Patrick M Killoran, Vicky Capel, Vera D'Aloisio, Adam Schofield, Tímea Aczél, Kata Bölcskei, Zsuzsanna Helyes, Bengt von Mentzer, David A Kendall, Chris R Coxon, Gillian A Hutcheon
OBJECTIVES: It has previously been shown that the peptide (34Pro,35Phe)CGRP27-37 is a potent calcitonin gene-related peptide, CGRP receptor antagonist, and in this project we aimed to improve the antagonist potency through the structural modification of truncated C-terminal CGRP peptides. METHODS: Six peptide analogues were synthesized and the anti-CGRP activity confirmed using both in vitro and in vivo studies. KEY FINDINGS: A 10 amino acid-containing peptide VPTDVGPFAF-NH2 (P006) was identified as a key candidate to take forward for in vivo evaluation, where it was shown to be an effective antagonist after intraperitoneal injection into mice...
September 23, 2023: Journal of Pharmacy and Pharmacology
Nur Amalina Md Isa, Shyam S Tummanapalli, Jeremy Chung Bo Chiang, Arun V Krishnan, Alessandro S Zagami, Eric B Papas, Maria Markoulli, Katherine Spira
No abstract text is available yet for this article.
September 23, 2023: Headache
Victor S Wang, Justin Kosman, Hsiangkuo Yuan, Clinton Lauritsen, Stephen Shrewsbury, Sheena K Aurora, Mary Hopkins, Stephen Silberstein
BACKGROUND: Dihydroergotamine (DHE), like triptans, is contraindicated in patients with ischemic heart disease or coronary vasospasm. Its true safety, tolerability, and efficacy in patients with cardiovascular risk without ischemic heart disease or coronary vasospasm remain unclear. OBJECTIVES: To assess the safety, tolerability, and effectiveness of repetitive intravenous DHE in patients with cardiovascular risk factors. METHODS: A single-center, retrospective cohort study was conducted at the Jefferson Headache Center inpatient unit for refractory chronic migraine patients treated with our intravenous DHE protocol between January 1, 2019, and October 15, 2019...
September 23, 2023: Headache
Turker Oba, Zeynep Ece Kaya Gulec, Feyza Cicek, Ugur Uygunoglu, Feyza Onder
BACKGROUND: Migraine is a neurovascular disease that can cause ocular and systemic ischemic damage. Despite from aura, a limited number of studies have considered the effect of the chronic migraine in cases without aura. Our aim was to evaluate the differences in the retinal and optic disc microvasculature among episodic and chronic migraine cases without aura using optical coherence tomography angiography (OCTA) imaging. METHODS: 45 cases with migraine, and 25 control subjects were included in this prospective, cross-sectional study...
September 20, 2023: Photodiagnosis and Photodynamic Therapy
Evangelia Ioannidou, Charalampos Tsakiris, Dimitrios G Goulis, Athanasios Christoforidis, Dimitrios Zafeiriou
INTRODUCTION: Migraine is a neurologic condition characterized by hypersensitivity to auditory, olfactory, visual, and cutaneous stimuli; vomiting and nausea; and severe headache. It is the most frequent headache syndrome in children and can be categorized in chronic and/or episodic. Multiple dietary supplements have been inaugurated for the management of migraine, the most prevalent of which is vitamin D. BACKGROUND: In recent years, vitamin D deficiency has been a global public health problem, with 30-80% of the worldwide population having vitamin D deficiency...
September 16, 2023: European Journal of Paediatric Neurology: EJPN
Hye Yeon Ko, Hae Jeong Nam, Min Hee Kim
OBJECTIVES: The aims of this study were to investigate the cumulative recurrence rate of SSNHL and to determine association between comorbidities and recurrence of SSNHL by comparing patients with and without recurrence. METHODS: Using the National Health Insurance Claims Database (NHICD) from 2009 to 2020, we conducted a population-based study. We only enrolled patients whose records showed a prescription for steroid and audiometry findings as well as an appropriate diagnostic code...
