Emma C Hevia, Leslie Wooten, Amy L Carr
BACKGROUND: Stenotrophomonas maltophilia is an opportunistic, gram-negative bacillus with few therapeutic options due to a high level of intrinsic resistance. Trimethoprim/sulfamethoxazole (SXT) is recommended as the first-line treatment; however, minocycline (MIN) has been shown to have similar clinical outcomes in treating S. maltophilia and addresses concern for increasing resistance to SXT. OBJECTIVE: The objective of this study is to evaluate the efficacy and safety outcomes of nonurinary, monomicrobial infections due to S...
September 30, 2023: Annals of Pharmacotherapy
Shahnaz Rimaz, Parastoo Tajzadeh, Milad Bahrami, Mehdi Nooghabi, Babak Eshrati, Sohrab Effati, Maryam Yaghoobi
BACKGROUND: Healthcare-associated infections are a major cause of mortality worldwide, especially in intensive care units where severely ill patients have limited physical space. AIMS: To investigate the incidence, microbial aetiology, antimicrobial resistance profile, and mortality rate of healthcare-associated infections in intensive care units in the Islamic Republic of Iran. METHODS: This observational study retrospectively reviewed the medical records of 1722 intensive care units patients with confirmed healthcare-associated infections at hospitals affiliated with Mashhad University of Medical Sciences in 2017-2019...
September 9, 2023: Eastern Mediterranean Health Journal
Susana Arias-Rivera, María Nieves Moro-Tejedor, Marta Raurell-Torredà, Irene Cortés-Puch, Fernando Frutos-Vivar, Cristina Andreu-Vázquez, María Mar Sánchez-Sánchez, Raquel Sánchez-Izquierdo, Lorena Oteiza-López, Sonia López-Cuenca, Marta Checa-López, Raquel Jareño-Collado, Virginia López-López, Eva Isabel Sánchez-Muñoz, Luis Fernando Carrasco Rodríguez-Rey, María Jesús Frade-Mera, Rebeca Padilla-Peinado, Alejandro Huete-García, Amanda Lesmes-González Aledo, Federico Gordo-Vidal, Ana Rodríguez-Merino, Mónica Vázquez-Calatayud, Gloria Vázquez-Grande, Dolores Mateo, Raquel Herrero-Hernández
AIM: To translate and culturally adapt the FRAIL scale into Spanish and perform a preliminary test of diagnostic accuracy in patients admitted to intensive care units. DESIGN: Cross-sectional diagnostic study. METHODS: Five intensive care units (ICU) in Spain were participated. Stage 1: Three native Spanish-speaking bilingual translators familiar with the field of critical care translated the scale from English into Spanish. Stage 2: Three native English-speaking bilingual translators familiar with critical care medicine...
September 29, 2023: Nursing Open
Vahid Ghanbari, Alireza Khatony, Maryam Janatolmakan, Shahab Rezaeian, Leili Rostamnia
INTRODUCTION: COVID-19 rapidly spread throughout the world. Stay-at-home and social distance strategies accompanied by fear of contamination with COVID-19 caused significant disruptions in daily life. The study focused on the impact of the COVID-19 pandemic on emergency visit and patients' outcome in the emergency department (ED). METHOD: Administrative and clinical data of 25-hospital EDs in Kermanshah province of Iran from February 20, 2020, to February 18, 2021, were retrospectively analyzed with the comparable periods in the previous year...
September 29, 2023: BMC Emergency Medicine
Yu Zeng, Manping Qian, Xiaolin Yang, Qiang Gao, Chengxiao Zhang, Honglan Qi
An electrochemiluminescence (ECL) bioassay with high sensitivity and anti-fouling ability was developed for determination of matrix metalloproteinase 9 (MMP-9) secreted from living cells under external stimulation. A peptide with sequence of CLGRMGLPGK and a new cyclometalated iridium(III) complex bearing carboxyl group, (pq)2 Ir(dcbpy) (pq = 2-phenylquinoline, dcbpy = 2,2'-bipyridyl-4,4'-dicarboxyli acid, abbreviated as Ir) were employed as molecular recognition substrate and ECL emitter, respectively...
September 29, 2023: Mikrochimica Acta
L S Chew, X J Lim, C T Chang, R S Kamaludin, H L Leow, S Y Ong, N Saharuddin, N A Sanusi, N Kamaruzaman, Z Kamarruddin, R Philip
INTRODUCTION: Previous trials and real-world studies have shown that nirmatrelvir/ritonavir (Paxlovid®) reduces hospitalisation and deaths in symptomatic, high-risk, nonsevere COVID-19 patients. However, there was a scarcity of data on its effectiveness in the local setting. This study aimed to determine the effectiveness of Paxlovid® in reducing hospitalisation and mortality among COVID-19 patients and to identify the types of adverse events that occur after taking Paxlovid®...
September 2023: Medical Journal of Malaysia
Sheila A Boamah, Marie-Lee Yous, Harrison Gao, Rachel Weldrick, Vanina Dal Bello-Haas, Pamela Durepos
AIMS: To explore the lived experiences of caregivers of people living in long-term care (LTC) homes during the initial phases of the COVID-19 pandemic and potential supports and resources needed to improve caregivers' quality of life. BACKGROUND: Carers (or care partners) of adults in LTC contribute substantially to the health and well-being of their loved ones by providing physical care, emotional support and companionship. Despite their critical role, little is known about how caregivers have been impacted by the pandemic...
