keyword
https://read.qxmd.com/read/38536822/immediate-postnatal-prediction-of-death-or-bronchopulmonary-dysplasia-among-very-preterm-and-very-low-birth-weight-infants-based-on-gradient-boosting-decision-trees-algorithm-a-nationwide-database-study-in-japan
#1
JOURNAL ARTICLE
Kota Yoneda, Tomohisa Seki, Yoshimasa Kawazoe, Kazuhiko Ohe, Naoto Takahashi
INTRODUCTION: Bronchopulmonary dysplasia (BPD) poses a substantial global health burden. Individualized treatment strategies based on early prediction of the development of BPD can mitigate preterm birth complications; however, previously suggested predictive models lack early postnatal applicability. We aimed to develop predictive models for BPD and mortality based on immediate postnatal clinical data. METHODS: Clinical information on very preterm and very low birth weight infants born between 2008 and 2018 was extracted from a nationwide Japanese database...
2024: PloS One
https://read.qxmd.com/read/38536515/blood-pressure-in-preterm-infants-with-bronchopulmonary-dysplasia-in-the-first-three-months-of-life
#2
JOURNAL ARTICLE
Judit Klara Kiss, Anna Gajda, Judit Mari, Csaba Bereczki
BACKGROUND: Neonatal hypertension is common in preterm infants with bronchopulmonary dysplasia (BPD). Our study aimed to examine blood pressure variation in the first three months of life in preterm BPD patients. METHODS: We conducted a retrospective, single-centre study at the Neonatal Intensive Care Unit of the University of Szeged, Hungary. We collected blood pressure data from 26 preterm infants (born at < 30 weeks gestation) with moderate or severe BPD over three years (2019-2021)...
March 27, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38534776/the-influence-of-neurotrophins-on-the-brain-lung-axis-conception-pregnancy-and-neonatal-period
#3
REVIEW
Federica D'Amico, Cecilia Lugarà, Giovanni Luppino, Carlo Giuffrida, Ylenia Giorgianni, Eleonora Maria Patanè, Sara Manti, Antonella Gambadauro, Mariarosaria La Rocca, Tiziana Abbate
Neurotrophins (NTs) are four small proteins produced by both neuronal and non-neuronal cells; they include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). NTs can exert their action through both genomic and non-genomic mechanisms by interacting with specific receptors. Initial studies on NTs have identified them only as functional molecules of the nervous system. However, recent research have shown that some tissues and organs (such as the lungs, skin, and skeletal and smooth muscle) as well as some structural cells can secrete and respond to NTs...
March 15, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533296/retrospective-comparative-analysis-of-neonatal-mortality-and-morbidity-in-preterm-singleton-and-multiple-births-single-center-experience
#4
JOURNAL ARTICLE
Mohammad Alhasoon, Bader Alqahtani, Mohamad Alreefi, Abdulaziz Homedi, Ghadah Alnami, Saif Alsaif, Kamal Ali
Objective. To compare mortality and major neonatal morbidities between singleton preterm infants and preterm infants of multiple gestations born <33 weeks' gestation. Method. Case-control study of preterm multiples and singletons <33 weeks' born at King Abdul-Aziz Medical City Riyadh (KAMC-R) between January 2017 and December 2020. Out-born infants and infants with lethal congenital abnormalities were excluded from the study. Mortality and major neonatal morbidities including bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), sepsis and surgical necrotizing enterocolitis (NEC) were compared between preterm singletons and multiples...
