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JOURNAL ARTICLE
Maeda Kazuki, Taira Kobayashi, Shogo Emura, Takanobu Okazaki, Shingo Mochizuki, Tomoyasu Sato, Masato Taniguchi, Daisuke Futagami, Risa Inoue, Mayu Tomota, Toshifumi Hiraoka, Takashi Shimonaga, Hitoshi Tachibana, Haruna Shimizu, Shinya Takahashi
BACKGROUND: Endovascular treatment (EVT) for aortoiliac (AI) occlusive lesions is now conducted worldwide, but there are challenges in EVT for complex AI lesions. The VIABAHN VBX (W.L. Gore & Associates, Flagstaff, AZ) is a next-generation balloon-expandable covered stent designed for use with complex AI lesions. The purpose of this study is to evaluate the medium-term outcomes of VIABAHN VBX for such lesions. METHODS: Symptomatic patients who underwent EVT with VIABAHN VBX for an AI lesion from 2018 to 2020 at 7 Japanese centers were reviewed retrospectively...
April 9, 2024: Annals of Vascular Surgery
#22
JOURNAL ARTICLE
Sarah Alexander, John A Kairalla, Sumit Gupta, Emily Hibbitts, Hannah Weisman, Doralina Anghelescu, Naomi J Winick, Kevin R Krull, Wanda L Salzer, Michael J Burke, Lia Gore, Meenakshi Devidas, Leanne Embry, Elizabeth A Raetz, Stephen P Hunger, Mignon L Loh, Kristina K Hardy
PURPOSE: Many children treated for ALL develop long-term neurocognitive impairments. Increased risk of these impairments is associated with treatment and demographic factors. Exposure to anesthesia is an additional possible risk factor. This study evaluated the impact of cumulative exposure to anesthesia on neurocognitive outcomes among a multicenter cohort of children with ALL. METHODS: This study was embedded in AALL1131, a Children's Oncology Group phase III trial for patients with high-risk B-ALL...
April 11, 2024: Journal of Clinical Oncology
#23
JOURNAL ARTICLE
Natalie T Tanke, Ziqing Liu, Michaelanthony T Gore, Pauline Bougaran, Mary B Linares, Allison Marvin, Arya Sharma, Morgan Oatley, Tianji Yu, Kaitlyn Quigley, Sarah Vest, Jeanette Gowen Cook, Victoria L Bautch
BACKGROUND: Endothelial cells regulate their cell cycle as blood vessels remodel and transition to quiescence downstream of blood flow-induced mechanotransduction. Laminar blood flow leads to quiescence, but how flow-mediated quiescence is established and maintained is poorly understood. METHODS: Primary human endothelial cells were exposed to laminar flow regimens and gene expression manipulations, and quiescence depth was analyzed via time-to-cell cycle reentry after flow cessation...
April 11, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
#24
Joy M Davis, Tullia Rushton, Felicity Nsiah, Rebecca L Stone, Anna L Beavis, Stéphanie L Gaillard, Alice Dobi, Amanda N Fader
Dedifferentiated endometrial carcinoma is a rare, highly aggressive subtype of endometrial cancer associated with poor survival outcomes. Current guidelines recommend treatment of advanced-stage disease with surgical staging or cytoreduction and platinum/taxane-based chemotherapy. Despite these approaches, the achievement of long-term remission or prolonged survival is challenging. Recent Phase III studies demonstrate that the addition of PD-1 inhibitors to standard chemotherapy significantly improves progression-free survival in patients with measurable, mismatch repair deficient (dMMR) and proficient (pMMR) advanced-stage or recurrent endometrial carcinoma...
June 2024: Gynecologic Oncology Reports
#25
JOURNAL ARTICLE
Insight into the autoproteolysis mechanism of the RsgI9 anti-σ factor from Clostridium thermocellum.
