Julia C Hotek, Julio A Chirinos, Theodore J Detwiler, Hillary K Regan, Christopher P Regan
Pulsatile hemodynamics analyses provide important information about the ventricular-arterial system which cannot be inferred by standard blood pressure measurements. Pulse wave analysis (PWA), wave separation analysis (WSA), and wave power analysis (WPA) characterize arterial hemodynamics with limited preclinical applications. Integrating these tools into preclinical testing may enhance understanding of disease or therapeutic effects on cardiovascular function. We used a canine rapid ventricular pacing (RVP) heart failure model to: (1) Characterize hemodynamics in response to RVP and (2) assess analyses from flow waveforms synthesized from pressure compared to those derived from measured flow...
June 2023: Physiological Reports
Jing Wen, Li Zou, Ziwen Jiang, Yufeng Li, Jiaxin Tao, Yifang Liu, Wenning Fu, Xue Bai, Jing Mao
BACKGROUND: Previous studies have suggested that ambient temperature is associated with the morbidity and mortality of stroke although results among these investigations remained unclear. Therefore, the purpose of present meta-analysis was to summarize the evidence of the relationship between ambient temperature and stroke morbidity and mortality. METHODS: A systematic search of the PubMed, Embase, and Web of Science databases was from inception to April 13, 2022...
June 2, 2023: Brain and Behavior
Jungsoo Lee, Yun-Hee Kim
BACKGROUND: In stroke patients, preserved cognitive function plays a role in motor recovery, but there is insufficient evidence on the involved mechanisms. These mechanisms require investigation in the human brain, which is composed of large-scale functionally specialized networks. OBJECTIVE: In this study, we investigated the role of cognition-related networks on upper extremity motor recovery using neuroimaging data of subacute stroke patients. METHODS: This study retrospectively analyzed cohort data of 108 subacute ischemic stroke patients...
June 2, 2023: Neurorehabilitation and Neural Repair
Yeun Jie Yoo, Seong Hoon Lim, Youngkook Kim, Joon-Sung Kim, Bo Young Hong, Mi-Jeong Yoon, Hanee Rim, Geun-Young Park
BACKGROUND: The cerebellum plays a crucial role in functional movement by influencing sensorimotor coordination and learning. However, the effects of cortico-cerebellar connectivity on the recovery of upper extremity motor function after stroke have not been investigated. We hypothesized that the integrity of the cortico-cerebellar connections would be reduced in patients with a subacute middle cerebral artery (MCA) stroke, and that this reduction may help to predict chronic upper extremity motor function...
June 2, 2023: Neurorehabilitation and Neural Repair
Benjamin Chong, Alan Wang, Cathy M Stinear
Baseline scores after stroke have long been known as a good predictor of post-stroke outcomes. Similarly, the extent of baseline impairment has been shown to strongly correlate with spontaneous recovery in the first 3 to 6 months after stroke, a principle known as proportional recovery. However, recent critiques have proposed that proportional recovery is confounded, most notably by mathematical coupling and ceiling effects, and that it may not be a valid model for post-stroke recovery. This article reviews the current understanding of proportional recovery after stroke, discusses its supposed confounds of mathematical coupling and ceiling effects, and comments on the validity and usefulness of proportional recovery as a model for post-stroke recovery...
June 2, 2023: Neurorehabilitation and Neural Repair
Frederico Pieruccini-Faria, Benjamin Cornish, Malcolm Binns, Julia Fraser, Seyyed M H Haddad, Kelly Sunderland, Joel Ramirez, Derek Beaton, Donna Kwan, Allison A Dilliott, Christopher Scott, Yanina Sarquis-Adamson, Alanna Black, Karen Van Ooteghem, Leanne Casaubon, Dar Dowlatshahi, Ayman Hassan, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, Brian Tan, Robert Hegele, Dennis Bulman, Mahdi Ghani, John Robinson, Ekaterina Rogaeva, Sali Farhan, Sean Symons, Nuwan Nanayakkara, Stephen R Arnott, Courtney Berezuk, Melissa Holmes, Sabrina Adamo, Miracle Ozzoude, Mojdeh Zamyadi, Wendy Lou, Sujeevini Sujanthan, Robert Bartha, Sandra E Black, Richard H Swartz, William McIlroy, Manuel Montero-Odasso
BACKGROUND: Acute change in gait speed while performing a mental task [dual-task gait cost (DTC)], and hyperintensity magnetic resonance imaging signals in white matter are both important disability predictors in older individuals with history of stroke (poststroke). It is still unclear, however, whether DTC is associated with overall hyperintensity volume from specific major brain regions in poststroke. METHODS: This is a cohort study with a total of 123 older (69 ± 7 years of age) participants with history of stroke were included from the Ontario Neurodegenerative Disease Research Initiative...
