Yannick Béjot, Abderrahmane Bourredjem, Emmanuelle Mimeau, Julien Joux, Annie Lannuzel, Caroline Misslin-Tritsch, Claire Bonithon-Kopp, Devi Rochemont, Mathieu Nacher, André Cabie, Marie-Laure Lalanne Mistrih, Isabelle Fournel
BACKGROUND: Social deprivation may have a deleterious influence on post-stroke outcomes, but available data in the literature are mixed. AIM: The aim of this cohort study was to evaluate the impact of social deprivation on one-year survival in patients with first-ever stroke. METHODS: Social deprivation was assessed at individual level with the EPICES score, a validated multidimensional questionnaire, in 1312 patients with ischemic stroke (IS), and 228 patients with spontaneous intracerebral hemorrhage (ICH), who were prospectively enrolled in six French study centers...
October 24, 2020: European Journal of Neurology
Jahanavi M Ramakrishna, Claudia R Libertin, Jason Siegel, Matthew J Binnicker, Dana Harris, Gautam V Matcha, Thomas Caulfield, W D Freeman
The COVID-19 pandemic continues to overwhelm global healthcare systems. While the disease primarily causes pulmonary complications, reports of central nervous system (CNS) involvement have recently emerged ranging from encephalopathy to stroke. This raises a practical dilemma for clinicians as to when to pursue neuroimaging and lumbar tap with cerebrospinal fluid (CSF) analysis in COVID-19 patients with neurological symptoms. We present a case of an encephalopathic patient infected with SARS-CoV-2 with no pulmonary symptoms...
October 23, 2020: Romanian Journal of Internal Medicine
Victoria Bitsadze, Jamilya Khizroeva, Ismail Elalamy, Makatsariya Alexander
Objectives Assess all risk factors of venous thromboembolism (VTE) in pregnancy and puerperium. Methods Different guidelines for VTE prevention have been analyzed. Results Various recommendations have appeared for practitioners during the last 10-15 years on the basis of the risk factors analysis in order to prevent VTE in pregnant women more effectively. Nevertheless, none of these recommendations can yet take into account all risk factors, although convenient scoring systems have emerged for risk assessment and clear recommendations on anti-thrombotic prophylaxis regimens in risk groups in recent years...
October 26, 2020: Journal of Perinatal Medicine
Duraisamy Kempuraj, Ramasamy Thangavel, Deepak D Kempuraj, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Sudhanshu P Raikwar, Smita A Zaheer, Shankar S Iyer, Raghav Govindarajan, Premkumar Nattanmai Chandrasekaran, Asgar Zaheer
Neuroinflammation leads to neurodegeneration, cognitive defects, and neurodegenerative disorders. Neurotrauma/traumatic brain injury (TBI) can cause activation of glial cells, neurons, and neuroimmune cells in the brain to release neuroinflammatory mediators. Neurotrauma leads to immediate primary brain damage (direct damage), neuroinflammatory responses, neuroinflammation, and late secondary brain damage (indirect) through neuroinflammatory mechanism. Secondary brain damage leads to chronic inflammation and the onset and progression of neurodegenerative diseases...
October 24, 2020: BioFactors
Sabina Serra, Julietta Kugler, Martina Hug, Annette Hackenberg, Beatrice Latal, Nadia Khan
AIM: To preoperatively assess the neurodevelopment of a predominantly white population of children with moyamoya angiopathy (MMA). METHOD: Assessments of 40 children with MMA (24 females, 16 males; mean age 6y 11mo, range 20mo-16y) included tests for non-verbal IQ and fine motor skills, and questionnaires on quality of life, behaviour, and executive functions. The Paediatric Stroke Outcome Measure (PSOM) score was evaluated by a paediatric neurologist. RESULTS: Children with MMA had significantly lower non-verbal IQ scores (mean IQ 92...
October 24, 2020: Developmental Medicine and Child Neurology
Andreas Goette, Lars Eckardt, Marco Valgimigli, Thorsten Lewalter, Petra Laeis, Paul-Egbert Reimitz, Rüdiger Smolnik, Wolfgang Zierhut, Jan G Tijssen, Pascal Vranckx
AIMS: This subgroup analysis of the ENTRUST-AF PCI trial ( Identifier: NCT02866175; Date of registration: August 2016) evaluated type of AF, and CHA2 DS2 -VASc score parameters as predictors for clinical outcome. METHODS: Patients were randomly assigned after percutaneous coronary intervention (PCI) to either edoxaban (60 mg/30 mg once daily [OD]; n = 751) plus a P2Y12 inhibitor for 12 months or a vitamin K antagonist [VKA] (n = 755) plus a P2Y12 inhibitor and aspirin (100 mg OD, for 1-12 months)...
