Sten Rasmussen, Kristian Kjaer Petersen, Martin Kaae Kristiansen, Jakob Skallerup, Christopher Aboo, Mikkel Eggert Thomsen, Emilie Skjoldemose, Nia Kristine Jørgensen, Allan Stensballe, Lars Arendt-Nielsen
BACKGROUND: This exploratory study investigates if intra-articular injected gold microparticles in knee osteoarthritis (KOA) reduce immunomodulatory-based pain via proteomic changes in the synovial fluid (SF) and serum. METHODS: Thirty patients with moderate KOA were included. Intraarticular injections with 20 mg gold microparticles (72.000 particles, 20-40 µm in diameter) using the patient's synovial fluid (SF) as carrier were performed. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores for pain, stiffness, and function were assessed at inclusion, 8 weeks and 2 years The PainDetect questionnaire, pain pressure threshold (PPT), temporal summation (TS), and conditioned pain modulation (CPM), and pain diary were assessed at inclusion and 8 weeks...
April 2022: European Journal of Pain: EJP