keyword
https://read.qxmd.com/read/33071616/analysis-of-genetic-variants-in-scn1a-scn2a-kcnk18-trpa1-and-stx1a-as-a-possible-marker-of-migraine
#1
Marta Kowalska, Michał Prendecki, Magdalena Kapelusiak-Pielok, Teresa Grzelak, Urszula Łagan-Jędrzejczyk, Małgorzata Wiszniewska, Wojciech Kozubski, Jolanta Dorszewska
Background: Migraine is a polygenetic disease, considered as a channelopathy. The dysregulation of ion functioning due to genetic changes may activate the trigeminovascular system and induce migraine attack both migraine with aura (MA) and without aura (MO). Objectives: The aim of the study was to analyze the following variants of genes encoding ion channels and associated protein: c.3199G>A SCN1A , c.56G>A SCN2A , c.28A>G and c.328T>C KCNK18 , c.3053A>G TRPA1 , c...
April 2020: Current Genomics
https://read.qxmd.com/read/33071500/benign-paroxysmal-positional-vertigo-after-oral-and-maxillofacial-surgery-our-experience-and-review-of-literature
#2
Marzia Petrocelli, Carolina Sbordone, Giovanni Salzano, Giovanni Dell'Aversana Orabona, Francesco Maria Cassandro, Alfonso Scarpa, Luca Ramaglia, Giorgio Iaconetta, Luigi Califano, Ettore Cassandro
Objectives: The aim of our study is to evaluate the influence of patient risk factors and the length of surgical time on the onset of BPPV (benign paroxysmal positional vertigo) and suggest surgical and clinical strategies to prevent this rare complication. Method: Our retrospective study analyzes that, in 2 years, 281 patients, divided into three groups, underwent wisdom teeth extraction, sinus lift elevation and orthognathic surgery, at the Oral and Maxillofacial Department of the University of Naples "Federico II...
December 2020: Journal of Maxillofacial and Oral Surgery
https://read.qxmd.com/read/33070926/aneurysmal-subarachnoid-hemorrhage-in-patients-with-migraine-and-tension-headache-a-cohort-comparison-study
#3
Layton Lamsam, Hriday P Bhambhvani, Ajith Thomas, John K Ratliff, Justin M Moore
Migraine headache is a common condition with an estimated lifetime prevalence of greater than 20%. While it is a well-established risk factor for cardiovascular disease and ischemic stroke, its association with subarachnoid hemorrhage is largely unexplored. We sought to compare the incidence of aneurysmal subarachnoid hemorrhage in a cohort of migraine patients with a cohort of patients with tension headache. A cohort comparison study utilizing the MarketScan insurance claims database compared patients diagnosed with migraine who were undergoing treatment with abortive or prophylactic pharmacotherapy (treatment cohort) and patients diagnosed with tension headache who had never been diagnosed with a migraine and who were naïve to migraine pharmacotherapy (control cohort)...
September 2020: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/33070917/primary-headache-associated-with-sexual-activity-a-case-series-of-13-patients
#4
Buse Cagla Ari, Fusun Mayda Domac, Samiye Ulutas
Primary headache associated with sexual activity is an infrequent kind of headache mostly seen in the male gender and initiates during the third decade. Although the pathophysiology is still unknown, it is a benign type of headache and must be reminded of the differential diagnosis of the secondary headache. Thirteen patients were diagnosed and assessed by their clinical and demographic data. The mean age was 37.07 ± 7.67. Headache was usually localized at the bilateral occipital area or diffuse, starting with a severe ache and sudden explosive intensity in association with pre orgasm in eight patients and orgasm in five patients with a mean VAS score of 7...
