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JOURNAL ARTICLE
Haytham Senbill, Donia Karawia, Jehan Zeb, Nouf M Alyami, Rafa Almeer, Sahidur Rahman, Olivier Sparagano, Aiswarya Baruah
BACKGROUND: The Middle East and North Africa (MENA) offer optimal climatic conditions for tick reproduction and dispersal. Research on tick-borne pathogens in this region is scarce. Despite recent advances in the characterization and taxonomic explanation of various tick-borne illnesses affecting animals in Egypt, no comprehensive examination of TBP (tick-borne pathogen) statuses has been performed. Therefore, the present study aims to detect the prevalence of pathogens harbored by ticks in Egypt...
June 2024: PLoS Neglected Tropical Diseases
#42
JOURNAL ARTICLE
Mathilde S Merridale-Punter, Anke K Wiethoelter, Charles M El-Hage, Cameron Patrick, Peta L Hitchens
Despite several millions of working equids worldwide, there are few published studies regarding the epidemiology of their health and welfare. Data collected by non-governmental organisations (NGOs) operating in the working equid sphere therefore have important epidemiological value and could be used towards animal health surveillance. The aim of this study was to identify common clinical findings and mortality patterns of working equids in low- and middle-income countries and investigate their epidemiology using data collected from an international NGO...
2024: PloS One
#43
JOURNAL ARTICLE
Ellen Yeats, Ning Lu, Greyson Stocker, Mahmoud Komaiha, Jonathan R Sukovich, Zhen Xu, Timothy L Hall
Histotripsy is a non-invasive ablation technique that focuses ultrasound pulses into the body to destroy tissues via cavitation. Heterogeneous acoustic paths through tissue introduce phase errors that distort and weaken the focus, requiring additional power output from the histotripsy transducer to perform therapy. This effect, termed phase aberration, limits the safety and efficacy of histotripsy ablation. It has been shown in vitro that the phase errors from aberration can be corrected by receiving the acoustic signals emitted by cavitation...
June 5, 2024: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
#44
MULTICENTER STUDY
Coleen S Sabatini, Eric W Edmonds, Jeffrey J Nepple, Elizabeth S Liotta, Katelyn Hergott, Michael Quinn, Crystal A Perkins, Philip L Wilson, Ying Li, Henry B Ellis, Nirav K Pandya, Andrew T Pennock, David D Spence, Samuel C Willimon, Donald S Bae, Mininder S Kocher, Michael T Busch, David N Williams, Benton E Heyworth
OBJECTIVES: To compare the clinical, radiographic, and patient-reported outcomes of nonoperative and operative treatment of adolescents with comminuted "Z-type" midshaft clavicle fractures. DESIGN: Prospective observational cohort. SETTING: Eight tertiary care pediatric centers. PATIENT SELECTION CRITERIA: Patients aged 10-18 years who were treated either operatively or nonoperatively for a diaphyseal clavicle fracture between 2013 and 2017 were screened/enrolled at the time of injury...
July 1, 2024: Journal of Orthopaedic Trauma
#45
JOURNAL ARTICLE
Bhavik Dalal, Takeshi Tada, Daxesh P Patel, Sharon R Pine, Mohammed Khan, Takahiro Oike, Yasuyuki Kanke, Amelia L Parker, Majda Haznadar, Leila Toulabi, Kristopher W Krausz, Ana I Robles, Elise D Bowman, Frank J Gonzalez, Curtis C Harris
PURPOSE: Non-smokers account for 10-13% of all lung cancer cases in the United States. Etiology is attributed to multiple risk factors including exposure to secondhand smoking, asbestos, environmental pollution, and radon, but these exposures are not within the current eligibility criteria for early lung cancer screening by low-dose computed tomography (LDCT). EXPERIMENTAL DESIGN: Urine samples were collected from two independent cohorts comprising 846 participants (exploratory cohort) and 505 participants (validation cohort)...
