S Cabon, F Porée, G Cuffel, O Rosec, F Geslin, P Pladys, A Simon, G Carrault
BACKGROUND: In the European Union, 300,000 newborn babies are born prematurely every year. Their care is ensured in Neonatal Intensive Care Units (NICU) where vital signs are constantly monitored. In addition, other descriptors such as motion, facial and vocal activities have been shown to be essential to assess neurobehavioral development. AIM: In the scope of the European project Digi-NewB, we aimed to develop and evaluate a new audio-video device designed to non-invasively acquire multi-modal data (audio, video and thermal images), while fitting the wide variety of bedding environment in NICU...
January 5, 2021: Early Human Development
Bellami Kerin, Sanjeev Rajakulendran, Dimitri M Kullmann, Aidan Neligan, Matthew C Walker
PURPOSE: Over the last decade, the range of treatments available for the management of super-refractory status epilepticus (SRSE) has expanded. However, it is unclear whether this has had an impact on its high mortality and morbidity. The aim of this study was to investigate whether there has been a change in the outcome of SRSE over time in a neurological intensive care unit (ICU) within a tertiary centre. METHODS: Analysis of a retrospective cohort of 53 admissions from 45 patients to the neurological ICU at the National Hospital for Neurology and Neurosurgery, Queen Square, London, between January 2004 and September 2018...
January 4, 2021: Seizure: the Journal of the British Epilepsy Association
Anthony Cyr, Yanjun Zhong, Steven E Reis, Rami A Namas, Andrew Amoscato, Brian Zuckerbraun, Jason Sperry, Ruben Zamora, Yoram Vodovotz, Timothy R Billiar
BACKGROUND: Trauma is the leading cause of death and disability for individuals under age 55. Many severely injured trauma patients experience complicated clinical courses despite appropriate initial therapy. We sought to identify novel circulating metabolomic signatures associated with clinical outcomes following trauma. STUDY DESIGN: Untargeted metabolomics and circulating plasma immune mediator analysis was performed on plasma collected during three post-injury time periods (<6h, 6h-24h, D2-D5) in critically ill trauma patients enrolled between April 2004 and May 2013 at UPMC Presbyterian Hospital in Pittsburgh, PA...
January 13, 2021: Journal of the American College of Surgeons
Robert Jh Miller, Jonathan G Howlett, Nowell M Fine
The advent of newly available medical therapies for HFrEF has resulted in many potential therapeutic combinations, increasing treatment complexity. Publication of expert consensus guidelines and initiative aimed to improve treatment implementation have emphasized sequential, stepwise initiation and titration of medical therapy, which is labour intensive. Data taken from heart failure registries shows suboptimal use of medications, prolonged titration time and consequently little change in dose intensity, all of which, indicate therapeutic inertia...
January 13, 2021: Canadian Journal of Cardiology
Kendall A Ulbrich, Katelyn Zumpf, Jody D Ciolino, Malika Shah, Emily S Miller, Katherine L Wisner
OBJECTIVE: To determine whether full-term neonates with in utero exposure to selective serotonin reuptake inhibitors (SSRI) require respiratory support in the delivery room, as indicated by the standardized Neonatal Resuscitation Program [NRP] algorithm, significantly more often than non-exposed neonates. STUDY DESIGN: In this retrospective cohort study, we extracted data from medical records of full-term neonates with and without in utero SSRI exposure, defined as documentation of third trimester maternal SSRI treatment...
January 13, 2021: Journal of Pediatrics
Karen Harpster, Stephanie Merhar, Venkata Sita Priyanka Illapani, Colleen Peyton, Beth Kline-Fath, Nehal A Parikh
OBJECTIVE: To evaluate the prevalence and associations between structural MRI (sMRI) injury/abnormality at term equivalent age and absent fidgety General Movements Assessment (GMA) and abnormal Hammersmith Infant Neurological Examination (HINE) scores among very preterm infants at 3-4 months corrected age. STUDY DESIGN: This prospective cohort study enrolled 392 infants born ≤32 weeks' gestation from five neonatal intensive care units in the greater Cincinnati area between September 2016 and October 2019...
January 13, 2021: Journal of Pediatrics
Jinyu Liu
OBJECTIVES: Though many studies have explored differences between spouses and adult children in dementia care, empirical evidence is lacking on racial- and ethnic-minority populations. To fill this research gap, this study examined care tasks, caregiver burden, and depressive symptoms of Chinese spouse and adult-child caregivers in dementia care. Guided by the stress process model, this study asked 3 questions: Do spouse and adult-child caregivers take up different care tasks and experience different levels of caregiver burden and depressive symptoms? Does gender moderate the differences between spouse and adult-child caregivers? Whether care tasks and burden mediate the association between being a spouse/adult-child caregiver and depressive symptoms? SETTING AND PARTICIPANTS: Data were collected from a questionnaire-based survey of Chinese Americans who provided care for their family members with dementia in New York City...
