T Horowitz, E Tabouret, T Graillon, B Salgues, O Chinot, A Verger, E Guedj
Positron emission tomography (PET) is a powerful tool that can help physicians manage primary brain tumours at diagnosis and follow-up. In this context, PET imaging is used with three main types of radiotracers: 18 F-FDG, amino acid radiotracers, and 68 Ga conjugated to somatostatin receptor ligands (SSTRs). At initial diagnosis, 18 F-FDG helps to characterize primary central nervous system (PCNS) lymphomas and high-grade gliomas, amino acid radiotracers are indicated for gliomas, and SSTR PET ligands are indicated for meningiomas...
March 16, 2023: Revue Neurologique
Eman M Khedr, Mohammed A Abbas, Ayman Gamea, Mohamed A Sadek, Ahmed F Zaki
BACKGROUND: Previous studies in headache patients measured the cerebrovascular reactivity (CVR) in response to photic stimulation but they have yielded contradictory results. The purpose of study was to measure CVR of both migraine and chronic tension headache (TTH) patients in response to photic stimulation. METHODS: The study included 37 migraineurs and 24 chronic TTH patients compared with 50 age- and sex-matched healthy volunteers. Peak systolic, end diastolic, mean flow velocities and CVR (PSV, EDV, MFV, and CVR) were measured using TCD ultrasonography of the middle, anterior, posterior cerebral and vertebral arteries (MCA, ACA, PCA, and VA) before and after 100 s of 14 Hz photic stimulation...
March 17, 2023: BMC Neurology
Gabriel Gárate, María Toriello, Vicente González-Quintanilla, Sara Pérez-Pereda, Jorge Madera, Marta Pascual, José Manuel Olmos, Julio Pascual
BACKGROUND: Headache is among the most frequent symptoms of acute COVID-19 infection. Its mechanisms remain obscure, but due to its migraine-like characteristics, the activation of the trigeminal system could account for its underlying pathophysiology. METHODS: Our aim was to compare the serum levels of CGRP, as a theoretical marker of trigemino-vascular activation, in 25 COVID-19 inpatients with lung involvement experiencing headache, against 15 COVID-19 inpatients without headache and with those of 25 matched healthy controls with no headache history...
March 17, 2023: BMC Neurology
Eric J Shumski, Melissa N Anderson, Julianne D Schmidt, Robert C Lynall
Previous research among adolescents has shown differences in symptoms and neurocognitive performance between sport-related (SRC) and motor vehicle crash (MVC) concussion mechanisms. Limited research has focused on young adults. The purpose of our study was to compare symptoms, balance, and neurocognitive performance between SRC and MVC mechanisms in young adults. Forty-three (58.1% female, age = 25.5 ± 3.2 years, days since concussion = 12.8 ± 12.7) and 26 (76.9% female, age = 24...
March 17, 2023: Applied Neuropsychology. Adult
Anna Esparham, Alit Stark-Inbar, Leia Jekel, Shira Tamir, Liron Rabany, Alon Ironi, Jessica Gautreaux, Rashmi Rao
Nearly 10% of children and adolescents in the United States experience migraine. Pharmacologic treatment of migraine in adolescents is limited due to only few US Food and Drug Administration (FDA)-approved medications, limited efficacy, or lack of tolerability. Remote Electrical Neuromodulation (REN) is a nonpharmacologic abortive treatment for migraine, cleared by the FDA for patients aged 12 years and above. This study evaluated real-world efficacy of REN in adolescents aged 12 to 17 years. Real-world data were collected from patients aged 12 to 17 years treated with the REN device (Nerivio) from January 1, 2021, to May 31, 2022...
February 21, 2023: Pediatric Neurology
Bin Yu, Wei Zhang, Chunmei Zhao, Yan Xing, Lan Meng, Fang Luo
BACKGROUND: Whether ultrasound-guided stellate ganglion block (SGB) is a valuable therapeutic option for the treatment of patients with chronic migraine (CM) is worth exploring. If SGB is proven to be effective for CM, the identification of potential predictors for the effectiveness of SGB warrants further investigation. This study aimed to investigate the effectiveness and safety of SGB in patients with CM, and to explore the predictive factors for its treatment effectiveness. METHODS: This is a retrospective observational study...
March 16, 2023: Pain Practice: the Official Journal of World Institute of Pain
Sait Ashina, Agustin Melo-Carrillo, Ajayi Toluwanimi, Nicolas Bolo, Edina Szabo, David Borsook, Rami Burstein
BACKGROUND: The goal of this observational, open-label, cohort study was to determine whether prophylactic migraine treatment with galcanezumab, a peripherally acting drug, alters the incidence of premonitory symptoms, and/or occurrence of headache after exposure to triggers or aura episodes in treatment-responders (≥ 50% reduction in monthly migraine days [MMD]), super-responders (≥ 70%), non-responders (< 50%) and super non-responders (< 30%)...