October 24, 2020: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Rahil Ghahramani, Mohammad Kermani-Alghoraishi, Hamidreza Roohafza, Saeide Bahrani, Mohammad Talaei, Minoo Dianatkhah, Nizal Sarrafzadegan, Masoumeh Sadeghi
BACKGROUND: Besides the traditional cardiovascular risk factor, some novel risk factors like occupation and career can play an important role in cardiovascular disease (CVDs) incidence. OBJECTIVE: To assess the association between occupational categories and their positions with cardiovascular events (CVEs) in an Iranian male population. METHODS: We followed 2134 men aged 35-65 years for 14 years during the Isfahan Cohort Study (2001-2015) for CVEs including ischemic heart disease and stroke...
October 2020: International Journal of Occupational and Environmental Medicine
Michal Horowitz
No abstract text is available yet for this article.
October 24, 2020: Journal of Physiology
Miwa Sarashina-Motoi, Hiroyuki Iwano, Ko Motoi, Suguru Ishizaka, Yasuyuki Chiba, Shingo Tsujinaga, Michito Murayama, Masahiro Nakabachi, Shinobu Yokoyama, Hisao Nishino, Kazunori Okada, Sanae Kaga, Toshihisa Anzai
PURPOSE: To investigate the influence of changes in vortices within the left ventricle (LV) on energy efficiency (EE) in normal and diseased hearts. METHODS: We performed vector flow mapping echocardiography in 36 normal participants (N), 36 patients with dilated cardiomyopathy (D), and 36 patients with LV hypertrophy (H). The circulation of the main anterior vortex was measured as a parameter of vortex strength. Energy loss (EL) was measured for one cardiac cycle, and EE was calculated as EL divided by stroke work (SW), which represents the loss of kinetic energy per unit of LV external work...
October 24, 2020: Journal of Clinical Ultrasound: JCU
Jianfei Gao, Tingting Qian, Wei Wang
C1q/tumor necrosis factor-related protein-3 (CTRP3) had shown its angiogenesis and enhancement of mitochondrial biogenesis properties in the treatment of myocardial infarction, but its potential roles in cerebral ischemic stroke had not been fully understood. This study aimed to clarify the underlying mechanism of how CTRP3 regulated mitochondrial functions in hippocampal neuronal cells (HPPNCs) after oxygen-glucose deprivation (OGD)/reoxygenation (R) treatment. Results showed that impeded CTRP3 expression and weakened viability were detected in OGD/R treated HPPNCs...
October 23, 2020: Neurochemical Research
Natasha Ting Lee, Carly Selan, Joanne S J Chia, Sharelle A Sturgeon, David K Wright, Akram Zamani, Melrine Pereira, Harshal H Nandurkar, Maithili Sashindranath
Stroke is caused by obstructed blood flow (ischaemia) or unrestricted bleeding in the brain (haemorrhage). Global brain ischaemia occurs after restricted cerebral blood flow e.g. during cardiac arrest. Following ischaemic injury, restoration of blood flow causes ischaemia-reperfusion (I/R) injury which worsens outcome. Secondary injury mechanisms after any stroke are similar, and encompass inflammation, endothelial dysfunction, blood-brain barrier (BBB) damage and apoptosis. We developed a new model of transient global forebrain I/R injury (dual carotid artery ligation; DCAL) and compared the manifestations of this injury with those in a conventional I/R injury model (middle-cerebral artery occlusion; MCAo) and with intracerebral haemorrhage (ICH; collagenase model)...
October 23, 2020: Scientific Reports
Victor C Urrutia
No abstract text is available yet for this article.
October 23, 2020: Neurology
Patrick M Boyle, Juan Carlos Del Álamo, Nazem Akoum
The current paradigm of stroke risk assessment and mitigation in patients with atrial fibrillation (AF) is centred around clinical risk factors which, in the presence of AF, lead to thrombus formation. The mechanisms by which these clinical risk factors lead to thromboembolism, including any role played by atrial fibrosis, are not understood. In patients who had embolic stroke of undetermined source (ESUS), the problem is compounded by the absence of AF in a majority of patients despite long-term monitoring...
October 23, 2020: Heart
Kolja Sievert, Jiangtao Yu, Stefan Bertog, Marius Hornung, Ralph Stephan von Bardeleben, Sameer Gafoor, Markus Reinartz, Predrag Matic, Ilona Hofmann, Iris Grunwald, Nalan Schnelle, Horst Sievert
BACKGROUND: A patent foramen ovale (PFO) has been associated with embolic strokes and transient ischemic attacks (TIAs). Catheter closure of PFO is effective in preventing recurrent events. Residual shunts and procedure or device related complications can occur, including atrial fibrillation and thrombus formation. This study examines the initial experience with a new PFO closure device, the IrisFIT PFO-Occluder (Lifetech Scientific, Shenzhen, China). METHODS: 95 patients with indications for PFO closure underwent percutaneous closure with the IrisFIT PFO-Occluder...