Allen Takayesu, Brendan J Mahoney, Andrew K Goring, Tobie Jessup, Rachel R Ogorzalek Loo, Joseph A Loo, Robert T Clubb
Clostridium thermocellum is a potential microbial platform to convert abundant plant biomass to biofuels and other renewable chemicals. It efficiently degrades lignocellulosic biomass using a surface displayed cellulosome, a megadalton sized multienzyme containing complex. The enzymatic composition and architecture of the cellulosome is controlled by several transmembrane biomass-sensing RsgI-type anti-σ factors. Recent studies suggest that these factors transduce signals from the cell surface via a conserved RsgI extracellular (CRE) domain (also called a periplasmic domain) that undergoes autoproteolysis through an incompletely understood mechanism...
April 10, 2024: Proteins
#26
Katherine Jane Chua, Alice Barr, Miranda Prints, Rachel Ruskin, Rebecca Brooks
•Chronic chemical peritonitis caused by spontaneous rupture of a mature cystic teratoma may result in prolonged hospitalization and respiratory decline and can mimic a gynecologic malignancy.•Earlier surgical intervention for mature teratoma may prevent morbidity.•Inclusion of a gynecologic oncologist is advised for management discussions and/or surgical back-up.•Complex benign gynecologic surgeries may have some benefit for gynecologic oncologic trainees, which can be used for later oncologic cases...
June 2024: Gynecologic Oncology Reports
#27
Li Zhui, Jiang Chuli, Feng Yangyang, Zhao Yu, Ren Wei
Recurrence of a lung tumor invading the subclavian artery, causing stenosis and leading to finger ulcers as the initial symptom, is rare. We employed endovascular techniques, inserting a Viabahn® VBX covered stent (W. L. Gore & Associates, Flagstaff, Arizona) to aid in ulcer healing and improve the patient's quality of life. The patient, a 73-year-old male, had a history of lung adenocarcinoma resection two years prior but had not undergone follow-up examinations or cancer-specific treatments...
March 2024: Curēus
#28
JOURNAL ARTICLE
Anuja Nitin Moharir, Ashwini Nerkar Rajbhoj, Rucha Gore, Anuja Hakkepatil, Pradnya Prabhakar Mali, Hiroj S Bagde
Fluctuations in androgenic hormonal levels are noticeable through women's menstrual cycle. Changes in estrogen and progesterone have been shown to affect periodontium. Many women report an increase in gingival inflammation and discomfort associated with their menstrual cycle, most commonly before the menstrual period. Approximately 80% of women experience complaints of premenstrual syndrome (PMS) 7 to 10 days before menstruation. Therefore, the present study was carried out to check prevalence of PMS and its oral and periodontal manifestations in patients attending dental hospital...
February 2024: Journal of Pharmacy & Bioallied Sciences
#29
JOURNAL ARTICLE
Brittney L Dickey, L Robert Gore, Robbert Slebos, Bradley Sirak, Kimberly A Isaacs-Soriano, Kayoko Kennedy, Kristen Otto, J Trad Wadsworth, Christine H Chung, Anna R Giuliano
BACKGROUND: Human Papillomavirus-associated oropharyngeal cancer (HPV-OPC) incidence is increasing among men in the United States. Poor dental health has previously been associated with risk of head and neck cancers, oral HPV infection, and persistence but it is not understood whether dental health is associated with outcomes. We sought to determine the association of dental health with progression free survival and overall mortality among men with an HPV-OPC. METHODS: A cross sectional study of men diagnosed with HPV-OPC between 2014-2020 at Moffitt Cancer Center in Tampa, FL was conducted...
