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JOURNAL ARTICLE
Patricia Mester, Ulrich Räth, Stephan Schmid, Martina Müller, Christa Buechler, Vlad Pavel
Adiponectin is low in obesity, plays a crucial role in metabolic health, and, moreover, possesses immunoregulatory properties. However, studies examining its levels in patients with systemic inflammatory response syndrome (SIRS) or sepsis have yielded conflicting results. While females typically have higher systemic adiponectin levels than males, research on sex-specific associations in this context is limited. In this study of 156 SIRS/sepsis patients, including those with liver cirrhosis, we aimed to explore the relationship between plasma adiponectin, body mass index (BMI), gender, disease severity, and underlying etiological conditions...
December 12, 2023: Biomedicines
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JOURNAL ARTICLE
Boris Cvek
Recent efforts to repurpose disulfiram, a drug used in alcohol-aversion therapy for decades, for other diseases suggest the molecule is almost an in vitro panacea: it seems to be effective against various cancers (by multiple mechanisms of action), Alzheimer's disease, obesity and metabolic syndrome, pythiosis, lyme borreliosis, COVID-19, and sepsis. The problem is that the molecule almost does not exist in the body after ingestion and, most importantly, is not the pharmacologically active entity in alcoholic patients, being rather a prodrug...
December 14, 2023: ACS Medicinal Chemistry Letters
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JOURNAL ARTICLE
Chi Kin Wong, Brent A McLean, Laurie L Baggio, Jacqueline A Koehler, Rola Hammoud, Nikolaj Rittig, Julian M Yabut, Randy J Seeley, Theodore J Brown, Daniel J Drucker
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exert anti-inflammatory effects relevant to the chronic complications of type 2 diabetes. Although GLP-1RAs attenuate T cell-mediated gut and systemic inflammation directly through the gut intraepithelial lymphocyte GLP-1R, how GLP-1RAs inhibit systemic inflammation in the absence of widespread immune expression of the GLP-1R remains uncertain. Here, we show that GLP-1R activation attenuates the induction of plasma tumor necrosis factor alpha (TNF-α) by multiple Toll-like receptor agonists...
January 2, 2024: Cell Metabolism
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JOURNAL ARTICLE
Thoriso C Mokoala, Vhusani Sididzha, Etsumang D Molefe, Thifhelimbilu E Luvhengo
BACKGROUND: Diabetes foot sepsis (DFS) is the leading cause of amputation of lower extremities. Over 50 % of patients who have had major lower extremity amputation due to DFS are dead within 4 years following the procedure. AIM: To determine the life expectancy of patients following amputation for DFS at a regional hospital in South Africa. METHODS: We conducted an audit of patients who had DFS and were admitted over a 5-year period. The duration from admission to time of death was recorded in days...
December 14, 2023: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
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JOURNAL ARTICLE
Peter G Passias, Waleed Ahmad, Bhaveen H Kapadia, Oscar Krol, Joshua Bell, Pramod Kamalapathy, Bailey Imbo, Peter Tretiakov, Tyler Williamson, Oluwatobi O Onafowokan, Ankita Das, Rachel Joujon-Roche, Kevin Moattari, Lara Passfall, Nicholas Kummer, Shaleen Vira, Virginie Lafage, Bassel Diebo, Andrew J Schoenfeld, Hamid Hassanzadeh
HYPOTHESIS: Revascularization is a more effective intervention to reduce future postop complications. METHODS: Patients undergoing elective spine fusion surgery were isolated in the PearlDiver database. Patients were stratified by having previous history of vascular stenting (Stent), coronary artery bypass graft (CABG), and no previous heart procedure (No-HP). Means comparison tests (chi-squared and independent samples t-tests, as appropriate) compared differences in demographics, diagnoses, and comorbidities...
