Epshita A Islam, Jamie E Fegan, Takele A Tefera, David M Curran, Regula C Waeckerlin, Dixon Ng, Sang Kyun Ahn, Chun Heng Royce Lai, Quynh Huong Nguyen, Megha Shah, Liyuwork Tesfaw, Kassaye Adamu, Wubet W Medhin, Abinet Legesse, Getaw Deresse, Belayneh Getachew, Neil Rawlyk, Brock Evans, Andrew Potter, Anthony B Schryvers, Scott D Gray-Owen, Trevor F Moraes
Pasteurella multocida can infect a multitude of wild and domesticated animals, with infections in cattle resulting in hemorrhagic septicemia (HS) or contributing to bovine respiratory disease (BRD) complex. Current cattle vaccines against P. multocida consist of inactivated bacteria, which only offer limited and serogroup specific protection. Here, we describe a newly identified surface lipoprotein, PmSLP, that is present in nearly all annotated P. multocida strains isolated from cattle. Bovine associated variants span three of the four identified phylogenetic clusters, with PmSLP-1 and PmSLP-2 being restricted to BRD associated isolates and PmSLP-3 being restricted to isolates associated with HS...
March 24, 2023: PLoS Pathogens