April 9, 2024: BMC Oral Health
#30
JOURNAL ARTICLE
Frederick S Vom Saal, Michael Antoniou, Scott M Belcher, Ake Bergman, Ramji K Bhandari, Linda S Birnbaum, Aly Cohen, Terrence J Collins, Barbara Demeneix, Anne Marie Fine, Jodi A Flaws, Veronique Gayrard, William H Goodson, Andrea C Gore, Jerrold J Heindel, Patricia A Hunt, Taisen Iguchi, Christopher D Kassotis, Andreas Kortenkamp, Robin Mesnage, Jane Muncke, John Peterson Myers, Angel Nadal, Retha R Newbold, Vasantha Padmanabhan, Paola Palanza, Zandra Palma, Stefano Parmigiani, Lyn Patrick, Gail S Prins, Cheryl S Rosenfeld, Niels E Skakkebaek, Carlos Sonnenschein, Ana M Soto, Shanna H Swan, Julia A Taylor, Pierre-Louis Toutain, Frank A von Hippel, Wade V Welshons, Daniel Zalko, R Thomas Zoeller
BACKGROUND: The European Food Safety Authority (EFSA) recommended lowering their estimated tolerable daily intake (TDI) for bisphenol A (BPA) 20,000-fold to <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>0.2</mml:mn><mml:mtext> ng</mml:mtext><mml:mo>/</mml:mo><mml:mi>kg</mml:mi><mml:mtext> body weight </mml:mtext><mml:mo>(</mml:mo><mml:mtext>BW</mml:mtext><mml:mo>)</mml:mo><mml:mo>/</mml:mo><mml:mtext>day</mml:mtext></mml:mrow></mml:math>...
April 2024: Environmental Health Perspectives
#31
Celestine He, Daniela Suarez-Rebling, Mona Saleh, Lakshmi Kowtha, Valentin Kolev
Primary squamous cell carcinoma of the rectovaginal septum is rare, with only a few previous cases being reported. We present a case of a 55-year-old woman with primary squamous cell carcinoma of the rectovaginal septum, which was discovered after 2 months of postmenopausal bleeding. Her imaging, surgical course, pathology and treatment course are presented here. To our knowledge, this is only the third such reported case in the literature and management underscores the need for multidisciplinary involvement...
June 2024: Gynecologic Oncology Reports
#32
JOURNAL ARTICLE
Frank Ssedyabane, Joseph Ngonzi, Deusdedit Tusubira, Josephine Nambi Najjuma, Rogers Kajabwangu, Christopher Okeny, Doreen Nuwashaba, Alexcer Namuli, Nixon Niyonzima
INTRODUCTION: Tissue expression of P16ink4A is correlated with cervical lesions. In this study we determined the association between serum P16ink4A concentrations and cervical lesions among women attending the cervical cancer clinic at Mbarara Regional Hospital (MRRH) South Western Uganda. MATERIAL AND METHODS: We recruited 90 cervical intraepithelial neoplasia (CIN) cases, 90 cervical cancer (CC) cases before treatment and 90 controls. Clinical and demographic data were recorded...
June 2024: Gynecologic Oncology Reports
#33
Cameron M Harris, Miller P Singleton, Theresa Samulski, Leslie H Clark
•Primary peritoneal clear cell carcinoma can arise from endometriotic implants within the abdomen and pelvis.•Immunohistochemistry can be used to confirm primary disease site. Endometriotic origin can be inferred based on clinical history and intraoperative findings suggestive of endometriosis.•While no standardized treatment exists, consideration should be given to cytoreductive surgery with adjuvant chemotherapy. Adjuvant radiation can also be considered for local control.
June 2024: Gynecologic Oncology Reports
#34
JOURNAL ARTICLE
Julia M Dexter, Lindsay W Brubaker, Benjamin G Bitler, Barbara A Goff, Usha Menon, Katherine N Moore, Karthik M Sundaram, Christine S Walsh, Saketh R Guntupalli, Kian Behbakht
Early diagnosis and screening of ovarian cancer remain significant challenges to improving patient outcomes. There is an urgent need to implement both established and modern strategies to address the "early detection" conundrum, especially as new research continues to uncover the complexities of the disease. The discussion provided is the result of a unique research conference focused on reviewing early detection modalities and providing insight into future approaches.
June 2024: Gynecologic Oncology Reports
#35
JOURNAL ARTICLE
Lindsey Finch, Danyal Ahsan Muhammad, Dennis S Chi
INTRODUCTION: We sought to demonstrate a method of performing open cholecystectomy at the time of cytoreductive surgery for ovarian cancer. CASE/METHODS: In this surgical film, we present the case of a 78-year-old woman with metastatic high-grade serous ovarian cancer who underwent primary cytoreductive surgery at Memorial Sloan Kettering Cancer Center (New York, NY). The surgery was recorded via video, and important steps of performing a cholecystectomy were highlighted...