2024: Global Pediatric Health
https://read.qxmd.com/read/38530261/effect-of-early-vs-late-inguinal-hernia-repair-on-serious-adverse-event-rates-in-preterm-infants-a-randomized-clinical-trial
#5
JOURNAL ARTICLE
Martin L Blakely, Andrea Krzyzaniak, Melvin S Dassinger, Claudia Pedroza, Jorn-Hendrik Weitkamp, Ankush Gosain, Michael Cotten, Susan R Hintz, Henry Rice, Sherry E Courtney, Kevin P Lally, Namasivayam Ambalavanan, Catherine M Bendel, Kim Chi T Bui, Casey Calkins, Nicole M Chandler, Roshni Dasgupta, Jonathan M Davis, Katherine Deans, Daniel A DeUgarte, Jeffrey Gander, Carl-Christian A Jackson, Martin Keszler, Karen Kling, Stephen J Fenton, Kimberley A Fisher, Tyler Hartman, Eunice Y Huang, Saleem Islam, Frances Koch, Shabnam Lainwala, Aaron Lesher, Monica Lopez, Meghna Misra, Jamie Overbey, Brenda Poindexter, Robert Russell, Steven Stylianos, Douglas Y Tamura, Bradley A Yoder, Donald Lucas, Donald Shaul, P Ben Ham, Colleen Fitzpatrick, Kara Calkins, Aaron Garrison, Diomel de la Cruz, Shahab Abdessalam, Charlotte Kvasnovsky, Bradley J Segura, Joel Shilyansky, Lynne M Smith, Jon E Tyson
IMPORTANCE: Inguinal hernia repair in preterm infants is common and is associated with considerable morbidity. Whether the inguinal hernia should be repaired prior to or after discharge from the neonatal intensive care unit is controversial. OBJECTIVE: To evaluate the safety of early vs late surgical repair for preterm infants with an inguinal hernia. DESIGN, SETTING, AND PARTICIPANTS: A multicenter randomized clinical trial including preterm infants with inguinal hernia diagnosed during initial hospitalization was conducted between September 2013 and April 2021 at 39 US hospitals...
March 26, 2024: JAMA
https://read.qxmd.com/read/38528568/an-epidemiological-investigation-of-high-risk-infants-for-respiratory-syncytial-virus-infections-a-retrospective-cohort-study
#6
JOURNAL ARTICLE
Michela Servadio, Marco Finocchietti, Chiara Vassallo, Riccardo Cipelli, Franca Heiman, Giulia Di Lucchio, Bianca Oresta, Antonio Addis, Valeria Belleudi
BACKGROUND: Respiratory Syncytial Virus (RSV) infections may lead to severe consequences in infants born preterm with breathing problems (such as bronchopulmonary dysplasia (BPD) and respiratory distress syndrome (RDS)) or congenital heart diseases (CHD). Since studies investigating the influence of different gestational age (WGA) and concomitant specific comorbidities on the burden of RSV infections are scarce, the present study aimed to better characterize these high-risk populations in the Italian context...
March 25, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38523376/comparison-of-prematurity-related-outcomes-and-complications-in-very-low-birth-weight-vlbw-neonates-fed-with-mother-s-own-milk-versus-donor-milk-a-comparative-study
#7
JOURNAL ARTICLE
Majid Karoobi, Amir Azimi, Hamed Zarei, Maryam Saboute, Nasrin Khalessi, Zahra Vahedi
BACKGROUND: When mother`s own milk (MOM) is unavailable or insufficient, donor milk (DM) from a human milk bank serves as an alternative feeding option. Our study sought to investigate and compare the outcomes and complications of very low birth weight (VLBW) preterm infants who receive MOM versus DM. METHODS: In this retrospective cohort study conducted between 2018 and 2022, we compared 70 VLBW preterm infants exclusively fed with DM to 70 randomly selected counterparts fed with MOM...
2024: Turkish Journal of Pediatrics
https://read.qxmd.com/read/38522947/association-of-hyaluronan-and-proteoglycan-link-protein-1-gene-with-the-need-of-home-oxygen-therapy-in-premature-japanese-infants-with-bronchopulmonary-dysplasia
#8
JOURNAL ARTICLE
Masato Ito, Ayumi Sasaki, Mitsuhiro Haga, Ayaka Iwatani, Eri Nishimura, Hirokazu Arai, Nobuhiko Nagano, Shutaro Suga, Shunsuke Araki, Asami Konishi, Yoshihiro Onouchi, Fumihiko Namba
BACKGROUND: Bronchopulmonary dysplasia (BPD) has a lasting effect on the respiratory function of infants, imposing chronic health burdens. BPD is influenced by various prenatal, postnatal, and genetic factors. This study explored the connection between BPD and home oxygen therapy (HOT), and then we examined the association between HOT and a specific single-nucleotide polymorphism (SNP) in the hyaluronan and proteoglycan link protein 1 ( HAPLN1 ) gene among premature Japanese infants. MATERIALS AND METHODS: Prenatal and postnatal data from 212 premature infants were collected and analyzed by four SNPs (rs975563, rs10942332, rs179851, and rs4703570) around HAPLN1 using the TaqMan polymerase chain reaction method...
