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Sepsis

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https://read.qxmd.com/read/100001003/emergency-management-of-sepsis-the-simple-stuff-saves-lives
#1
David Sweet , Julian Marsden , Kendall Ho , Christina Krause , James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: British Columbia Medical Journal
https://read.qxmd.com/read/32226779/differential-thermoregulatory-and-inflammatory-patterns-in-the-circadian-response-to-lps-induced-septic-shock
#2
Malena Lis Mul Fedele, Ignacio Aiello, Carlos Sebastián Caldart, Diego Andrés Golombek, Luciano Marpegan, Natalia Paladino
Sepsis is caused by a dysregulated host response to infection, and characterized by uncontrolled inflammation together with immunosuppression, impaired innate immune functions of phagocytes and complement activation. Septic patients develop fever or hypothermia, being the last one characteristic of severe cases. Both lipopolysaccharide (LPS) and Tumor Necrosis Factor (TNF)-α- induced septic shock in mice is dependent on the time of administration. In this study, we aimed to further characterize the circadian response to high doses of LPS...
2020: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/32226310/is-intensive-glucose-control-bad-for-critically-ill-patients-a-systematic-review-and-meta-analysis
#3
Ren-Qi Yao, Chao Ren, Guo-Sheng Wu, Yi-Bing Zhu, Zhao-Fan Xia, Yong-Ming Yao
Background: The monitoring and management of blood glucose concentration are standard practices in critical settings as hyperglycaemia has been shown close association with poorer outcomes. Several meta-analyses have revealed that intensive glucose control has no benefit in decreasing short-term mortality among critically ill patients, while the studies these meta-analyses have incorporated have been largely divergent. We aim to perform a more comprehensive meta-analysis addressing this problem to provide stronger evidence...
2020: International Journal of Biological Sciences
https://read.qxmd.com/read/32225172/oropharyngeal-colostrum-therapy-reduces-the-incidence-of-ventilator-associated-pneumonia-in-very-low-birth-weight-infants-a-systematic-review-and-meta-analysis
#4
REVIEW
Aijia Ma, Jing Yang, Yang Li, Xuepeng Zhang, Yan Kang
BACKGROUND: Oropharyngeal colostrum (OC) is a novel feeding strategy to prevent complications of prematurity. A meta-analysis was conducted to investigate whether very low birth weight infants (VLBWs) can benefit from OC. METHODS: Randomized controlled trials (RCTs) were searched from Embase, PubMed, Web of Science, and Cochrane Central Register of Controlled Trials from the date of inception until May 2019. RCTs were eligible if they used OC therapy on VLBW infants...
March 30, 2020: Pediatric Research
https://read.qxmd.com/read/32224930/a-cecal-slurry-mouse-model-of-sepsis-leads-to-acute-consumption-of-vitamin-c-in-the-brain
#5
David C Consoli, Jordan J Jesse, Kelly R Klimo, Adriana A Tienda, Nathan D Putz, Julie A Bastarache, Fiona E Harrison
Vitamin C (ascorbate, ASC) is a critical antioxidant in the body with specific roles in the brain. Despite a recent interest in vitamin C therapies for critical care medicine, little is known about vitamin C regulation during acute inflammation and critical illnesses such as sepsis. Using a cecal slurry (CS) model of sepsis in mice, we determined ASC and inflammatory changes in the brain following the initial treatment. ASC levels in the brain were acutely decreased by approximately 10% at 4 and 24 h post CS treatment...
March 26, 2020: Nutrients
https://read.qxmd.com/read/32224855/mucosal-vaccination-with-lactococcus-lactis-secreting-surface-immunological-protein-induces-humoral-and-cellular-immune-protection-against-group-b-streptococcus-in-a-murine-model
#6
Diego A Diaz-Dinamarca, Carlos Hernandez, Daniel F Escobar, Daniel A Soto, Guillermo A Muñoz, Jesús F Badilla, Ricardo A Manzo, Flavio Carrión, Alexis M Kalergis, Abel E Vasquez
Group B Streptococcus (GBS) is the primary etiological agent of sepsis and meningitis in newborns and is associated with premature birth and stillbirth. The development of a licensed vaccine is one of the pending challenges for the World Health Organization. Previously, we showed that oral immunization with surface immune protein (SIP) decreases vaginal colonization of GBS and generates functional opsonizing antibodies, which was determined by opsonophagocytic assays (OPA) in vitro. We also showed that the protein has an adjuvant vaccine profile...
