Fabiano Pinheiro da Silva, André Nicolau Aquime Gonçalves, Amaro Nunes Duarte-Neto, Thomaz Lüscher Dias, Hermes Vieira Barbeiro, Cristiane Naffah Souza Breda, Leandro Carvalho Dantas Breda, Niels Olsen Saraiva Câmara, Helder I Nakaya
Septic shock is a life-threatening clinical condition characterized by a robust immune inflammatory response to disseminated infection. Little is known about its impact on the transcriptome of distinct human tissues. To address this, we performed RNA sequencing of samples from the prefrontal cortex, hippocampus, heart, lung, kidney and colon of seven individuals who succumbed to sepsis and seven uninfected controls. We identified that the lungs and colon were the most affected organs. While gene activation dominated, strong inhibitory signals were also detected, particularly in the lungs...
September 20, 2023: Journal of Cellular and Molecular Medicine