Kimberley W J van der Sloot, Johan L Tiems, Marijn C Visschedijk, Eleonora A M Festen, Hendrik M van Dullemen, Rinse K Weersma, Gursah Kats-Ugurlu, Gerard Dijkstra
BACKGROUND AND AIMS: Patients with inflammatory bowel disease are at increased risk of colorectal neoplasia (CRN) due to mucosal inflammation. As current surveillance guidelines form a burden on patients and healthcare costs, stratification of high-risk patients is crucial. Cigarette smoke reduces inflammation in ulcerative colitis (UC) but not Crohn's disease (CD) and forms a known risk factor for CRN in the general population. Due to this divergent association, the effect of smoking on CRN in IBD is unclear and subject of this study...
January 13, 2021: Clinical Gastroenterology and Hepatology
Matteo Bramuzzo, Paolo Lionetti, Erasmo Miele, Claudio Romano, Serena Arrigo, Sabrina Cardile, Giovanni Di Nardo, Maria Teresa Illiceto, Maria Pastore, Enrico Felici, Maurizio Fuoti, Claudia Banzato, Michele Citrano, Mauro Congia, Lorenzo Norsa, Elena Pozzi, Giovanna Zuin, Anna Agrusti, Martina Bianconi, Claudia Grieco, Fabiola Giudici, Marina Aloi, Patrizia Alvisi
BACKGROUND: Adult patients with both inflammatory bowel disease (IBD) and celiac disease (CeD) have peculiar phenotypic features. This study aimed at describing the characteristics and natural history of children with both IBD and CeD. METHODS: This was a case-control study based on a national registry. Cases included children diagnosed with both IBD and CeD. Two matched IBD controls without CeD, and 2 matched CeD controls were selected for each case. Inflammatory bowel disease phenotype and natural history, comprising growth and pubertal development, were compared between groups...
January 16, 2021: Inflammatory Bowel Diseases
Giovanni Di Nardo, Paolo Quitadamo, Mara Quatrini, Francesco Malfona, Maria Luisa Moleti, Ursula La Rocca, Margherita Velardi, Pasquale Parisi, Anna Maria Testi
No abstract text is available yet for this article.
January 16, 2021: Inflammatory Bowel Diseases
Allison D Ta, Nicholas J Ollberding, Rebekah Karns, Yael Haberman, Adina L Alazraki, David Hercules, Robert Baldassano, James Markowitz, Melvin B Heyman, Sandra Kim, Barbara Kirschner, Jason M Shapiro, Joshua Noe, Maria Oliva-Hemker, Anthony Otley, Marian Pfefferkorn, Richard Kellermayer, Scott Snapper, Shervin Rabizadeh, Ramnik Xavier, Marla Dubinsky, Jeffrey Hyams, Subra Kugathasan, Anil G Jegga, Jonathan R Dillman, Lee A Denson
BACKGROUND: Transmural healing (TH) is associated with better long-term outcomes in Crohn disease (CD), whereas pretreatment ileal gene signatures encoding myeloid inflammatory responses and extracellular matrix production are associated with stricturing. We aimed to develop a predictive model for ileal TH and to identify ileal genes and microbes associated with baseline luminal narrowing (LN), a precursor to strictures. MATERIALS AND METHODS: Baseline small bowel imaging obtained in the RISK pediatric CD cohort study was graded for LN...
January 16, 2021: Inflammatory Bowel Diseases
Unmesha Roy Paladhi, Ali H Harb, Scott G Daniel, Ghadeer K Dawwas, Erin M Schnellinger, Colin Wollack, Faten N Aberra, Meenakshi Bewtra, Jesse A Green, Jan-Michael A Klaproth, Gary R Lichtenstein, Akriti Saxena, Shivali Berera, Anna Buchner, Shivan J Mehta, Mark T Osterman, Farzana Rashid, Vesselin Tomov, Freddy Caldera, Saha Sumona, Uma Mahadevan, Abhik Roy, Lisa Nessel, Gary D Wu, Kyle Bittinger, James D Lewis
No abstract text is available yet for this article.
January 16, 2021: Inflammatory Bowel Diseases
Nilesh Chande, Siddharth Singh, Neeraj Narula, Morris Gordon, M Ellen Kuenzig, Tran M Nguyen, John K MacDonald, Brian G Feagan
No abstract text is available yet for this article.