January 13, 2021: Journal of the American Medical Directors Association
Chunmei Zhang, Xi Chen, Chao Wang, Yu Ran, Kai Sheng
Cardiomyocytes injury caused by sepsis is a complication of common clinical critical illness and an important cause of high mortality in intensive care unit (ICU) patients. Therefore, lipopolysaccharide (LPS)-induced H9c2 cells were used to simulate the cardiomyocytes injury in vitro. The aim of this study was to investigate whether X-box binding protein 1 (XBP1) exacerbated LPS-induced cardiomyocytes injury by downregulating Xlinked inhibitor of apoptosis protein (XIAP) through activating the NF-κB signaling pathway...
January 16, 2021: Inflammation
Maxens Decavèle, Aliénor Dreyfus, Nicolas Gatulle, Nicolas Weiss, Caroline Houillier, Sophie Demeret, Julien Mayaux, Isabelle Rivals, Martin Dres, Julie Delemazure, Elise Morawiec, Charles-Edouard Luyt, Khe Hoang-Xuan, Sylvain Choquet, Thomas Similowski, Alexandre Demoule
INTRODUCTION: To describe the reasons for intensive care unit (ICU) admission and to evaluate the outcomes and prognostic factors of patients with primary central nervous system lymphoma (PCNSL) admitted to the ICU. PATIENTS AND METHODS: Retrospective observational cohort study of 101 PCNSL patients admitted to 3 ICUs over a two-decade period. RESULTS: Acute respiratory failure, mainly secondary to aspiration pneumonia and Pneumocystis jirovecii pneumonia, was the leading reason for ICU admission (33%)...
January 16, 2021: Journal of Neurology
Ashok Kumar, Ravi Prakash Yadav, Sriparna Basu, T B Singh
OBJECTIVE: To compare the effect of suctioning first or drying first on the composite outcome of hypothermia or respiratory distress in depressed newborns requiring delivery room resuscitation. DESIGN: Open-label, randomized, parallel-group, controlled trial. SETTING: Delivery room and neonatal intensive care unit of a tertiary-care teaching hospital. PATIENTS: Depressed newborns (n=154) requiring initial steps of resuscitation at birth...
January 15, 2021: Indian Pediatrics
Sudha Rao, Vrushabh Gavali, Shakuntala S Prabhu, Radhika Mathur, Larissa Robert Dabre, Sanjay B Prabhu, Minnie Bodhanwala
OBJECTIVES: To study clinical characteristics and outcome of children with admitted to a paediatric hospital in Mumbai, India. METHODS: Review of medical records of 969 children admitted between 19 March and 7 August, 2020, to assess the clinico-demographic characteristics, disease severity and factors predicting outcome in COVID-19 children. Variables were compared between children who were previously healthy (Group I) and those with co-morbidity (Group II). RESULTS: 123 (71 boys) children with median (IQR) age of 3 (0...
January 11, 2021: Indian Pediatrics
Tsuei-Hung Wang, Lee-Wen Pai, Ya-Ling Tzeng, Tzu-Pei Yeh, Yu-Kuei Teng
AIM: To evaluate the effectiveness of nurses and midwives-led psychological interventions on the perinatal depressive symptoms. DESIGN: A systematic review and meta-analysis based on the PRISMA guidelines. METHODS: Six databases were searched, including PubMed, MEDLINE, Cochrane Library, EMBASE, Web of Science and CINAHL. The search date range was before 30 September 2019. We used the Cochrane risk of bias tool to evaluate the quality of the included studies and Review Manager software 5...
January 15, 2021: Nursing Open
Ravi Taneja, Robert Sibbald, Launa Elliott, Elizabeth Burke, Kristen A Bishop, Philip M Jones, Mark Goldszmidt
PURPOSE: A discordance, predominantly towards overtreatment, exists between patients' expressed preferences for life-sustaining interventions and those documented at hospital admission. This quality improvement study sought to assess this discordance at our institution. Secondary objectives were to explore if internal medicine (IM) teams could identify patients who might benefit from further conversations and if the discordance can be reconciled in real-time. METHODS: Two registered nurses were incorporated into IM teams at a tertiary hospital to conduct resuscitation preference conversations with inpatients either specifically referred to them (group I, n = 165) or randomly selected (group II, n = 164) from 1 August 2016 to 31 August 2018...
