Junjie Ma, Egon Urgard, Solveig Runge, Cajsa H Classon, Laura Mathä, Julian M Stark, Liqin Cheng, Javiera A Álvarez, Silvia von Zedtwitz, Austeja Baleviciute, Sergio Martinez Hoyer, Muzhen Li, Anne Marleen Gernand, Lisa Osbelt, Agata Anna Bielecka, Till R Lesker, Huey-Jy Huang, Susanne Vrtala, Louis Boon, Rudi Beyaert, Mikael Adner, Itziar Martinez Gonzalez, Till Strowig, Juan Du, Susanne Nylén, Stephan P Rosshart, Jonathan M Coquet
Allergic disorders are caused by a combination of hereditary and environmental factors. The hygiene hypothesis postulates that early-life microbial exposures impede the development of subsequent allergic disease. Recently developed "wildling" mice are genetically identical to standard laboratory specific pathogen-free (SPF) mice but are housed under seminatural conditions and have rich microbial exposures from birth. Thus, by comparing conventional SPF mice with wildlings, we can uncouple the impact of lifelong microbial exposures from genetic factors on the allergic immune response...
September 29, 2023: Science Immunology