keyword
https://read.qxmd.com/read/31861678/deuterium-depleted-water-as-adjuvant-therapeutic-agent-for-treatment-of-diet-induced-obesity-in-rats
#41
Tetiana Halenova, Igor Zlatskiy, Anton Syroeshkin, Tatiana Maximova, Tatiana Pleteneva
In this study, we present the potential application of deuterium-depleted water (DDW) for the prevention and adjuvant treatment of obesity in rats. We tested the hypothesis that DDW can alleviate diet-induced obesity (DIO) and its associated metabolic impairments. Rats fed a high-fat diet had an increased body weight index (BWI), glucose concentration, and level of certain proinflammatory cytokines; decreased levels of insulin in the serum; decreased tryptophan and serotonin in the brain, and a decreased concentration of some heavy metals in the liver...
December 19, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/31858120/decreased-aerobic-exercise-capacity-after-long-term-remission-from-cushing-syndrome-exploration-of-mechanisms
#42
Sean H P P Roerink, Matthew S Cocks, Margreet A E M Wagenmakers, Raffaella P Rodighiero, Juliette A Strauss, Sam O Shepherd, Theo S Plantinga, Dick H J Thijssen, Maria T E Hopman, Alberto M Pereira, Jan W Smit, Anton J M Wagenmakers, Romana T Netea-Maier, Ad R M M Hermus
BACKGROUND: Although major improvements are achieved after cure of Cushing syndrome (CS), fatigue and decreased quality of life persist. This is the first study to measure aerobic exercise capacity in patients in remission of CS for more than 4 years in comparison with matched controls, and to investigate whether the reduction in exercise capacity is related to alterations in muscle tissue. METHODS: Seventeen patients were included. A control individual, matched for sex, estrogen status, age, body mass index, smoking, ethnicity, and physical activity level was recruited for each patient...
April 1, 2020: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31846650/primary-cilia-signaling-promotes-axonal-tract-development-and-is-disrupted-in-joubert-syndrome-related-disorders-models
#43
Jiami Guo, James M Otis, Sarah K Suciu, Christy Catalano, Lei Xing, Sandii Constable, Dagmar Wachten, Stephanie Gupton, Janice Lee, Amelia Lee, Katherine H Blackley, Travis Ptacek, Jeremy M Simon, Stephane Schurmans, Garret D Stuber, Tamara Caspary, E S Anton
Appropriate axonal growth and connectivity are essential for functional wiring of the brain. Joubert syndrome-related disorders (JSRD), a group of ciliopathies in which mutations disrupt primary cilia function, are characterized by axonal tract malformations. However, little is known about how cilia-driven signaling regulates axonal growth and connectivity. We demonstrate that the deletion of related JSRD genes, Arl13b and Inpp5e, in projection neurons leads to de-fasciculated and misoriented axonal tracts...
December 16, 2019: Developmental Cell
https://read.qxmd.com/read/31846042/long-term-surveillance-of-biologic-therapies-in-systemic-onset-juvenile-idiopathic-arthritis-data-from-the-german-biker-registry
#44
Ariane Klein, Jens Klotsche, Boris Hügle, Kirsten Minden, Anton Hospach, Frank Weller-Heinemann, Tobias Schwarz, Frank Dressler, Ralf Trauzeddel, Markus Hufnagel, Ivan Foeldvari, Michael Borte, Jasmin Kuemmerle-Deschner, Jürgen Brunner, Prasad Thomas Oommen, Dirk Föll, Klaus Tenbrock, Andreas Urban, Gerd Horneff
OBJECTIVE: Using data from the German Biologics JIA Registry (BIKER), long-term safety of biologics for systemic-onset JIA with regard to adverse events of special interest was assessed. METHODS: Safety assessments were based on adverse event reports after first dose through 90 days after last dose. Rates of adverse event, serious adverse event and 25 predefined adverse events of special interest were analysed. Incidence rates were compared for each biologic against all other biologics combined applying a mixed-effect Poisson model...
December 17, 2019: Rheumatology
https://read.qxmd.com/read/31809218/safety-implications-of-combined-antiretroviral-and-anti-tuberculosis-drugs
#45
REVIEW
Maddalena Cerrone, Margherita Bracchi, Sean Wasserman, Anton Pozniak, Graeme Meintjes, Karen Cohen, Robert J Wilkinson
Introduction : Antiretroviral and anti-tuberculosis (TB) drugs are often co-administered in people living with HIV (PLWH). Early initiation of antiretroviral therapy (ART) during TB treatment improves survival in patients with advanced HIV disease. However, safety concerns related to clinically significant changes in drug exposure resulting from drug-drug interactions, development of overlapping toxicities and specific challenges related to co-administration during pregnancy represent barriers to successful combined treatment for HIV and TB...