September 2020: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/33070914/the-prevalence-of-migraine-in-multiple-sclerosis-ms-a-systematic-review-and-meta-analysis
#5
REVIEW
Omid Mirmosayyeb, Mahdi Barzegar, Nasim Nehzat, Vahid Shaygannejad, Mohammad Ali Sahraian, Mahsa Ghajarzadeh
OBJECTIVES: We designed this systematic review to estimate pooled prevalence of migraine in patients with multiple sclerosis (MS). METHODS: We searched PubMed, Scopus, EMBASE, CINAHL, Web of Science, google scholar and gray literature including references from identified studies, conference abstracts which were published up to December 2019. The search strategy included the MeSH and text words as ((Disorder,Migraine OR Disorders,MigraineDisorder OR Migraine OR Migraines, OR MigraineHeadache OR MigraineHeadaches) AND (Multiple Sclerosis OR Sclerosis, Multiple) OR Sclerosis, Disseminated) OR Disseminated Sclerosis) OR MS (Multiple Sclerosis)) OR Multiple Sclerosis, Acute Fulminating)...
September 2020: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/33070469/comparing-propofol-with-placebo-for-early-resolution-of-acute-migraine-in-adult-emergency-department-patients-a-double-blind-randomised-controlled-trial
#6
Robert Meek, Andis Graudins, Micah McDonald, Daniel McGannon, Ezra Limm
OBJECTIVE: To compare propofol with placebo in adult ED patients with acute migraine. Primary outcome was headache resolution by 1 h. Secondary outcome was reduction in headache severity by two or more points on a numerical rating scale. METHODS: Double-blind randomised controlled clinical trial comparing propofol (10 mg/mL) with placebo (20% intralipid). Adults with acute migraine without aura were included. The study drug was administered as an initial dose of 4 mL followed by up to five doses of 2 mL, delivered 5 min apart...
October 17, 2020: Emergency Medicine Australasia: EMA
https://read.qxmd.com/read/33069931/multiple-sclerosis-diagnosis-delay-and-its-associated-factors-among-iranian-patients
#7
Farzaneh Mobasheri, Abbas Rahimi Jaberi, Jafar Hasanzadeh, Mohammad Fararouei
OBJECTIVE: A long diagnostic delay in multiple sclerosis (MS) reduces the chance of early access to disease modifying therapies with potential to impact on disease trajectory. The aims of this study were to determine the delay in diagnosis of MS and its associated factors in Iran. METHODS: Our study was conducted on 536 MS patients who were selected from Multiple sclerosis registry database and neurology clinics in southern part of Iran. Data were collected via a face-to-face interview administered questionnaire...
October 4, 2020: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/33069214/impact-of-galcanezumab-on-total-pain-burden-findings-from-phase-3-randomized-double-blind-placebo-controlled-studies-in-patients-with-episodic-or-chronic-migraine-evolve-1-evolve-2-and-regain-trials
#8
Jessica Ailani, J Scott Andrews, Mallikarjuna Rettiganti, Robert A Nicholson
BACKGROUND: Focus on the frequency of migraine pain may undervalue the total burden of migraine as pain duration and severity may present unique, additive burden. A composite measure of total pain burden (TPB; frequency, severity, and duration) may provide a more comprehensive characterization of pain burden and treatment response in patients with episodic migraine (EM) or chronic migraine (CM). The impact of galcanezumab versus placebo on TPB among patients with EM or CM was analyzed...
October 17, 2020: Journal of Headache and Pain
https://read.qxmd.com/read/33067273/management-of-chronic-headache-with-referral-from-primary-care-to-direct-access-to-mri-compared-with-neurology-services-an-observational-prospective-study-in-london
#9
Tiago Rua, Asif Mazumder, Yvonne Akande, Charikleia Margariti, Juliana Ochulor, Joanna Turville, Reza Razavi, Janet L Peacock, Paul McCrone, Vicky Goh, James Shearer, Shazia Afridi
OBJECTIVES: To evaluate the cost, accessibility and patient satisfaction implications of two clinical pathways used in the management of chronic headache. INTERVENTION: Management of chronic headache following referral from Primary Care that differed in the first appointment, either a Neurology appointment or an MRI brain scan. DESIGN AND SETTING: A pragmatic, non-randomised, prospective, single-centre study at a Central Hospital in London...
