Michael M Boyiadzis, Ivan Aksentijevich, Daniel A Arber, John Barrett, Renier J Brentjens, Jill Brufsky, Jorge Cortes, Marcos De Lima, Stephen J Forman, Ephraim J Fuchs, Linda J Fukas, Steven D Gore, Mark R Litzow, Jeffrey S Miller, John M Pagel, Edmund K Waller, Martin S Tallman
Acute leukemia is a constellation of rapidly progressing diseases that affect a wide range of patients regardless of age or gender. Traditional treatment options for patients with acute leukemia include chemotherapy and hematopoietic cell transplantation. The advent of cancer immunotherapy has had a significant impact on acute leukemia treatment. Novel immunotherapeutic agents including antibody-drug conjugates, bispecific T cell engagers, and chimeric antigen receptor T cell therapies have efficacy and have recently been approved by the US Food and Drug Administration (FDA) for the treatment of patients with acute leukemia...
October 2020: Journal for Immunotherapy of Cancer
Ting Wang, D Mitchell Wilkes, Muwei Li, Xi Wu, John C Gore, Zhaohua Ding
The hemodynamic response function (HRF) characterizes temporal variations of blood oxygenation level-dependent (BOLD) signals. Although a variety of HRF models have been proposed for gray matter responses to functional demands, few studies have investigated HRF profiles in white matter particularly under resting conditions. In the present work we quantified the nature of the HRFs that are embedded in resting state BOLD signals in white matter, and which modulate the temporal fluctuations of baseline signals...
2020: Cerebral cortex communications
Jorge L Alió Del Barrio, Maninder Bhogal, Marcus Ang, Mohammed Ziaei, Scott Robbie, Andrea Montesel, Daniel M Gore, Jodhbir S Mehta, Jorge L Alió
Corneal transplantation is the most commonly performed human tissue transplantation procedure worldwide. Because of the large number of transplants, corneal graft failure has become one of the most common indications for corneal transplantation. The relatively recently developed lamellar transplant techniques have brought about specific potential complications leading to graft failure that may require different approaches to repeat transplantation other than penetrating keratoplasty (PK). On the other hand, these new lamellar techniques also provide novel ways of rescuing failed penetrating grafts, with potential advantages over successive PKs, such as reduced intra-operative risks and faster visual rehabilitation...
October 13, 2020: Survey of Ophthalmology
Yurui Gao, Anirban Sengupta, Muwei Li, Zhongliang Zu, Baxter P Rogers, Adam W Anderson, Zhaohua Ding, John C Gore
OBJECTIVE: In vivo functional changes in white matter during the progression of Alzheimer's disease (AD) have not been previously reported. Our objectives are to measure changes in white matter functional connectivity (FC) in an elderly population undergoing cognitive decline as AD develops, to establish their relationship to neuropsychological scores of cognitive abilities, and to assess the performance in prediction of AD using white matter FC measures as features. METHODS: Analyses were conducted using resting state functional MRI and neuropsychological data from 383 ADNI participants, including 136 cognitive normal (CN) controls, 46 with significant memory concern, 83 with early mild cognitive impairment (MCI), 37 with MCI, 46 with late MCI, and 35 with AD dementia...
2020: PloS One
Naoki Yoshioka, Kensuke Takagi, Yasuhiro Morita, Makoto Kawase, Itsuro Morishima
Arterio-ureteral fistulas are relatively rare, but a potentially life-threatening condition because of the possible massive bleeding. An 82-year-old woman with a history of hysterectomy and irradiation for uterine cancer was treated with ureteric stents for recurrent bilateral ureteral stenosis. During the adjustments of the stent, removing the right ureteric stent immediately resulted in massive hematuria. Computed tomography showed that the right ureter coursed above and seemed to be connected to the right external iliac artery...