June 5, 2024: Clinical Cancer Research
#46
JOURNAL ARTICLE
Thazin N Aung, Jonathan Warrell, Sandra Martinez-Morilla, Niki Gavrielatou, Ioannis Vathiotis, Vesal Yaghoobi, Harriet M Kluger, Mark Gerstein, David L Rimm
PURPOSE: We aim to improve the prediction of response or resistance to immunotherapies in melanoma patients. This goal is based on the hypothesis that current gene signatures predicting immunotherapy outcomes show only modest accuracy due to the lack of spatial information about cellular functions and molecular processes within tumors and their microenvironment. EXPERIMENTAL DESIGN: We collected gene expression data spatially from three cellular compartments defined by CD68+macrophages, CD45+leukocytes and S100B+tumor cells in 55-immunotherapy-treated melanoma specimens using Digital Spatial Profiling-Whole Transcriptome Atlas (DSP-WTA)...
June 5, 2024: Clinical Cancer Research
#47
JOURNAL ARTICLE
Flurina A M Saner, Kazuaki Takahashi, Timothy Budden, Ahwan Pandey, Dinuka Ariyaratne, Tibor A Zwimpfer, Nicola S Meagher, Sian Fereday, Laura Twomey, Kathleen I Pishas, Therese Hoang, Adelyn Bolithon, Nadia Traficante, Kathryn Alsop, Elizabeth L Christie, Eun-Young Kang, Gregg S Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J Riggan, Jennifer Alsop, Matthias W Beckmann, Jessica Boros, Alison H Brand, Angela Brooks-Wilson, Michael E Carney, Penny Coulson, Madeleine Courtney-Brooks, Kara L Cushing-Haugen, Cezary Cybulski, Mona El-Bahrawy, Esther Elishaev, Ramona Erber, Simon A Gayther, Aleksandra Gentry-Maharaj, C Blake Gilks, Paul R Harnett, Holly R Harris, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y Hernandez, Anna Jakubowska, Mercedes Jimenez-Linan, Michael E Jones, Scott H Kaufmann, Catherine J Kennedy, Tomasz Kluz, Jennifer M Koziak, Björg Kristjansdottir, Nhu D Le, Marcin Lener, Jenny Lester, Jan Lubiński, Constantina Mateoiu, Sandra Orsulic, Matthias Ruebner, Minouk J Schoemaker, Mitul Shah, Raghwa Sharma, Mark E Sherman, Yurii B Shvetsov, T Rinda Soong, Helen Steed, Paniti Sukumvanich, Aline Talhouk, Sarah E Taylor, Robert A Vierkant, Chen Wang, Martin Widschwendter, Lynne R Wilkens, Stacey J Winham, Michael S Anglesio, Andrew Berchuck, James D Brenton, Ian Campbell, Linda S Cook, Jennifer A Doherty, Peter A Fasching, Renée Turzanski Fortner, Marc T Goodman, Jacek Gronwald, David G Huntsman, Beth Y Karlan, Linda E Kelemen, Usha Menon, Francesmary Modugno, Paul D P Pharoah, Joellen M Schildkraut, Karin Sundfeldt, Anthony J Swerdlow, Ellen L Goode, Anna DeFazio, Martin Köbel, Susan J Ramus, David D L Bowtell, Dale W Garsed
PURPOSE: To evaluate RB1 expression and survival across ovarian carcinoma histotypes, and how co-occurrence of BRCA1 or BRCA2 (BRCA) alterations and RB1 loss influences survival in tubo-ovarian high-grade serous carcinoma (HGSC). EXPERIMENTAL DESIGN: RB1 protein expression was classified by immunohistochemistry in ovarian carcinomas of 7436 patients from the Ovarian Tumor Tissue Analysis consortium. We examined RB1 expression and germline BRCA status in a subset of 1134 HGSC, and related genotype to overall survival (OS), tumor-infiltrating CD8+ lymphocytes and transcriptomic subtypes...
June 5, 2024: Clinical Cancer Research
#48
JOURNAL ARTICLE
Lin Zhou, Xinrui Zhang, Weiju Hao, Sida Sun, Ruirui Wang, Handing Liu
A facile solid-state approach is employed to synthesize a novel magnetoplumbite-type oxide of NdMgAl11 O19 , which integrates spinel-stacking layers (MgAl2 O4 ) with Nd-O6 mirror plane structures. The resulting NdMgAl11 O19 exhibits remarkable catalytic activity and conversion efficiency during the sulfur reduction reaction (SRR) in lithium-sulfur batteries. By employing the 2D projection mapping technique of in situ confocal Raman spectroscopy and electrochemical technique, it is discovered that the exposed mirror plane structure of Nd-O6 can effectively suppress the undesiring disproportionation reaction (S8 2- →S6 2- +1/4 S8 ) of long-chain lithium polysulfides at the initial stages of sulfur reduction, thereby promoting the positive process of sulfur to lithium sulfide...