December 2024: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/38513806/concurrent-progestogen-and-cerclage-to-reduce-preterm-birth-a-multicenter-international-retrospective-cohort
#9
JOURNAL ARTICLE
Jorge E Tolosa, Rupsa C Boelig, Joseph Bell, María Martínez-Baladejo, Jill Stoltzfus, Julio Mateus, Joanne N Quiñones, Santiago Galeano-Herrera, Leonardo Pereira, Richard Burwick, Luisa López-Torres, Catalina Valencia, Vincenzo Berghella
OBJECTIVE: We aimed to evaluate whether cerclage with progestogen therapy was superior to cerclage alone in the prevention of spontaneous preterm birth (sPTB) in singleton pregnancies METHODS: : This is an international retrospective cohort study of singleton pregnancies, without major anomaly or aneuploidy, and with cerclage placed at 10 different institutions in the United States and Colombia from June 2016-June 2020. Exclusion criteria were: lack of documentation regarding whether progestogen was or was not prescribed, delivery outcome unavailable, and pregnancy termination (spontaneous or induced) prior to 16 weeks' gestation...
March 19, 2024: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/38513690/need-for-gastrostomy-tube-in-periviable-infants
#10
JOURNAL ARTICLE
Erica E ElSeed Peterson, Jared T Roeckner, Taylor W Deall, Michele Karn, Jose R Duncan, Jaime Flores-Torres, Ambuj Kumar, Tara M Randis
OBJECTIVE:  We sought to identify clinical and demographic factors associated with gastrostomy tube (g-tube) placement in periviable infants. STUDY DESIGN:  We conducted a single-center retrospective cohort study of live-born infants between 22 and 25 weeks' gestation. Infants not actively resuscitated and those with congenital anomalies were excluded from analysis. RESULTS:  Of the 243 infants included, 158 survived until discharge...
March 21, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38511245/nesfatin-1-alleviates-hyperoxia-induced-bronchopulmonary-dysplasia-bpd-via-the-nuclear-factor-%C3%AE%C2%BAb-nf-%C3%AE%C2%BAb-p65-signaling-pathway
#11
JOURNAL ARTICLE
Li Zhang, Zhang Zhuo, Lijuan Chen, Jiao Liu, Jiang Huang, Jian Deng, Wei Lu, Xian Jiang
Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease in newborns, which severely influences the health of infants and lacks effective clinical treatment strategies. The pathogenesis of BPD is correlated to enhanced inflammation and activated oxidative stress (OS). The application of antioxidants and anti-inflammatory treatment could be hot spots for BPD treatment. Nesfatin-1, a peptide with a suppressive property against inflammation, was tested herein for its potential therapeutic value in BPD...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38510082/hyperglycemia-in-pregnancy-did-not-worsen-the-short-term-outcomes-of-very-preterm-infants-a-propensity-score-matching-study
#12
JOURNAL ARTICLE
Ying Li, Wei Shen, Rong Zhang, Jian Mao, Ling Liu, Yan-Mei Chang, Xiu-Zhen Ye, Yin-Ping Qiu, Li Ma, Rui Cheng, Hui Wu, Dong-Mei Chen, Ling Chen, Ping Xu, Hua Mei, San-Nan Wang, Fa-Lin Xu, Rong Ju, Xiao-Mei Tong, Xin-Zhu Lin, Fan Wu
BACKGROUND: Hyperglycemia in pregnancy (HGP) has generally been considered a risk factor associated with adverse outcomes in offspring, but its impact on the short-term outcomes of very preterm infants remains unclear. METHODS: A secondary analysis was performed based on clinical data collected prospectively from 28 hospitals in seven regions of China from September 2019 to December 2020. According to maternal HGP, all infants were divided into the HGP group or the non-HGP group...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38509583/the-diaphragmatic-initiated-ventilatory-assist-diva-trial-study-protocol-for-a-randomized-controlled-trial-comparing-rates-of-extubation-failure-in-extremely-premature-infants-undergoing-extubation-to-non-invasive-neurally-adjusted-ventilatory-assist-versus
