Mirela V Simon, Seward B Rutkove, Long Ngo, Corey R Fehnel, Alvin S Das, Todd Sarge, Somnath Bose, Magdy Selim, Sandeep Kumar
OBJECTIVE: The laryngeal adductor reflex (LAR) is vital for airway protection and can be electrophysiologically obtained under intravenous general anesthesia (IGA). This makes the electrophysiologic LAR (eLAR) an important tool for monitoring of the vagus nerves and relevant brainstem circuitry during high-risk surgeries. We investigated the intra-class variability of normal and expected abnormal eLAR. METHODS: Repeated measures of contralateral R1 (cR1) were performed under IGA in 58 patients...
March 26, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Takayuki Takimoto, Hiromitsu Sumikawa, Yoshikazu Inoue, Toru Arai
No abstract text is available yet for this article.
April 17, 2024: American Journal of Respiratory and Critical Care Medicine
Jinrui Miao, Run Tong, Yongming Zhang, Mingming Deng, Yiding Bian, Ruixia Li, Gang Hou
No abstract text is available yet for this article.
April 17, 2024: American Journal of Respiratory and Critical Care Medicine
Hoang Van Phan, Alexandra Tsitsiklis, Cole P Maguire, Elias K Haddad, Patrice M Becker, Seunghee Kim-Schulze, Brian Lee, Jing Chen, Annmarie Hoch, Harry Pickering, Patrick van Zalm, Matthew C Altman, Alison D Augustine, Carolyn S Calfee, Steve Bosinger, Charles B Cairns, Walter Eckalbar, Leying Guan, Naresh Doni Jayavelu, Steven H Kleinstein, Florian Krammer, Holden T Maecker, Al Ozonoff, Bjoern Peters, Nadine Rouphael, Ruth R Montgomery, Elaine Reed, Joanna Schaenman, Hanno Steen, Ofer Levy, Joann Diray-Arce, Charles R Langelier
Age is a major risk factor for severe coronavirus disease 2019 (COVID-19), yet the mechanisms behind this relationship have remained incompletely understood. To address this, we evaluated the impact of aging on host immune response in the blood and the upper airway, as well as the nasal microbiome in a prospective, multicenter cohort of 1031 vaccine-naïve patients hospitalized for COVID-19 between 18 and 96 years old. We performed mass cytometry, serum protein profiling, anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody assays, and blood and nasal transcriptomics...
April 17, 2024: Science Translational Medicine
Kavita De, Juan M Belardinelli, Arun Prasad Pandurangan, Teddy Ehianeta, Elena Lian, Zuzana Palčeková, Ha Lam, Mercedes Gonzalez-Juarrero, Josephine M Bryant, Tom L Blundell, Julian Parkhill, R Andres Floto, Todd L Lowary, William H Wheat, Mary Jackson
Mycobacterium abscessus is increasingly recognized as the causative agent of chronic pulmonary infections in humans. One of the genes found to be under strong evolutionary pressure during adaptation of M. abscessus to the human lung is embC which encodes an arabinosyltransferase required for the biosynthesis of the cell envelope lipoglycan, lipoarabinomannan (LAM). To assess the impact of patient-derived embC mutations on the physiology and virulence of M. abscessus , mutations were introduced in the isogenic background of M...
April 23, 2024: Proceedings of the National Academy of Sciences of the United States of America
Emily Yassaie, Anusha Hennedige, Christopher Parks
Neonates born with severe multisuture synostosis can present as an emergency. The severe craniocerebral disproportion with or without underlying hydrocephalus and retruded midface can result in raised intracranial pressure and airway compromise within the first few days or weeks of life. This presents a challenging multidisciplinary condition. There is no international consensus on management. There are limited publications available describing the approach to treatment. In our unit, children who present in the neonatal period with severe multisuture synostosis are offered early open extensive suturectomy within the first few months of life...