June 2, 2023: Neurorehabilitation and Neural Repair
Hisataka Ominato, Yuki Komabayashi, Shiori Suzuki, Isamu Kunibe
BACKGROUND The nasogastric tube (NGT) is a common medical device, and serious complications associated with NGT insertions are rare. The most common serious complication is tracheal insertion; cervical emphysema and pneumomediastinum are rare. There are several methods for confirming the location of the NGT, but a single method of confirmation is often inadequate. Confirmation by air insufflation into the NGT is currently not recommended and is highly invasive. Here, we report a case of cervical emphysema and pneumomediastinum caused by an NGT...
June 3, 2023: American Journal of Case Reports
Wenzhong Hou, Jianping Yao, Junjie Liu, Xiaohong Lin, JueXian Wei, Xiaofan Yin, Hongbiao Huang, Xiaohui Chen, Guo-Yuan Yang, Xiaosong He
AIM: Blood-brain barrier (BBB) dysfunction is one of the hallmarks of ischemic stroke. USP14 has been reported to play a detrimental role in ischemic brain injury. However, the role of USP14 in BBB dysfunction after ischemic stroke is unclear. METHODS: In this study, we tested the role of USP14 in disrupting BBB integrity after ischemic stroke. The USP14-specific inhibitor IU1 was injected into middle cerebral artery occlusion (MCAO) mice once a day. The Evans blue (EB) assay and IgG staining were used to assess BBB leakage 3 days after MCAO...
June 2, 2023: CNS Neuroscience & Therapeutics
Cheng-Liang Zhang, Ling-Li Fang, Chuan-Liu Wang, Ping Li, Ming Yang, Jian-Wei Xu
OBJECTIVE: Mesencephalic astrocyte-derived neurotrophic factor (MANF) expressions are dramatically up-regulated in injured brain tissues, thereby conferring neurological protective effects. We intended to determine significance of serum MANF as a prognostic biomarker of intracerebral hemorrhage (ICH). METHODS: In this prospective, observational study done from February 2018 to July 2021, 124 patients with new-onset primary supratentorial ICH were consecutively enrolled...
June 2, 2023: BMC Neurology
Wei Liao, Chunming He, Shaochun Yang, Man Zhou, Chuan Zeng, Muyun Luo, Junjian Yu, Shuo Hu, Yanyu Duan, Ziyou Liu
BACKGROUND: There is a mutual hemodynamic and pathophysiological basis between the heart and brain. Glutamate (GLU) signaling plays an important role in the process of myocardial ischemia (MI) and ischemic stroke (IS). To further explore the common protective mechanism after cardiac and cerebral ischemic injuries, the relationship between GLU receptor-related genes and MI and IS were analyzed. RESULTS: A total of 25 crosstalk genes were identified, which were mainly enriched in the Toll-like receptor signaling pathway, Th17 cell differentiation, and other signaling pathways...
June 2, 2023: BMC Genomics
Haiqing Zhang, Qin Fang, Meng Li, Liangle Yang, Xuefeng Lai, Hao Wang, Meian He, Zhichao Wang, Weijia Kong, Xiaomin Zhang
We aimed to investigate the association between hearing loss and all-cause and cardiovascular disease (CVD) mortality, and whether the relationship could be modified by chronic conditions in middle-aged and older Chinese adults. We selected 18,625 participants who underwent audiometry in 2013 from the Dongfeng-Tongji Cohort conducted in China, and followed them until December 2018. Hearing loss was grouped as normal, mild, and moderate or severe by pure-tone hearing threshold at speech (0.5, 1, and 2 kHz) and high frequency (4 and 8 kHz)...
June 3, 2023: Environmental Science and Pollution Research International
Federico Geraldini, Paolo Diana, Davide Fregolent, Alessandro De Cassai, Annalisa Boscolo, Tommaso Pettenuzzo, Nicolò Sella, Irene Lupelli, Paolo Navalesi, Marina Munari
PURPOSE: Endovascular treatment for stroke patients usually requires anesthesia care, with no current consensus on the best anesthetic management strategy. Several randomized controlled trials and meta-analyses have attempted to address this. In 2022, additional evidence from three new trials was published: the GASS trial, the CANVAS II trial, and preliminary results from the AMETIS trial, prompting the execution of this updated systematic review and meta-analysis. The primary objective of this study was to evaluate the effects of general anesthesia and conscious sedation on functional outcomes measured with the modified Rankin scale (mRS) at three months...
June 2, 2023: Canadian Journal of Anaesthesia
T Gabriel, P Klose
BACKGROUND: Complex regional pain syndrome (CRPS) affects 10-15% of patients following injuries (fractures, surgery) to the outer extremities and people after a stroke. The affected area hurts, is inflamed and lacks strength, while mobility and sensitivity are restricted. Complementary medicine as part of integrative medicine offers additional effective treatment options. RESEARCH QUESTION: Complementary therapies that extend the guideline recommendations, demonstrate clinical evidence and/or are plausible are presented...
