Huirui Sun, Linghua Zhang, Zhixian Liu, Yanping Zhang, Jieping Li, Kunfang Pang
The selection of different examination sequences of painless gastroscopy in patients with difficult airway risk was explored in this study. A total of 45 patients undergoing painless gastroscopy with Mallampati airway score of III-IV were randomly assigned into two groups (A group and B group) according to the sequence of colonoscopy and gastroscopy. Group A was first examined by gastroscopy after anesthesia, and then by colonoscopy. Group B was examined in the opposite order, first by colonoscopy, and then by gastroscopy...
March 26, 2023: Biotechnology & Genetic Engineering Reviews
András Széll
This recommendation summarizes the recent neonatal resuscitation guidelines of the European Resuscitation Council (ERC), but it takes into account the guidelines of the American Heart Association (AHA) and the statements of the International Liaison Committee on Resuscitation (ILCOR) Consensus on Science with Treatment Recommendations (CoSTR) for neonatal life support. The goal of the management of the newly born infants is to support the cardiorespiratory transition. Personnel and equipment should be prepared for neonatal life support before every delivery...
March 26, 2023: Orvosi Hetilap
Noémi Szabó Némedi, Gerda Lóczi, Enikő Kovács, Endre Zima
The fourth element of chain-of-survival contains advanced life support and post-resuscitation treatment. Both treatment options influence the outcome of patients suffering cardiac arrest. Advanced life support includes all interventions that require special medical equipment and expertise. High-quality chest compressions and early defibrillation (if indicated) compose the main elements of advanced life support. Clarifying and treating the cause of cardiac arrest have also high priority, in which point-of-care ultrasound plays an important role...
March 26, 2023: Orvosi Hetilap
Mehmet Semih Demirtas, Huseyin Erdal, Fatih Kilicbay, Gaffari Tunc
BACKGROUND: Transient tachypnea of the newborn (TTN), which is the most common respiratory disease in the neonatal period, increases respiratory workload in newborns. We purposed to evaluate the oxidative stress (OS) status and thiol disulfide hemostasis in late preterm and term newborns with TTN in this study. METHODS: The study was carried out in a single-centre neonatal intensive care unit to investigate the effect of continuous airway positive pressure (CPAP) on the oxidative system in newborns with TTN...
March 25, 2023: BMC Pediatrics
Seth Bollenbecker, Kylie Heitman, Brian Czaya, Molly Easter, Meghan June Hirsch, Shia Vang, Elex Harris, E Scott Helton, Jarrod W Barnes, Christian Faul, Stefanie Krick
An elevation in serum phosphate-also called hyperphosphatemia-is associated with reduced kidney function in chronic kidney disease (CKD). Reports show CKD patients are more likely to develop lung disease and have poorer kidney function that positively correlates with pulmonary obstruction. However, the underlying mechanisms are not well understood. Here, we report that two murine models of CKD, which both exhibit increased serum levels of phosphate and fibroblast growth factor (FGF) 23, a regulator of phosphate homeostasis, develop concomitant airway inflammation...
March 25, 2023: Scientific Reports
Laura C Saunders, Guilhem J Collier, Ho-Fung Chan, Paul J C Hughes, Laurie J Smith, James Watson, James Meiring, Zoë Gabriel, Thomas Newman, Megan Plowright, Phillip Wade, James A Eaden, S Thomas, S Strickland, L Gustafsson, Jody Bray, Helen Marshall, David J Capener, Leanne Armstrong, Jennifer Rodgers, Martin Brook, Alberto M Biancardi, Madhwesha R Rao, Graham Norquay, Oliver Rodgers, Ryan Munro, James E Ball, Neil J Stewart, Allan Lawrie, Gisli Jenkins, James Grist, Fergus Gleeson, Rolf F Schulte, Kevin M Johnson, Frederick J Wilson, Anthony Cahn, Andrew J Swift, Smitha Rajaram, Gary H Mills, Lisa Watson, Paul J Collini, Rod Lawson, A A Roger Thompson, Jim M Wild
BACKGROUND: Microvascular abnormalities and impaired gas transfer have been observed in patients with COVID-19. The progression of pulmonary changes in these patients remains unclear. RESEARCH QUESTION: Do patients hospitalised due to COVID-19 without evidence of architectural distortion on structural imaging show longitudinal improvements in lung function measured using 1 H and 129 Xe magnetic resonance imaging between 6-52 weeks after hospitalisation? STUDY DESIGN AND METHODS: Patients who were hospitalised due to COVID-19 pneumonia underwent a pulmonary 1 H and 129 Xe MRI protocol at 6, 12, 25 and 51 weeks after hospital admission in a prospective cohort study between 11/2020 and 02/2022...
