Yejin Kim, Sola Han, Hae Sun Suh
Migraine is an enormous burden on society, but relevant studies are limited. The population of interest of this study was migraine or probable migraine (PM) in Korea. In this population, we aimed to assess the productivity loss through the level of severity defined by monthly migraine days (MMD) and analgesic frequency and to estimate costs and associated factors of productivity loss. We conducted an online survey of adults with migraine symptoms. We defined migraine and PM using the modified International Classification of Headache Disorders, second edition...
2022: PloS One
Pierluigi Valente, Antonella Marte, Francesca Franchi, Bruno Sterlini, Silvia Casagrande, Anna Corradi, Pietro Baldelli, Fabio Benfenati
Proline-rich transmembrane protein 2 (PRRT2) is a neuron-specific protein implicated in the control of neurotransmitter release and neural network stability. Accordingly, PRRT2 loss-of-function mutations associate with pleiotropic paroxysmal neurological disorders, including paroxysmal kinesigenic dyskinesia, episodic ataxia, benign familial infantile seizures, and hemiplegic migraine. PRRT2 is a negative modulator of the membrane exposure and biophysical properties of Na+ channels NaV 1.2/NaV 1.6 predominantly expressed in brain glutamatergic neurons...
November 28, 2022: Molecular Neurobiology
Diego Raimondo, Antonio Raffone, Federica Renzulli, Giada Sanna, Arianna Raspollini, Linda Bertoldo, Manuela Maletta, Jacopo Lenzi, Giulia Rovero, Antonio Travaglino, Antonio Mollo, Renato Seracchioli, Paolo Casadio
STUDY OBJECTIVE: To assess prevalence of central sensitization (CS) and its association with demographic and clinical factors in patients with endometriosis. DESIGN: Single-center, observational, cross-sectional study. SETTING: Tertiary center. PATIENTS: Consecutive patients with endometriosis referred to the center from January 15, 2022, to April 30, 2022. INTERVENTIONS: For each enrolled patient, demographic and clinical data were collected, and the presence of CS was measured using the CS Inventory questionnaire (score ≥40)...
October 29, 2022: Journal of Minimally Invasive Gynecology
A C Novo, P A Pinzón-Benavides, P Rozas-Fernández, M Martínez-Palicio, A García-Rúa, C Antón-González, I Casado-Menéndez, R Suárez-Moro, M T Temprano-Fernández
INTRODUCTION: Transient ischaemic attack (TIA) has classically been defined as an episode of self-limited focal neurological deficit lasting up to 24 hours, with no neuroimaging evidence of established acute ischaemic injury. However, the definition of this entity is changing, and is adapting to new times and new diagnostic techniques, including magnetic resonance imaging (MRI) with diffusion sequences. An early and comprehensive approach to TIA, including MRI, is important to rule out clinically recovered established ischaemic strokes, in order to optimise the diagnostic and therapeutic management of patients...
December 1, 2022: Revista de Neurologia
Mohamed Sheikh Hassan, Nor Osman Sidow, Nur Adam Mohamed
Transient global amnesia (TGA) is an uncommon clinical syndrome characterized by short-term memory loss and disorientation that resolves in 24 h. Here, we report a 60-year-old male patient who presented with a sudden onset of disorientation and short-term memory loss and started to ask about his whereabouts and what happened. He had no significant past medical or psychiatric disorder. Likewise, the patient did not have a recent history of head trauma, substance abuse, loss of consciousness, seizure disorder, or migraine...
November 2022: Clinical Case Reports
Shaohua Lyu, Claire Shuiqing Zhang, Jingbo Sun, Heng Weng, Charlie Changli Xue, Xinfeng Guo, Anthony Lin Zhang
BACKGROUND: Migraine is a chronic neurological disease causing significant socioeconomic burden and impaired quality of life. Chinese medicine is commonly used for migraine in China. Clinical trials have generated evidence of the effectiveness of Chinese medicine therapies for migraine. However, little is known about how to use these therapies to treat migraine in real-world clinical settings. METHODS: In this retrospective study, we analyzed data from the electronic medical records (EMRs) of 2,023 migraine patients who attended the Guangdong Provincial Hospital of Chinese Medicine (GPHCM) between July 2018 and July 2020...
2022: Frontiers in Medicine
Katharina Kaltseis, Till Hamann, Charly Gaul, Gregor Broessner
OBJECTIVE: Along with the development of novel migraine therapies as the monoclonal antibodies against calcitonin gene-related peptide (CGRP) and its receptor, the question arises if the treatment of chronic migraine (CM) and medication overuse headache (MOH) must be reconsidered. Have previous therapeutic approaches, including glucocorticoids, lost their role in the management of this debilitating disorder? In this narrative review, we present an overview of the available treatment options in CM and MOH in light of CGRP antibodies as well as an evaluation of the role of glucocorticoids in withdrawal therapy...