October 16, 2020: BMJ Open
https://read.qxmd.com/read/33066724/plasma-levels-of-cgrp-and-expression-of-specific-micrornas-in-blood-cells-of-episodic-and-chronic-migraine-subjects-towards-the-identification-of-a-panel-of-peripheral-biomarkers-of-migraine
#10
Rosaria Greco, Roberto De Icco, Chiara Demartini, Anna Maria Zanaboni, Elena Tumelero, Grazia Sances, Marta Allena, Cristina Tassorelli
BACKGROUND: Migraine can manifest with an episodic or a chronic pattern in a continuum of disease severity. Multiple factors are associated with the progression of the pattern from episodic to chronic. One of the most consistently reported factors is the overuse of medications (MO) for the acute treatment of migraine attacks. The mechanisms through which MO facilitates the transformation of episodic migraine (EM) into chronic migraine (CM) are elusive. In order to provide insights into these mechanisms, the present study aims to identify possible peripheral biomarkers associated with the two forms of migraine, and with the presence of MO...
October 16, 2020: Journal of Headache and Pain
https://read.qxmd.com/read/33063862/efficacy-of-galcanezumab-for-migraine-prevention-in-patients-with-a-medical-history-of-anxiety-and-or-depression-a-post-hoc-analysis-of-the-phase-3-randomized-double-blind-placebo-controlled-regain-and-pooled-evolve-1-and-evolve-2-studies
#11
Todd A Smitherman, Gretchen E Tietjen, Kory Schuh, Vladimir Skljarevski, Sarah Lipsius, Deborah N D'Souza, Eric M Pearlman
OBJECTIVE: This post hoc analysis evaluated the efficacy of galcanezumab for the prevention of migraine in patients with and without comorbid anxiety and/or depression. BACKGROUND: Patients with migraine have a higher risk of anxiety and/or depression. Given the high prevalence of psychiatric symptoms and their potential negative prognostic impact, determining the efficacy of migraine treatments in patients with these comorbidities is important. METHODS: The results of 2 phase 3 episodic migraine studies of patients with 4-14 migraine headache days (MHD) per month were pooled...
October 16, 2020: Headache
https://read.qxmd.com/read/33063855/e-consultation-in-headache-medicine-a-quality-improvement-pilot-study
#12
Jennifer Robblee, Amaal J Starling
INTRODUCTION: Access to headache consultations by a headache specialist is limited. E-consultations are an efficient approach shown to reduce costs and improve continuity of care with the primary care provider. Indications, suitability, and uptake in the headache population are not well studied. METHODS: This quality improvement pilot aims to explore the appropriateness of e-consultations for patients referred to a headache specialist. E-consultation feasibility was explored through (1) retrospective review of completed face-to-face consultations; (2) prospective survey of providers to identify face-to-face consultations appropriate for e-consultation; (3) cross-sectional review of the current waiting list to assess theoretical triaging to face-to-face vs e-consultation; and (4) prospective review of all e-consultations requested from an academic headache clinic to improve the understanding of e-consultation feasibility and referral triage...
October 16, 2020: Headache
https://read.qxmd.com/read/33063620/comorbidities-are-prevalent-and-detrimental-for-employment-outcomes-in-people-of-working-age-with-multiple-sclerosis
#13
Jing Chen, Bruce Taylor, Tania Winzenberg, Andrew J Palmer, Andrea Kirk-Brown, Pieter van Dijk, Steve Simpson, Leigh Blizzard, Ingrid van der Mei
BACKGROUND: More work is needed to understand the burden of comorbidities in people with multiple sclerosis (MS). OBJECTIVE: To assess prevalence of 30 comorbidities and impacts of comorbidities on employment outcomes in a working-aged MS cohort. METHODS: Participants were from the Australian MS Longitudinal Study ( n  = 929). Information on specific comorbidity was obtained (whether or not each was present, doctor-diagnosed, limited their activities and being treated)...
October 2020: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/33059476/no-additive-effect-of-combining-sumatriptan-and-olcegepant-in-the-gtn-mouse-model-of-migraine
#14
Charlotte Ernstsen, Sarah L Christensen, Jes Olesen, David M Kristensen
INTRODUCTION: Despite recent advances in migraine treatment there is a need for therapies with higher clinical efficacy and/or fewer side effects. Triptans (5-HT1B/1D/1F agonists) are essential in the present treatment regime and gepants (CGRP-receptor antagonists) are recognized as effective in acute migraine treatment. Triptans and gepants have different mechanisms of action and here we tested the hypothesis that a combination of these drugs (sumatriptan and olcegepant) would result in an additive effect...