September 22, 2023: Laryngoscope
Laura Zaranek, Hanna Sobe, Matthias Richter, Anke Hübler, Reinhard Berner, Maja von der Hagen, Thea Koch, Rainer Sabatowski, Anna Klimova, Gudrun Goßrau
BACKGROUND: Girls and women are more frequently affected by headache than boys and men. The influence of gender on the effectiveness of headache therapies has so far been hardly investigated. We examined gender differences in the outpatient multimodal Dresden Child and Adolescent Headache Program DreKiP. METHODS: We treated 140 patients with primary headache in a 15-hour structured group program. At baseline (T0) and six (T1) and twelve months (T2) after the end of the program, data on headache-related limitation of daily activities (PedMIDAS) as well as headache frequency, intensity, and pain-related disability (P-PDI) were collected...
September 22, 2023: Der Schmerz
Dilara Onan, Esme Ekizoğlu, Halime Arıkan, Bahar Taşdelen, Aynur Özge, Paolo Martelletti
BACKGROUND: Pharmacological treatment is the primary approach in chronic migraine (CM), although non-drug interventions such as physical therapy are used as adjunct treatments. We aimed to review the efficacy of physical therapy and rehabilitation approaches for CM and their impact on quality of life (QoL) and disability. METHODS: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and included randomized controlled trials (RCTs) in adults with CM...
August 16, 2023: Journal of Integrative Neuroscience
Eric K Kim, Maxwell Hum, Jeffrey D Sharon
OBJECTIVE: Investigate the relationship between Vestibular Migraine Patient Assessment Tool and Handicap Inventory (VM-PATHI) scores and daily dizziness symptoms. STUDY DESIGN: Prospective cohort analysis of 52 patients with vestibular migraine (VM). SETTING: Tertiary referral center. PATIENTS: Fifty-two patients diagnosed with VM or probable VM according to Barany Society criteria. INTERVENTIONS: Subjects reported their dizzy symptoms (on a scale of 0 [no symptoms], 1 [mild], 2 [moderate], and 3 [severe]) every day for 1 month via automated text messaging linked to a cloud-based research database...
September 15, 2023: Otology & Neurotology
Tao Wang, Yanan Li, Shuai Miao, Chunxiao Yang, Wei Xie, Huijuan Yuan, Wenhao Bai, Han Xiao, Shengyuan Yu
BACKGROUND: Migraine treatment research has made much great progress over the past decade. However, there have been few bibliometric studies conducted so far. In this study, bibliometric analysis was used to explore the current status and future trends of migraine treatment research. METHODS: Migraine treatment-related articles were retrieved from the Web of Science Core Collection on December 7, 2022. Quantitative variables were analyzed by the R-tool bibliometrix and Excel 2020...
2023: Journal of Pain Research
Linda Papa, John J Cienki, Jason W Wilson, Virginia Axline, Emily A Coyle, Ryan C Earwood, Josef G Thundiyil, Jay G Ladde
Previous studies have suggested that there are sex differences in the treatment and outcome of neurological emergencies; however, research identifying the role these sex differences play in the management of neurological emergencies is lacking. More knowledge of the way sex factors into the pathophysiology of neurological emergencies will be helpful in improving outcomes for these patients. The aim of this cross-sectional study was to assess the prevalence and management of neurological emergencies while evaluating sex differences in the diagnosis and treatment of these emergencies...
2023: Neurotrauma reports
Tian Fang, Zhihao Zhang, Huijie Zhou, Wanchun Wu, Fuqing Ji, Liqun Zou
BACKGROUND: The relationship between migraine and breast cancer risk has generated conflicting findings. We attempted to assess the association between migraine and breast cancer risk using Mendelian randomization (MR) analysis. METHODS: We selected genetic instruments associated with migraine from a recently published genome-wide association studies (GWAS). Inverse variant weighted (IVW) analysis was adopted as the main method, and we also performed the weighted-median method and the MR‒Egger, MR pleiotropy residual sum and outlier (MR-PRESSO), and MR Robust Adjusted Profile Score (MR-RAPS) methods as supplements...