#13
JOURNAL ARTICLE
David N Matlock, Sarah J Ratcliffe, Sherry E Courtney, Haresh Kirpalani, Kimberly Firestone, Howard Stein, Kevin Dysart, Karen Warren, Mitchell R Goldstein, Kelli C Lund, Aruna Natarajan, Ejigayehu Demissie, Elizabeth E Foglia
BACKGROUND: Invasive mechanical ventilation contributes to bronchopulmonary dysplasia (BPD), the most common complication of prematurity and the leading respiratory cause of childhood morbidity. Non-invasive ventilation (NIV) may limit invasive ventilation exposure and can be either synchronized or non-synchronized (NS). Pooled data suggest synchronized forms may be superior. Non-invasive neurally adjusted ventilatory assist (NIV-NAVA) delivers NIV synchronized to the neural signal for breathing, which is detected with a specialized catheter...
March 20, 2024: Trials
https://read.qxmd.com/read/38508328/tgf-%C3%AE-egfr-signaling-promotes-lipopolysaccharide-induced-abnormal-elastin-deposition-and-alveolar-simplification
#14
JOURNAL ARTICLE
Jianhui Li, Jian Cao, Chongbing Yan, Xiaohui Gong
Bronchopulmonary dysplasia (BPD) is characterized by shortened secondary septa and fewer, larger alveoli. Elastin deposition to the distal tips of the secondary septa is critical for elongation of the secondary septa. Alveolar myofibroblasts, which are thought to migrate to the septal tips during alveolarization, are mainly responsible for elastin production and deposition. Antenatal exposure to inflammation induces abnormal elastin deposition, thereby increasing the risk of developing BPD. Here, we found that lipopolysaccharide (LPS) significantly increased the expression of transforming growth factor-α (TGF-α) in an LPS-induced rat model of BPD and in LPS-treated human pulmonary epithelial cells (BEAS-2B)...
March 18, 2024: Experimental Cell Research
https://read.qxmd.com/read/38503240/cellular-senescence-in-chronic-lung-diseases-from-newborns-to-the-elderly-an-update-literature-review
#15
REVIEW
Ziyun Liu, Yiqi Zhang, Danni Li, Jianhua Fu
The role of cellular senescence in age-related diseases has been fully recognized. In various age-related-chronic lung diseases, the function of alveolar epithelial cells (AECs) is impaired and alveolar regeneration disorders, especially in bronchopulmonary dysplasia,pulmonary fibrosis (PF), chronic obstructive pulmonary disease (COPD), cancer, etc. Except for age-related-chronic lung diseases, an increasing number of studies are exploring the role of cellular senescence in developmental chronic lung diseases, which typically originate in childhood and even in the neonatal period...
March 18, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38502251/ampk-mtor-tp53-signaling-pathway-regulation-by-calcitonin-gene-related-peptide-reduces-oxygen-induced-lung-damage-in-neonatal-rats-through-autophagy-promotion
#16
JOURNAL ARTICLE
Shaohua Wang, Zhengzhuang Zou, Zanmei Tang, Jian Deng
Our previous studies indicated that calcitonin gene-related peptide (CGRP) alleviates hyperoxia-induced lung injury and suggested the possible involvement of autophagy in this process. Herein, we aimed to further explore the potential involvement of tumor protein p53 (TP53) and autophagy in the mode of action of CGRP against hyperoxia-induced lung injury in vitro and in vivo. The study conducted tests on type II alveolar epithelial cells (AECII) and rats that were subjected to hyperoxia treatment or combined treatment of hyperoxia with CGRP, CGRP inhibitor, rapamycin (an autophagy agonist), 3-methyladenine (3-MA, an autophagy inhibitor), TP53 silencing/inhibitor (pifithrin-α), or expression vector/activator (PRIMA-1 (2,2-bis(hydroxymethyl)-3-quinuclidinone)) and their corresponding controls...