April 17, 2024: Journal of Craniofacial Surgery
Hao Meng, Dongxue Zhang, Yifan Que, Peng Hu, Runsheng Wang, Yunfei Liao, Guogang Xu
BACKGROUND: Asthma is widely recognized as an inflammatory disorder. In the context of this inflammatory microenvironment, the involvement of hypoxia and its impact on related pathways have drawn considerable attention. However, the exact role of hypoxia, a prevalent environmental factor, in the development and progression of asthma remains poorly understood. METHODS: Mice were treated with house dust mite (HDM) extracts for 23 days to induce asthma. Mice were divided into room air (RA) group and intermittent hypoxic (IH) group by exposing to different conditions and IH preconditioning (IHP) were underwent to the above groups before the hypoxic regimen...
April 2024: Immunity, Inflammation and Disease
M Cristina Vazquez Guillamet, Rodrigo Vazquez Guillamet, Ashraf Rjob, Daniel Reynolds, Bijal Parikh, Vladimir Despotovic, Derek E Byers, Ali H Ellebedy, Marin H Kollef, Philip A Mudd
RATIONALE: Recent studies suggest that both hypo- and hyperinflammatory acute respiratory distress syndrome (ARDS) phenotypes characterize severe COVID-19-related pneumonia. The role of lung Severe Acute Respiratory Syndrome - Coronavirus 2 (SARS-CoV-2) viral load in contributing to these phenotypes remains unknown. OBJECTIVES: To redefine COVID-19 ARDS phenotypes when considering quantitative SARS-CoV-2 RT-PCR in the bronchoalveolar lavage of intubated patients...
April 17, 2024: Journal of Intensive Care Medicine
Helga Elidottir, Selma R Bjarnadottir, Olafur Baldursson, Brynja Jonsdottir
BACKGROUND: Cystic fibrosis (CF) is most common in populations of Northern European ancestry where the F508del variant predominates. In 2020, Iceland became a member of the European Cystic Fibrosis Society Patient Registry, and we launched an epidemiological study of CF in Iceland. The study aimed to determine the prevalence and the genetic variants present in the country. Furthermore, we aimed to describe the previous and the current situation regarding lung function, infections, complications, treatment, and follow-up to understand the strengths and weaknesses of CF care in Iceland...
April 17, 2024: Pediatric Pulmonology
Po-Yang Tsou, Ignacio E Tapia
STUDY OBJECTIVES: Congenital central hypoventilation syndrome (CCHS) is a rare disease predisposing children to respiratory failure due to abnormal ventilatory drive. Variability in hypoventilation and respiratory support need have been reported. We aim to identify clinical variables associated with incident tracheostomy and common etiologies of hospitalization among children with CCHS. METHODS: Hospital discharge records were obtained for children (<21 years) with CCHS hospitalized between 2006 and 2019 from the Kid's Inpatient Database...
April 17, 2024: Pediatric Pulmonology
Lana Mukharesh, Katie A Krone, Thomas E Hamilton, Hester F Shieh, Charles J Smithers, Zachary A Winthrop, Eleanor D Muise, Russell W Jennings, Somala Mohammed, Farokh R Demehri, Benjamin Zendejas, Gary A Visner
BACKGROUND: Tracheobronchomalacia (TBM) is characterized by excessive dynamic airway collapse. Severe TBM can be associated with substantial morbidity. Children with secondary TBM associated with esophageal atresia/tracheoesophageal fistula (EA/TEF) and vascular-related airway compression (VRAC) demonstrate clinical improvement following airway pexy surgery. It is unclear if children with severe primary TBM, without secondary etiologies (EA/TEF, vascular ring, intrinsic pulmonary pathology, or complex cardiac disease) demonstrate clinical improvement following airway pexy surgery...
April 17, 2024: Pediatric Pulmonology
Adrienne R Azurdia, Jarvis Walters, Chris R Mellon, Salvatore C Lettieri, Tammy R Kopelman, Paola Pieri, Iman Feiz-Erfan
BACKGROUND: The halo fixation device introduces a significant obstacle for clinicians attempting to secure a definitive airway in trauma patients with cervical spine injuries. The authors sought to determine the airway-related mortality rate of adult trauma patients in halo fixation requiring endotracheal intubation. METHODS: This study was a retrospective chart review of patients identified between 2007 and 2012. Only adult trauma patients who were intubated while in halo fixation were included in the study...
