Ling Li, Mingyue Huo, Tianzi Zuo, Yuhang Wang, Yingmin Chen, Yunfeng Bao
OBJECTIVES: To evaluate the predictive value of dual-energy CT (DECT) quantitative parameters and clinical influence factors for intracerebral hemorrhage (ICH) complications after endovascular treatment in patients with acute ischemic stroke (AIS). METHODS: Seventy-two consecutive patients who underwent brain DECT immediately after endovascular treatment for AIS from November 2017 to October 2019 were included. Retrospectively, the volume of brain parenchymal hyperdensity area (HDA), the maximum iodine concentration, and maximum CT value on DECT images was evaluated and measured by two radiologists blinded to any clinical information independently...
July 27, 2021: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Jean Jacques Noubiap, John L Fitzgerald, Celine Gallagher, Gijo Thomas, Melissa E Middeldorp, Prashanthan Sanders
BACKGROUND: Smoking cessation after a first cardiovascular event reduces the risk of recurrent vascular events and mortality. This systematic review and meta-analysis aimed to summarize data on the rates, predictors, and the impact of smoking cessation in patients after a stroke or transient ischemic attack (TIA). METHODS: MEDLINE, EMBASE and Web of Science were searched to identify all published studies providing relevant data through May 20, 2021. Random-effects meta-analysis method was used to pool proportions...
July 27, 2021: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Sarah A Levy, Elizabeth Pedowitz, Laura K Stein, Mandip S Dhamoon
Objectives Stroke and post-stroke complications are associated with high morbidity, mortality, and cost. Our objective was to examine healthcare utilization and hospice enrollment for stroke patients at the end of life. Materials and methods The 2014 Nationwide Readmissions Database is a national database of > 14 million admissions. We used validated ICD-9 codes to identify fatal ischemic stroke, summarized demographics and hospitalization characteristics, and examined healthcare use within 30 days before fatal stroke admission...
July 27, 2021: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Michal Hodor
I study how family spillovers shape healthcare consumption through two main sources: a learning channel whereby family members share information about their health insurance and the effectiveness of healthcare, and a behavioral channel whereby risk perception and habits are shared and transmitted. I exploit two types of sudden health shocks to identify a causal effect operating through each channel: a spouse's non-fatal heart attack or stroke and a severe injury to a child. I incorporate these shocks into an event-study framework to quantify the effect of spillovers on healthcare consumption of a non-injured adult family member...
July 17, 2021: Journal of Health Economics
Megan A Rech, Elisabeth Donahey, Joshua M DeMott, Laura L Coles, Gary D Peksa
BACKGROUND: Treatment of acute ischemic stroke (AIS) with intravenous alteplase within 4.5 h of symptom onset is associated with neurologic improvement. High baseline blood pressure (BP) and BP variability during the first 24 h of AIS is associated with increased early adverse events and death. The purpose of this study is to characterize the incidence of poor neurologic outcome in patients treated with alteplase for AIS who received antihypertensive medications prior to and within the first 24 h following alteplase administration compared with patients who did not...
July 22, 2021: American Journal of Emergency Medicine
Ingela Wennman, Eric Carlström, Bengt Fridlund, Helle Wijk
BACKGROUND: The time elapsing from the alarm being raised to arrival at the stroke unit is crucial for patients suffering a conceivable stroke. More knowledge is needed about critical incidents-both favourable and unfavourable-affecting the lead time in the care chain. AIM: To explore favourable and unfavourable critical incidents (CIs), affecting lead times in the care chain from the alerted ambulance to the stroke unit, as experienced by nurses, for low-priority patients suffering a conceivable acute stroke...
July 27, 2021: International Emergency Nursing
Wen-Jun Tu, Bao-Hua Chao, Lin Ma, Feng Yan, Lei Cao, Hancheng Qiu, Xun-Ming Ji, Long-De Wang
BACKGROUND: There is currently a lack of data on stroke hospitalizations and long-term outcomes in China. Therefore, we investigated 12-month stroke fatality, disability, and recurrence rates after the first-ever stroke METHODS: This was a prospective nationwide hospital-based cohort study. From August to September 2019, all patients with first-ever stroke (ischemic stroke [IS], intracerebral hemorrhage [ICH], and subarachnoid hemorrhage [SAH]) and with symptom onset within 14 days from 232 hospitals were included...