January 2020: Expert Opinion on Drug Safety
https://read.qxmd.com/read/31801772/anton-s-syndrome-a-rare-and-unusual-form-of-blindness
#46
Faisal Bashir Chaudhry, Samavia Raza, Usman Ahmad
Anton syndrome is characterised by visual anosognosia. It results from damage to both occipital lobes, while the anterior visual pathways remain intact. We describe four cases of Anton's syndrome. First case is that of a 73-year-old woman, who presented with two separate events of intraparenchymal brain haemorrhage, 4 years apart. Her first stroke affected the left and second affected the right occipital lobe. Bilateral occipital lobe damage resulted in cortical blindness. Second case is an 88-year-old man, who suffered from two ischaemic strokes, 2 days apart...
December 3, 2019: BMJ Case Reports
https://read.qxmd.com/read/31796081/eda-edar-edaradd-and-wnt10a-allelic-variants-in-patients-with-ectodermal-derivative-impairment-in-the-spanish-population
#47
María Carmen Martínez-Romero, María Juliana Ballesta-Martínez, Vanesa López-González, María José Sánchez-Soler, Ana Teresa Serrano-Antón, María Barreda-Sánchez, Lidya Rodriguez-Peña, María Teresa Martínez-Menchon, José Frías-Iniesta, Paloma Sánchez-Pedreño, Pablo Carbonell-Meseguer, Guillermo Glover-López, Encarna Guillén-Navarro
BACKGROUND: Ectodermal dysplasias (ED) are a group of genetic conditions affecting the development and/or homeostasis of two or more ectodermal derivatives. An attenuated phenotype is considered a non-syndromic trait when the patient is affected by only one impaired ectodermal structure, such as in non-syndromic tooth agenesis (NSTA) disorder. Hypohidrotic ectodermal dysplasia (HED) is the most highly represented ED. X-linked hypohidrotic ectodermal dysplasia (XLHED) is the most common subtype, with an incidence of 1/50,000-100,000 males, and is associated with the EDA gene (Xq12-q13...
December 3, 2019: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/31770777/levosimendan-reduces-mortality-and-low-cardiac-output-syndrome-in-cardiac-surgery
#48
Carolyn Weber, Matthias Esser, Kaveh Eghbalzadeh, Anton Sabashnikov, Ilija Djordjevic, Johanna Maier, Julia Merkle, Yeong-Hoon Choi, Navid Madershahian, Oliver Liakopoulos, Antje Christin Deppe, Thorsten C W Wahlers
BACKGROUND:  There has been conflicting evidence concerning the effect of levosimendan on clinical outcomes in patients undergoing cardiac surgery. Therefore, we performed a systematic review and conducted this meta-analysis to provide evidence for/against the administration of levosimendan in cardiac surgery patients. METHODS:  We performed a meta-analysis from literature search in PubMed, EMBASE, and Cochrane Library. Only randomized controlled trials comparing the administration of levosimendan in cardiac surgery patients with a control group (other inotrope, standard therapy/placebo, or an intra-aortic balloon pump) were included...
November 26, 2019: Thoracic and Cardiovascular Surgeon
https://read.qxmd.com/read/31763405/details-on-high-frequency-blood-collection-data-analysis-available-material-and-patient-characteristics-in-biomarcs
#49
Eric Boersma, Maxime M Vroegindewey, Victor J van den Berg, Folkert W Asselbergs, Pim van der Harst, Bas Kietselaer, Timo Lenderink, Anton J Oude Ophuis, Victor A W M Umans, Robbert J de Winter, Rohit M Oemrawsingh, K Martijn Akkerhuis
The Biomarker Study to Identify the Acute Risk of a Coronary Syndrome (BIOMArCS) is a prospective, observational study that has been designed to study the evolution of blood biomarkers in post-acute coronary syndrome (ACS) patients. In our recently published study "Temporal evolution of Myeloperoxidase and Galectin 3 during 1 year after acute coronary syndrome admission" [1] in the American Heart Journal , we demonstrated that repeatedly measuring MPO and Galectin-3 does not aid to differentiate between patients with and without adverse cardiac events during 1-year follow-up...
December 2019: Data in Brief
https://read.qxmd.com/read/31740517/teaching-neuroimages-frey-syndrome
#50
Anton Shcherbina, Elie Sader
No abstract text is available yet for this article.
