Palvi Gotra, Nidhi Bhardwaj, Abhilash Ludhiadch, Gagandeep Singh, Anjana Munshi
Epilepsy and migraine are both episodic disorders and share clinical as well as pathophysiological mechanisms. The prevalence of epilepsy in migraine patients is generally higher than normal as compared to general population and vice versa. Various environmental risk factors and genetic factors have been reported to be associated with susceptibility of these comorbid diseases. Specific genes have been implicated in the pathogenesis of the two diseases. However, the shared genetic susceptibility has not been explored extensively...
April 15, 2021: Molecular Neurobiology
Elizabeth Faust, Irina Pivneva, Karen Yang, Keith A Betts, Zubair Ahmed, Shivang Joshi, Rebecca Hogan, Andrew Blumenfeld, Jack Schim, Alexander Feoktistov, Kenneth Carnes, Mark Bensink, Eric Q Wu, Denise E Chou, David Chandler
INTRODUCTION: Erenumab, a first-in-class monoclonal antibody targeting the calcitonin gene-related peptide pathway, was approved by the US Food and Drug Administration in 2018 for the prevention of migraine in adults. There is limited data available on its impact in real-world settings. The study aim was to characterize the real-world treatment profiles, clinical outcomes, and healthcare resource utilization of patients prescribed erenumab from select major US headache centers. METHODS: A retrospective chart review of patients with migraine treated with erenumab for at least 3 months across five major headache centers was conducted...
April 15, 2021: Neurology and Therapy
Elena Bonora, Sanjiban Chakrabarty, Georgios Kellaris, Makiko Tsutsumi, Francesca Bianco, Christian Bergamini, Farid Ullah, Federica Isidori, Irene Liparulo, Chiara Diquigiovanni, Luca Masin, Nicola Rizzardi, Mariapia Giuditta Cratere, Elisa Boschetti, Valentina Papa, Alessandra Maresca, Giovanna Cenacchi, Rita Casadio, Pierluigi Martelli, Ivana Matera, Isabella Ceccherini, Romana Fato, Giuseppe Raiola, Serena Arrigo, Sara Signa, Angela Rita Sementa, Mariasavina Severino, Pasquale Striano, Chiara Fiorillo, Tsuyoshi Goto, Shumpei Uchino, Yoshinobu Oyazato, Hisayoshi Nakamura, Sushil K Mishra, Yu-Sheng Yeh, Takema Kato, Kandai Nozu, Jantima Tanboon, Ichiro Morioka, Ichizo Nishino, Tatsushi Toda, Yu-Ichi Goto, Akira Ohtake, Kenjiro Kosaki, Yoshiki Yamaguchi, Ikuya Nonaka, Kazumoto Iijima, Masakazu Mimaki, Hiroki Kurahashi, Anja Raams, Alyson MacInnes, Mariel Alders, Marc Engelen, Gabor Linthorst, Tom de Koning, Wilfred den Dunnen, Gerard Dijkstra, Karin van Spaendonck, Dik C van Gent, Eleonora M Aronica, Paolo Picco, Valerio Carelli, Marco Seri, Nicholas Katsanis, Floor A M Duijkers, Mariko Taniguchi-Ikeda, Roberto De Giorgio
Abnormal gut motility is a feature of several mitochondrial encephalomyopathies, and mutations in genes such as TYMP and POLG, have been linked to these rare diseases. The human genome encodes three DNA ligases, of which only one, ligase III (LIG3), has a mitochondrial splice variant and is crucial for mitochondrial health. We investigated the effect of reduced LIG3 activity and resulting mitochondrial dysfunction in seven patients from three independent families, who showed the common occurrence of gut dysmotility and neurological manifestations reminiscent of mitochondrial neurogastrointestinal encephalomyopathy...
April 15, 2021: Brain
Linda Al-Hassany, Antoinette MaassenVanDenBrink
PURPOSE OF REVIEW: The aim of this study was to review current evidence concerning potential risks and interactions associated with concomitant use of drugs indicated for the abortive treatment of migraine, namely triptans and ditans, and more recently developed drugs used for the preventive treatment. The latter drug class encompasses monoclonal antibodies (mAbs), which target either calcitonin gene-related peptide (CGRP) or its receptor. RECENT FINDINGS: To date, no pharmacokinetic interactions between these drug classes have been reported...