March 16, 2023: Journal of Headache and Pain
Rebecca B Siegel, Sergey M Motov, Evie G Marcolini
BACKGROUND: Droperidol is a butyrophenone, with antiemetic, sedative, anxiolytic, and analgesic properties. Although droperidol was once widely used in both emergency and perioperative settings, use of the medication declined rapidly after a 2001 U.S. Food and Drug Administration (FDA) boxed warning called the medication's safety into question. OBJECTIVE: The purpose of this clinical review was to provide evidence-based answers to questions about droperidol's safety and to examine its efficacy in its various clinical indications...
March 14, 2023: Journal of Emergency Medicine
Shangyue Yu, Fan Chunlan, Li Yilin, Pei Hailuan, Tian Yingying, Zuo Zeping, Wang Zijian, Liu Chuang, Zhao Xinyue, Wang Zhibin
ETHNOPHARMACOLOGICAL RELEVANCE: Yufeng Ningxin Tablet (YNT) is a traditional Chinese medicine formula, that has been used clinically to treat migraine for many years. It is composed of one herb Pueraria lobata var. lobata (Willd.) Ohwi (Relevant Chinese name: Gegen). Previously, it has been recorded by traditional Chinese doctor that Gegen could be used as medicine to treat migraine. However, the underlying mechanism of action remains to be investigated. AIM OF THE STUDY: It was to explore the effect and mechanism of YNT on migraine based on network pharmacology and experimental verification...
March 14, 2023: Journal of Ethnopharmacology
Thanin Asawavichienjinda, Seelwan Sathitratanacheewin, Ronpichai Chokesuwattanaskul
BACKGROUND: A new migraine prevention, CGRP monoclonal antibodies (mAbs), is injectable on a monthly or quarterly basis. In clinical practice, some patients reported that drug effectiveness does not last until the upcoming scheduled injection, a so-called "wearing-off" effect. We aimed to evaluate the wearing-off effect of the CGRP mAbs for migraine prevention in patients with different monthly migraine days. METHODS: We conducted a literature search for studies that reported migraine frequency after CGRP monoclonal antibody administration from MEDLINE, SCOPUS, Web of Science, and Cochrane Database from inception through February 2022...
April 2023: Cephalalgia: An International Journal of Headache
Etedal Ahmed A Ibrahim, Wadia Abdalla Balla Elhardallo, Khabab Abbasher Hussien Mohamed Ahmed, Mohammed E Abdalla Omer, Mohammed Mahmmoud Fadelallah Eljack
UNLABELLED: Topiramate is an antiepileptic medication originally and one of the first-line drugs for migraine prophylaxis. Herein, we aimed to assess the outcome of topiramate in migraine prophylaxis by evaluating the reduction in frequency and/or severity of attacks and addressing the most common adverse effects associated with it. METHODS: A descriptive, prospective hospital-based study was conducted at Ibrahim Malik Hospital, National Center of Neurological Disease and Sciences from October 2018 to May 2019...
March 2023: Annals of Medicine and Surgery
Xue Song, Jiaqi Wang, Lu Bai, Wei Zou
BACKGROUND: Migraine is a serious global health concern that imposed a huge economic burden on social health care. Over the past few decades, the analgesic effects of acupuncture have been widely recognized, and there is a growing body of research on acupuncture for migraine. Citation analysis is a branch of bibliometrics that helps researchers analyze and identify historical or landmark studies within the scientific literature. Currently, there is no analysis of the 100 most highly cited publications on acupuncture for migraine...
2023: Journal of Pain Research
Claudia Altamura, Giovanna Viticchi, Angelo Cascio Rizzo, Paola Maggio, Nicoletta Brunelli, Marilena Marcosano, Vincenzo Di Lazzaro, Fabrizio Fiacco, Elio Clemente Agostoni, Mauro Silvestrini, Fabrizio Vernieri
INTRODUCTION: The mechanisms subtending the increased stroke risk in migraine with aura (MA) are not fully understood. Our study aims to evaluate if the clinical profile in stroke patients with MA differentiates from those without MA. METHODS: We retrieved the prospective registered electronic clinical dossiers of adult patients younger than 60 years with acute ischemic stroke admitted in four hospitals between January 2016 and June 2022. Patients were classified by the history of MA (MA+ and MA-)...
