BreAnna Kinghorn, Margaret Rosenfeld, Erin Sullivan, Frankline Onchiri, Thomas W Ferkol, Scott D Sagel, Sharon D Dell, Carlos Milla, Adam J Shapiro, Kelli M Sullivan, Maimoona A Zariwala, Jessica E Pittman, Federico Mollica, Harm A W M Tiddens, Mariette Kemner-van de Corput, Michael R Knowles, Stephanie D Davis, Margaret W Leigh
RATIONALE: Primary ciliary dyskinesia (PCD) is characterized by impaired mucociliary clearance, recurrent respiratory infections, and progressive airway damage and obstructive lung disease. While the association of ciliary ultrastructure defect/genotype with severity of airflow obstruction has been well characterized, their association with airway abnormalities on chest computed tomography (CT) has been minimally evaluated. OBJECTIVES: We sought to delineate the association of ciliary defect class/genotype with chest CT scores in children with PCD...
November 28, 2022: Annals of the American Thoracic Society
See-Wei Low, Robert J Lentz, Heidi Chen, James Katsis, Matthew C Aboudara, Samuel Whatley, Rafael Paez, Otis B Rickman, Fabien Maldonado
BACKGROUND: Electromagnetic navigational bronchoscopy has been the dominant bronchoscopic technology for targeting small peripheral lesions and now includes digital tomosynthesis-electromagnetic navigational bronchoscopy (DT-ENB), allowing near-real-time intraprocedural nodule visualization. Shape-sensing robotic-assisted bronchoscopy (ssRAB), with improved catheter stability and articulation, recently became available. Although the diagnostic performance of these two methods seems higher than that of legacy systems, data remain limited...
October 29, 2022: Chest
Amanda Feldt, Anita Kärner Köhler, Sara Bergstrand
BACKGROUND: Continuous positive airway pressure is a non-invasive therapy beneficial for patients with acute respiratory failure. The need for this therapy outside intensive care units is growing, but nurses face many challenges to enable this therapy in general medical wards. AIMS AND OBJECTIVES: The aim of the study was to explore nurses' strategies for enabling continuous positive airway pressure therapy in a general medical ward context. METHOD: An explorative qualitative design was used including semi-structured interviews with 15 Swedish nurses...
November 28, 2022: Scandinavian Journal of Caring Sciences
Wupeng Liao, Hazel Y C Foo, Thi Ngoc Quy Tran, Christina L L Chai, W S Fred Wong
BACKGROUND AND PURPOSE: Alveolar macrophages (AMs) contribute to airway inflammation and remodeling in allergic asthma. Calcaratarin D (CalD), a labdane diterpenoid isolated from the rhizomes of the medicinal plant Alpinia calcarata, has recently been shown to possess anti-inflammatory properties. The present study evaluated protective effects of CalD in a house dust mite (HDM)-induced asthma mouse model. EXPERIMENTAL APPROACH: The effects of CalD on AMs in contributing to anti-inflammatory effects in asthma were investigated through a series of in vivo, ex vivo and in vitro experiments...
November 28, 2022: British Journal of Pharmacology
Louisa L Y Chan, Akshamal M Gamage, Chee Wah Tan, Kai Sen Tan, Jing Liu, Douglas Jie Wen Tay, Randy Jee Hiang Foo, Laurent Rénia, De Yun Wang, Lin-Fa Wang
Bats are reservoir hosts for various zoonotic viruses with pandemic potential in humans and livestock. In vitro systems for studying bat host-pathogen interactions are of significant interest. Here, we establish protocols to generate bat airway organoids (AOs) and airway epithelial cells differentiated at the air-liquid interface (ALI-AECs) from tracheal tissues of the cave-nectar bat Eonycteris spelaea . In particular, we describe steps which enable laboratories that do not have access to live bats to perform extended experimental work upon procuring an initial batch of bat primary airway tissue...
November 28, 2022: Emerging Microbes & Infections
Linfan Su, Ruxuan Chen, Jinmei Luo, Yi Xiao
BACKGROUND: Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder and induces a growing health care burden. However, a large proportion of patients with OSA do not receive appropriate treatment and are underdiagnosed or misdiagnosed in primary care. A contributing factor to the phenomenon is the lack of education, which reflects the current inadequacies in medical education. Therefore, assessing the level of knowledge and attitudes toward OSA and associated factors among resident physicians is highly warranted...