April 12, 2021: Current Opinion in Neurology
Antonella Riva, Antonietta Coppola, Ganna Balagura, Marcello Scala, Michele Iacomino, Francesca Marchese, Elisabetta Amadori, Simona Lattanzi, Roberta Meo, Salvatore Striano, Vincenzo Salpietro, Federico Zara, Carlo Minetti, Pasquale Striano, Leonilda Bilo
Most families with genetic epilepsy with febrile seizures plus show a mutation in the sodium channel alpha 1 subunit gene, however, but there is much phenotypic heterogeneity and focal epilepsy remains relatively rare. Here, we report a family with electroclinical features indicative of temporal-parietal-occipital carrefour epilepsy with common occurrence of post-ictal migraine. We studied a four-generation family including nine affected subjects by means of EEG and MRI. Genetic testing was performed by targeted re-sequencing (gene panel)...
April 12, 2021: Epileptic Disorders: International Epilepsy Journal with Videotape
Larysa M Malanchuk, Mariia O Riabokon, Artem S Malanchuk, Svitlana S Riabokon, Serhiy L Malanchuk, Viktoriia M Martyniuk, Tetiana A Grabchak, Inna B Pitsyk
OBJECTIVE: The aim: To evaluate the parameters of menstrual function in 1015 women of reproductive age and to establish the relationship between the detected menstrual disorders and the development of migraine and/or irritable bowel syndrome (IBS). PATIENTS AND METHODS: Materials and methods: During 2018-2020, a survey of women of reproductive age in the Ternopil region (Ukraine) was conducted. To interview the study respondents, we developed a questionnaire that assessed the parameters of menstrual function (age of menarche; regularity and cyclicity of menstrual changes; duration of the menstrual cycle and menstruation itself; the amount of blood loss with the pictogram, the presence of clots and their size) identify characteristic changes in health, symptoms of irritable bowel syndrome and migraine associated with the menstrual cycle...
2021: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Isra Tamim, David Y Chung, Andreia Lopes de Morais, Inge C M Loonen, Tao Qin, Amrit Misra, Frieder Schlunk, Matthias Endres, Steven J Schiff, Cenk Ayata
Spreading depression (SD) is an intense and prolonged depolarization in the central nervous systems from insect to man. It is implicated in neurological disorders such as migraine and brain injury. Here, using an in vivo mouse model of focal neocortical seizures, we show that SD may be a fundamental defense against seizures. Seizures induced by topical 4-aminopyridine, penicillin or bicuculline, or systemic kainic acid, culminated in SDs at a variable rate. Greater seizure power and area of recruitment predicted SD...
April 13, 2021: Nature Communications
Yichen Guo
No abstract text is available yet for this article.
April 13, 2021: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Passakorn Suanrueang, Yong-Jiang Shen, Hsiao-Fang Lin, Tze-Kiong Er, Mein-Woei Suen, Fu-An Shieh
BACKGROUND: Older persons are affected by mental and neurological disorders differently, and gender plays a significant role influencing geriatric disorder differentiation. Accordingly this study characterized gender differences in geriatric syndromes among hospitalized elderly Thai patients. METHODS: Probabilities of disease occurrence reflecting gender differences were calculated using historical data obtained from the Ministry of Public Health website, Thailand...
April 13, 2021: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Adeel S Zubair, Jason J Sico, Deena E Kuruvilla
No abstract text is available yet for this article.
April 13, 2021: Pain Medicine
Adisa Kuburas, Bianca N Mason, Benjamin Hing, Anne-Sophie Wattiez, Alyssa S Reis, Levi P Sowers, Cristina Moldovan Loomis, Leon F Garcia-Martinez, Andrew F Russo
The neuropeptides CGRP and PACAP have emerged as mediators of migraine, yet the potential overlap of their mechanisms remains unknown. Infusion of PACAP, like CGRP, can cause migraine in people, and both peptides share similar vasodilatory and nociceptive functions. In this study, we have used light aversion in mice as a surrogate for migraine-like photophobia to compare CGRP and PACAP and ask whether CGRP or PACAP actions were dependent on each other. Similar to CGRP, PACAP induced light aversion in outbred CD-1 mice...