January 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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JOURNAL ARTICLE
Raneen Abu Shqara, Daniel Glikman, Saher Jad, Hagai Rechnitzer, Lior Lowenstein, Maya Frank Wolf
BACKGROUND: Clinical chorioamnionitis refers to the presence of maternal fever (≥38°C) and at least 2 clinical signs: (1) maternal tachycardia (>100 bpm), (2) fetal tachycardia (>160 bpm), (3) maternal leukocytosis >15,000/mm2 , (4) purulent vaginal discharge, and (5) uterine tenderness. Few data exist to guide the appropriate management of women with isolated intrapartum fever in the absence of other clinical signs suggesting chorioamnionitis. OBJECTIVE: This study compared maternal and neonatal infectious outcomes and microbiological outcomes between women with isolated intrapartum fever and women with clinical chorioamnionitis...
November 2023: American Journal of Obstetrics and Gynecology
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REVIEW
Marta Palomo, Ana Belén Moreno-Castaño, María Queralt Salas, Silvia Escribano-Serrat, Montserrat Rovira, Elena Guillen-Olmos, Sara Fernandez, Helena Ventosa-Capell, Lina Youssef, Fatima Crispi, Meritxell Nomdedeu, Julia Martinez-Sanchez, Blanca De Moner, Maribel Diaz-Ricart
The endothelium is a biologically active interface with multiple functions, some of them common throughout the vascular tree, and others that depend on its anatomical location. Endothelial cells are continually exposed to cellular and humoral factors, and to all those elements (biological, chemical, or hemodynamic) that circulate in blood at a certain time. It can adapt to different stimuli but this capability may be lost if the stimuli are strong enough and/or persistent in time. If the endothelium loses its adaptability it may become dysfunctional, becoming a potential real danger to the host...
2023: Frontiers in Medicine
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JOURNAL ARTICLE
Thais G Sardinha, Giuliane J Lajos, Renato T Souza, Jose G Cecatti, Adriana G Luz, Maria Lúcia R Oppermann, Rodolfo C Pacagnella, Carolina C Ribeiro-Do-Valle, Guilherme M Nobrega, Thayna B Griggio, Charles M Charles, Carla Silveira, Maria J Miele, Ricardo P Tedesco, Karayna G Fernandes, Sérgio Ha Martins-Costa, Frederico Ja Peret, Francisco E Feitosa, Evelyn Traina, Edson V Cunha Filho, Janete Vettorazzi, Samira M Haddad, Carla B Candreucci, José P Guida, Mario D Correa Junior, Marcos Ab Dias, Leandro G Oliveira, Elias F Melo Junior, Marília Gq Da Luz, Maria Laura Costa
OBJECTIVES: To compare maternal and perinatal outcomes among women with obesity, overweight, and normal body mass index, associated with COVID-19 infection during pregnancy and postpartum. METHOD: Prospective Cohort Study, within the REBRACO (Brazilian Network of COVID-19 in Pregnancy) multicenter initiative. Confirmed positive cases of SARS-CoV-2 were included, and women categorized into three groups according to their pre-pregnancy BMI: obesity (BMI ≥ 30), overweight (BMI <30 but >25), and normal BMI...
November 27, 2023: International Journal of Gynaecology and Obstetrics
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JOURNAL ARTICLE
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Linqi Feng, Panpan Li, Yang Sun, Wei Yi
Bone marrow mesenchymal stem cells (BMSCs) are a promising new therapy for sepsis, a common cause of death in hospitals. However, the global epidemic of metabolic syndromes, including obesity and pre-obesity, threatens the health of the human BMSC pool. The therapeutic effects of BMSCs are primarily due to the secretion of the small extracellular vesicles containing lipids, proteins, and RNA. Accordingly, studies on BMSCs, their small extracellular vesicles, and their modifications in obese individuals are becoming increasingly important...
November 24, 2023: International Immunopharmacology
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JOURNAL ARTICLE
Amar D Desai, Noelle Desir, Shari R Lipner
INTRODUCTION: Socioeconomic status and comorbidities are associated with increased mortality in patients with external surface burn patients, however differences between pediatric and adult burn populations have not been adequately studied. OBJECTIVES: Our objectives were to explore the presentation, management, and outcomes of external surface burns across age groups. METHODS: The 2017 National Inpatient Sample (NIS) was queried for patients with any diagnosis of external body surface burns...