June 5, 2024: Small Methods
#49
JOURNAL ARTICLE
Neepa Gurbani, Zarmina Ehsan, Melodie Boh, Christine L Schuler, Narong Simakajornboon
INTRODUCTION: Obstructive sleep apnea (OSA) in infants is treated with low flow oxygen via nasal cannula (NC), CPAP (continous positive airway pressure), or surgery. Literature supports the use of high flow NC (HFNC) in children in the outpatient setting, however there is limited data on the use of HFNC in infants. OBJECTIVE: The purpose of this study was to compare HFNC and low-flow oxygen as treatments for OSA in infants. METHODS: A prospective pilot study was performed at two institutions...
June 5, 2024: Pediatric Pulmonology
#50
(no author information available yet)
M. Lagadari, N. R. Zgajnar, L. I. Gallo and M. D. Galigniana, 'Hsp90-binding immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity', Molecular Oncology 10, no. 7 (2016): 1086-1098, https://doi.org/10.1016/j.molonc.2016.05.002. The above article, published online on 17 May 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Kevin Ryan and John Wiley and Sons Ltd. The retraction has been agreed due to several instances of image manipulation in figures 1C, 5B, 4A and 5A...
June 5, 2024: Molecular Oncology
#51
(no author information available yet)
L. Wang, Y. Gao, D. Tong, X. Wang, C. Guo, B. Guo, Y. Yang, L. Zhao, J. Zhang, J. Yang, Y. Qin, L. Liu, and C. Huang, "MeCP2 Drives Hepatocellular Carcinoma Progression Via Enforcing HOXD3 Promoter Methylation and Expression Through the HB-EGF/EGFR Pathway," Molecular Oncology 15, no. 11 (2021): 3147-3163, https://doi.org/10.1002/1878-0261.13019. The above article, published online on 24 May 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Kevin Ryan; FEBS Press; and John Wiley and Sons Ltd...
June 5, 2024: Molecular Oncology
#52
JOURNAL ARTICLE
Brechje Dandachi-FitzGerald, Sanne T L Houben, Nick J Broers, Harald Merckelbach
BACKGROUND: Clients' adverse experiences during psychotherapy are rarely monitored in clinical practice or research trials. One obstacle here is the lack of a measure to gauge both positive and negative experiences during psychotherapy. We developed and evaluated a new instrument for measuring such experiences. METHOD: The Positive and Negative Experiences of Psychotherapy (PNEP) questionnaire was developed based on pilot data, a literature review, and two existing scales for measuring primarily adverse experiences during psychotherapy...
2024: Clinical Psychology & Psychotherapy
#53
JOURNAL ARTICLE
Francesco Ditonno, Eugenio Bologna, Leslie Claire Licari, Antonio Franco, Christopher L Coogan, Daniel F Roadman, Carol L Feng, Jonathan Huang, Kalyan Latchamsetty, Edward E Cherullo, Riccardo Autorino
No abstract text is available yet for this article.
June 5, 2024: BJU International
#54
JOURNAL ARTICLE
Georg L Goebel, Nicole Giannino, Philipp Lampe, Xiaqiu Qiu, Jeffrey Schloßhauer, Jochen Imig, Sonja Sievers, Peng Wu
Proteolysis targeting chimeras (PROTACs) are new chemical modalities that degrade proteins of interest, including established kinase targets and emerging RNA-binding proteins (RBPs). Whereas diverse sets of biochemical, biophysical and cellular assays are available for the evaluation and optimizations of PROTACs in understanding the involved ubiquitin-proteasome-mediated degradation mechanism and the structure-degradation relationship, a phenotypic method profiling the cellular morphological changes is rarely used...
June 4, 2024: Chembiochem: a European Journal of Chemical Biology
#55
JOURNAL ARTICLE
Caitlin E Smith, Ben L Gilby, Jason van de Merwe, Jodi Jones, Heidi Tait, Kathy A Townsend
Anthropogenic debris is a global threat that impacts threatened species through various lethal and sub-lethal consequences, as well as overall ecosystem health. This study used a database of over 24,000 beach surveys of marine debris collated by the Australian Marine Debris Initiative from 2012 to 2021, with two key objectives: (1) identify variables that most influence the occurrence of debris hotspots on a continental scale and (2) use these findings to identify likely hotspots of interaction between threatened species and marine debris...