March 26, 2020: Vaccines
https://read.qxmd.com/read/32224769/surviving-sepsis-campaign-guidelines-on-the-management-of-critically-ill-adults-with-coronavirus-disease-2019-covid-19
#7
Waleed Alhazzani, Morten Hylander Møller, Yaseen M Arabi, Mark Loeb, Michelle Ng Gong, Eddy Fan, Simon Oczkowski, Mitchell M Levy, Lennie Derde, Amy Dzierba, Bin Du, Michael Aboodi, Hannah Wunsch, Maurizio Cecconi, Younsuck Koh, Daniel S Chertow, Kathryn Maitland, Fayez Alshamsi, Emilie Belley-Cote, Massimiliano Greco, Matthew Laundy, Jill S Morgan, Jozef Kesecioglu, Allison McGeer, Leonard Mermel, Manoj J Mammen, Paul E Alexander, Amy Arrington, John E Centofanti, Giuseppe Citerio, Bandar Baw, Ziad A Memish, Naomi Hammond, Frederick G Hayden, Laura Evans, Andrew Rhodes
BACKGROUND: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed. METHODS: We formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU...
March 27, 2020: Critical Care Medicine
https://read.qxmd.com/read/32224589/-good-s-syndrome-developing-hemophagocytic-lymphohistiocytosis-following-thymectomy
#8
Michiko Yamada, Masahiro Yoshida, Shutaro Oiwa, Daichi Watanabe, Junya Saga, Shota Yamada, Michihiro Ono, Tomoyuki Abe, Shigeyuki Fujii, Masahiro Maeda, Miri Fujita, Satoshi Iyama, Junji Kato
This report presents the case of a 68-year-old female patient previously diagnosed with thymoma by her local doctor. She was referred to our hospital for surgery, and the thymoma was removed and diagnosed as a World Health Organization (WHO) classification type AB thymoma. After surgery, she experienced general malaise, a loss of appetite, and weight loss, so she visited our hospital in May 2019. A blood test showed hypogammaglobulinemia and low B lymphocytes. A bone marrow examination revealed no morphological abnormalities...
2020: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://read.qxmd.com/read/32223817/pneumococcal-sepsis-induced-purpura-fulminans-in-an-asplenic-adult-patient-with-disseminated-intravascular-coagulation
#9
Pin-Yi Huang, Hsu-Tang Cheng
No abstract text is available yet for this article.
March 1, 2020: American Surgeon
https://read.qxmd.com/read/32223739/ralstonia-mannitolilytica-an-unusual-pathogen-in-the-neonatal-intensive-care-unit-a-case-of-neonatal-sepsis-and-literature-review
#10
Panagiotis Lampropoulos, Despoina Gkentzi, Sotirios Tzifas, Georgia Kapnisi, Ageliki Karatza, Fevronia Kolonitsiou, Gabriel Dimitriou
BACKGROUND: Premature infants are considered high-risk subgroup for neonatal sepsis due to yet defective immune system, interventions practised and synergy of factors favoring multiple resistance of Gram-positive and Gram-negative pathogens to antimicrobial agents. CASE PRESENTATION: We present a case of late-onset neonatal sepsis in a premature infant caused by an uncommon pathogen; a premature infant of extremely low birth weight had in his 4th week of life severe clinical deterioration with lethargy, fever, pallor, 1 mottling, abdominal distention, tachycardia, and worsening respiratory impairment...