October 1, 2023: Dermatology Practical & Conceptual
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JOURNAL ARTICLE
Adriana Wegner Araya, Pamela Céspedes Fernández, Patricio Astudillo Paredes, Adriana Diettes González, Franco Diaz Rubio, Christian Scheu Gonçalves, Verónica Chauriye Kuncar, Tomás Gaete Amenábar, Marta Zamora Astudillo, Carlos Acuña Aguirre, Michele Drago Thibaut, Víctor Monreal Eloaiza, Michelangelo Lapadula Amelina, Pietro Pietroboni Fuster, Javier Varela Ortiz, Alena Gallardo Martínez, Karin Scheuch Ruiz, Andrés Manen Chinchón, María-José Villarroel Carreño
OBJECTIVES: To characterize the COVID-19 disease profile in Chilean children hospitalized in pediatric intensive care units (PICU) and to evaluate risk factors associated with severe COVID-19. PATIENTS AND METHOD: A multicenter prospective cohort study with patients 0-18 years of age with confirmed SARS-CoV-2 hospitalized in PICU. Clinical, laboratory, imaging, and therapeutic variables were recorded. We compared "mild/moderate COVID-19" with ''severe COVID-19" using median with interquartile range (IQR), Mann-Whitney U test, two-tailed Fisher's test, and forward binary multivariate analysis to adjust variables for "severe COVID-19"...
October 2023: Andes pediatrica: revista Chilena de pediatría
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JOURNAL ARTICLE
Christine Schreiner, Andreas Müller, Till Dresbach
Mother's own milk is recognized as the optimal feeding not only for term but also for preterm infants. In addition to risk reduction for sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, and retinopathy of prematurity in the early infancy, feeding preterm infants with mother's own milk is also associated with a better neurodevelopmental outcome; lower rates of otitis media, gastroenteritis, and respiratory infections; and a reduced risk of cardiovascular disease, obesity, and diabetes later in life...
November 15, 2023: Breastfeeding Medicine
#53
JOURNAL ARTICLE
Ralph Hsiao, Erik Youngson, Alika Lafontaine, Kamran Fathimani, David C Williams
BACKGROUND: Internationally, Indigenous Peoples experience worse surgical outcomes than non-Indigenous patients, but equity of surgical care is less well studied in Canada. This study compares outcomes after appendectomy in First Nations and non-First Nations patients. METHODS: In this population-based study, we reviewed administrative data of patients who underwent appendectomy between Apr. 1, 2004, and Mar. 31, 2017, in Northern Alberta. Demographic variables and characteristics of surgical care for First Nations and non-First Nations patients were collected...
2023: Canadian Journal of Surgery. Journal Canadien de Chirurgie
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JOURNAL ARTICLE
Lilly Y Liu, Timothy Wen, Uma M Reddy, Mirella Mourad, Dena Goffman, Lisa Nathan, Jean-Ju Sheen, Mary E D'Alton, Alexander M Friedman
OBJECTIVE: To evaluate the prevalence, timing, clinical risk factors, and adverse outcomes associated with postpartum readmissions for maternal sepsis. METHODS: We conducted a retrospective cohort study of delivery hospitalizations and 60-day postpartum readmissions for females aged 15-54 years with and without sepsis using the 2016-2020 Nationwide Readmissions Database. Temporal trends in sepsis diagnoses during delivery hospitalizations and 60-day postpartum readmissions were analyzed with the National Cancer Institute's Joinpoint Regression Program to estimate the average annual percent change with 95% CIs...
November 9, 2023: Obstetrics and Gynecology
#55
JOURNAL ARTICLE
Tsegamlak Kuemlachew Derse, Michael Tamene Haile, Tekalign Markos Chamiso
BACKGROUND: Diabetic ketoacidosis is a potentially fatal disease that affects adults. Therefore, rapid detection and treatment are required to decrease mortality rates. Most of the earlier research on diabetic ketoacidosis in Ethiopia concentrated on its prevalence and associated factors. This study aimed to assess the treatment outcomes of diabetic ketoacidosis and its associated factors in adult patients admitted to St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia, in 2023...