June 2024: Global Change Biology
#56
JOURNAL ARTICLE
A E Ynsaurralde-Rivolta, A Gambini, V Alberio, V Savy, L Ratner, A Guberman, C Vázquez Echegaray, M I Gismondi, A Currá, R Bevacqua, D Salamone
The efficiency of bovine in vitro embryo production can be significantly improved by splitting embryos at different stages. However, the blastocyst quality of in vitro-produced demi-embryos remains unexplored. The objective of this research was to compare embryo developmental rates and quality of bovine demi-embryos produced by two different strategies: (a) embryo bisection (BSEC) and (b) 2-cell blastomere separation (BSEP). To determine demi-embryos quality, we evaluated total blastocyst cell number and proportion of SOX2+ cells...
June 2024: Reproduction in Domestic Animals
#57
JOURNAL ARTICLE
Roohi Chhabra, Andrew Davenport
BACKGROUND: Debate continues as to the optimum hemodialysis (HD) dialysate calcium concentration. Although current guidelines advocate 1.25-1.5 mmol/L, some investigators have suggested these may cause calcium gains. As such we investigated whether using dialysate calcium of 1.25 mmol/L risked calcium gains, and whether there were differences between hemodiafiltration and high flux HD. METHODS: We continuously collect an aliquot of effluent dialysate during dialysis sessions, and calculated dialysis calcium mass balance by the difference between the amount of calcium delivered as fresh dialysate and that lost in effluent dialysate...
June 4, 2024: Artificial Organs
#58
JOURNAL ARTICLE
Wenying Liu, Rui Liu, Qingyu Qin, Hualei Wang, Xinxue Zhang, Ganlu Meng
BACKGROUND: In our previous study, we successfully identified five peptides from wheat gluten: Ala-Pro-Ser-Tyr (APSY), Leu-Tyr (LY), Pro-Tyr (PY), Arg-Gly-Gly-Tyr (RGGY) and Tyr-Gln (YQ). Molecular docking and molecular dynamics simulation methods were employed to investigate the interaction between these antioxidant peptides and the Kelch-like ECH-associated protein 1 (Keap1 protein), revealing the molecular mechanism of their non-competitive binding. In addition, the total antioxidant capacity of the five peptides was determined using the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) method...
June 5, 2024: Journal of the Science of Food and Agriculture
#59
JOURNAL ARTICLE
Xiaojing Xiong, Zheng Zheng, Chunlin Liu, Xinyu Wang, Shuai Luo, Qinqin Xie, Yang Liu, Qingwei Chen, Minming Zheng
SARS-CoV-2 infection has been associated with the increased incidence of acute macular neuroretinopathy (AMN), an infrequent ocular disorder. However, the precise mechanisms underpinning AMN in the context of SARS-CoV-2 infection (AMN-SARS-CoV-2) remain elusive. In this case-control study, 14 patients diagnosed with AMN-SARS-CoV-2 between 2022/12 and 2023/3 were enrolled and compared with 14 SARS-CoV-2-infected individuals without AMN, who served as controls (SARS-CoV-2-no AMN). Metabolomic profiling using ultrahigh-performance liquid chromatography-online electrospray mass spectrometry revealed significant alterations in serum metabolites in AMN-SARS-CoV-2 patients...
June 2024: Journal of Medical Virology
#60
JOURNAL ARTICLE
John O Cisar, Xiaocong Wang, Robert J Woods, Kenneth D Cain, Gregory D Wiens
A mouse monoclonal antibody (mAb FL100A) previously prepared against Flavobacterium psychrophilum (Fp) CSF259-93 has now been examined for binding to lipopolysaccharides (LPS) of this strain and Fp 950106-1/1. The corresponding O-polysaccharides (O-PS) of these strains are formed by identical trisaccharide repeats composed of l-Rhamnose (l-Rha), 2-acetamido-2-deoxy-l-fucose (l-FucNAc) and 2-acetamido-4-R1 -2,4-dideoxy-d-quinovose (d-Qui2NAc4NR1 ) where R1 represents a dihydroxyhexanamido moiety. The O-PS loci of these strains are also identical except for the gene (wzy1 or wzy2) that encodes the polysaccharide polymerase...
June 4, 2024: Journal of Fish Diseases
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