K P Matchett, J R Wilson-Kanamori, J R Portman, C A Kapourani, F Fercoq, S May, E Zajdel, M Beltran, E F Sutherland, J B G Mackey, M Brice, G C Wilson, S J Wallace, L Kitto, N T Younger, R Dobie, D J Mole, G C Oniscu, S J Wigmore, P Ramachandran, C A Vallejos, N O Carragher, M M Saeidinejad, A Quaglia, R Jalan, K J Simpson, T J Kendall, J A Rule, W M Lee, M Hoare, C J Weston, J C Marioni, S A Teichmann, T G Bird, L M Carlin, N C Henderson
The liver has a unique ability to regenerate1,2 ; however, in the setting of acute liver failure (ALF), this regenerative capacity is often overwhelmed, leaving emergency liver transplantation as the only curative option3-5 . Here, to advance understanding of human liver regeneration, we use paired single-nucleus RNA sequencing combined with spatial profiling of healthy and ALF explant human livers to generate a single-cell, pan-lineage atlas of human liver regeneration. We uncover a novel ANXA2+ migratory hepatocyte subpopulation, which emerges during human liver regeneration, and a corollary subpopulation in a mouse model of acetaminophen (APAP)-induced liver regeneration...
May 1, 2024: Nature