2024: Surgical Neurology International
Matthew Mitchell, Mopileola Tomi Adewumi, Lauren Welby Berra, Randall Holdgraf
Mpox is a double-stranded DNA virus of the Orthopoxvirus genus related to smallpox virus endemic to Africa with more than 16,000 cases reported in nonendemic countries in 2022. Classically associated with adult men who have sex with men (MSM), Mpox was once labeled a public health emergency by the World Health Organization as concerning to the general population. Supraglottitis is a rare complication of Mpox that is underreported in the literature and presents a potential airway emergency. Prompt identification is necessary for preventing airway decompensation...
2024: Proceedings of the Baylor University Medical Center
Minsun Lee, Jiyeon Yang, Jeongwon Park, Youngwook Lim, Changsoo Kim
This study aimed to investigate the airborne exposure to aerosols according to the particle size distribution of three different spray types ( nano-nozzled spray gun , low-temperature steam spray , and fogger ) and compare the concentrations of inhaled aerosols between children and adults. Airborne aerosols released from three products were observed using size-segregated particle measurements, and particle concentrations deposited in the respiratory tracts of adults and children were estimated using multi-path particle dosimetry lung deposition models...
April 16, 2024: International Journal of Environmental Health Research
Hanna Sterzik, Matthias Kumpf, Christian F Poets, Bianca Haase
No abstract text is available yet for this article.
April 16, 2024: Acta Paediatrica
Blanca E R G Bica, Alexandre Wagner S de Souza, Ivânio Alves Pereira
Relapsing polychondritis is a rare multisystem disease involving cartilaginous and proteoglycan-rich structures. The diagnosis of this disease is mainly suggested by the presence of flares of inflammation of the cartilage, particularly in the ears, nose or respiratory tract, and more rarely, in the presence of other manifestations. The spectrum of clinical presentations may vary from intermittent episodes of painful and often disfiguring auricular and nasal chondritis to an occasional organ or even life-threatening manifestations such as lower airway collapse...
April 16, 2024: Advances in Rheumatology
Andrea Irouschek, Joachim Schmidt, Torsten Birkholz, Horia Sirbu, Andreas Moritz
BACKGROUND: Double-lumen tubes (DLTs) are the preferred device for lung isolation. Conventional DLTs (cDLT) need a bronchoscopic position control. Visualisation of correct DLT positioning could be facilitated by the use of a video double-lumen tube (vDLT). During the SARS-CoV-2-pandemic, avoiding aerosol-generation was suggesting using this device. In a large retrospective series, we report both general and pandemic related experiences with the device. METHODS: All anesthesia records from patients aged 18 years or older undergoing surgery from April 1st, 2020 to December 31st, 2021 in the department of thoracic surgery requiring intraoperative lung isolation were analyzed retrospectively...
April 16, 2024: Journal of Cardiothoracic Surgery
Zhaoyang Yan, Xinjian Xu, Bin Guo, Pengzeng Wang, Linpeng Niu, Zhanjie Gao, Yusen Yuan, Fei Li, Ming He
BACKGROUND: The gastric conduit is the most commonly used replacement organ for reconstruction after minimally invasive McKeown esophagectomy. Although the optimal route of gastric conduit remains controversial, the posterior mediastinal route is physiologically preferable but is not without disadvantages. Here, we report the safety and efficacy of a method of gastric conduit reconstruction via the anterior of the pulmonary hilum route. METHODS: We have used the anterior of the pulmonary hilum route since 2021...
April 16, 2024: Journal of Cardiothoracic Surgery
Pasquale Tondo, Anela Hoxhallari, Donato Lacedonia, Pietro Magaletti, Roberto Sabato, Maria Pia Foschino Barbaro, Giulia Scioscia
PURPOSE: Asthma, obstructive sleep apnea (OSA), rhinosinusitis, and esophageal reflux are conditions that may overlap, forming a syndrome known as CORE. Whenever clinical remission of severe asthma (SA) is not achieved, it is essential to investigate the presence of comorbidities, in particular the presence of OSA that may lead to the diagnosis of CORE syndrome. METHODS: The study was conducted on naive patients with SA and concomitant rhinosinusitis and esophageal reflux, referred to our institute since 2018...
April 16, 2024: Sleep & Breathing
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