2020: SAGE Open Medical Case Reports
Arabinda Mishra, Feng Wang, Li Min Chen, John C Gore
This study aims to evaluate how parameters derived from diffusion tensor imaging reflect axonal disruption and demyelination in specific white matter tracts within the spinal cord of squirrel monkeys following traumatic injuries, and their relationships to function and behavior. After a unilateral section of the dorsal white matter tract of the cervical spinal cord, we found that both lesioned dorsal and intact lateral tracts on the lesion side exhibited prominent disruptions in fiber orientation, integrity and myelination...
October 14, 2020: Scientific Reports
Shweta Gore, Tirupathi Chindam, Allon Goldberg, Min H Huang, Michael Shoemaker, Jennifer Blackwood
Selecting valid and reliable PA assessments in chronic obstructive pulmonary disease (COPD) is crucial to ensure that the information obtained is accurate, valuable, and meaningful. The purpose of this systematic review was to compare the validity and reliability among PA assessments in COPD. An electronic database search of PubMed and CINAHL was completed in December 2019 using MeSH terms on physical activity, COPD, validation, and questionnaires. Transparency in reporting was assessed with the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) checklist while methodological quality was assessed with the modified Quality Appraisal tool for Reliability studies (QAREL) for reliability studies and the Quality Appraisal of Validity Studies (QAVALS) for validity studies...
October 15, 2020: COPD
Anita Svadzian, Giorgia Sulis, Genevieve Gore, Madhukar Pai, Claudia M Denkinger
INTRODUCTION: Although universal drug susceptibility testing (DST) is a component of the End-TB Strategy, over 70% of drug-resistant tuberculosis (DR-TB) cases globally remain undetected. This detection gap reflects difficulties in DST scale-up and substantial heterogeneity in policies and implemented practices. We conducted a systematic review and meta-analysis to assess whether implementation of universal DST yields increased DR-TB detection compared with only selectively testing high-risk groups...
October 2020: BMJ Global Health
Simone Feurstein, Ayodeji Adegunsoye, Danijela Mojsilovic, Rekha Vij, Allison H West DePersia, Padma Sheila Rajagopal, Afaf Osman, Robert H Collins, Raymond H Kim, Steven D Gore, Peter Greenberg, Lucy A Godley, Zejuan Li, Daniela Del Gaudio, Hari Prasanna Subramanian, Soma Das, Tom Walsh, Suleyman Gulsuner, Jeremy P Segal, Aliya N Husain, Sandeep Gurbuxani, Mary-Claire King, Mary E Strek, Jane E Churpek
Telomere biology disorders (TBDs) present heterogeneously, ranging from infantile bone marrow failure associated with very short telomeres to adult-onset interstitial lung disease (ILD) with normal telomere length. Yield of genetic testing and phenotypic spectra for TBDs caused by the expanding list of telomere genes in adults remain understudied. Thus, we screened adults aged ≥18 years with a personal and/or family history clustering hematologic disorders and/or ILD enrolled on The University of Chicago Inherited Hematologic Disorders Registry for causative variants in 13 TBD genes...
October 13, 2020: Blood Advances
Annabel Higgins, Wayne W Morriss, Adrian W Gelb, Emmanuel M Makasa, Julian Gore-Booth, Mauricio Vasco, Jannicke Mellin-Olsen
No abstract text is available yet for this article.
March 2020: Anesthesia and Analgesia
Shinichi Iwakoshi, Masahiro Inagaki, Yutaka Yoshiyama, Yuichi Shimohara, Masanori Yamashita, Shigeo Ichihashi, Kimihiko Kichikawa
PURPOSE: In endovascular aneurysm repair, parallel stent graft deployment is sometimes utilized to preserve the distal branch perfusion. However, there will be some gutter space around 2 stent grafts, which may cause endoleak. The "eye of the tiger" technique was invented to minimize this leak when deploying a small side-branch stent graft in conjunction with a large aortic endograft. The purpose of this case report is to describe our modified technique for 2 small endografts deployed in double D-shape in order to prevent gutter leak, which we applied in endovascular treatment for a hypogastric artery aneurysm...
October 9, 2020: Vascular and Endovascular Surgery
Kellie J Goodlet, Stephanie Gore, Marissa Stoffel, Michael D Nailor
No abstract text is available yet for this article.