March 19, 2024: Inflammation
https://read.qxmd.com/read/38501327/inpatient-education-reduces-length-of-outpatient-oxygen-therapy-in-bronchopulmonary-dysplasia-a-quality-improvement-project
#17
JOURNAL ARTICLE
Kathryn E K Berlin, Joanne Lagatta, Sara Dawson, Margaret Malnory, William Scott, Alicia Sprecher
BACKGROUND: Patients discharged on home oxygen therapy (HOT) for bronchopulmonary dysplasia (BPD) often receive months of this therapy. A previous trial comparing two methods of HOT weaning showed that increased parent involvement in HOT weaning decreased HOT duration. Our outpatient team uses a standard protocol for outpatient HOT weaning, starting at the first clinic visit 4-6 weeks after discharge. AIM: To shorten HOT duration by teaching parents the outpatient HOT weaning process before neonatal intensive care unit (NICU) discharge...
March 19, 2024: Pediatric Pulmonology
https://read.qxmd.com/read/38499706/deep-learning-model-for-prediction-of-bronchopulmonary-dysplasia-in-preterm-infants-using-chest-radiographs
#18
JOURNAL ARTICLE
Hao-Yang Chou, Yung-Chieh Lin, Sun-Yuan Hsieh, Hsin-Hung Chou, Cheng-Shih Lai, Bow Wang, Yi-Shan Tsai
Bronchopulmonary dysplasia (BPD) is common in preterm infants and may result in pulmonary vascular disease, compromising lung function. This study aimed to employ artificial intelligence (AI) techniques to help physicians accurately diagnose BPD in preterm infants in a timely and efficient manner. This retrospective study involves two datasets: a lung region segmentation dataset comprising 1491 chest radiographs of infants, and a BPD prediction dataset comprising 1021 chest radiographs of preterm infants. Transfer learning of a pre-trained machine learning model was employed for lung region segmentation and image fusion for BPD prediction to enhance the performance of the AI model...
March 18, 2024: J Imaging Inform Med
https://read.qxmd.com/read/38493255/effects-of-postnatal-corticosteroids-on-lung-development-in-newborn-animals-a-systematic-review
#19
Irene M Lok, Kimberley E Wever, Roos J S Vliegenthart, Wes Onland, Anton H van Kaam, Minke van Tuyl
BACKGROUND: Postnatal systemic corticosteroids reduce the risk of bronchopulmonary dysplasia but the effect depends on timing, dosing, and type of corticosteroids. Animal studies may provide valuable information on these variable effects. This systematic review summarizes the effects of postnatal systemic corticosteroids on lung development in newborn animals. METHODS: A systematic search was performed in PubMed and Embase in December 2022. The protocol was published on PROSPERO (CRD42021177701)...
March 16, 2024: Pediatric Research
https://read.qxmd.com/read/38491484/irf4-mediated-treg-phenotype-switching-can-aggravate-hyperoxia-induced-alveolar-epithelial-cell-injury
#20
JOURNAL ARTICLE
He Langyue, Zhu Ying, Jiang Jianfeng, Zhu Yue, Yao Huici, Lu Hongyan
Bronchopulmonary dysplasia (BPD) is characterized by alveolar dysplasia, and evidence indicates that interferon regulatory factor 4 (IRF4) is involved in the pathogenesis of various inflammatory lung diseases. Nonetheless, the significance and mechanism of IRF4 in BPD remain unelucidated. Consequently, we established a mouse model of BPD through hyperoxia exposure, and ELISA was employed to measure interleukin-17 A (IL-17 A) and interleukin-6 (IL-6) expression levels in lung tissues. Western blotting was adopted to determine the expression of IRF4, surfactant protein C (SP-C), and podoplanin (T1α) in lung tissues...
March 15, 2024: BMC Pulmonary Medicine
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