July 27, 2021: Brain Research Bulletin
Noelle V Pavlovic, Nisha A Gilotra, Christopher S Lee, Chiadi Ndumele, Dimitra Mammos, Cheryl Dennison Himmelfarb, Martha Abshire Saylor
BACKGROUND: Fatigue is a common and distressing symptom of heart failure and has important implications for patient-reported and clinical outcomes. Despite being a common and bothersome symptom, fatigue has been understudied in heart failure. OBJECTIVE: To synthesize existing literature on fatigue in heart failure through a systematic literature review guided by the biopsychosocial model of health. METHODS: A systematic search of the literature was performed on March 18th , 2020, using Pubmed, Embase, and CINAHL...
July 27, 2021: Journal of Cardiac Failure
Christopher C Butler, Ly-Mee Yu, Jienchi Dorward, Oghenekome Gbinigie, Gail Hayward, Benjamin R Saville, Oliver Van Hecke, Nicholas Berry, Michelle A Detry, Christina Saunders, Mark Fitzgerald, Victoria Harris, Ratko Djukanovic, Stephan Gadola, John Kirkpatrick, Simon de Lusignan, Emma Ogburn, Philip H Evans, Nicholas P B Thomas, Mahendra G Patel, F D Richard Hobbs
BACKGROUND: Doxycycline is often used for treating COVID-19 respiratory symptoms in the community despite an absence of evidence from clinical trials to support its use. We aimed to assess the efficacy of doxycycline to treat suspected COVID-19 in the community among people at high risk of adverse outcomes. METHODS: We did a national, open-label, multi-arm, adaptive platform randomised trial of interventions against COVID-19 in older people (PRINCIPLE) across primary care centres in the UK...
July 27, 2021: Lancet Respiratory Medicine
Teun M Klein Gunnewiek, Anouk H A Verboven, Iris Pelgrim, Mark Hogeweg, Chantal Schoenmaker, Herma Renkema, Julien Beyrath, Jan Smeitink, Bert B A de Vries, Peter-Bram A C 't Hoen, Tamas Kozicz, Nael Nadif Kasri
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is often caused by an adenine to guanine variant at m.3243 (m.3243A>G) of the MT-TL1 gene. To understand how this pathogenic variant affects the nervous system, we differentiated human induced pluripotent stem cells (iPSCs) into excitatory neurons with normal (low heteroplasmy) and impaired (high heteroplasmy) mitochondrial function from MELAS patients with the m.3243A>G pathogenic variant. We combined micro-electrode array (MEA) measurements with RNA sequencing (MEA-seq) and found reduced expression of genes involved in mitochondrial respiration and presynaptic function, as well as non-cell autonomous processes in co-cultured astrocytes...
July 16, 2021: Stem Cell Reports
Koji Tsutsumi, Osamu Ishida, Nozomu Yamanaka, Kanako Hayashi, Kenichi Hashizume
OBJECTIVES: The open-style stent graft technique has been changing the strategy for true distal arch aneurysms extending to the descending aorta. Our mid-term results of surgical repair using a J-graft open stent graft are presented. METHODS: Between May 2015 and June 2020, 69 patients with a distal arch aneurysm (53 males, median age 74 years) underwent total arch replacement combined with J-graft open stent deployment. All 59 surviving patients were followed for a median follow-up period of 1...
July 30, 2021: Interactive Cardiovascular and Thoracic Surgery
Denes Stefler, Elvire Landstra, Martin Bobak
BACKGROUND: The aim of this analysis was to examine the prospective association between household availability of lard, butter, margarine and vegetable oil with all-cause mortality and cardiovascular disease (CVD) incidence in a general population sample in Russia. METHODS: Data from the Russian Longitudinal Monitoring Survey were used. 6618 adult individuals with no previous CVD who were recruited for the study in 1994 and followed-up in subsequent years were included in the analysis...
July 30, 2021: European Journal of Public Health
Wiebe G Knol, Ricardo P J Budde, Edris A F Mahtab, Jos A Bekkers, Ad J J C Bogers
OBJECTIVES: Although the incidence of perioperative stroke after cardiac surgery gradually decreased over the last decades, there is much variation between centres. This review aimed to create a concise overview of the evidence on possible surgical strategies to prevent embolic stroke in patients with intimal aortic atherosclerosis. METHODS: The PubMed and EMBASE databases were searched for studies on surgical management of aortic atherosclerosis and the association with perioperative stroke in cardiac surgery, including specific searches on the most common types of surgery...
July 30, 2021: European Journal of Cardio-thoracic Surgery
Jie Guo, Jun Lv, Yu Guo, Zheng Bian, Bang Zheng, Man Wu, Ling Yang, Yiping Chen, Jian Su, Jianqiang Zhang, Jvying Yao, Junshi Chen, Zhengming Chen, Canqing Yu, Liming Li
BACKGROUND: Blood pressure (BP) categories are useful to simplify preventions in public health, and diagnostic and treatment approaches in clinical practice. Updated evidence about the associations of BP categories with cardiovascular diseases (CVDs) and its subtypes is warranted. METHODS AND FINDINGS: About 0.5 million adults aged 30 to 79 years were recruited from 10 areas in China during 2004-2008. The present study included 430 977 participants without antihypertension treatment, cancer, or CVD at baseline...