September 24, 2020: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Fernando J Rascón-Ramírez, Ángela María Carrascosa-Granada, Andrés Camilo Vargas-Jiménez, Borja Ferrández-Pujante, Francisco Ortuño-Andériz
The coronavirus disease 2019 (COVID-19) has amazed by its distinct forms of presentation and severity. COVID-19 patients can develop large-scale ischemic strokes in previously healthy patients without risk factors, especially in patients who develop an acute respiratory distress syndrome (SARS-CoV-2). We hypothesize that ischemic events are usually the result of the combined process of a pro-inflammatory and pro-coagulant state plus vascular endothelial dysfunction probably potentiated by hypoxia, hemodynamic instability, and immobilization, as reported in other cases...
September 6, 2020: Neurocirugía
Daniel Fife, Clair Blacketer, R Karl Knight, James Weaver
BACKGROUND: We estimated stroke risk associated with new exposure to haloperidol, or any typical antipsychotic, versus atypical antipsychotic among patients aged ≥65 years regardless of dementia status. METHODS: IBM MarketScan Medicare Supplemental Database data (January 1, 2001 to December 31, 2017) were used. Stroke risk for new users of typical antipsychotics (T1 cohort) or haloperidol (T2 cohort) was compared with new users of atypical antipsychotics (C1 cohort) aged ≥65 years...
September 28, 2020: American Journal of Geriatric Psychiatry
Susanne Guidetti, Martha Gustavsson, Kerstin Tham, Magnus Andersson, Uno Fors, Charlotte Ytterberg
BACKGROUND: Globally, there is a growing use of Information and Communication Technology (ICT), including mobile phones, tablets and computers, which are being integrated into people's daily activities. An ICT-based intervention called F@ce was developed in order to provide a structure for the process in stroke rehabilitation and facilitate change by integrating a global problem-solving strategy using SMS alerts. The aim of the study was to evaluate the feasibility of i) F@ce within in-patient and primary care rehabilitation after stroke, ii) the study design and outcome measures used, and iii) the fidelity, adherence and acceptability of the intervention...
October 23, 2020: BMC Neurology
Melissa D Stockbridge, Alexandra Walker, William Matchin, Bonnie L Breining, Julius Fridriksson, Argye E Hillis, Gregory Hickok
People with aphasia demonstrate impaired production of bound inflectional morphemes, such as noun plurals and possession. They often show greater difficulty in marking possession versus plurality. Using a new tool for eliciting language, the Morphosyntactic Generation test, we assessed people with primary progressive aphasia and those in the acute and chronic phase following left hemisphere stroke. Clinical profiles were associated with different strengths and weaknesses in language production. Performance of the plural was stronger than possessive in group analyses...
October 23, 2020: Cognitive Neuropsychology
Jacek Piegza, Lech Poloński, Aneta Desperak, Andrzej Wester, Marianna Janion, Wiesław Mazurek, Wojciech Wojakowski, Adam Witkowski, Dariusz Dudek, Mariusz Gąsior
BACKGROUND: There are no data regarding the mortality rate, risks and benefits of particular reperfusion methods and pharmacological treatment complications in patients aged over 100 years with acute coronary syndromes. We sought to assess the treatment of myocardial infarction (MI) in patients older than 100 years and to determine prognostic factors for this group. METHODS: Among the 716,566 patients recorded between 2003 and 2018 in the Polish Registry of Acute Coronary Syndromes, 104 patients aged ≥100 with MI were included...
October 21, 2020: Journal of Clinical Medicine
Sanghun Lee, Ok Joon Kim, Kee Ook Lee, Hyeju Jung, Seung-Hun Oh, Nam Keun Kim
Although intravenous administration of mesenchymal stem cells (MSCs) is effective for experimental stroke, low engraftment and the limited functional capacity of transplanted cells are critical hurdles for clinical applications. C-C motif chemokine ligand 2 (CCL2) is associated with neurological repair after stroke and delivery of various cells into the brain via CCL2/CCR2 (CCL2 receptor) interaction. In this study, after CCL2-overexpressing human umbilical cord-derived MSCs (hUC-MSCs) were intravenously transplanted with mannitol in rats with middle cerebral arterial occlusion, we compared the differences between four different treatment groups: mannitol + CCL2-overexpressing hUC-MSCs (CCL2-MSC), mannitol + naïve hUC-MSCs (M-MSC), mannitol only, and control...
October 21, 2020: International Journal of Molecular Sciences
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