March 23, 2023: Chest
Wen-Jing Wang, Kun Peng, Xue Lu, Yan-Yan Zhu, Zhao Li, Qing-Hua Qian, Ya-Xin Yao, Lin Fu, Yan Wang, Yi-Chao Huang, Hui Zhao, Hua Wang, De-Xiang Xu, Zhu-Xia Tan
Accumulating evidences demonstrate that long-term exposure to atmospheric fine particles and air pollutants elevates the risk of chronic obstructive pulmonary disease (COPD). Cadmium (Cd) is one of the important toxic substances in atmospheric fine particles and air pollutants. In this study, we aimed to establish a mouse model to evaluate whether respiratory Cd exposure induces COPD-like lung injury. Adult male C57BL/6 mice were exposed to CdCl2 (10 mg/L, 4 h per day) by inhaling aerosol for either 10 weeks (short-term) or 6 months (long-term)...
March 23, 2023: Science of the Total Environment
Dimitrios Toumpanakis, Omar S Usmani
Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder, characterized by panacinar emphysema mainly in the lower lobes, and predisposes to chronic obstructive pulmonary disease (COPD) at a younger age, especially in patients with concomitant cigarette smoking. Alpha-1 antitrypsin (a1-AT) is a serine protease inhibitor that mainly blocks neutrophil elastase and maintains protease/antiprotease balance in the lung and AATD is caused by mutations in the SERPINA1 gene that encodes a1-AT protein. PiZZ is the most common genotype associated with severe AATD, leading to reduced circulating levels of a1-AT...
March 23, 2023: Respiratory Medicine
Linlin Meng, Muyun Wang, Yixuan Gao, Liangzhi Chen, Kun Wang, Wei Gao, Qinghua Liu
Acute lung injury (ALI) or its severe form, acute respiratory distress syndrome (ARDS) is a life-threatening illness without effective therapeutic interventions currently. Multiple lines of evidence indicated that overwhelming inflammatory responses and impaired epithelial barrier contributed to the pathogenesis of ALI/ARDS. Recently, dopamine (DA) system was identified to participate in various pulmonary diseases. Here, we discovered that dopamine D1-like receptors mainly expressed in macrophages and airway epithelial cells (AECs), which were downregulated by lipopolysaccharide (LPS) challenge in ALI mouse lung...
March 23, 2023: Free Radical Biology & Medicine
Stefanie Dichtl, Gabriel Diem, Michael Jäger, Viktoria Zaderer, Gaia Lupoli, Christopher Dächert, Maximilian Muenchhoff, Alexander Graf, Helmut Blum, Oliver T Keppler, Cornelia Lass-Flörl, Günter Weiss, Doris Wilflingseder, Wilfried Posch
The identification of the SARS-CoV-2 Omicron variants BA.4/BA.5, BF.7 and BQ.1.1 immediately raised concerns regarding the efficacy of currently used monoclonal antibody therapies. Here we examined the activity of monoclonal antibody therapies and antiviral drugs against clinical specimens for SARS-CoV-2 Omicron BA.4/BA.5, BF.7 and BQ.1.1 employing an immunofluorescence neutralization assay. Further we explored treatment of BA.4/BA.5 infections with efficient antiviral drugs and monoclonal antibodies in a 3D model of primary human bronchial epithelial cells...
March 23, 2023: Antiviral Research
Murtaza Mohemadali Contractor, Kalyani Bhate, Pushkar P Waknis, Sayali Awate, Sherwin Samuel
INTRODUCTION AND IMPORTANCE: Temporomandibular joint (TMJ) ankylosis triad includes TMJ ankylosis, micrognathia, and obstructive sleep apnea (OSA) which is common in long-standing cases of TMJ ankylosis. Unilateral long-standing cases of TMJ ankylosis also result in a severe discrepancy in the midline of the chin. CASE PRESENTATION: A young adult female presented with restricted mouth opening and daylight sleepiness. Her AHI was mild and there was excessive facial disfigurement...
March 23, 2023: International Journal of Surgery Case Reports
Mariana Carregã, Patrícia Sousa, Gustavo Rocha, Manuel Ferreira-Magalhães, Inês Azevedo
BACKGROUND: There is lack of evidence synthesis on the global consequences of bronchopulmonary dysplasia (BPD) in adolescence. AIM: Assess the impact of bronchopulmonary dysplasia on respiratory and non-respiratory outcomes in adolescents. METHODS: A systematic review of studies assessing the outcomes of adolescents aged 10 to 19 years-old with BPD was conducted. We independently screened studies published until 6th March 2023 in PubMed® and Scopus® databases...
March 21, 2023: Early Human Development
Junhyeok Ock, Dayeong Hong, Sojin Moon, Yong-Seok Park, Dong-Woo Seo, Joo Heung Yoon, Sung-Hoon Kim, Namkug Kim
BACKGROUND AND OBJECTIVES: Proper airway management during emergencies can prevent serious complications. However, cricothyroidotomy is challenging in patients with obesity. Since this technique is not performed frequently but at a critical time, the opportunity for trainees is rare. Simulators for these procedures are also lacking. Therefore, we proposed a realistic and interactive cricothyroidotomy simulator. METHODS: All anatomical structures were modeled based on computed tomography images of a patient with obesity...
