Adelheid Weidinger, Nadja Milivojev, Arthur Hosmann, J Catharina Duvigneau, Csaba Szabo, Gabor Törö, Laurin Rauter, Annette Vaglio-Garro, Garik V Mkrtchyan, Lidia Trofimova, Rinat R Sharipov, Alexander M Surin, Irina A Krasilnikova, Vsevolod G Pinelis, Laszlo Tretter, Rudolf Moldzio, Hülya Bayır, Valerian E Kagan, Victoria I Bunik, Andrey V Kozlov
Brain injury is accompanied by neuroinflammation, accumulation of extracellular glutamate and mitochondrial dysfunction, all of which cause neuronal death. The aim of this study was to investigate the impact of these mechanisms on neuronal death. Patients from the neurosurgical intensive care unit suffering aneurysmal subarachnoid hemorrhage (SAH) were recruited retrospectively from a respective database. In vitro experiments were performed in rat cortex homogenate, primary dissociated neuronal cultures, B35 and NG108-15 cell lines...
March 11, 2023: Redox Biology