January 16, 2021: Inflammatory Bowel Diseases
Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Agnieszka Zawada, Anna Maria Rychter, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
Patients suffering from Crohn's disease and ulcerative colitis are at higher risk of osteoporosis due to lower bone mineral density. Risk factors of osteoporosis are divided into unmodifiable, namely, age, gender, genetic factors, as well as modifiable, including diet, level of physical activity, and the use of stimulants. Coffee and tea contain numerous compounds affecting bone metabolism. Certain substances such as antioxidants may protect bones; other substances may increase bone resorption. Nevertheless, the influence of coffee and tea on the development and course of inflammatory bowel diseases is contradictory...
January 13, 2021: Nutrients
Georges Tarris, Alexis de Rougemont, Maëva Charkaoui, Christophe Michiels, Laurent Martin, Gaël Belliot
Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a multifactorial disease in which dietary, genetic, immunological, and microbial factors are at play. The role of enteric viruses in IBD remains only partially explored. To date, epidemiological studies have not fully described the role of enteric viruses in inflammatory flare-ups, especially that of human noroviruses and rotaviruses, which are the main causative agents of viral gastroenteritis. Genome-wide association studies have demonstrated the association between IBD, polymorphisms of the FUT2 and FUT3 genes (which drive the synthesis of histo-blood group antigens), and ligands for norovirus and rotavirus in the intestine...
January 13, 2021: Viruses
Zhaohuan Lou, Huajun Zhao, Guiyuan Lyu
The "lung and large intestine being interior-exteriorly related" is one of the classical theories in traditional Chinese medicine, which indicates a close correlation between the lung and large intestine in physiology and pathology, and plays a pivotal role in guiding the treatment of the lung and bowel diseases. Modern medicine has revealed some connections between the lung and large intestine in tissue origin and mucosal immunity, and preliminarily illuminated the material basis and possible regulatory mechanism of the theory...
December 25, 2020: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
Hadeel A Alsufyani, Mahmoud H Mosli, Omar I Saadah
BACKGROUND AND AIMS: Children with inflammatory bowel disease (IBD) generally show an alteration in their fat and soft tissue mass contents. These alterations may influence disease severity and increase the risk of post-operative complications. METHODS: This is a retrospective cross-sectional study of patients with IBD, diagnosed and followed up between 2013 and 2018, in Jeddah, Saudi Arabia, who had dual-energy x-ray absorptiometry (DXA) scans for bone density evaluation...
January 14, 2021: International Journal of Clinical Practice
Xin Gao, Yu Tang, Na Lei, Ying Luo, Pingrun Chen, Chang Liang, Shihao Duan, Yan Zhang
Studies have demonstrated that inflammatory bowel disease (IBD) patients are at an increased risk of developing anxiety and/or depression. IBD patients with depression/anxiety have higher rates of hospitalization and increased disease severity than those without. So far, there is a paucity of data concerning the impact of anxiety/depression on Chinese IBD patients. The aim of this study was to find out the prevalence of symptoms of anxiety/depression in Chinese IBD population and its impact on IBD-related features...
January 14, 2021: Scientific Reports
Hye-Young Jin, Jae-Sang Lim, Yena Lee, Yunha Choi, Seak-Hee Oh, Kyung-Mo Kim, Han-Wook Yoo, Jin-Ho Choi
BACKGROUND: Endocrine complications such as impaired growth, delayed puberty, and low bone mineral density (BMD) can be associated with inflammatory bowel disease (IBD) in children and adolescents. This study was performed to investigate the frequency, characteristics, and outcomes of endocrine complications of IBD in children and adolescents. METHODS: This study included 127 patients with IBD diagnosed before 18 years of age [117 with Crohn disease (CD) and 10 with ulcerative colitis (UC)]...
January 14, 2021: BMC Pediatrics
Shara Francesca Rapa, Rosanna Di Paola, Marika Cordaro, Rosalba Siracusa, Ramona D'Amico, Roberta Fusco, Giuseppina Autore, Salvatore Cuzzocrea, Hermann Stuppner, Stefania Marzocco
Intestinal epithelial barrier impairment plays a key pathogenic role in inflammatory bowel diseases (IBDs). In particular, together with oxidative stress, intestinal epithelial barrier alteration is considered as upstream event in ulcerative colitis (UC). In order to identify new products of natural origin with a potential activity for UC treatment, this study evaluated the effects of plumericin, a spirolactone iridoid, present as one of the main bioactive components in the bark of Himatanthus sucuuba (Woodson)...