November 27, 2022: Headache
Marina Vives-Mestres, Amparo Casanova, Xavier Puig, Josep Ginebra, Noah Rosen
OBJECTIVE: To assess whether alcohol intake is associated with the onset of migraine attacks up to 2 days after consumption in individuals with episodic migraine (EM). BACKGROUND: Although alcohol has long been suspected to be a common migraine trigger, studies have been inconclusive in proving this association. METHODS: This was an observational prospective cohort study among individuals with migraine who registered to use a digital health platform for headache...
November 27, 2022: Headache
Rupa Radhakrishnan, Lindsey A G Shea, Sumit Pruthi, Victoria M Silvera, Thangamadhan Bosemani, Nilesh K Desai, Donald L Gilbert, Orit A Glenn, Carolina V Guimaraes, Mai-Lan Ho, H F Samuel Lam, Mohit Maheshwari, David M Mirsky, Helen R Nadel, Sonia Partap, Gary R Schooler, Unni K Udayasankar, Matthew T Whitehead, Jason N Wright, Cynthia K Rigsby
Childhood ataxia may be due to multifactorial causes of impairment in the coordination of movement and balance. Acutely presenting ataxia in children may be due to infectious, inflammatory, toxic, ischemic, or traumatic etiology. Intermittent or episodic ataxia in children may be manifestations of migraine, benign positional vertigo, or intermittent metabolic disorders. Nonprogressive childhood ataxia suggests a congenital brain malformation or early prenatal or perinatal brain injury, and progressive childhood ataxia indicates inherited causes or acquired posterior fossa lesions that result in gradual cerebellar dysfunction...
November 2022: Journal of the American College of Radiology: JACR
Lara Senn, Anna-Maria Costa, Rossella Avallone, Katarzyna Socała, Piotr Wlaź, Giuseppe Biagini
The peroxisome proliferator-activated receptor gamma (PPARγ), which belongs to the family of nuclear receptors, has been mainly studied as an important factor in metabolic disorders. However, in recent years the potential role of PPARγ in different neurological diseases has been increasingly investigated. Especially, in the search of therapeutic targets for patients with epilepsy the question of the involvement of PPARγ in seizure control has been raised. Epilepsy is a chronic neurological disorder causing a major impact on the psychological, social, and economic conditions of patients and their families, besides the problems of the disease itself...
November 24, 2022: Pharmacology & Therapeutics
Sawan Kumar, Jyotdeep Kour Raina, Amrit Sudershan, Kanak Mahajan, Raman Jasrotia, Chinmoyee Maharana, Rakesh K Panjalia, Parvinder Kumar
INTRODUCTION: Migraine is a neurovascular disorder and is clinically characterized by episodic attacks of mild to severe headaches. Due to the involvement of multiple environmental and genetic factors, it has become a much more complex neurological condition to understand. Apart from the environmental variables, a plethora of genes have been implicated, and one such example is ESR1. The present study was focused to find out the association of two important polymorphisms, namely, PvuII and XbaI of the ESR1 with migraine in the population of Jammu and Kashmir (UT)...
November 25, 2022: European Neurology
Jennifer Carroll, Lisa Pabst, Daniel C Koboldt, Samuel J Franklin, Samantha Choi, Richard K Wilson, Warren Lo
BACKGROUND: Cockayne syndrome is a rare DNA repair disorder marked by premature aging, poor growth, and intellectual disability. Neurological complications such as seizures, movement disorder, and stroke have been reported. Hemiplegic migraine has not been reported in association with Cockayne syndrome. METHODS: We report a male with Cockayne syndrome due to biallelic heterozygous pathogenic variants in ERCC6 who presented repeatedly with transient focal neurological deficits and headache, which were consistent with hemiplegic migraine...
October 28, 2022: Pediatric Neurology
Ahmed I Foudah, Sushma Devi, Mohammed H Alqarni, Aftab Alam, Mohammad Ayman Salkini, Manish Kumar, Husam Saad Almalki
This study aimed to investigate the antimigraine potential of quercetin in migraine pain induced by nitroglycerin (NTG), 10 mg/kg, intraperitoneal injection in rats. Quercetin was administered orally for 1 week, and behavioral parameters associated with pain were assessed 30 min after NTG injection. At the end of the study, the rats were killed so that immunohistochemical examination of their brains could be performed. The time and frequency of rearing and sniffing in the category of exploratory behavior, walking in the category of locomotor behavior, and total time spent in the light chamber were reduced in the disease control group compared with the normal group during the assessment of behavioral parameters...
November 17, 2022: Nutrients
Sara Bottiroli, Marta Matamala-Gomez, Marta Allena, Elena Guaschino, Natascia Ghiotto, Roberto De Icco, Grazia Sances, Cristina Tassorelli
BACKGROUND: given the limited efficacy, tolerability, and accessibility of pharmacological treatments for chronic migraine (CM), new complementary strategies have gained increasing attention. Body ownership illusions have been proposed as a non-pharmacological strategy for pain relief. Here, we illustrate the protocol for evaluating the efficacy in decreasing pain perception of the enfacement illusion of a happy face observed through an immersive virtual reality (VR) system in CM. METHOD: the study is a double-blind randomized controlled trial with two arms, involving 100 female CM patients assigned to the experimental group or the control group...