April 10, 2021: Journal of Neuroscience
Katharina Kaltseis, Florian Frank, Gregor Broessner
Persistent migraine aura without infarction is a rare but debilitating condition. Treatment options are mostly anecdotal and limited due to inefficacy and side effects. We present a 16-year-old female patient with triple X syndrome, having persistent aura symptoms for over 2 years, consisting of continuous visual and sensory sensations. Previous treatments with seven different migraine preventatives were not successful. The patient successfully responded to zonisamide against refractory prolonged aura and remained symptom-free under the ongoing treatment without any relevant side effects...
April 12, 2021: BMJ Case Reports
Hiroshi Yamaguchi, Kandai Nozu, Shinya Ishiko, Hiroaki Nagase, Takeshi Ninchoji, China Nagano, Hiroki Takeda, Ai Unzaki, Kazuto Ishibashi, Ichiro Morioka, Kazumoto Iijima, Akihito Ishida
OBJECTIVES: To examine the association between the number of visits to the emergency department (ED) by children for night-time headaches and exposure to multifaceted factors, such as meteorological conditions and air pollution. DESIGN: We conducted a clinical observational time-series analysis study. SETTING: We reviewed consecutive patients younger than 16 years of age at the primary ED centre in Kobe city, Japan, during the night shift (19:30-7:00 hours) between 1 January 2011 and 31 December 2019...
April 12, 2021: BMJ Open
Lawrence Richer, Kai On Wong, Karen J B Martins, Thilinie Rajapakse, Farnaz Amoozegar, Werner J Becker, Scott W Klarenbach
No abstract text is available yet for this article.
April 13, 2021: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Scott Rosenthal, Marcy Yonker
PURPOSE OF REVIEW: The purpose of this review was to summarize the current literature about telemedicine in pediatric headache and to provide practical guidance for its implementation. RECENT FINDINGS: There are few studies dedicated to telemedicine in pediatric headache, and existing studies are small. Patients and families report high levels of satisfaction with telemedicine, and most are willing to continue telemedicine visits in the future. Telemedicine demonstrated similar reductions in headache frequency, severity, and duration as patients treated in-person...
April 12, 2021: Current Neurology and Neuroscience Reports
Sylvain Redon, Maya Elzière, Anne Donnet
The presence of endolymphatic hydrops has been studied in many neurological disorders. The pathophysiological mechanisms may involve CSF pressure variations, transmitted to the innear ear. This hydrops could play a role in vestibular or cochlear symptoms. For the ENT specialist, the etiological diagnosis of endolymphatic hydrops is a challenge, and neurological etiologies must be known. The treatment of these neurological causes could be effective on cochleo-vestibular symptoms. The knowledge of endolymphatic hydrops could also be a target for noninvasive tests, able to estimate CSF pressure variations...
April 9, 2021: Journal of Vestibular Research: Equilibrium & Orientation
Majed Al-Hayani, Hanin AboTaleb, Abdulrahman Bazi, Badrah Alghamdi
Background: Psychiatric comorbidity is common among migraineurs, such as anxiety and depression. This type of comorbidity contributed to migraine chronicity, management efficacy, and increasing the risk for other comorbidities. This study designed to estimate the prevalence of Depression, Anxiety, and Stress (DAS) symptoms among Saudi migraine patients using the validated instrument (DASS-21) and considering socio-demographic factors and individual differences that affect migraine progression and prognosis...
April 12, 2021: International Journal of Neuroscience
Masaru Tanaka, Nóra Török, László Vécsei
No abstract text is available yet for this article.
April 12, 2021: Expert Opinion on Pharmacotherapy
(no author information available yet)
No abstract text is available yet for this article.
April 10, 2021: European Journal of Ophthalmology
Hassan Kesserwani
Hypnic headaches are unique as they are exclusively nocturnal, occurring in rapid-eye movement (REM) and non-REM sleep. Their nocturnal nature suggests a role for cyclic mechanisms involving the hypothalamus despite conflicting imaging results for the role of the posterior hypothalamus. Nevertheless, pharmacological therapeutics acting as highly effective agents, such as caffeine and melatonin, can modulate the sleep-wake cycle. In addition, indole agents such as indomethacin that are anti-nociceptive and affect cerebral blood flow also prove to be efficacious...
March 9, 2021: Curēus
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