Walter C Jean
An endoscopic "keyhole" approach to a deep-lying skull base lesion can be a daunting challenge. For the pineal region, the techniques for endoscopic resection of solid tumors in this location are also new.1,2 In such a situation, surgical rehearsal in virtual reality (VR) can significantly improve the surgeon's confidence.3 In this operative video, we demonstrate the use of VR in surgical planning and rehearsal to determine the best approach to a large, solid pineal tumor in a 46-yr-old patient. Using the patient's computed tomography angiography and magnetic resonance imaging, a VR model of his anatomy was created (SNAP VR360 version 3...
September 7, 2020: Operative Neurosurgery (Hagerstown, Md.)
Hu Xing, Liu Jing-Ping, Qin Kun-Ming, Liao Shen-Chao, Tang Chun-Hai, Wu Jing-Zhan
Pineal region is deep located and tightly connected with surrounding important nerves, blood vessels, and other critical structure. Tumors in the regions are more commonly observed in children with complex pathology, difficult surgery, and poor prognosis. However, excision surgery on large tumor in the pineal region and extending into the third ventricle is characterized by high difficulty and uneasy treatment. Related experience and knowledge about excising large tumor in children pineal region which extending into the third ventricle by transcallosal-lateral ventricle-choroid fissure approach was described in the paper...
June 25, 2020: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Fadi Almahariq, Marina Raguz, Dominik Romic, Domagoj Dlaka, Darko Oreskovic, Patricija Sesar, Darko Chudy
Background: Biphasic tumors of the central nervous system are rarely described and mainly consisted out of the glial and mesenchymal component. The tumor originated out of both astrocytes and pinealocytes, best to our knowledge, has not been described. We present a case of a brain tumor consisted out of pilocytic astrocytoma (PA) and pineocytoma as components situated in the pineal region and posterior cranial fossa in young adult. Case Description: We present a 21-year-old patient with a history of intermittent headache, followed by nausea and vomiting, double vision, and dextropulsion...
2020: Surgical Neurology International
David Freeman, Daniel Guillaume, William Robert Bell, Clark C Chen
No abstract text is available yet for this article.
April 28, 2020: World Neurosurgery
Elke Pfaff, Christian Aichmüller, Martin Sill, Damian Stichel, Matija Snuderl, Matthias A Karajannis, Martin U Schuhmann, Jens Schittenhelm, Martin Hasselblatt, Christian Thomas, Andrey Korshunov, Marina Rhizova, Andrea Wittmann, Anna Kaufhold, Murat Iskar, Petra Ketteler, Dietmar Lohmann, Brent A Orr, David W Ellison, Katja von Hoff, Martin Mynarek, Stefan Rutkowski, Felix Sahm, Andreas von Deimling, Peter Lichter, Marcel Kool, Marc Zapatka, Stefan M Pfister, David T W Jones
Tumors of the pineal region comprise several different entities with distinct clinical and histopathological features. Whereas some entities predominantly affect adults, pineoblastoma (PB) constitutes a highly aggressive malignancy of childhood with a poor outcome. PBs mainly arise sporadically, but may also occur in the context of cancer predisposition syndromes including DICER1 and RB1 germline mutation. With this study, we investigate clinico-pathological subgroups of pineal tumors and further characterize their biological features...
February 2020: Acta Neuropathologica
Anna Cho, Steve S Cho, Vivek P Buch, Love Y Buch, John Y K Lee
INTRODUCTION: Second Window Indocyanine Green (SWIG) is a novel technique for real-time, intraoperative tumor visualization using a high dose infusion of Indocyanine Green (ICG) 24 hours before surgery 1, 2 . Due to pathologic diversity found in the pineal region, tissue diagnosis in patients with pineal region mass is essential to optimize further clinical management 3 . CASE DESCRIPTION: We present a case of a 75-year-old woman with known pineal region mass for 18 years, who presented with progressive classic signs and symptoms of obstructive hydrocephalus over the past six months...
October 26, 2019: World Neurosurgery
Sergio Moreno-Jiménez, Néstor Martínez-Vaca, Bárbara Pérez-Aguilar, Brenda Gómez-Calva, Jorge J Díaz-Chávez, Michel G Mondragón-Soto
Background: Stereotactic biopsy has been reported as a useful and safety procedure in pediatric patients. In adult patients exist more controversy because a greater number of diagnostic options. Objective: To demonstrate its usefulness and safety in adult patients with posterior fossa pathology. Method: From 2006-2014, 23 patients were operated from posterior fossa. Variables: age, gender, state, pre- and postoperative diagnosis, stereotactic device, location and complications...