2022: Frontiers in Psychiatry
Michael C Spaeder, J Randall Moorman, Liza P Moorman, Michelle A Adu-Darko, Jessica Keim-Malpass, Douglas E Lake, Matthew T Clark
Acute respiratory failure requiring the initiation of invasive mechanical ventilation remains commonplace in the pediatric intensive care unit (PICU). Early recognition of patients at risk for respiratory failure may provide clinicians with the opportunity to intervene and potentially improve outcomes. Through the development of a random forest model to identify patients at risk for requiring unplanned intubation, we tested the hypothesis that subtle signatures of illness are present in physiological and biochemical time series of PICU patients in the early stages of respiratory decompensation...
2022: Frontiers in Pediatrics
Shuliang Chen, Qi Li, Xueliang Zou, Zhijun Zhong, Qian Ouyang, Mengmeng Wang, Yaxing Luo, Dongyuan Yao
OBJECTIVE: To investigate whether continuous positive airway pressure (CPAP) treatment would change EEG activities associated with cyclic alternating pattern (CAP subtype A1, A2, and A3) and non-CAP (NCAP) during non-rapid eye movement sleep stage 3 (N3) in patients with obstructive sleep apnea (OSA). METHODS: The effects of CPAP treatment on the percentages of sleep stage N3 occupied by the CAP and NCAP, power of EEG waves in the CAP and NCAP were examined in 18 patients with moderate-to-severe OSA undergoing polysomnographic recordings...
2022: Nature and Science of Sleep
Constance S Harrell Shreckengost, Jorge Esteban Foianini, Karen Milenka Moron Encinas, Hugo Tola Guarachi, Katrina Abril, Dina Amin, David Berkowitz, Christine Aisha Castater, J Miller Douglas, April A Grant, Onkar Vohra Khullar, Andrea Nichole Lane, Alice Lin, Abesh Niroula, Azhar Nizam, Ammar Rashied, Alexandra W Reitz, Steven M Roser, Julia Spychalski, Sérgio Samir Arap, Ricardo Ferreira Bento, Pedro Prosperi Desenzi Ciaralo, Rui Imamura, Luiz Paulo Kowalski, Ali Mahmoud, Alessandro Wasum Mariani, Carlos Augusto Metidieri Menegozzo, Hélio Minamoto, Fábio Luiz M Montenegro, Paulo Manoel Pêgo-Fernandes, Jones Santos, Edivaldo Massozo Utiyama, Jithin K Sreedharan, Or Kalchiem-Dekel, Jonathan Nguyen, Rohan K Dhamsania, Kerianne Allen, Adrian Modzik, Vikas Pathak, Cheryl White, Juan Blas, Issa Talal El-Abur, Gabriel Tirado, Carlos Yánez Benítez, Thomas G Weiser, Mark Barry, Marissa Boeck, Michael Farrell, Anya Greenberg, Phoebe Miller, Paul Park, Maraya Camazine, Deidre Dillon, Randi N Smith
UNLABELLED: Timing of tracheostomy in patients with COVID-19 has attracted substantial attention. Initial guidelines recommended delaying or avoiding tracheostomy due to the potential for particle aerosolization and theoretical risk to providers. However, early tracheostomy could improve patient outcomes and alleviate resource shortages. This study compares outcomes in a diverse population of hospitalized COVID-19 patients who underwent tracheostomy either "early" (within 14 d of intubation) or "late" (more than 14 d after intubation)...
November 2022: Critical care explorations
Rewan Abdelwahab, Elliott Campbell, Renee Pride, Addison Demer, Nahid Y Vidal
No abstract text is available yet for this article.
December 2022: JAAD Case Reports
Abimbola O Ajibowo, Olasunkanmi A Kolawole, Haleema Sadia, Oyovwike S Amedu, Hassan A Chaudhry, Helai Hussaini, Eloho Hambolu, Tuba Khan, Humaira Kauser, Aadil Khan
Acute respiratory distress syndrome (ARDS) is an inflammatory process in the lungs that induces non-hydrostatic protein-rich pulmonary edema. ARDS occurs in roughly half of coronavirus disease 2019 (COVID-19) pneumonia patients, with most of them requiring intensive care. Oxygen saturation, partial pressure of the oxygen, and the fraction of the inspired oxygen are health indicators that may indicate a severe illness necessitating further investigation. As treatments have evolved, a typical pattern of ARDS has likewise evolved...
October 2022: Curēus
Suman Rastogi, Nava R Sharma, Bandana Rastogi, Madalasa Pokhrel, Jagdish Sharma
Penetrating injuries to the precordium are life-threatening and require early detection and immediate intervention. We present a case of penetrating cardiac injury who presented with a definitive airway and hemodynamically unstable. During the primary survey, the patient had a cardiac arrest with pulseless ventricular tachycardia. The patient was resuscitated as per advanced cardiac life support (ACLS) and advanced trauma life support (ATLS) guidelines with manual digital compression at the penetrating site leading to a return of spontaneous circulation (ROSC)...
