Kangkang Zha, Meijun Tan, Yiqiang Hu, Weixian Hu, Shengming Zhang, Yanzhi Zhao, Ze Lin, Wenqian Zhang, Hang Xue, Bobin Mi, Wu Zhou, Qian Feng, Faqi Cao, Guohui Liu
Bone nonunion poses an urgent clinical challenge that needs to be addressed. Recent studies have revealed that the metabolic microenvironment plays a vital role in fracture healing. Macrophages and bone marrow-derived mesenchymal stromal cells (BMSCs) are important targets for therapeutic interventions in bone fractures. Itaconate is a TCA cycle metabolite that has emerged as a potent macrophage immunomodulator that limits the inflammatory response. During osteogenic differentiation, BMSCs tend to undergo aerobic glycolysis and metabolize glucose to lactate...
July 2024: Bioactive Materials