November 19, 2019: Neurology
https://read.qxmd.com/read/31736812/changes-in-body-fat-and-related-biochemical-parameters-associated-with-atypical-antipsychotic-drug-treatment-in-schizophrenia-patients-with-or-without-metabolic-syndrome
#51
Elena G Kornetova, Alexander N Kornetov, Irina A Mednova, Viktoria V Dubrovskaya, Anastasia S Boiko, Nikolay A Bokhan, Anton J M Loonen, Svetlana A Ivanova
Background: Metabolic syndrome (MetS) is a common problem in schizophrenia patients and associated with increased mortality due to cardiovascular disease. Second-generation antipsychotics (SGAs) play an important role in facilitating MetS. Objective: The study aimed to assess weight changes and alterations of indicators of body fat composition and lipid-glucose metabolism induced by reinitiating atypical antipsychotics in patients with schizophrenia when with or without MetS. Methods: After giving informed consent, newly admitted patients with a clinical diagnosis of schizophrenia (ICD-10: F20) and an age between 18 and 55 years were included...
2019: Frontiers in Psychiatry
https://read.qxmd.com/read/31714607/topography-of-behavior-problems-among-children-with-neurodevelopmental-conditions-profile-differences-and-overlaps
#52
Emily Gardiner, Anton R Miller, Lucyna M Lach
BACKGROUND: This exploratory proof of principle study examined the extent to which behavior problems represent a functional characteristic that crosses diagnostic boundaries. METHODS: This cross-sectional study pertains to 179 caregivers of children, aged 4-13 years (M = 8.27) with cerebral palsy (n = 77), autism spectrum disorder (n = 58), and global developmental delay/intellectual disability (n = 44). Caregivers completed the Strengths and Difficulties Questionnaire, which provides a measure of conduct problems, emotional symptoms, hyperactivity-inattention, peer problems, as well as total difficulties...
January 2020: Child: Care, Health and Development
https://read.qxmd.com/read/31687570/acute-effects-of-methcathinone-and-manganese-in-mice-a-dose-response-study
#53
Andres Asser, Sulev Kõks, Ursel Soomets, Anton Terasmaa, Martin Sauk, Mall Eltermaa, Piret Piip, Kumari Ubhayasekera, Jonas Bergquist, Pille Taba
An intravenously injectable illicit drug made by mixing pseudoephedrine, potassium permanganate, vinegar and water, yielding methcathinone (Mcat) and manganese (Mn), induces an extrapyramidal syndrome with parkinsonism, dystonia, gait and balance disorders similar to manganism. Although the cause of the syndrome is largely attributed to Mn, the interaction of the drug's individual components is not known and the role of Mcat is possibly underestimated. Aim of the present study was to analyze dose-dependent behavioral effects of the mixture and its two main active components Mcat and Mn in an acute setting and determine the lethal doses of each substance...
September 2019: Heliyon
https://read.qxmd.com/read/31673100/glp-1-receptor-agonist-liraglutide-has-a-neuroprotective-effect-on-an-aged-rat-model-of-wolfram-syndrome
#54
Kadri Seppa, Maarja Toots, Riin Reimets, Toomas Jagomäe, Tuuliki Koppel, Maia Pallase, Stine Hasselholt, Maiken Krogsbæk Mikkelsen, Jens Randel Nyengaard, Eero Vasar, Anton Terasmaa, Mario Plaas
Wolfram syndrome (WS) is a rare neurodegenerative disorder that is mainly characterized by diabetes mellitus, optic nerve atrophy, deafness, and progressive brainstem degeneration. Treatment with GLP-1 receptor agonists has shown a promising anti-diabetic effect in WS treatment in both animal models and in human patients. Since previous research has tended to focus on investigation of the WS first symptom, diabetes mellitus, the aim of the present study was to examine liraglutide effect on WS-associated neurodegeneration...
October 31, 2019: Scientific Reports
https://read.qxmd.com/read/31671663/gender-differences-in-the-pharmacological-actions-of-pegylated-glucagon-like-peptide-1-on-endothelial-progenitor-cells-and-angiogenic-precursor-cells-in-a-combination-of-metabolic-disorders-and-lung-emphysema
#55
Olga Victorovna Pershina, Angelina Vladimirovna Pakhomova, Darius Widera, Natalia Nicolaevna Ermakova, Anton Alexandrovich Epanchintsev, Edgar Sergeevich Pan, Vyacheslav Andreevich Krupin, Olga Evgenevna Vaizova, Olesia Dmitrievna Putrova, Lubov Alexandrovna Sandrikina, Irina Vitalevna Kurochkina, Sergey Georgievich Morozov, Aslan Amirkhanovich Kubatiev, Alexander Mikhaylovich Dygai, Evgenii Germanovich Skurikhin
In clinical practice, the metabolic syndrome (MetS) is often associated with chronic obstructive pulmonary disease (COPD). Although gender differences in MetS are well documented, little is known about sex-specific differences in the pathogenesis of COPD, especially when combined with MetS. Consequently, it is not clear whether the same treatment regime has comparable efficacy in men and women diagnosed with MetS and COPD. In the present study , using sodium glutamate, lipopolysaccharide, and cigarette smoke extract, we simulated lipid metabolism disorders, obesity, hyperglycemia, and pulmonary emphysema (comorbidity) in male and female C57BL/6 mice...