March 30, 2020: Infectious Disorders Drug Targets
https://read.qxmd.com/read/32223486/reducing-post-extubation-failure-rates-in-very-preterm-infants-is-bipap-better-than-cpap
#11
Letizia Capasso, Angela Carla Borrelli, Julia Cerullo, Maria Angela Caiazzo, Clara Coppola, Marta Palma, Francesco Raimondi
Background and Aim: CPAP is currently used in neonates after mechanical ventilation though it may occasionally be associated with air leaks syndromes or it may fail to support the baby. The pressure difference offered by BiPAP respect to CPAP may be an advantage to the spontaneously breathing patient. In this study, we compared the efficacy of CPAP and BiPAP in the first week post extubation in a series of very preterm infants. Methods: Inborn neonates less than 30 weeks of gestational age who were intubated shortly after birth from January 2011 to December 2017 were enrolled in a retrospective study...
March 29, 2020: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/32223437/survival-outcomes-and-use-of-acuity-scoring-systems-following-tracheotomy-in-veteran-patients
#12
Carol M Bier-Laning, Jeffrey Hotaling, W Jeffrey Canar, Aziz A Ansari
OBJECTIVES: To determine whether established prognosis tools used in the general population of critically ill patients will accurately predict tracheotomy-related outcomes and survival outcomes in critically ill patients undergoing tracheotomy. METHODS: Retrospective chart review of 94 consecutive critically ill patients undergoing isolated tracheotomy. RESULTS: Logistic Organ Dysfunction System (LODS) and sepsis-related organ failure assessment (SOFA) scores, 2 validated measures of acuity in critically ill patients, were calculated for all patients...
March 30, 2020: American Journal of Hospice & Palliative Care
https://read.qxmd.com/read/32223305/fatal-case-of-bacteremia-caused-by-streptococcus-suis-in-a-splenectomized-man-and-a-review-of-the-european-literature
#13
Zsuzsanna Ágoston, Gabriella Terhes, Péter Hannauer, Márió Gajdács, Edit Urbán
Streptococcus suis is an emerging zoonotic human pathogen, which is a causative agent of invasive infections in people who are in close contact with infected pigs or contaminated pork products. It is associated with severe systemic infections, most commonly meningitis and sepsis, which may lead to high rates of morbidity and mortality. Serotype 2 is the most prevalent type in S. suis infections in humans. We have reported a case of a very rapidly proceeding fatal human S. suis infection in a splenectomized, but otherwise immunocompetent patient in Hungary...
March 30, 2020: Acta Microbiologica et Immunologica Hungarica
https://read.qxmd.com/read/32222812/surviving-sepsis-campaign-guidelines-on-the-management-of-critically-ill-adults-with-coronavirus-disease-2019-covid-19
#14
Waleed Alhazzani, Morten Hylander Møller, Yaseen M Arabi, Mark Loeb, Michelle Ng Gong, Eddy Fan, Simon Oczkowski, Mitchell M Levy, Lennie Derde, Amy Dzierba, Bin Du, Michael Aboodi, Hannah Wunsch, Maurizio Cecconi, Younsuck Koh, Daniel S Chertow, Kathryn Maitland, Fayez Alshamsi, Emilie Belley-Cote, Massimiliano Greco, Matthew Laundy, Jill S Morgan, Jozef Kesecioglu, Allison McGeer, Leonard Mermel, Manoj J Mammen, Paul E Alexander, Amy Arrington, John E Centofanti, Giuseppe Citerio, Bandar Baw, Ziad A Memish, Naomi Hammond, Frederick G Hayden, Laura Evans, Andrew Rhodes
BACKGROUND: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed. METHODS: We formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU...
March 28, 2020: Intensive Care Medicine
https://read.qxmd.com/read/32222722/long-noncoding-rna-dancr-suppressed-lipopolysaccharide-induced-septic-acute-kidney-injury-by-regulating-mir-214-in-hk-2-cells
#15
Huajie Zhao, Bing Chen, Zhenyu Li, Bin Wang, Liyu Li
BACKGROUND Acute kidney injury (AKI) is one of the most important causes of death in sepsis patients. Here, we first measured the level of DANCR (differentiation antagonizing nonprotein coding RNA) expression in AKI, and the potential mechanism was further elucidated. MATERIAL AND METHODS We used qRT-PCR to examine the level of DANCR in patient blood serum samples and in HK-2 cells. In addition, DANCR overexpression was established using lentiviral transfection in HK-2 cells. Subsequently, Cell Counting Kit-8 (CCK-8) assay and flow cytometry were applied to evaluate the role of DANCR in HK-2 cells treated with lipopolysaccharide (LPS)...