January 15, 2021: Canadian Journal of Anaesthesia
Thomas M Donaldson
Time-limited trials of intensive care have arisen in response to the increasing demand for intensive care treatment for patients with a low chance of surviving their critical illness, and the clinical uncertainty inherent in intensive care decision-making. Intensive care treatment is reported by most patients to be a significantly unpleasant experience. Therefore, patients who do not survive intensive care treatment are exposed to a negative dying experience. Time-limited trials of intensive care treatment in patients with a low chance of surviving have both a small chance of benefiting this patient group and a high chance of harming them by depriving them of a good death...
January 15, 2021: Medicine, Health Care, and Philosophy
Nahed Abdel-Haq, Basim I Asmar, Maria P Deza Leon, Eric J McGrath, Harbir S Arora, Katherine Cashen, Bradley Tilford, Ahmad Charaf Eddine, Usha Sethuraman, Jocelyn Y Ang
This study was conducted to assess the clinical spectrum, management, and outcome of SARS-CoV-2-related multisystem inflammatory syndrome in children (MIS-C). We reviewed medical records of children with MIS-C diagnosis seen at the Children's Hospital of Michigan in Detroit between April and June 2020. Thirty-three children were identified including 22 who required critical care (group 1) and 11 with less intense inflammation (group 2). Children in group 1 were older (median 7.0 years) than those in group 2 (median 2...
January 16, 2021: European Journal of Pediatrics
Amy E Peden, Pooria Sarrami, Michael Dinh, Christine Lassen, Benjamin Hall, Hatem Alkhouri, Lovana Daniel, Brian Burns
INTRODUCTION: Despite being a preventable cause of death, drowning is a global public health threat. Australia records an average of 288 unintentional drowning deaths per year; an estimated annual economic burden of $1.24 billion AUD ($2017). On average, a further 712 hospitalisations occur due to non-fatal drowning annually. The Australian state of New South Wales (NSW) is the most populous and accounts for 34% of the average fatal drowning burden. This study aims to explore the demographics and outcome of patients who are admitted to hospitals for drowning in NSW and also investigates prediction of patients' outcome based on accessible data...
January 15, 2021: BMJ Open
Anna L Funk, Todd A Florin, Stuart R Dalziel, Santiago Mintegi, Marina I Salvadori, Daniel Joseph Tancredi, Mark I Neuman, Daniel C Payne, Amy C Plint, Terry P Klassen, Richard Malley, Lilliam Ambroggio, Kelly Kim, Nathan Kuppermann, Stephen B Freedman
INTRODUCTION: Relatively limited data are available regarding paediatric COVID-19. Although most children appear to have mild or asymptomatic infections, infants and those with comorbidities are at increased risk of experiencing more severe illness and requiring hospitalisation due to COVID-19. The recent but uncommon association of SARS-CoV-2 infection with development of a multisystem inflammatory syndrome has heightened the importance of understanding paediatric SARS-CoV-2 infection...
January 15, 2021: BMJ Open
Januar Wibawa Martha, Arief Wibowo, Raymond Pranata
PURPOSE: This meta-analysis aimed to evaluate the prognostic performance of elevated lactate dehydrogenase (LDH) in patients with COVID-19. METHODS: A systematic literature search was performed using PubMed, Embase and EuropePMC on 19 November 2020. The outcome of interest was composite poor outcome, defined as a combined endpoint of mortality, severity, need for invasive mechanical ventilation and need for intensive care unit care. Severity followed the included studies' criteria...
January 15, 2021: Postgraduate Medical Journal
Henna Karoliina Ruutiainen, Miia Marjukka Kallio, Sini Karoliina Kuitunen
OBJECTIVES: Automated dispensing cabinets (ADCs) are used in hospitals to improve medication safety and decrease costs. However, ADCs do not completely eliminate the risk of mistakes between look-alike, sound-alike (LASA) medicines. The aim of this study was to identify the characteristics of LASA medicines and determine the factors related to their safe storage in ADCs. METHODS: The medication selection of one hospital pharmacy's ADC located in an intensive care unit was observed...
January 15, 2021: European Journal of Hospital Pharmacy. Science and Practice
Julia I Bandini, Alexis Coulourides Kogan, Bonnie Olsen, Jessica Phillips, Rebecca L Sudore, David B Bekelman, Sangeeta C Ahluwalia
BACKGROUND: Group visits have the potential to help patients identify their health care values and engage in the emotionally and cognitively challenging task of advance care planning (ACP) in a resource-efficient manner by providing a forum for social learning and social support. OBJECTIVE: To evaluate the feasibility and acceptability of disease-specific group visits for patients with heart failure and their caregivers. DESIGN: Feasibility trial of a 90-minute group visit held for 10 separate groups and led by a trained facilitator using the video-based PREPARE for Your Care ACP tool...
January 2021: Journal of the American Board of Family Medicine: JABFM
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