November 21, 2022: Journal of Clinical Medicine
Chiara Demartini, Rosaria Greco, Giulia Magni, Anna Maria Zanaboni, Benedetta Riboldi, Miriam Francavilla, Cristina Nativi, Stefania Ceruti, Cristina Tassorelli
Preclinical data point to the contribution of transient receptor potential ankyrin 1 (TRPA1) channels to the complex mechanisms underlying migraine pain. TRPA1 channels are expressed in primary sensory neurons, as well as in glial cells, and they can be activated/sensitized by inflammatory mediators. The aim of this study was to investigate the relationship between TRPA1 channels and glial activation in the modulation of trigeminal hyperalgesia in preclinical models of migraine based on acute and chronic nitroglycerin challenges...
November 15, 2022: International Journal of Molecular Sciences
Tatiana O Kolesnikova, Konstantin A Demin, Fabiano V Costa, Konstantin N Zabegalov, Murilo S de Abreu, Elena V Gerasimova, Allan V Kalueff
Channelopathies are a large group of systemic disorders whose pathogenesis is associated with dysfunctional ion channels. Aberrant transmembrane transport of K+ , Na+ , Ca2+ and Cl- by these channels in the brain induces central nervous system (CNS) channelopathies, most commonly including epilepsy, but also migraine, as well as various movement and psychiatric disorders. Animal models are a useful tool for studying pathogenesis of a wide range of brain disorders, including channelopathies. Complementing multiple well-established rodent models, the zebrafish ( Danio rerio ) has become a popular translational model organism for neurobiology, psychopharmacology and toxicology research, and for probing mechanisms underlying CNS pathogenesis...
November 12, 2022: International Journal of Molecular Sciences
Satoshi Kitagawa, Chunhua Tang, Miyuki Unekawa, Yohei Kayama, Jin Nakahara, Mamoru Shibata
A migraine is clinically characterized by repeated headache attacks that entail considerable disability. Many patients with migraines experience postdrome, the symptoms of which include tiredness and photophobia. Calcitonin gene-related peptide (GGRP) is critically implicated in migraine pathogenesis. Cortical spreading depolarization (CSD), the biological correlate of migraine aura, sensitizes the trigeminovascular system. In our previous study, CSD caused hypomotility in the light zone and tendency for photophobia at 72 h, at which time trigeminal sensitization had disappeared...
November 9, 2022: International Journal of Molecular Sciences
Chisato Iba, Miyuki Unekawa, Yoshikane Izawa, Jin Nakahara, Tsubasa Takizawa
Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches, including migraines; however, the underlying mechanisms remain unknown. Therefore, we investigated whether chronic treatment with Goreisan affects cortical spreading depolarization (CSD) in migraines. CSD susceptibility was assessed in male and female C57BL/6 mice by comparing CSD threshold, propagation velocity, and CSD frequency between animals treated with Goreisan for approximately 3 weeks and the corresponding controls with a potassium-induced CSD model...
November 9, 2022: International Journal of Molecular Sciences
Zoe Tasma, Andrew Siow, Paul W R Harris, Margaret A Brimble, Simon J O'Carroll, Debbie L Hay, Christopher S Walker
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide expressed in the trigeminal ganglia (TG). The TG conducts nociceptive signals in the head and may play roles in migraine. PACAP infusion provokes headaches in healthy individuals and migraine-like attacks in patients; however, it is not clear whether targeting this system could be therapeutically efficacious. To effectively target the PACAP system, an understanding of PACAP receptor distribution is required. Therefore, this study aimed to characterize commercially available antibodies and use these to detect PACAP-responsive receptors in the TG...
November 9, 2022: International Journal of Molecular Sciences
Patrizia Ferroni, Raffaele Palmirotta, Gabriella Egeo, Cinzia Aurilia, Maria Giovanna Valente, Antonella Spila, Alberto Pierallini, Piero Barbanti, Fiorella Guadagni
White matter hyperintensities (WMHs) in migraine could be related to inflammatory and antioxidant events. The aim of this study is to verify whether migraine patients with WMHs carry a genetic pro-inflammatory/pro-oxidative status. To test this hypothesis, we analyzed lymphotoxin alpha ( LTA ; rs2071590T and rs2844482G) and superoxide dismutase 1 ( SOD1 ; rs2234694C) and 2 ( SOD2 ; rs4880T) gene polymorphisms (SNPs) in 370 consecutive patients affected by episodic (EM; n = 251) and chronic (CM; n = 119) migraine and in unrelated healthy controls (n = 100)...
November 9, 2022: International Journal of Molecular Sciences
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