James E Frampton
No abstract text is available yet for this article.
January 16, 2021: CNS Drugs
Yuan-Feng Zhang, Zhi-Qiang Xu, Hong-Jie Zhou, Ya-Zhen Liu, Xiao-Jiang Jiang
INTRODUCTION: The efficacy of vitamin D for migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of vitamin D versus placebo on treatment in migraine patients. METHODS: We search PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases through April 2020 for randomized controlled trials assessing the effect of vitamin D versus placebo on treatment efficacy in migraine patients. This meta-analysis is performed using the random-effect model...
January 2021: Clinical Neuropharmacology
Francesca Puledda, Owen O'Daly, Christoph Schankin, Dominic Ffytche, Steven Cr Williams, Peter J Goadsby
Here we investigate brain functional connectivity in patients with visual snow syndrome (VSS). Our main objective was to understand more about the underlying pathophysiology of this neurological syndrome. Twenty-four patients with VSS and an equal number of gender and age-matched healthy volunteers attended MRI sessions in which whole-brain maps of functional connectivity were acquired under two conditions: at rest while watching a blank screen and during a visual paradigm consisting of a visual-snow like stimulus...
January 15, 2021: Human Brain Mapping
Richard B Lipton, Elizabeth K Seng, Min Kyung Chu, Michael L Reed, Kristina M Fanning, Aubrey Manack Adams, Dawn C Buse
OBJECTIVE: To examine the influences of depression and anxiety on headache-related disability in people with episodic migraine or chronic migraine. BACKGROUND: Depression and anxiety are common comorbidities in people with migraine, especially among those with chronic migraine. METHODS: This cross-sectional analysis of data from the longitudinal, internet-based Chronic Migraine Epidemiology and Outcomes Study assessed sociodemographic and headache features, and headache-related disability (Migraine Disability Assessment Scale)...
September 2020: Headache
Hugo Pedder, Sofia Dias, Meg Bennetts, Martin Boucher, Nicky J Welton
BACKGROUND: Network meta-analysis (NMA) synthesizes direct and indirect evidence on multiple treatments to estimate their relative effectiveness. However, comparisons between disconnected treatments are not possible without making strong assumptions. When studies including multiple doses of the same drug are available, model-based NMA (MBNMA) presents a novel solution to this problem by modeling a parametric dose-response relationship within an NMA framework. In this article, we illustrate several scenarios in which dose-response MBNMA can connect and strengthen evidence networks...
January 15, 2021: Medical Decision Making: An International Journal of the Society for Medical Decision Making
Kaveh Ebahimzadeh, Mahdi Gholipour, Mohammad Samadian, Mohammad Taheri, Soudeh Ghafouri-Fard
Migraine is a common neurovascular condition. This disorder has a complex genetic background. Several single-nucleotide polymorphisms (SNPs) or mutations within genes regulating glutamatergic neurotransmission, cortical excitability, ion channels, and solute carriers have been associated with polygenic and monogenic forms of migraine. SNPs within ACE, DBH, TRPM8, COMT, GABRQ, CALCA, TRPV1, and other genes have been reported to affect the risk of migraine or the associated clinical parameters. The distribution of some HLA alleles within the HLA-DRB1, HLA-DR2, HLA-B, and HLA-C regions have also been found to differ between migraineurs and healthy subjects...
January 14, 2021: Journal of Molecular Neuroscience: MN
Fernando Luiz R Dantas, François Dantas, Antônio Carlos Caires, Ricardo V Botelho
Over the years, knowledge regarding the natural history of Chiari malformation type I (CM-I) has improved. However, there are still uncertainties in the literature regarding asymptomatic and oligosymptomatic patients with CM-I. We performed a literature review in order to determine the natural history of CM-I in symptomatic patients who were not operated and in asymptomatic adult patients. Among symptomatic patients, the most frequent symptom was headache (77%). Cough-related headache alone (34%), migraine-related headache alone (21...
December 13, 2020: Curēus
Amnon A Berger, Jamal Hasoon
No abstract text is available yet for this article.
October 2020: Saudi Journal of Anaesthesia
Bing Hu, Simon Akerman, Peter J Goadsby
Vagus nerve stimulation (VNS) is a promising neuromodulation approach used in the treatment of migraine, whose therapeutic mechanism is largely unknown. Previous studies suggest that VNS's anti-nociceptive effects may, in part, involved engaging opioidergic mechanisms. We used a validated preclinical model of head pain, with good translational outcomes in migraine, acute intracranial-dural stimulation, and has responded to invasive VNS. We tested the effects of μ (MOR), δ (DOR) and κ (KOR) opioid receptor agonists in this model, and subsequently the effects of opioid receptor antagonists against VNS-mediated neuronal inhibition...
January 11, 2021: Neuropharmacology
Pamela M Rist, Julie E Buring, Nancy R Cook, JoAnn E Manson, Tobias Kurth
BACKGROUND: There is interest in whether supplements, including vitamin D and marine omega-3 (n-3) fatty acids, may be effective migraine prophylaxis. However, few studies have evaluated whether vitamin D or n-3 fatty acid supplementation may reduce migraine frequency or severity. METHODS: Participants in the VITamin D and OmegA-3 TriaL (VITAL) were assigned to vitamin D3 (2000 IU/d) or marine n-3 fatty acid (1 g/d) supplementation in a two-by-two factorial design...