September 29, 2023: Journal of Advanced Nursing
F Alonso Lloret, S Gil Domínguez, V M Fontecha Merino, C Rodríguez Ferreiro, A Mendoza Soto
INTRODUCTION: Levels of stress and anxiety suffered by parents of children with congenital heart disease (PCUCS) during their children's admission for cardiac surgery may be higher than those suffered by other parents who go through the same experience. OBJECTIVE: General objective of this study was to measure the stress and anxiety suffered by PCUCS and parents of children undergoing renal surgery (PCURS) in relation to the intervention of their children. The specific objective of the quantitative study was to compare global stress and anxiety according to sex, time of the perioperative period, and cohort...
September 27, 2023: Enfermería intensiva
Camille S L Galloway, Deana Simonetto, Robert Shave, Ryan Wilson, Laura L Struik, Colin Wallace, John R Vyselaar, Jordan Webber, Kathy L Rush
BACKGROUND: Growing evidence indicates that chronic high-intensity endurance exercise predisposes male, middle-aged athletes to increased risk of atrial fibrillation (AF). The aetiology of AF in endurance athletes is multifactorial and remains incompletely understood. Despite their unique training demands, AF care in athletes remains largely based on evidence derived from the general population. Understanding the experiences of athletes with AF provides a necessary foundation for addressing challenges in managing their condition and identifying gaps in care...
September 27, 2023: Heart, Lung & Circulation
Andrea Heras, Rachel Chambers, Zenna Solomon, Lauren Blatt, Camilia R Martin
Premature births account for over 10% of live births worldwide. Bronchopulmonary dysplasia (BPD) represents a severe sequela in neonates born very prematurely and remains the most common chronic neonatal lung disease, often leading to serious adverse consequences in adulthood. Nutrition plays a crucial role in lung development and repair. Ongoing research has primarily focused on the pathogenesis and prevention of BPD in preterm birth. However, infants with established BPD need specialist medical care that persists throughout their hospitalization and continues after discharge...
September 9, 2023: Seminars in Perinatology
Rita Dadiz, Jesse Bender, Beverley Robin
In situ simulations, those conducted in the actual clinical environment, confer a high level of contextual fidelity and have been applied to the operations testing of new healthcare environments (HCE) to identify potential threats to patient, family and staff safety. By conducting simulation-based operations testing, these latent safety threats (LSTs) - which are weaknesses in communications, human factors, system process and technologies, and the way they are linked together - can be identified and corrected prior to moving patients into the new HCE...
September 20, 2023: Seminars in Perinatology
Jack C Pluenneke, Adham M Mohamed, Charles H Hayes, Timothy P Berry, Elizabeth L Thomas, Larisa Zhurav, Jonathan B Kozinn, Michelle M Haines, Julie A Welge
OBJECTIVES: To describe cangrelor use in patients on concurrent mechanical circulatory support who underwent postpercutaneous coronary intervention. DESIGN: A single-center, retrospective, cohort study. SETTING: At a quaternary teaching hospital. PARTICIPANTS: Included patients were ≥18 years old, admitted to the intensive care unit, underwent percutaneous coronary intervention with stent placement, initiated on mechanical circulatory support, and received cangrelor in the postpercutaneous coronary intervention period...
September 6, 2023: Journal of Cardiothoracic and Vascular Anesthesia
Brenda Hiu Yan Law, Georg M Schmölzer
OBJECTIVE: Mask positive pressure ventilation (PPV) in the delivery room is routinely delivered with set peak inflation pressures. To aid mask PPV, stand-alone respiratory function monitors (RFMs) have been used in the delivery room, while ventilator-based, volume-targeted ventilation (VTV) is routinely used in the neonatal intensive care unit (NICU). DESIGN: This is a prospective, randomised, crossover simulation study. Participants were briefly trained to use a neonatal ventilator for volume-targeted mask ventilation (VTV-PPV), then performed mask ventilation on a manikin in a randomised order using VTV-PPV, T-piece PPV or T-piece PPV with RFM visible...
September 29, 2023: Archives of Disease in Childhood. Fetal and Neonatal Edition
Samanta Rj, Ercole A, Harris S, Summers C
BACKGROUND: Low tidal volume mechanical ventilation (LTVV; <8 mLkg-1 predicted body weight) is a well-established standard of care associated with better outcomes. We used data collated in multi-centre, electronic health record ICU databases from the UK and USA to study the use of LTVV in routine clinical practice. RESEARCH QUESTION: What were the factors associated with adherence to LTVV in the United Kingdom and North America? STUDY DESIGN: Retrospective, multi-centre study of mechanically ventilated patients across the UK and USA...
September 27, 2023: Chest
Hugo Bellut, Marine Arrayago, Marlène Amara, Ariane Roujansky, Maité Micaelo, Fabrice Bruneel, Jean-Pierre Bedos
Ceftobiprole (CBP) is an anti-methicillin-resistant Staphylococcus aureus (MRSA) cephalosporin with a wide spectrum of activity. We aimed to describe our experience of real-life use of CBP for the treatment of severe infections of critically ill patients with multiple infected sites and related trough CBP concentrations. We performed a retrospective, observational, monocentric study in our intensive care unit (ICU) that included all patients treated with CBP for documented infections between January 2016 and December 2021...
September 27, 2023: Infectious diseases now
Shuang Liu, Pin Chen, Hantao Yang, Tao Xie, Tengfei Liu, Chen Li, Liangliang Yang, Zeyang Li, