Pengfei Xie, Meipan Yin, Wei He, Yaozhen Ma, Chunxia Li, Zhen Li, Xiaobing Li, Shuai Wang, Gang Wu
Background: Neoplastic esophagogastric anastomotic strictures after resection of esophageal cancer is a very difficult problem in clinical practice. We aim at to investigate the safety and feasibility of arterial infusion chemotherapy in treatment of neoplastic esophagogastric anastomotic strictures after esophagectomy. Methods: From October 2014 to December 2019, 50 patients with Neoplastic esophagogastric anastomotic strictures after resection of esophageal cancer were assessed retrospectively...
2021: Frontiers in Oncology
Hai-Xia Wang, Xu-Hui Qin, Jinhua Shen, Qing-Hua Liu, Yun-Bo Shi, Lu Xue
Placenta-specific protein 9 (PLAC9) is a putative secretory protein that was initially identified in the placenta and is involved in cell proliferation and motility. Bioinformatics analyses revealed that PLAC9 is repressed in lung cancers (LCs), especially lung adenocarcinomas, compared to that in the paired adjacent normal tissues, indicating that PLAC9 might be involved in the pathogenesis of pulmonary diseases. To investigate the potential role of PLAC9 in the abnormal reprogramming of airway epithelial cells (AECs), a key cause of pulmonary diseases, we constructed a stable PLAC9-overexpressing human bronchial epithelial cell line (16HBE-GFP- Plac9 )...
2021: Frontiers in Oncology
Vidya S Kollu, Pramod K Kalagara, Shehla Islam, Asmita Gupte
Candida blankii  is an emerging pathogenic fungus, first identified in 1968 as a new species. In the past five years, it has been identified in cystic fibrosis patient's airways and as fungemia in immunocompromised patients (post lung transplant and preterm neonates). It has been postulated to be a possible opportunistic pathogen based on the published case reports. We report a case of C. blankii fungemia with possible endocarditis in an immunocompetent individual. To our knowledge, this is also the first case of C...
May 10, 2021: Curēus
Atsushi Torii, Hideo Saka, Rieko Nishimura, Yushi Saito, Masahide Oki
There is no standard treatment for smooth muscle tumour of uncertain malignant potential (STUMP) but it usually has a good prognosis. Airway stenting is performed to manage central airway patency. In the present case, it was no treatment for STUMP, but performance status was good, so airway stenting was performed.
July 2021: Respirology Case Reports
Rita Amaral, Tiago Jacinto, Andrei Malinovschi, Christer Janson, David Price, João A Fonseca, Kjell Alving
Background: Blood eosinophil (B-Eos) count is an emerging biomarker in the management of respiratory disease but determinants of B-Eos count besides respiratory disease are poorly described. Therefore, we aimed to evaluate the influence of non-respiratory diseases on B-Eos count, in comparison to the effect on two other biomarkers: fraction of exhaled nitric oxide (FeNO) and C-reactive protein (CRP), and to identify individual characteristics associated with B-Eos count in healthy controls...
June 2021: Clinical and Translational Allergy
Kazuya Tone, Mark H T Stappers, Remi Hatinguais, Ivy M Dambuza, Fabián Salazar, Carol Wallace, Raif Yuecel, Petruta L Morvay, Kazuyoshi Kuwano, Janet A Willment, Gordon D Brown
Environmental factors, particularly fungi, influence the pathogenesis of allergic airway inflammation, but the mechanisms underlying these effects are still unclear. Melanin is one fungal component which is thought to modulate pulmonary inflammation. We recently identified a novel C-type lectin receptor, MelLec (Clec1a), which recognizes fungal 1,8-dihydroxynaphthalene (DHN)-melanin and is able to regulate inflammatory responses. Here we show that MelLec promotes pulmonary allergic inflammation and drives the development of Th17 T-cells in response to spores of Aspergillus fumigatus ...
2021: Frontiers in Immunology
Olumuyiwa A Bamgbade, Vivian O Magboh, Ajibola U Otegbeye, Mmakgomo B King, Olusanya J Oluwole, Bolusefe T Olatunji
Tracheal extubation is an aerosol-generating medical procedure. A difficult tracheal extubation results in a serious complication that increases the risk of respiratory aerosol and pathogen spread, especially during the COVID-19 pandemic. The management of difficult extubation is potentially even more challenging during the pandemic. We report two cases of difficult extubation due to endotracheal tube cuff malfunction during the COVID-19 pandemic. Special airway maneuvers and infection control measures were employed to successfully manage the unexpected dilemma...
June 8, 2021: Journal of Taibah University Medical Sciences
Jasmeet Soar, Bernd W Böttiger, Pierre Carli, Keith Couper, Charles D Deakin, Therese Djärv, Carsten Lott, Theresa Olasveengen, Peter Paal, Tommaso Pellis, Gavin D Perkins, Claudio Sandroni, Jerry P Nolan
These European Resuscitation Council Advanced Life Support guidelines are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. This section provides guidelines on the prevention of and ALS treatments for both in-hospital cardiac arrest and out-of-hospital cardiac arrest.
June 8, 2021: Notfall & Rettungsmedizin
I Yilmaz, D Ozden, G G Arslan
Background: Endotracheal suctioning is a vital procedure performed by intensive care nurses to maintain airway patency and optimal gas exchange in critically ill patients under mechanical ventilation. As the procedure can cause several complications, intensive care nurses should have adequate evidence-based knowledge on how to perform the procedure. Aims: This study aimed at examining intensive care nurses' knowledge and experience of the closed suctioning system...
June 2021: Nigerian Journal of Clinical Practice
Meenakshi Sinha, Ajoy K Behera, Ramanjan Sinha, Arti Parganiha, Babita Pande, Richa Sharma, Atanu K Pati
The commonly observed nocturnal attack of asthma is accompanied by circadian variations in airway inflammation and other physiological variables. It is also documented to present with a significantly higher risk of adverse cardiovascular events that are associated with lower heart rate variability (HRV) and depressed sympathetic and enhanced parasympathetic modulations. However, available literature is scarce with regard to the impact of alteration in circadian rhythmicity of long-term HRV and its day-night variation in asthmatic patients...
June 14, 2021: Chronobiology International
Vijay Hadda, Tejas Menon Suri, Sourabh Pahuja, Mohamad El-Khatib, Laura D Ciobanu, Bruno Cabrita, Habib Md Reazaul Karim, Igor Barjaktarevic, Claudia Crimi, Giancarlo Garuti, Saurabh Mittal, Pawan Tiwari, Karan Madan, Anant Mohan, Zuhal Karakurt, Antonio Esquinas
Non-invasive ventilation (NIV) is a mainstay of management of chronic respiratory failure in many disorders which are known to cause abnormal airway secretion clearance. Currently, there is no guidance regarding either the secretion handling during NIV use or the role of NIV in secretion management in these patients. The aim of this document was to provide an overview of the various techniques available in the management of respiratory secretions and their use in conjunction with NIV. Literature search was performed using the keywords, "(secretion OR secretions) AND (noninvasive ventilation OR NIV)" on PubMed and EMBASE...
June 7, 2021: Monaldi Archives for Chest Disease
Ah-Cann C, Wimmer Vc, Weeden Ce, Marceaux C, Law Cw, Galvis L, Filby Ce, Liu J, Breslin K, Willson T, Ritchie Me, Blewitt Me, Asselin-Labat Ml
Development of a branching tree in the embryonic lung is critical for the formation of a fully mature functional lung at birth. Sox9+ cells present at the tip of the primary embryonic lung endoderm are multipotent cells responsible for branch formation and elongation. We performed a genetic screen and identified Aurora kinase b (Aurkb) as a critical regulator of Sox9+ cells ex vivo. In vivo conditional knockout studies confirmed that Aurkb was critical for lung development but was not necessary for postnatal growth and the repair of the adult lung after injury...
June 14, 2021: Development
Silpa D Krefft, Andrea Oh, Lauren M Zell-Baran, Jenna Wolff, Camille M Moore, Tony V Macedonia, Cecile S Rose
PURPOSE: We noted incidental findings on chest computed tomography (CT) imaging of expiratory central airway collapse (ECAC) in dyspneic patients after military deployment to southwest Asia (mainly Iraq and Afghanistan). We developed a standardized chest CT protocol with dynamic expiration to enhance diagnostic reliability and investigated demographic, clinical, and deployment characteristics possibly associated with ECAC. MATERIALS AND METHODS: We calculated ECAC in 62 consecutive post-9/11 deployers with dyspnea who underwent multi-detector chest CT acquisition...