2019: Cirugia y Cirujanos
Karen O'Connell, Darach Crimmins, Sarah Power, Keith L Ligon, Jane Cryan, Alan Beausang
No abstract text is available yet for this article.
June 24, 2019: Clinical Neuropathology
Haydee Martínez, Michelle Nagurney, Zi-Xuan Wang, Charles G Eberhart, Christopher M Heaphy, Mark T Curtis, Fausto J Rodriguez
Pineal parenchymal tumors are rare neoplasms, ranging from WHO Grade I to IV. There are few studies characterizing the molecular profiles of these tumors. ATRX alterations are strongly associated with the presence of the alternative lengthening of telomeres (ALT) phenotype, and within the central nervous system they tend to occur in subsets of gliomas, including those with IDH, NF1, or histone (H3 K27M or G34) mutations. Here, we identified ATRX frameshift mutations by next generation sequencing associated with corresponding protein loss in 2 cases of pineal parenchymal tumors of intermediate differentiation (PPTID) developing in a 21-year-old woman and a 64-year-old man...
May 27, 2019: Journal of Neuropathology and Experimental Neurology
David Mathieu, Christian Iorio-Morin
Pineal region tumors represent a heterogeneous group of different histologic entities, for which the management can be a significant challenge, due to their critical location and frequent aggressive behavior. Traditional management includes surgical resection, fractionated radiation therapy, and chemotherapy. Stereotactic radiosurgery (SRS) is being increasingly used in the treatment of these tumors. It is used as primary therapy for pineocytomas and papillary tumors of the pineal region, as an adjuvant radiation boost in combination with radiation or chemotherapy for pineoblastomas and germ cell tumors, or in the context of tumor recurrence...
May 16, 2019: Progress in Neurological Surgery
Marcin Braun, Bartłomiej Tomasik, Michał Bieńkowski, Karol Wiśniewski, Dorota-Jesionek Kupnicka, Dariusz Jaskólski, Wielisław Papierz, Jacek Fijuth, Radzislaw Kordek
BACKGROUND: Papillary tumors of the pineal region (PTPRs) are malignant World Health Organization grade II/III tumors; however, they may perfectly mimic benign tumors (e.g., pineocytomas [World Health Organization grade I]). CASE DESCRIPTION: We present a case of a 28-year-old man with a 35-mm tumor of the pineal region. Considering the typical radiological and pathologic presentation, the tumor was first diagnosed as pineocytoma. However, despite first total resection, the tumor recurred after 7 years...
December 2018: World Neurosurgery
Toshiaki Bando, Yasushi Ueno, Narihide Shinoda, Yukihiro Imai, Kazuhito Ichikawa, Yoji Kuramoto, Takahiro Kuroyama, Daisuke Shimo, Kazuyuki Mikami, Shinya Hori, Masato Matsumoto, Osamu Hirai
Pineal parenchymal tumor of intermediate differentiation (PPTID) is rare. The WHO first classified PPTID in 2000 as a pineal parenchymal tumor (PPT) with an intermediate prognosis between pineocytoma (PC) and pineoblastoma (PB). It is considered an intermediate-grade tumor and divided into WHO grade II or III. The number of available reports about PPTID is presently limited, and the appropriate management for this tumor has not yet been determined. The authors report a rare case of PC in a 63-year-old woman who presented with lower-extremity weakness and gait disturbance...
July 20, 2018: Journal of Neurosurgery
Hamidah Alias, Sie Chong D Lau, Ilse Schuitema, Leo M J de Sonneville
Objective: This study aimed to evaluate neuropsychological consequences in survivors of childhood brain tumor. Method: A case-control study was conducted over a period of 4 months in a tertiary referral center in Kuala Lumpur, Malaysia. Fourteen survivors of childhood brain tumor aged 7-18 years, who were off-treatment for at least 1 year and were in remission, and 31 unrelated healthy controls were recruited. The median age at diagnosis was 8.20 years (range: 0.92-12.96 years). The diagnoses of brain tumors were medulloblastoma, germ cell tumor, pineocytoma, pilocystic astrocytoma, suprasellar germinoma, and ependymoma...
2018: Frontiers in Psychology
María de Los Ángeles Cañizares Méndez, Manuel Amosa Delgado, Juan Antonio Álvarez Salgado, Jorge Javier Villaseñor Ledezma, Elena Capilla Cabezuelo, Francisco Díaz Crespo
Papillary tumor of the pineal region is a rare neuroepithelial tumor characterized by papillary architecture and epithelial cytology, immunopositivity for cytokeratin and ependymal differentiation. It is considered grade II-III by the World Health Organization and was first described by Jouvet in 2003. We present a 34-year-old male with headaches, blurred vision and normal examination. Radiological study showed a nodulocystic lesion in the pineal region compatible with pineocytoma. Surgery was performed using an infratentorial supracerebellar approach, finding a cystic tumor in the quadrigeminal cistern which was completely resected...