January 11, 2021: American Journal of Medicine
Faraidoon Haghdoost, Simona Sacco
No abstract text is available yet for this article.
December 18, 2020: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Yago Leira, Clara Domínguez, Pablo Ameijeira, Esteban López-Arias, Paulo Ávila-Gómez, María Pérez-Mato, Tomás Sobrino, Francisco Campos, Juan Blanco, Rogelio Leira
The anti-inflammatory effect of OnabotulinumtoxinA (OnabotA) has been a matter of discussion for many years. In chronic migraine, however, increased pro-inflammatory state is associated with good response to OnabotA. We aimed to investigate whether a mild systemic inflammatory state elicited by a common oral infection (periodontitis) could enhance treatment response to OnabotA. In this study, we included 61 chronic migraineurs otherwise healthy treated with OnabotA of which 7 were poor responders and 54 good responders...
January 13, 2021: Scientific Reports
Antonina D'Amico, Cristina Galati, Maria Laura Manzo, Federica Reina, Giovanna Martina Nocera, Vincenzo Raieli
BACKGROUND: Red ear syndrome (RES) is a neurological syndrome that is characterized by attacks of redness and pain that is localized in the earlobe, accompanied by a burning sensation, swelling or otalgia. The exact pathophysiology of RES is not known. Several pediatric cases have been described. They show an extreme variability in clinical presentation and therapeutic response, and therefore there are numerous difficulties in the diagnostic-therapeutic approach and in the comprehension of the physiopathology...
January 6, 2021: International Journal of Pediatric Otorhinolaryngology
Sara Gil-Perotín, Teresa Jaijo, Andrés G Verdú, Pilar Rubio, Miguel Mazón, Raquel Gasqué-Rubio, Samuel Díaz
BACKGROUND: Recessive mutations in the SLC4A4 gene cause a syndrome characterised by proximal renal tubular acidosis (pRTA), mental retardation, dental and ocular abnormalities, and hemiplegic migraine. Rare cases involving the development of epilepsy or its severe complication-status epilepticus-have been described. METHODS: The clinical and genetic status of four affected members in a Spanish family was studied. The SLC4A4 gene mutation was detected with a next-generation sequencing (NGS) panel in the proband, and Sanger confirmed the putative mutations in affected relatives...
January 13, 2021: Neurological Sciences
XiaoGuang Lin, ZhongQuan Yi, XueLing Zhang, QinQin Liu, Hui Zhang, RuYuan Cai, ChaoChun Chen, HongJie Zhang, PanWen Zhao, PingLei Pan
BACKGROUND: Migraine is one of the most common disabling diseases in the world. Its recurrent attacks may lead to abnormalities in the structure of the brain and retina. An increasing number of studies have investigated retinal nerve fiber layer (RNFL) thickness alterations in migraine by the optical coherence tomography (OCT); however, no consensus has yet reached. METHOD: We searched Pubmed, Embase, and Web of Science databases to identify studies that investigated RNFL thickness in migraine by OCT measurement and performed a meta-analysis of eligible studies...
January 13, 2021: Neurological Sciences
T Cosslett, C Mitchell
No abstract text is available yet for this article.
January 13, 2021: Journal of Neurology
Daniel Zielonka
INTRODUCTION: Zduńska et al. [1] present the results of a pilot study exploring changes in melatonin serum concentration in migraine patients, and the clinical implications of these changes. CLINICAL REFLECTIONS: Melatonin secretion may be altered for several reasons, and migraine is one of those clinical conditions where melatonin secretion can be changed. Correlations between migraine clinical phenotype and melatonin secretion pat-terns may bring exciting results...
January 13, 2021: Neurologia i Neurochirurgia Polska
Seonghoon Kim, Dae-Woong Bae, Sang-Gue Park, Jeong-Wook Park
The response to pain is highly individual and can be influenced by complex emotional perception. This study aims to investigate the status of the pain-related emotional response, and the influence on headache characteristics and disability in migraine. We studied the pain-related emotional response in 145 consecutive migraine patients using the Pain Anxiety Symptoms Scale (PASS), the Pain Catastrophizing Scale (PCS), and the Pain Sensitivity Questionnaire (PSQ) and compared them with 106 healthy controls. We investigated the relationship between emotional factors and migraine characteristics...
January 12, 2021: Scientific Reports
Roberta Noseda, Francesca Bedussi, Claudio Gobbi, Chiara Zecca, Alessandro Ceschi
OBJECTIVE: To assess the safety profile of erenumab, galcanezumab and fremanezumab in pregnancy and lactation. METHODS: Safety reports of suspected adverse drug reactions were retrieved from VigiBase as of 31 December 2019, for a case-by-case assessment and disproportionality analysis using the reporting odds ratio (ROR). RESULTS: There were 94 safety reports: 50 (53.2%) on erenumab, 31 (33.0%) on galcanezumab, and 13 (13.8%) on fremanezumab...
January 12, 2021: Cephalalgia: An International Journal of Headache
Teresa Catarci
BACKGROUND: Persistent migraine with aura and neuroimaging examinations revealing ischaemia in the contralateral cortex may be associated with migrainous infarction. Despite being a neurological symptom that is distinct from migraine with aura, the visual snow phenomenon may also be associated with cerebral ischaemia. Here we describe a patient who reported short-lasting daily symptoms of visual snow that affected his entire visual field before becoming continuous and left-sided following acute occipital brain ischaemia...
January 12, 2021: Cephalalgia: An International Journal of Headache
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"