zhang, Mengxia Wu, Min Xu
Ulcerative colitis (UC) is a persistent inflammatory condition that specifically targets the colon and rectum. Existing therapies fail to adequately address the clinical requirements of people suffering from this ailment. Despite the acknowledged potential of nanomedicines in the field of anti-inflammatory treatment, their widespread use in clinical settings is impeded by their expensive nature and the uncertainty surrounding their safety profiles. This study illustrates that two naturally occurring phytochemicals, Costunolide (COS) and Glycyrrhizic acid (GA), form carrier-free, multifunctional spherical nanoparticles (NPs) through noncovalent interactions, such as π-π stacking and hydrogen bonding...
July 11, 2024: BMC Gastroenterology
Yuan-Yuan Li, Jing-Wen Sun, Lei Chen, Yong-Ming Lu, Qing-Xi Wu, Chao Yan, Yan Chen, Mei Zhang, Wen-Na Zhang
A new polysaccharide fraction (ATP) was obtained from Armillariella tabescens mycelium. Structural analysis suggested that the backbone of ATP was →4)-α-D-Glcp(1 → 2)-α-D-Galp(1 → 2)-α-D-Glcp(1 → 4)-α-D-Glcp(1→, which branched at O-3 of →2)-α-D-Glcp(1 → and terminated with T-α-D-Glcp or T-α-D-Manp. Besides, ATP significantly alleviated ulcerative colitis (UC) symptoms and inhibited the production of pro-inflammation cytokines (IL-1β, IL-6)...
July 9, 2024: International Journal of Biological Macromolecules
Huimin Zhang, Hailun Zheng, Qizhi Wang, Zhenzeng Ma, Wei Liu, Linxia Xu, Dapeng Li, Yu Zhu, Yongju Xue, Letian Mei, Xixiang Huang, Zhiguo Guo, Xiquan Ke
BACKGROUND: Sinomenine hydrochloride (SH) has anti-inflammatory and immunosuppressive effects, and its effectiveness in inflammatory diseases, such as rheumatoid arthritis, has been demonstrated. However, whether SH has a therapeutic effect on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in mice and its mechanism of action have not been clarified. This study aimed to investigate the therapeutic effects and mechanism of action of SH on UC. METHODS: Twenty-four mice were randomly divided into control, model, SH low-dose (SH-L, 20 mg/kg), and SH high-dose (SH-H, 60 mg/kg) groups with six mice in each group...
July 9, 2024: Clinics and Research in Hepatology and Gastroenterology
Marc Vidal-Delso, Marta Fortuny, Laura González-González, Anna Pèlach, Laura Soldevila, Sílvia Roure-Díez, Míriam Mañosa, Eugeni Domènech
No abstract text is available yet for this article.
July 9, 2024: Gastroenterología y Hepatología
Anna L Silverman, Dennis Shung, Ryan W Stidham, Gursimran S Kochhar, Marietta Iacucci
Artificial intelligence (AI) refers to computer-based methodologies which use data to teach a computer to solve pre-defined tasks; these methods can be applied to identify patterns in large multi-modal data sources. AI applications in inflammatory bowel disease (IBD) includes predicting response to therapy, disease activity scoring of endoscopy, drug discovery, and identifying bowel damage in images. As a complex disease with entangled relationships between genomics, metabolomics, microbiome, and the environment, IBD stands to benefit greatly from methodologies that can handle this complexity...
July 9, 2024: Clinical Gastroenterology and Hepatology
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.