October 15, 2020: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/33059243/inhibition-of-nr2a-reduces-calcitonin-gene-related-peptide-gene-expression-induced-by-cortical-spreading-depression-in-rat-amygdala
#15
Fan Bu, Mingming Yuan, Dongqing Ma, Ying Zhu, Minyan Wang
Despite robust evidence on the role of calcitonin gene-related peptide (CGRP) in migraine via both central and peripheral actions, relatively less is known about how CGRP in the limbic system is involved in migraine progression. This study investigated whether CGRP production machinery exists in the two key limbic regions including hippocampus and amygdala using cortical spreading depression (CSD) as a model of migraine and whether such alteration by CSD is sensitive to N-methyl-d-aspartate (NMDA) receptor regulation in rats...
October 8, 2020: Neuropeptides
https://read.qxmd.com/read/33058326/recognition-and-clinical-implications-of-high-prevalence-of-migraine-in-patients-with-brugada-syndrome-and-drug-induced-type-1-brugada-pattern
#16
Can Hasdemir, Figen Gokcay, Mehmet N Orman, Umut Kocabas, Serdar Payzin, Hatice Sahin, Dale R Nyholt, Charles Antzelevitch
INTRODUCTION: We have previously reported high 1-year prevalence of migraine in patients with atrial arrhythmias associated with DI-Type 1 BrP. The present study was designed to determine the lifetime prevalence of migraine in patients with Brugada syndrome (BrS)/drug-induced type 1 Brugada pattern (DI-Type 1 BrP) and control group, to investigate the demographic and clinical characteristics, and to identify clinical variables to predict underlying BrS/DI-Type 1 BrP among migraineurs...
October 15, 2020: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/33058053/botulinum-toxin-injection-in-the-management-of-chronic-migraine-the-saudi-experience-with-a-proposal-for-a-new-protocol
#17
Hussein Algahtani, Bader Shirah, Ghassan Sukkar, Hatim Bukhari, Ibraheem Meftah, Asim Alhazmi, Abid Alshareef, Abdulmohsin Algethami, Ammar Alshanqiti, Mahmoud Andeejani
There are no data from Saudi Arabia about the use of botulinum toxin for migraine prevention. In this article, we aim to study the clinical profile, safety, and response to treatment with botulinum toxin injection for migraine patients. In addition, we aim to share our experience with the use of botulinum toxin modified injection protocol (5/20/100 protocol) in the management of migraine in Saudi patients. A retrospective single-center observational study was conducted at King Abdulaziz Medical City in Jeddah, Saudi Arabia...
October 14, 2020: Acta Neurologica Belgica
https://read.qxmd.com/read/33057747/altered-local-and-distant-functional-connectivity-density-in-chronic-migraine-a-resting-state-functional-mri-study
#18
Lingling Dai, Yang Yu, Hongru Zhao, Xiaodong Zhang, Yunyan Su, Ximing Wang, Su Hu, Hui Dai, Chunhong Hu, Jun Ke
PURPOSE: Previous studies have indicated disrupted functional connectivity in multiple brain regions and resting-state networks in episodic migraine, but it is unclear how brain network property is disrupted in chronic migraine. METHODS: Using resting-state functional magnetic resonance imaging and voxel-wise functional connectivity density analysis, we examined the large-scale functional connectivity pattern over the whole brain in 17 patients with chronic migraine without medication overuse compared to 35 healthy controls...
October 14, 2020: Neuroradiology
https://read.qxmd.com/read/33057237/a-visual-guide-to-migraine-headaches
#19
Neil Savage
No abstract text is available yet for this article.
October 2020: Nature
https://read.qxmd.com/read/33057231/the-unique-demands-of-childhood-migraine
#20
Emily Sohn
No abstract text is available yet for this article.
October 2020: Nature
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