October 8, 2020: American Journal of Health-system Pharmacy: AJHP
Babasaheb Sopan Gore, Chun-Hsien Chiang, Chein Chung Lee, Yi-Lun Shih, Jeh-Jeng Wang
Unprecedented chemo- and regioselective synthesis of benzo[ a ]fluorenes and naphthamide-substituted benzo[ a ]fluorenes were constructed from the reaction of ( E )-2-aroyl-3-(2-(arylalkynes/alkenes)aryl)acrylonitrile scaffolds under metal-free conditions via the activation of nitriles and alkenes, respectively. A tentative reaction mechanism was proposed for this homofunctionalization of nitriles. Control experiments showed that the reaction proceeds via selective nitrile or alkene protonation, depending upon the substrates...
October 6, 2020: Organic Letters
Ritchie Chen, Felicity Gore, Quynh-Anh Nguyen, Charu Ramakrishnan, Sneha Patel, Soo Hyun Kim, Misha Raffiee, Yoon Seok Kim, Brian Hsueh, Esther Krook-Magnusson, Ivan Soltesz, Karl Deisseroth
Achieving temporally precise, noninvasive control over specific neural cell types in the deep brain would advance the study of nervous system function. Here we use the potent channelrhodopsin ChRmine to achieve transcranial photoactivation of defined neural circuits, including midbrain and brainstem structures, at unprecedented depths of up to 7 mm with millisecond precision. Using systemic viral delivery of ChRmine, we demonstrate behavioral modulation without surgery, enabling implant-free deep brain optogenetics...
October 5, 2020: Nature Biotechnology
Astrid De Boeck, Bo Young Ahn, Charlotte D'Mello, Xueqing Lun, Shyam V Menon, Mana M Alshehri, Frank Szulzewsky, Yaoqing Shen, Lubaba Khan, Ngoc Ha Dang, Elliott Reichardt, Kimberly-Ann Goring, Jennifer King, Cameron J Grisdale, Natalie Grinshtein, Dolores Hambardzumyan, Karlyne M Reilly, Michael D Blough, J Gregory Cairncross, V Wee Yong, Marco A Marra, Steven J M Jones, David R Kaplan, Kathy D McCoy, Eric C Holland, Pinaki Bose, Jennifer A Chan, Stephen M Robbins, Donna L Senger
Despite a deeper molecular understanding, human glioblastoma remains one of the most treatment refractory and fatal cancers. It is known that the presence of macrophages and microglia impact glioblastoma tumorigenesis and prevent durable response. Herein we identify the dual function cytokine IL-33 as an orchestrator of the glioblastoma microenvironment that contributes to tumorigenesis. We find that IL-33 expression in a large subset of human glioma specimens and murine models correlates with increased tumor-associated macrophages/monocytes/microglia...
October 5, 2020: Nature Communications
Matheus Baseggio, Matthew Murray, Maria Magallanes-Lundback, Nicholas Kaczmar, James Chamness, Edward S Buckler, Margaret E Smith, Dean DellaPenna, William F Tracy, Michael A Gore
Sweet corn (Zea mays L.) is highly consumed in the United States, but does not make major contributions to the daily intake of carotenoids (provitamin A carotenoids, lutein and zeaxanthin) that would help in the prevention of health complications. A genome-wide association study of seven kernel carotenoids and twelve derivative traits was conducted in a sweet corn inbred line association panel ranging from light to dark yellow in endosperm color to elucidate the genetic basis of carotenoid levels in fresh kernels...