June 2024: Gynecologic Oncology Reports
#36
JOURNAL ARTICLE
Emily MacArthur, Kara Long Roche, Joseph Sakran, Sunil H Patel, Peter Najjar, Karen H Lu, Megan Gornet, Anja S Frost, Meghan Walrath, Tom Bauer, Gyyong Oh, Rebecca Stone
Given the unremitting obstacles to effectively screen for and treat ovarian cancer (OC), prevention is a necessary countermeasure. The recent discovery of the fallopian tube as the origin of the most common and deadly type of OC, high grade serous cancer (HGSC), makes prevention through salpingectomy possible (Madsen et al., 2015). Opportunistic salpingectomy (OS) is the practice of removing the post-reproductive fallopian tubes at the time of other intraperitoneal surgery, or for sterilization in lieu of tubal ligation, to decrease OC risk (Falconer et al...
June 2024: Gynecologic Oncology Reports
#37
JOURNAL ARTICLE
Katyayani Papatla, Theofano Orfanelli, Guillaume Stoffels, Tracy Layne, Elena Baldwin, Aurora Leibold, Stephanie V Blank, Samantha Cohen
OBJECTIVE: National data have shown worse endometrial cancer (EC) outcomes among racial and ethnic minorities. We aimed to analyze EC patient outcomes within a large urban academic health system, with a focus on patterns of care and recurrence rates. METHODS: This was a retrospective chart review of EC patients at three system hospitals from 1/1/07-12/31/17. Demographic and clinical factors, including time from EMB to surgery, rate of chemotherapy completion, persistent or recurrent disease, and palliative care referrals were extracted...
June 2024: Gynecologic Oncology Reports
#38
Yi-Ching Huang, Peng-Chan Lin, Pei-Ying Wu, Nai-Syuan Chen, Meng-Ru Shen, Yu-Min Yeh, Ya-Min Cheng
INTRODUCTION: Lynch syndrome is caused by a germline mutation in mismatch repair (MMR) genes, leading to the loss of expression of MMR heterodimers, either MLH1/PMS2 or MSH2/MSH6, or isolated loss of PMS2 or MSH6. Concurrent loss of both heterodimers is uncommon, and patients carrying pathogenic variants affecting different MMR genes are rare, leading to the lack of cancer screening recommendation for these patients.Case presentation:Here, we reported a female with a family history of Lynch syndrome with MLH1 c...
June 2024: Gynecologic Oncology Reports
#39
JOURNAL ARTICLE
Emily R Hildebrandt, Shaneela A Hussain, Michelle A Sieburg, Rajani Ravishankar, Nadeem Asad, Sangram Gore, Takahiro Ito, James L Hougland, Timothy M Dore, Walter K Schmidt
Ras GTPases and other CaaX proteins undergo multiple post-translational modifications at their carboxyl-terminus. These events initiate with prenylation of a cysteine and are followed by endoproteolytic removal of the 'aaX' tripeptide and carboxylmethylation. Some CaaX proteins are only subject to prenylation, however, due to the presence of an uncleavable sequence. In this study, uncleavable sequences were used to stage Ras isoforms in a farnesylated and uncleaved state to address the impact of CaaX proteolysis on protein localization and function...
March 27, 2024: Bioorganic Chemistry
#40
JOURNAL ARTICLE
James Corden, Kamran Khan, Jan Hon Wong, Ruari Hodgin, Ferdinand Serracino-Inglott
OBJECTIVES: - fEVAR involves deploying a covered stent into the aorta followed by multiple visceral stents through fenestrations in the main body of graft. The most commonly used large sheaths for cannulation of visceral vessels are the Gore DrySeal Flex, Cook Performer Check-Flo and Medtronic Sentrant. None of these sheaths were designed for the insertion of multiple sheaths, and so a slow but steady leakage of blood occurs during the procedure. The aim of this paper is to assess in an in vitro setting which large bore sheath has the best valve for use when multiple smaller sheaths are inserted through it...
April 4, 2024: Annals of Vascular Surgery
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