September 20, 2023: BMC Cancer
Bianca Raffaelli, Thien Phu Do, Basit Ali Chaudhry, Messoud Ashina, Faisal Mohammad Amin, Håkan Ashina
OBJECTIVE: To explore and critically appraise the evidence supporting the role of estrogen withdrawal in menstrual migraine. MAIN BODY: Menstrual migraine, impacting about 6% of reproductive-age women, manifests as migraine attacks closely related to the menstrual cycle. The estrogen withdrawal hypothesis posits that the premenstrual drop in estrogen levels serves as a trigger of migraine attacks. Despite its wide acceptance, the current body of evidence supporting this hypothesis remains limited, warranting further validation...
September 21, 2023: Journal of Headache and Pain
Miguel Ángel Calleja-Hernández, Ángel Luis Guerrero-Peral, Pablo Irimia-Sieira, Icíar Martínez-López, Sonia Santos-Lasaosa, Maite Sarobe-Carricas, José María Serra López-Matencio, José Miguel Láinez-Andrés
OBJECTIVE: The objectives are to know the opinion of neurologists and hospital pharmacists on those aspects still under debate regarding the role of anti-Calcitonin Gene-related Peptide monoclonal antibodies in the preventive treatment of migraine. To identify those controversies that still exist. To propose agreed recommendations for improvement of care. And to promote access of clinicians and patients to these new treatments in the prevention of migraine with biological drugs, in order to improve patient care and follow-up...
September 18, 2023: Farmacia Hospitalaria
Asher George, Stephen Rayborn, Peyton Herrington, Svenja Albrecht, Adrian Billings
► large joint arthralgias ► history of type 1 diabetes, seizures, migraines.
September 2023: Journal of Family Practice
Emily Peterson, Allison Bernard, Robert A Beck
These agents are as effective as traditional acute and preventive treatments, cause fewer adverse effects, and can simplify regimens.
September 2023: Journal of Family Practice
Seyda Besen, Yasemin Ozkale, Serdar Ceylaner, Aytul Noyan, Ilknur Erol
BACKGROUND: Homocysteine (Hcy) is an endogenous nonprotein sulfur-containing amino acid biosynthesized from methionine by the removal of its terminal methyl group. Hyperhomocysteinemia (HHcy) has been linked to many systemic disorders, including stroke, proteinuria, epilepsy, psychosis, diabetes, lung disease, and liver disease. The clinical effects of high serum Hcy level, also known as hyperhomocysteinemia, have been explained by different mechanisms. However, little has been reported on the clinical and laboratory findings and etiologies of genetic HHcy in children...
September 20, 2023: Acta Neurologica Belgica
Agnete Skovlund Dissing, Xin Ying Lee, Ole Østerberg, Lene Hammer-Helmich
INTRODUCTION: Overuse of medication to treat migraine attacks can lead to development of a new type of headache or significant worsening of pre-existing headache, known as medication overuse headache. However, data concerning the burden of medication overuse (MO) in migraine are limited. This study aimed to assess the humanistic burden of MO in individuals with migraine from five European countries. METHODS: Data are from the 2020 National Health and Wellness Survey-a cross-sectional, population-based survey conducted in France, Germany, Italy, Spain, and the UK...
September 20, 2023: Neurology and Therapy
Cristina García-Iglesias, Ana González-Celestino, Álvaro Sierra Mencía, Yésica González Osorio, Andrea Recio García, Cristina Martínez-Badillo, Ana Echavarría Íñiguez, Berta Varona-Galán, David García-Azorín, Ángel Luis Guerrero-Peral
BACKGROUND: Since the first description of nummular headache (NH), more than 500 cases have been described, delineating its clinical phenotype and response to treatment. However, data on the natural history of NH and outcomes during long-term follow-up are not currently available. The present study aimed to describe the long-term outcomes and follow-up of a large series of patients with NH. METHODS: A descriptive observational ambisective study with a series of cases was conducted...
September 2023: Cephalalgia: An International Journal of Headache
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