April 22, 2018: Neurocirugía
Narendra Kumar, Gulladamane Yogesh Srinivasa, Renu Madan, Pravin Salunke
OBJECTIVES: Surgical excision of pineal parenchymal tumors(PPT), though desirable for good long term outcome, may not always be possible. Role of adjuvant radiotherapy (RT) in residual PPT's is not well delineated. The purpose of this single institutional retrospective study is to assess the role of radiotherapy in residual PPT's. PATIENTS AND METHODS: Between 2006-2016, fourteen patients with residual PPT's were treated with adjuvant radiotherapy (12 with 3D conformal RT)...
March 2018: Clinical Neurology and Neurosurgery
Fumiyuki Yamasaki, Yasuyuki Kinoshita, Takeshi Takayasu, Satoshi Usui, Manish Kolakshyapati, Motoki Takano, Sayuru Tsuyuguchi, Vishwa Jeet Amatya, Yuji Akiyama, Yukio Takeshima, Kazuhiko Sugiyama, Kaoru Kurisu
BACKGROUND: The differentiation of germinoma from other tumors by conventional magnetic resonance imaging (MRI) can be very difficult. The purpose of our study was to determine whether diffusion-weighted imaging (DWI) and single-voxel proton magnetic resonance spectroscopy (1H-MRS) could provide additional useful information for a definitive diagnosis of germinomas. METHODS: Our hospital's Institutional Review Board approved this retrospective study. We reviewed imaging studies of 26 patients with histologically confirmed germinomas who were treated at our hospital between 2003 and 2016...
April 2018: World Neurosurgery
Christian Iorio-Morin, Hideyuki Kano, Marshall Huang, L Dade Lunsford, Gabriela Simonová, Roman Liscak, Or Cohen-Inbar, Jason Sheehan, Cheng-Chia Lee, Hsiu-Mei Wu, David Mathieu
BACKGROUND: Pineal region tumors represent a rare and histologically diverse group of lesions. Few studies are available to guide management and the outcomes after stereotactic radiosurgery (SRS). METHODS: Patients who underwent SRS for a pineal region tumor and for whom at least 6 months of imaging follow-up was available were retrospectively assessed in 5 centers. Data were collected from the medical record and histology level analyses were performed, including actuarial tumor control and survival analyses...
November 2017: World Neurosurgery
Shannon Coy, Adrian M Dubuc, Sonika Dahiya, Keith L Ligon, Alexandre Vasiljevic, Sandro Santagata
Papillary tumor of the pineal region (PTPR) is a neuroepithelial neoplasm first described in 2003. Despite the anatomic association of PTPR with the pineal gland, the features of these tumors resemble those of the ependymal circumventricular subcommissural organ (SCO) of the posterior third ventricle. Given the presumed distinct derivation of PTPR and pineal parenchymal tumors, we hypothesized that expression of lineage-specific transcription factors could distinguish these tumors and provide additional insight into the differentiation of PTPR...
October 2017: American Journal of Surgical Pathology
Maurizio Iacoangeli, Roberto Colasanti, Domenic Esposito, Alessandro Di Rienzo, Lucia di Somma, Mauro Dobran, Maurizio Gladi, Massimo Scerrati
BACKGROUND: Different surgical approaches have been developed for dealing with third ventricle lesions, all aimed at obtaining a safe removal minimizing brain manipulation. The supraorbital subfrontal trans-lamina terminalis route, commonly employed only for the anterior third ventricle, could represent, in selected cases with endoscopic assistance, an alternative approach to posterior third ventricular lesions. METHODS: Seven patients underwent a supraorbital subfrontal trans-laminar endoscope-assisted approach to posterior third ventricle tumors (two craniopharyngiomas, one papillary tumor of the pineal region, one pineocytoma, two neurocytomas, one glioblastoma)...
April 2017: Acta Neurochirurgica
Supriya Mallick, Rony Benson, G K Rath
BACKGROUND/PURPOSE: Pineal parenchymal tumor constitutes less than 1% of all CNS tumors. Pineal parenchymal tumor of intermediate differentiation is a rare tumor arising from the pineal parenchyma lying between the spectrum of Pineocytoma and Pineoblastoma. METHODS AND MATERIALS: We performed PubMed search with the following MesH terms: "pineal parenchymal tumor, pineal parenchymal tumor of intermediate differentiation, pineal parenchymal tumor of intermediate differentiation AND treatment, and pineal parenchymal tumor of intermediate differentiation AND survival" to find all possible publications pertaining to PPTID...
November 2016: Radiotherapy and Oncology
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"