March 2020: Plant Genome
Sarah E Jensen, Jean Rigaud Charles, Kebede Muleta, Peter J Bradbury, Terry Casstevens, Santosh P Deshpande, Michael A Gore, Rajeev Gupta, Daniel C Ilut, Lynn Johnson, Roberto Lozano, Zachary Miller, Punna Ramu, Abhishek Rathore, M Cinta Romay, Hari D Upadhyaya, Rajeev K Varshney, Geoffrey P Morris, Gael Pressoir, Edward S Buckler, Guillaume P Ramstein
Successful management and utilization of increasingly large genomic datasets is essential for breeding programs to accelerate cultivar development. To help with this, we developed a Sorghum bicolor Practical Haplotype Graph (PHG) pangenome database that stores haplotypes and variant information. We developed two PHGs in sorghum that were used to identify genome-wide variants for 24 founders of the Chibas sorghum breeding program from 0.01x sequence coverage. The PHG called single nucleotide polymorphisms (SNPs) with 5...
March 2020: Plant Genome
Stefan P M Smorenburg, Matthew Montesano, Tijs J Hoogteijling, Maarten Truijers, Petr Symersky, Evert K Jansen, Harmen R Zandbergen, Willem Wisselink, Theodorus G van Schaik, Kak Khee Yeung
Background Endovascular repair has become a viable alternative for aortic pathological features, including those located within the aortic arch. We investigated the anatomic suitability for branched thoracic endovascular repair in patients previously treated with conventional open surgery for aortic arch pathological features. Methods and Results Patients who underwent open surgery for aortic arch pathological features at our institution between 2000 and 2018 were included. Anatomic suitability was determined by strict compliance with the anatomic criteria within manufacturers' instructions for use for each of the following branched thoracic stent grafts: Relay Plus Double-Branched (Terumo-Aortic), TAG Thoracic Branch Endoprosthesis (W...
October 3, 2020: Journal of the American Heart Association
Nelli Bejanyan, Meijie Zhang, Khalid Bo-Subait, Claudio Brunstein, Hailin Wang, Erica D Warlick, Sergio Giralt, Taiga Nishihori, Rodrigo Martino, Jakob Passweg, Ajoy Dias, Edward Copelan, Gregory Hale, Robert Peter Gale, Melhem Solh, Mohamed A Kharfan-Dabaja, Miguel Angel Diaz, Siddhartha Ganguly, Steven Gore, Leo F Verdonck, Nasheed M Hossain, Natasha Kekre, Bipin Savani, Michael Byrne, Christopher Kanakry, Mitchell S Cairo, Stefan Ciurea, Harry C Schouten, Christopher Bredeson, Reinhold Munker, Hillard Lazarus, Jean-Yves Cahn, Marjolein van Der Poel, David Rizzieri, Jean A Yared, Cesar Freytes, Jan Cerny, Mahmoud Aljurf, Neil D Palmisiano, Attaphol Pawarode, Vera Ulrike Bacher, Michael R Grunwald, Sunita Nathan, Baldeep Wirk, Gerhard C Hildebrandt, Sachiko Seo, Richard F Olsson, Biju George, Marcos de Lima, Christopher S Hourigan, Brenda Sandmaier, Mark Litzow, Partow Kebriaei, Wael Saber, Daniel Weisdorf
Myeloablative (MAC) as compared to reduced-intensity conditioning (RIC) is generally associated with lower relapse risk after allogeneic hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). However, disease specific risk factors in AML/MDS can further inform when MAC vs. RIC may yield differential outcomes. We analyzed HCT outcomes stratified by the disease risk index (DRI) in 4387 adults (age 40-65 years) to identify the impact of conditioning intensity...
September 30, 2020: Biology of Blood and Marrow Transplantation
Cristian E Boru, Pietro Termine, Pavlos Antypas, Angelo Iossa, Maria Chiara Ciccioriccio, Francesco De Angelis, Alessandra Micalizzi, Gianfranco Silecchia
BACKGROUND: Hiatal hernia repair (HHR) is still controversial during bariatric procedures, especially in case of laparoscopic sleeve gastrectomy (LSG). AIMS: to report the long-term results of concomitant HHR, evaluating the safety and efficacy of posterior cruroplasty (PC), simple or reinforced with biosynthetic, absorbable Bio-A® mesh (Gore, USA). Primary endpoint: PC's failure, defined as symptomatic HH recurrence, nonresponding to medical treatment and requiring revisional surgery...
October 2, 2020: Minerva Chirurgica
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