March 12, 2023: Computer Methods and Programs in Biomedicine
Shawn Tahata, Jody Weckwerth, Anna Ligezka, Miao He, Hee Eun Lee, Julie Heimbach, Samar H Ibrahim, Tamas Kozicz, Katryn Furuya, Eva Morava
Phosphomannomutase-2-congenital disorder of glycosylation (PMM2-CDG) is the most common CDG and presents with highly variable features ranging from isolated neurologic involvement to severe multi-organ dysfunction. Liver abnormalities occur in in almost all patients and frequently include hepatomegaly and elevated aminotransferases, although only a minority of patients develop progressive hepatic fibrosis and liver failure. No curative therapies are currently available for PMM2-CDG, although investigation into several novel therapies is ongoing...
March 17, 2023: Molecular Genetics and Metabolism
Morten Hostrup, Erik S Hansen, Søren M Rasmussen, Søren Jessen, Vibeke Backer
Athletes often experience lower airway dysfunction, such as asthma and exercise-induced bronchoconstriction (EIB), which affects more than half the athletes in some sports, not least in endurance sports. Symptoms include coughing, wheezing, and breathlessness, alongside airway narrowing, hyperresponsiveness, and inflammation. Early diagnosis and management are essential. Not only because untreated or poorly managed asthma and EIB potentially affects competition performance and training, but also because untreated airway inflammation can result in airway epithelial damage, remodeling, and fibrosis...
March 25, 2023: Scandinavian Journal of Medicine & Science in Sports
J Flageollet, L Poujol, F Jolivet, C Baudin Trehiou, F Lafuma, F Bernardin
OBJECTIVES: To describe endoscopic findings, foreign body location, success rate of removal and complications in dogs with bronchial vegetal foreign bodies. MATERIALS AND METHODS: The current study retrospectively evaluated the case records of dogs diagnosed with bronchial vegetal foreign bodies at a veterinary hospital centre between January 2010 and April 2020. Information retrieved included breed, sex, age, bodyweight, the season of presentation, presentation and duration of clinical signs, previous removal attempts performed by the referring veterinarian, foreign body location and endoscopic and imaging findings...
March 25, 2023: Journal of Small Animal Practice
Atsushi Uchiyama, Shigeki Ochiai, Yoshifumi Murayama
The use of noninvasive respiratory support is widespread in newborn infants with respiratory distress. As the use of noninvasive respiratory support has increased, so too have the number of modes available. Among these modes, low-flow nasal cannula and nasal continuous positive airway pressure (NCPAP) have been used for a long time and have known efficacy and safety in newborn infants needing respiratory support. High-flow nasal cannula (HFNC) has been newly introduced, and its efficacy and safety are currently being investigated...
March 25, 2023: Pediatrics International: Official Journal of the Japan Pediatric Society
Damon Monroe, Justin M Pyne, Steffane McLennan, Ryan Kimmis, Jenny Yoon, Vincent L Biron
Transoral robotic surgery (TORS) approach for the treatment of oropharyngeal cancer allows for reduced patient morbidity, amongst other advantages over the traditional lip-splitting mandibulotomy method. Free-flap reconstruction is commonly utilized in head and neck cancer surgeries; however, safety and outcomes of this technique in TORS procedures have not been well studied. The objective of this study was to perform a systematic review to evaluate the efficacy and safety of TORS with free-flap reconstruction (TORS-FFR) for oropharyngeal cancer...
March 25, 2023: Journal of Robotic Surgery
Decai Wang, Lizong Rao, Huiren Lei, Wencui Li, Qiufang Yu, Wei Li, Jianghong Wei, Shuyun Xu, Biwen Mo
Nowadays, the diagnosis and treatment of COPD are often based on the results of lung function tests. Certain individuals, however, are not candidates for lung function testing due to pulmonary bullae, cardiac failure, low lung function, and other factors. Therefore, we evaluated whether serum tyrosine3-monooxygenase/tryptophan5-monooxygenase activation protein β (14-3-3β) could be a biomarker for the diagnosis of stable COPD patients. The expression of serum 14-3-3β protein was evaluated by an enzyme-linked immunosorbent assay...
March 24, 2023: Scientific Reports
Ravi V Chacko, Nisha X Jain, Brandon J Baird, Alejandro A Palma
Emergency airway management requires matching the appropriate intubation tools to anticipated obstacles. Video laryngoscopy and flexible endoscopy are often used for difficult airways. Here we describe a case where neither method alone was anticipated to be sufficient. A 53-year-old female with an obstructing lung mass required intubation for a mixed type 1 and 2 respiratory failure. Chest x-ray revealed a tortuous subglottic obstruction. The patient could not be temporized on maximized non-invasive airway support...
March 9, 2023: American Journal of Emergency Medicine
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