Lillian N Tran, Guodong Rao, Nicholas E Robertson, Haylee C Hunsaker, Elizabeth Y Chiu, Brett A Poulin, Amy K Madl, Kent E Pinkerton, R David Britt, Tran B Nguyen
Electronic (e-) cigarette formulations containing nicotine salts from a range of organic acid conjugates and pH values have dominated the commercial market. The acids in the nicotine salt formulations may alter the redox environment in e-cigarettes, impacting free radical formation in e-cigarette aerosol. Here, the generation of aerosol mass and free radicals from a fourth-generation e-cigarette device was evaluated at 2 wt % nicotine salts (pH 7, 30:70 mixture propylene glycol to vegetable glycerin) across eight organic acids used in e-liquids: benzoic acid (BA), salicylic acid (SLA), lactic acid (LA), levulinic acid (LVA), succinic acid (SA), malic acid (MA), tartaric acid (TA), and citric acid (CA)...
May 22, 2024: Chemical Research in Toxicology