October 30, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/31648013/the-development-of-cell-senescence
#56
REVIEW
Silva-Álvarez, Pilar Picallos-Rabina, Lucía Antelo-Iglesias, Francisco Triana-Martínez, Antón Barreiro-Iglesias, Laura E Sánchez, Manuel Collado
Cellular senescence was traditionally considered a stress response that protected the organism by limiting the proliferation of damaged and unwanted cells. However, the recent identification of developmentally-programmed cellular senescence during embryo development has changed our view of the process. There are now a number of examples of developmental senescence in evolutionary distant organisms ranging from mammals to fish, showing senescence at various sites during specific time windows of development. Developmental senescence shares many features with stress-induced senescence but also present some specific characteristics...
October 21, 2019: Experimental Gerontology
https://read.qxmd.com/read/31603236/blindness-psychosis-and-the-visual-construction-of-the-world
#57
Thomas A Pollak, Philip R Corlett
The relationship between visual loss and psychosis is complex: congenital visual loss appears to be protective against the development of a psychotic disorder, particularly schizophrenia. In later life, however, visual deprivation or visual loss can give rise to hallucinosis, disorders of visual insight such as blindsight or Anton syndrome, or, in the context of neurodegenerative disorders, more complex psychotic presentations. We draw on a computational psychiatric approach to consider the foundational role of vision in the construction of representations of the world and the effects of visual loss at different developmental stages...
October 11, 2019: Schizophrenia Bulletin
https://read.qxmd.com/read/31535542/historical-evolution-of-the-diseases-caused-by-non-pigmented-rapidly-growing-mycobacteria-in-a-university-hospital
#58
M Garcia-Coca, G Rodriguez-Sevilla, M C Muñoz-Egea, C Perez-Jorge, N Carrasco-Anton, J Esteban
OBJECTIVE: Non-pigmented rapidly growing mycobacteria (NPRGM) are a group of organisms of increasing interest due to the growing number of potential patients and the difficulties for a proper treatment in many of them. However, the evolution of these diseases in a long period of time and its evolutionary changes has been described only in a scanty number of reports. METHODS: We performed a retrospective study between January 1st 2004 and December 31st 2017 in order to evaluate the clinical significance and types of diseases caused by NPRGM...
September 19, 2019: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://read.qxmd.com/read/31505498/initial-observations-on-the-effect-of-repeated-surfactant-dose-on-lung-volume-and-ventilation-in-neonatal-respiratory-distress-syndrome
#59
Merja Kallio, Anne-Sea van der Zwaag, Andreas D Waldmann, Marika Rahtu, Martijn Miedema, Thalia Papadouri, Anton H van Kaam, Peter C Rimensberger, Richard Bayford, Inéz Frerichs
BACKGROUND: Exogenous surfactant administration is an essential part of respiratory distress syndrome treatment in preterm infants. Current guidelines recommend the first dose to be given as early as possible, followed by an additional dose if symptoms persist. The effect of additional dosing on regional ventilation and lung volume has not been investigated so far. OBJECTIVES: The aim of this study was to assess changes in ventilation distribution, lung volume, and gas exchange following repeated surfactant dosing in invasively ventilated neonates...
2019: Neonatology
https://read.qxmd.com/read/31482689/whole-exome-sequencing-provides-insights-into-monogenic-disease-prevalence-in-northwest-russia
#60
Yury A Barbitoff, Rostislav K Skitchenko, Olga I Poleshchuk, Anton E Shikov, Elena A Serebryakova, Yulia A Nasykhova, Dmitrii E Polev, Anna R Shuvalova, Irina V Shcherbakova, Mikhail A Fedyakov, Oleg S Glotov, Andrey S Glotov, Alexander V Predeus
BACKGROUND: Allele frequency data from large exome and genome aggregation projects such as the Genome Aggregation Database (gnomAD) are of ultimate importance to the interpretation of medical resequencing data. However, allele frequencies might significantly differ in poorly studied populations that are underrepresented in large-scale projects, such as the Russian population. METHODS: In this work, we leveraged our access to a large dataset of 694 exome samples to analyze genetic variation in the Northwest Russia...
November 2019: Molecular Genetics & Genomic Medicine
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