2023: Diabetes, Metabolic Syndrome and Obesity
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JOURNAL ARTICLE
Kelsey M Gladen, David Tellez, Natalie Napolitano, Lauren R Edwards, Ronald C Sanders, Taiki Kojima, Matthew P Malone, Justine Shults, Conrad Krawiec, Shashikanth Ambati, Riley McCarthy, Aline Branca, Lee A Polikoff, Philipp Jung, Simon J Parsons, Palen Mallory, Kavipriya Komeswaran, Christopher Page-Goertz, Megan C Toal, G Kris Bysani, Keith Meyer, Fabrizio Chiusolo, Lily B Glater-Welt, Awni Al-Subu, Katherine Biagas, Jan Hau Lee, Michael Miksa, John S Giuliano, Krista L Kierys, Andrea M Talukdar, Michelle DeRusso, Laurence Cucharme-Crevier, Michelle Adu-Arko, Asha Shenoi, Dai Kimura, Molly Flottman, Shantaveer Gangu, Ashley D Freeman, Mark D Piehl, G A Nuthall, Keiko M Tarquinio, Ilana Harwayne-Gidansky, Tatsuya Hasegawa, Erin S Rescoe, Ryan K Breuer, Mioko Kasagi, Vinay M Nadkarni, Akira Nishisaki
OBJECTIVES: Extremes of patient body mass index are associated with difficult intubation and increased morbidity in adults. We aimed to determine the association between being underweight or obese with adverse airway outcomes, including adverse tracheal intubation (TI)-associated events (TIAEs) and/or severe peri-intubation hypoxemia (pulse oximetry oxygen saturation < 80%) in critically ill children. DESIGN/SETTING: Retrospective cohort using the National Emergency Airway for Children registry dataset of 2013-2020...
November 1, 2023: Pediatric Critical Care Medicine
#57
JOURNAL ARTICLE
Kevin Tea, Yuanhao Zu, Cheng Han Chung, Jaclyn Pagliaro, Diana Espinoza-Barrera, Prakriti Mehta, Himmat Grewal, Ivor S Douglas, Yasin A Khan, Jeffrey G Shaffer, Joshua L Denson
OBJECTIVES: Metabolic syndrome is known to predict outcomes in COVID-19 acute respiratory distress syndrome (ARDS) but has never been studied in non-COVID-19 ARDS. We therefore aimed to determine the association of metabolic syndrome with mortality among ARDS trial subjects. DESIGN: Retrospective cohort study of ARDS trials' data. SETTING: An ancillary analysis was conducted using data from seven ARDS Network and Prevention and Early Treatment of Acute Lung Injury Network randomized trials within the Biologic Specimen and Data Repository Information Coordinating Center database...
March 1, 2024: Critical Care Medicine
#58
LETTER
Hang Ruan, Qin Zhang, Xiao Ran
No abstract text is available yet for this article.
November 1, 2023: Critical Care Medicine
#59
REVIEW
Guoji Xiong, Kexin Zhang, Yujie Ma, Yixin Song, Wenqiang Zhang, Tongbing Qi, Hongyan Qiu, Junfeng Shi, Chengxia Kan, Jingwen Zhang, Xiaodong Sun
Subcellular organelles dysfunction is implicated in various diseases, including metabolic diseases, neurodegenerative diseases, cancer, and cardiovascular diseases. BAM15, a selective mitochondrial uncoupler, has emerged as a promising therapeutic agent due to its ability to enhance mitochondrial respiration and metabolic flexibility. By disrupting the coupling between electron transport and ATP synthesis, BAM15 dissipates the proton gradient, leading to increased mitochondrial respiration and energy expenditure...
2023: Frontiers in Endocrinology
#60
JOURNAL ARTICLE
Ankit Vyas, Rupak Desai, Advait Vasavada, Nitin Ghadge, Akhil Jain, Dishita Pandya, Carl J Lavie
BACKGROUND: Atrial fibrillation (AF) is an indicator of poor prognosis in patients with sepsis and can increase the risk of stroke and mortality. Data on the impact of severe obesity on the outcomes of sepsis complicated by AF remains poorly understood. METHODS: National Inpatient Sample (2018) and ICD-10 CM codes were used to identify the principal sepsis admissions with AF. We assessed comorbidities and outcomes of sepsis in people without obesity (BMI < 30) vs...
October 28, 2023: International Journal of Obesity
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