October 2022: Curēus
Ashes Rijal, Anish Shrestha, Sharmila Chaudhary, Anisha Shrestha
Facial puffiness as a consequence of superior vena cava syndrome (SVCS) can be a presentation from which the physician would have to conjecture a diagnosis of a mediastinal mass including lymphomas. Pediatric SVCS can rapidly progress and pose a greater challenge for airway protection as was in our case.
November 2022: Clinical Case Reports
Y Tamura, E Saiki, Y Hayashi
No abstract text is available yet for this article.
2022: Anaesthesia reports
S Kadian, G Jain, S Shekhar, P Chandran
No abstract text is available yet for this article.
2022: Anaesthesia reports
R Meierhans, H Gelpke, J Hetzel, C Madjdpour
Symptomatic tracheal stenosis is a rare but significant complication of long-term tracheal intubation and mechanical ventilation. Airway management for tracheal resection in severe tracheal stenosis, especially sequential stenoses, requires multidisciplinary planning. A valuable method of airway management is the insertion of a small-bore, cuffed tracheal tube (Tritube®, Ventinova Medical B.V., Eindhoven, The Netherlands) in combination with flow-controlled ventilation. In this case, a patient with tracheal stenosis following prolonged ventilation required resection of the stenosed tissue...
2022: Anaesthesia reports
Chihiro Tomiaki, Kosuke Miyauchi, Sewon Ki, Yoshie Suzuki, Narumi Suzuki, Hiroshi Morimoto, Yohei Mukoyama, Masato Kubo
Asthma is airway inflammatory diseases caused by the activation of group 2 innate lymphoid cells (ILC2s) and type 2 helper T (TH 2) cells. Cysteine proteases allergen cause tissue damage to airway epithelial cells and activate ILC2-mediated type 2 airway inflammation. FK506 is an immunosuppressive agent against calcium-dependent NFAT activation that is also effective against asthmatic inflammation. However, the effects of FK506 on cysteine protease allergen-mediated airway inflammation remain unclear. In this study, we investigated the suppressive effects of FK506 on airway inflammation...
2022: Frontiers in Immunology
Yingshuo Wang, Xinyan Dong, Caizhe Pan, Cihang Zhu, Hantao Qi, Yifan Wang, Hao Wei, Qiangmin Xie, Lei Wu, Huijuan Shen, Shuxian Li, Yicheng Xie
Monkey disease models, which are comparable to humans in terms of genetic, anatomical, and physiological characteristics, are important for understanding disease mechanisms and evaluating the efficiency of biological treatments. Here, we established an A.suum -induced model of asthma in cynomolgus monkeys to profile airway inflammation and remodeling in the lungs by single-cell RNA sequencing (scRNA-seq). The asthma model results in airway hyperresponsiveness and remodeling, demonstrated by pulmonary function test and histological characterization...
2022: Frontiers in Immunology
Florian Ettl, Christoph Schriefl, Jürgen Grafeneder, Dominik Gabriel Thallner, Matthias Mueller, Eva Fischer, Raphael Schlegel, Thorsten Sigmund, Michael Holzer, Sebastian Schnaubelt
BACKGROUND: Face-to-face medical education was restricted during the COVID-19 pandemic, leading to alternative teaching methods. Moodle® (Modular Object-Oriented Dynamic Learning Environment) - an online course format - has not yet been sufficiently evaluated for its feasibility and effectiveness in teaching cardiopulmonary resuscitation. METHODS: Medical students in the eighth semester took part in a Moodle® course teaching basic life support, the ABCDE-approach, airway management, and advanced life support...
2022: Frontiers in Public Health
Zeead AlGhamdi, Shaya Y Alqahtani, Khalid AlDajani, Ammar Alsaedi, Omar Al-Rubaish, Abdulmajeed Alharbi, Hatem Elbawab
BACKGROUND: Previous studies have been conducted to assess pneumothorax. However, few studies were done to assess pneumothorax in COVID-19 patients in the intensive care unit (ICU). OBJECTIVE: Our aim is to describe and analyze the prevalence, clinical characteristics, risk factors, and outcomes of COVID-19 pneumothorax patients in the intensive care unit. METHODS: We performed a retrospective review of the medical records of 418 patients, who tested positive for COVID-19 by polymerase chain reaction test and required ICU admission in King Fahad Hospital of The University from 02/01/2020 to 01/09/2021...
2022: International Journal of General Medicine
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