2021: PloS One
Lisandro D Colantonio, Richard J Reynolds, Tony R Merriman, Angelo Gaffo, Jasvinder A Singh, Timothy B Plante, Ninad S Chaudhary, Nicole D Armstrong, Elsayed Z Soliman, Jeffrey R Curtis, S Louis Bridges, Leslie Lang, George Howard, Monika M Safford, Kenneth G Saag, Paul Muntner, Marguerite Ryan Irvin
OBJECTIVE: Determine the association of serum urate levels with sudden cardiac death and incident coronary heart disease (CHD), separately, among adults without a history of CHD. METHODS: We conducted a case-cohort analysis of Black and White participants ≥45 years of age enrolled in the REason for Geographic And Racial Differences in Stroke (REGARDS) study without a history of CHD at baseline between 2003 and 2007. Participants were followed for sudden cardiac death or incident CHD (i...
June 15, 2021: Journal of Rheumatology
Na Tian, Ying Chen, Wenbo Sun, Huihua Liu, Xiaoyun Wang, Tiebin Yan, Rong Song
Intermuscular coupling is essential in the coordination of agonist and antagonist muscles. However, its dynamic characteristics are not fully understood, especially the alterations of intermuscular coupling induced by stroke and aging. This study aimed to investigate the aging- and stroke-related changes in the global and instantaneous intermuscular coupling between agonist and antagonist muscles. In the experiment, 8 patients after stroke, 18 healthy young subjects and 10 healthy middle-aged subjects were recruited and instructed to finish the elbow flexion and extension tasks...
July 30, 2021: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Zhixing Ren, Shen Wang, Dong Liu, Jie Yu, Xiaoyuan Zhang, Pingnan Zhao, Yuxuan Sun, Song Han
This study investigates the regulation of the vertical gene transfer of quinolones' antibiotic resistance genes (ARGs) through a combination of source modification and process control. In source prevention, 29 Escherichia coli (E. coli) DNA gyrase subunit A mutant proteins were constructed, the B-G mutant protein displayed the greatest reduction in binding effect (-25.98%). Based on this, a 3D-QSAR model was constructed, and LEV-2 and LEV-9 QNs derivatives were designed based on Levofloxacin (LEV), and their binding effect with B-G mutant protein was found be increased by 13...
July 16, 2021: Journal of Hazardous Materials
Grace J Kim, Avinash Parnandi, Sharon Eva, Heidi Schambra
PURPOSE: To address the gap in the literature and clarify the expanding role of wearable sensor data in stroke rehabilitation, we summarized the methods for upper extremity (UE) sensor-based assessment and sensor-based treatment. MATERIALS AND METHODS: The guideline outlined by the preferred reporting items for systematic reviews and meta-analysis extension for scoping reviews was used to complete this scoping review. Information pertaining to participant demographics, sensory information, data collection, data processing, data analysis, and study results were extracted from the studies for analysis and synthesis...
July 30, 2021: Disability and Rehabilitation
Ryan Weber, Martin McCullagh
The COVID-19 pandemic has demonstrated the need to develop potent and transferable therapeutics to treat coronavirus infections. Numerous antiviral targets are being investigated, but nonstructural protein 13 (nsp13) stands out as a highly conserved and yet understudied target. Nsp13 is a superfamily 1 (SF1) helicase that translocates along and unwinds viral RNA in an ATP-dependent manner. Currently, there are no available structures of nsp13 from SARS-CoV-1 or SARS-CoV-2 with either ATP or RNA bound, which presents a significant hurdle to the rational design of therapeutics...
July 30, 2021: Journal of Physical Chemistry. B
Xiaoyuan Guo, W Charles O'Neill, Brianna Vey, Tianen Christopher Yang, Thomas J Kim, Maryzeh Ghassemi, Ian Pan, Judy Wawira Gichoya, Hari Trivedi, Imon Banerjee
PURPOSE: Measurements of breast arterial calcifications (BAC) can offer a personalized, noninvasive approach to risk-stratify women for cardiovascular disease such as heart attack and stroke. We aim to detect and segment breast arterial calcifications in mammograms accurately and suggest novel measurements to quantify detected BAC for future clinical applications. METHODS: To separate BAC in mammograms, we propose a light-weight fine vessel segmentation method Simple Context U-Net (SCU-Net)...
July 30, 2021: Medical Physics
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