June 2, 2023: Der Schmerz
Jie Ding, Sung-Jin Lee, Lukas Vlahos, Kanako Yuki, Cara C Rada, Vincent van Unen, Meghah Vuppalapaty, Hui Chen, Asmiti Sura, Aaron K McCormick, Madeline Tomaske, Samira Alwahabi, Huy Nguyen, William Nowatzke, Lily Kim, Lisa Kelly, Douglas Vollrath, Andrea Califano, Wen-Chen Yeh, Yang Li, Calvin J Kuo
Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The Norrin/FZD4 /TSPAN12 pathway activates WNT/β-catenin signaling, which is essential for BBB and BRB function. However, systemic pharmacologic FZD4 stimulation is hindered by obligate palmitoylation and insolubility of native WNTs and suboptimal properties of the FZD4 -selective ligand Norrin. Here, we develop L6-F4-2, a non-lipidated, FZD4 -specific surrogate which significantly improves subpicomolar affinity versus native Norrin...
June 2, 2023: Nature Communications
David J Lin, Richard Hardstone, Julie A DiCarlo, Sydney Mckiernan, Samuel B Snider, Hannah Jacobs, Kimberly S Erler, Kelly Rishe, Pierce Boyne, Jeff Goldsmith, Jessica Ranford, Seth P Finklestein, Lee H Schwamm, Leigh R Hochberg, Steven C Cramer
BACKGROUND AND OBJECTIVES: The classic and singular pattern of distal greater than proximal upper extremity motor deficits after acute stroke does not account for the distinct structural and functional organization of circuits for proximal and distal motor control in the healthy CNS. We hypothesized that separate proximal and distal upper extremity clinical syndromes after acute stroke could be distinguished, and that patterns of neuroanatomical injury leading to these two syndromes would reflect their distinct organization in the intact CNS...
June 2, 2023: Neurology
Sean P Dukelow
No abstract text is available yet for this article.
June 2, 2023: Neurology
Jorge E Morais, Tiago M Barbosa, José A Bragada, Rodrigo Ramirez-Campillo, Daniel A Marinho
PURPOSE: The aim of this study was to assess the interaction of kinematic, kinetic, and energetic variables as speed predictors in adolescent swimmers in the front-crawl stroke. DESIGN: Ten boys (mean age [SD] = 16.4 [0.7] y) and 13 girls (mean age [SD] = 14.9 [0.9] y) were assessed. METHODS: The swimming performance indicator was a 25-m sprint. A set of kinematic, kinetic (hydrodynamic and propulsion), and energetic variables was established as a key predictor of swimming performance...
June 2, 2023: International Journal of Sports Physiology and Performance
Priya Dev, Kamalesh Chakravarty, Manoj Pandey, Rakesh Ranjan, Mareena Cyriac, Vijaya Nath Mishra, Abhishek Pathak
The role of environmental contaminants and their association with stroke is still being determined. Association has been shown with air pollution, noise, and water pollution; however, the results are inconsistent across studies. A systematic review and meta-analysis of the effect of persistent organic pollutants (POP) in ischemic stroke patients were conducted; a comprehensive literature search was carried out until 30th June 2021 from different databases. The quality of all the articles which met our inclusion criteria was assessed using Newcastle-Ottawa scaling; five eligible studies were included in our systematic review...
May 31, 2023: Toxicology
Ting Lei, Mingqing Li, Zewu Zhu, Junxiao Yang, Yihe Hu, Long Hua
BACKGROUND: Accumulating epidemiological studies have demonstrated that smoking caused damage to human health. However, these studies almost focused on the individual smoking pattern rather than the toxic ingredients of tobacco smoke. Despite the exact accuracy of cotinine as a smoking exposure biomarker, there were few studies investigating the association between serum cotinine and human health. This study aimed to provide novel evidence about the harmful effect of smoking on systemic health from the perspective of serum cotinine...
May 31, 2023: Science of the Total Environment
Riten Kumar, Michael J Rivkin, Leslie Raffini
Coronavirus disease 2019 (COVID-19) associated coagulopathy is multifactorial and involves inflammation driven hypercoagulability, endothelial dysfunction, platelet activation and impaired fibrinolysis. Hospitalized adults with COVID-19 are at an increased risk of both venous thrombo-embolism (VTE) and ischemic stroke, resulting in adverse outcomes including mortality. While children with COVID-19 follow a less severe course, both arterial and venous thrombosis have been reported in hospitalized children with COVID-19...
May 31, 2023: Journal of Thrombosis and Haemostasis: JTH
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