June 14, 2021: Journal of Thoracic Imaging
Stephanie E Teng, Jacqueline R Booth, Mark A Fritz, Michael W Groves, Gregory N Postma
OBJECTIVE: To review and establish current practices regarding airway management in vocal professionals undergoing surgery. STUDY DESIGN: Cross-sectional survey SETTING: The setting included practitioners that treat vocal professionals across international sub-specialty societies. SUBJECTS AND METHODS: A twenty-one-item survey was sent to practitioners that routinely treat vocal professionals including the American Broncho-Esophagological Association, European Laryngological Society, and 2017 Fall Voice Conference attendees...
June 10, 2021: Journal of Voice
Jialiang Sun, Yanan Li
Macrolide antibiotics are one of the most commonly used broad-spectrum antibiotics. They have an inhibitory effect on a variety of respiratory pathogens; besides, they have non-anti-infective effects, including anti-inflammatory, regulating airway secretion, immune regulation, and other effects. A growing number of studies have shown that the non-anti-infective effects of macrolides have important and potential value in the treatment of pediatric chronic airway diseases; the therapy was described as "long-term, low-dose usage"; unfortunately, there is no guideline or consensus that applies to children...
June 12, 2021: Pediatric Research
Nguyen Thanh Tung, Yueh-Lun Lee, Shang-Yang Lin, Chih-Da Wu, Hoang Ba Dung, Tran Phan Chung Thuy, Yi-Chun Kuan, Cheng-Yu Tsai, Chen-Chen Lo, Kang Lo, Kin-Fai Ho, Wen-Te Liu, Hsiao-Chi Chuang
This study aims to investigate the association of air pollution with overnight change in 4body composition and sleep-related parameters. Body composition of 197 subjects in New Taipei city was measured before and after sleep by bioelectric impedance analysis. Air pollutant data were collected from Taiwan Environmental Protection Administration. Sleep parameters were examined by polysomnography. We observed fine particulate matter (PM2.5 ) decreased arterial oxygen saturation (SaO2 ) and increased apnea-hypopnea index (AHI); NO2 increased arousal, AHI, and decreased mean SaO2 ; and O3 inmcreased mean SaO2 ...
June 4, 2021: Science of the Total Environment
Zhaozhong Zhu, Carlos A Camargo, Yoshihiko Raita, Michimasa Fujiogi, Liming Liang, Eugene P Rhee, Prescott G Woodruff, Kohei Hasegawa
BACKGROUND: Infants with bronchiolitis are at increased risk for developing asthma. Growing evidence suggests bronchiolitis is a heterogeneous condition. OBJECTIVE: To identify biologically-distinct subgroups based on the metabolome signatures (metabotypes) in infants with severe bronchiolitis and to examine their longitudinal relationships with asthma development. METHODS: In a multi-center prospective cohort study of infants (aged <12 months) hospitalized for bronchiolitis, the nasopharyngeal airway metabolome was profiled at hospitalization...
June 10, 2021: Journal of Allergy and Clinical Immunology
Alexander G Singer, Alan Katz, Lisa LaBine, Lisa M Lix, Marina Yogendran, Ian Sinha, Elissa M Abrams
BACKGROUND: The objective of this study was to determine primary prescription adherence for obstructive lung diseases (e.g., asthma, COPD) in an adult primary care patient population over a 3-year period. METHODS: A retrospective analysis of electronic medical record and administrative data was performed to determine primary adherence, defined as dispensation of a new prescription within 90 days of the date the prescription was written. Multivariable logistic regression models were used to test predictors of prescription primary adherence...
June 12, 2021: Allergy, Asthma, and Clinical Immunology
Wendi Wei, Weida Chen, Naifeng He
BACKGROUND: Asthma is a frequently occurring respiratory disease with an increasing incidence around the world. Airway inflammation and remodeling are important contributors to the occurrence of asthma. We conducted this study aiming at exploring the effect of Histone deacetylase 4 (HDAC4)-mediated Kruppel-like factor 5 (KLF5)/Slug/CXC chemokine ligand-12 (CXCL12) axis on the development of asthma in regulation of airway inflammation and remodeling. METHODS: An asthmatic rat model was induced by ovalbumin (OVA) irrigation, and determined HDAC4, KLF5, Slug, and CXCL12 expression in the lung tissues by RT-qPCR and Western blot assay...
June 12, 2021: Journal of Translational Medicine
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