2023: Frontiers in Neurology
Yasmin S Cypel, Dawne Vogt, Shira Maguen, Paul Bernhard, Elizabeth Lowery, William J Culpepper, Irvine Armand-Gibbs, Aaron I Schneiderman
Large-scale epidemiological studies suggest that veterans may have poorer physical health than nonveterans, but this has been largely unexamined in post-9/11 veterans despite research indicating their high levels of disability and healthcare utilization. Additionally, little investigation has been conducted on sex-based differences and interactions by veteran status. Notably, few studies have explored veteran physical health in relation to national health guidelines. Self-reported, weighted data were analyzed on post-9/11 U...
April 2023: Preventive Medicine Reports
Moein Ala, Mohammad Reza Fallahpour Khoshdel, Razieh Mohammad Jafari, Mehrdokht Sadrkhanloo, Sepideh Goudarzi, Meisam Asl Soleimani, Ahmad Reza Dehpour
BACKGROUND: Mesenteric ischemia has remained without effective pharmacological management for many years. Sumatriptan, an abortive medication for migraine and cluster headaches, has potent anti-inflammatory properties and ameliorated organ ischemia in previous animal studies. Similarly, inhibition of the kynurenine pathway ameliorated renal and myocardial ischemia/reperfusion (I/R) in many preclinical studies. Herein, we assessed the effect of sumatriptan on experimental mesenteric I/R and investigated whether kynurenine pathway inhibition is a mechanism underlying its action...
March 15, 2023: Pharmacological Reports: PR
Simona Maccora, Nadia Bolognini, Carlo Mannina, Angelo Torrente, Luisa Agnello, Bruna Lo Sasso, Marcello Ciaccio, Guido Sireci, Filippo Brighina
OBJECTIVE: The sound-induced flash illusion (SIFI) is a valid paradigm to study multisensorial perception. In the "fission" SIFI, multiple flashes are perceived when observing a single flash paired with two or more beeps. SIFI is largely dependent on visual and acoustic cortex excitability; in migraine, dysfunctional cortical excitability affects SIFI perception. Since estrogen peak occurring during ovulation can increase neuronal excitability, the present study aims to verify whether cortical excitability shifts linked to the menstrual cycle could influence SIFI...
March 15, 2023: Neurological Sciences
Marlon Graf, Edward Kim, Iris Brewer, Jennifer Hernandez, Jacquelyn W Chou, Jessica Cirillo, Christopher Jensen, Richard Lipton
OBJECTIVE: To characterize treatment decision-making processes and formalize consensus regarding key factors headache specialists consider in treatment decisions for patients with migraine, considering novel therapies. BACKGROUND: Migraine therapies have long been subject to binary classification, acute versus preventive, due to limitations of available drugs. The emergence of novel therapies that can be used more flexibly creates an opportunity to rethink this binary classification...
March 15, 2023: Headache
Purnima Pathak, Leiyu Yue, Shaloo Gupta, Juanzhi Fang, M Andy Cheadle, Santosh Tiwari, Matias Ferraris, Parth Joshi, Jeffrey Thompson, Roshani Shah, Pamela Vo
OBJECTIVE: The treatment landscape for the prevention of migraine has rapidly evolved in recent years with the advent of calcitonin gene-related peptide therapy, including erenumab. The objective of this study was to assess patient-reported treatment satisfaction among erenumab users. METHODS: This retrospective, cross-sectional study used data from the 2019 US National Health and Wellness Survey collected during March-July 2019. Respondents self-reporting physician-diagnosed migraine and currently using erenumab were analyzed...
March 15, 2023: Current Medical Research and Opinion
Luigi Francesco Iannone, Andrea Burgalassi, Giulia Vigani, Giorgio Tabasso, Francesco De Cesaris, Alberto Chiarugi, Pierangelo Geppetti
BACKGROUND: A pharmacological class effect was initially proposed for monoclonal antibodies against the calcitonin gene related peptide pathway. However, preliminary evidence shows that switching patients who were non-responding to one monoclonal antibody to another could provide some benefit. Herein, we assess treatment response to an anti-calcitonin gene related peptide/receptor monoclonal antibody in patients who have failed to respond to anti-calcitonin gene related peptide/ligand monoclonal antibodies calcitonin gene related peptide/ligand monoclonal antibodies and vice versa...
April 2023: Cephalalgia: An International Journal of Headache
Naveen George, Stewart J Tepper
Aims: To present a review of the mechanisms of action, available clinical data, and safety profiles of novel migraine therapeutics to inform practice. Methods: PubMed, Medline, and Google Scholar were searched for randomized controlled trials (24 publications), review articles (15 publications), and other pertinent literature (16 publications) discussing the novel migraine therapeutics available between the years 2010 and 2021. All publications were reviewed to assess the mechanism of action, relevant clinical data, and side effect profile for each novel treatment...
January 2023: Journal of Oral & Facial Pain and Headache
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