Katerina Trkova, David Sumerauer, Adela Bubenikova, Lenka Krskova, Ales Vicha, Miroslav Koblizek, Josef Zamecnik, Bruno Jurasek, Martin Kyncl, Bela Malinova, Barbora Ondrova, David T W Jones, Martin Sill, Martina Strnadova, Lucie Stolova, Adela Misove, Vladimir Benes, Michal Zapotocky
In this study, we provide a comprehensive clinical and molecular biological characterization of radiation-induced gliomas (RIG), including a risk assessment for developing gliomas. A cohort of 12 patients who developed RIG 9.5 years (3-31 years) after previous cranial radiotherapy for brain tumors or T-cell acute lymphoblastic leukemia was established. The derived risk of RIG development based on our consecutive cohort of 371 irradiated patients was 1.6% at 10 years and 3.02% at 15 years...
February 7, 2024: Scientific Reports