January 12, 2021: Biomedicines
Stephen J O'Brien, Jacob Hallion, Katharina M Scheurlen, Casey Fiechter, James Burton, Mason Paas, Miranda Schmidt, Sarah Gardner, Maurice R Eichenberger, Jianmin Pan, Shesh Rai, Susan Galandiuk
BACKGROUND: Ileal pouch-anal anastomosis (IPAA) is a common surgical treatment for ulcerative colitis. Afferent limb stenosis is an infrequent complication following IPAA, suggesting underlying Crohn's disease (CD). We hypothesized that CD-related single nucleotide polymorphisms (SNPs) are associated with afferent limb stenosis. METHODS: Afferent limb stenosis and CD control group patients were recruited from a prospective institutional inflammatory bowel disease database and associated biobank...
January 14, 2021: Journal of Gastrointestinal Surgery
Jung Rock Moon, Chang Kyun Lee, Sung Noh Hong, Jong Pil Im, Byong Duk Ye, Jae Myung Cha, Sung-Ae Jung, Kang-Moon Lee, Dong Il Park, Yoon Tae Jeen, Young Sook Park, Jae Hee Cheon, Hyesung Kim, BoJeong Seo, Youngdoe Kim, Hyo Jong Kim
No abstract text is available yet for this article.
January 15, 2021: Gut and Liver
Mohammed Hasosah, Amirah Alqahtani, Ali Almehaidib, Mansour Qurashi
No abstract text is available yet for this article.
December 30, 2020: Inflammatory Bowel Diseases
Vibeke Andersen, Andreas Kristian Pedersen, Sören Möller, Anders Green
Background: Chronic inflammatory diseases (CIDs) may share aetiological factors across diseases. We used registry data to evaluate the risk of developing five common childhood CIDs dependent on the parents' disease status. Methods: We performed a national population-based registry study by linking data from the national Danish health registers from January 1973 to March 2016 to evaluate any potential associations between parents' disease and development of CIDs among the offspring...
2021: Clinical Epidemiology
Georges Tarris, Alexis de Rougemont, Marie Estienney, Maeva Charkaoui, Thomas Mouillot, Bernard Bonnotte, Christophe Michiels, Laurent Martin, Gaël Belliot
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is related to immunological and microbial factors, with the possible implication of enteric viruses. We characterized the interaction between human noroviruses (HuNoVs) and blood group antigens in refractory CD and UC using HuNoV virus-like particles (VLPs) and histological tissues. Immunohistochemistry was conducted on inflammatory tissue samples from the small intestine, colon, and rectum in 15 CD and 9 UC patients...
January 13, 2021: MSphere
Luoyan Ai, Yimeng Ren, Mingming Zhu, Shiyuan Lu, Yun Qian, Zhaofei Chen, Antao Xu
OBJECTIVE: As a canonical membrane tethering factor, the function of synbindin has been expanding and indicated in immune response. Here, we investigated the role of synbindin in the regulation of toll-like receptor 4 (TLR4) signalling and macrophage response to microbiota during colitis. DESIGN: Three distinct mouse models allowing global, myeloid-specific or intestinal epithelial cell-specific synbindin heterozygous deletion were constructed and applied to reveal the function of synbindin during dextran sodium sulfate (DSS) colitis...
January 13, 2021: Gut
Zhaofeng Shen, Kai Zheng, Jiandong Zou, Peiqing Gu, Jing Xing, Lu Zhang, Lei Zhu, Hong Shen
BACKGROUND: Ulcerative colitis (UC) is an intestinal inflammatory disease characterized by inflammation of the colonic mucosa. With unknown pathogenesis, it has become a chronic lifetime disorder worldwide. In patients with moderately active UC, several therapies (e.g., aminosalicylates, corticosteroids, immunosuppressants, and biologics) are recommended for induction (or maintenance) of remission. Given the side effects and disease burden, it is difficult for most patients to achieve ideal treatment goals in clinical practice...
January 13, 2021: Trials
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