March 29, 2020: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/32221627/-improved-patient-safety-through-a-clinical-decision-support-system-in-laboratory-medicine
#16
REVIEW
F Eckelt, J Remmler, T Kister, M Wernsdorfer, H Richter, M Federbusch, M Adler, A Kehrer, M Voigt, C Cundius, J Telle, J Thiery, T Kaiser
BACKGROUND: Laboratory diagnostics are essential for diagnosis, initiation of therapy, and monitoring of patients. Laboratory results that are overlooked or incorrectly interpreted lead to adverse events and endanger patient safety. Clinical decision support systems (CDSSs) may facilitate appropriate interpretation of results and subsequent medical response. OBJECTIVES: The research project on digital laboratory medicine (AMPEL) aims at developing a CDSS based on laboratory diagnostics, which supports practitioners in ensuring the necessary medical consequences...
March 27, 2020: Der Internist
https://read.qxmd.com/read/32221619/down-regulation-of-lncrna-casc9-aggravates-sepsis-induced-acute-lung-injury-by-regulating-mir-195-5p-pdk4-axis
#17
Huai-Rong Wang, Xiu-Yan Guo, Xin-Yan Liu, Xuan Song
BACKGROUND: Long non-coding RNA (lncRNA) cancer susceptibility candidate 9 (CASC9) is reported to be linked to cancers. This research aims to explore the role and possible mechanism of CASC9 in lung injury induced by sepsis. METHODS: Lipopolysaccharide (LPS) induced human small airway epithelial cells (HSAECs) were established in vitro to mimic sepsis-induced lung injury. The effects of CASC9 and miR-195-5p on HSAECs viability were studied by CCK-8 assay. Interactions between CASC9 and miR-195-5p were determined by bioinformatics analysis, RT-PCR, dual luciferase reporter assay, and RNA immunoprecipitation assay...
March 27, 2020: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/32221163/epidemiology-clinical-and-microbiologic-profile-and-risk-factors-for-inpatient-mortality-in-pediatric-severe-sepsis-in-the-united-states-from-2003-to-2014-a-large-population-analysis
#18
Aravind Thavamani, Krishna Kishore Umapathi, Harshitha Dhanpalreddy, Jasmine Khatana, Kobkul Chotikanatis, Veerajalandhar Allareddy, Aparna Roy
OBJECTIVE: To evaluate the national trends in pediatric severe sepsis in the United States from 2003 to 2014. STUDY DESIGN: For this study, we included nonoverlapping years of Kids Inpatient database and National Inpatient Sample database while including hospitalizations of children between 1 and 20 years of age from more than 4200 hospitals across the United States. We identified patient hospitalizations with severe sepsis using specific ICD codes and modified Angus Criteria...
March 25, 2020: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/32221047/hdac6-promotes-sepsis-development-by-impairing-phb1-mediated-mitochondrial-respiratory-chain-function
#19
Shi-Dong Guo, Sheng-Tao Yan, Wen Li, Hong Zhou, Jian-Ping Yang, Yao Yao, Mei-Jia Shen, Liu-Wei Zhang, Hong-Bo Zhang, Li-Chao Sun
OBJECTIVE: This study was aimed at investigating the regulation of mitochondrial function by histone deacetylase 6 (HDAC6) and the role of HDAC6 in the development and progression of sepsis. RESULTS: HDAC6 downregulated PHB1 and subsequently promoted the development of CLP-induced sepsis. Inhibition of HDAC6 significantly attenuated CLP-induced sepsis through inhibition of mitochondrial dysfunction and reduced oxidant production, thus protecting the rats from oxidative injury...
March 28, 2020: Aging
https://read.qxmd.com/read/32220828/correction-towards-understanding-global-patterns-of-antimicrobial-use-and-resistance-in-neonatal-sepsis-insights-from-the-neoamr-network
#20
(no author information available yet)
No abstract text is available yet for this article.
March 27, 2020: Archives of Disease in Childhood
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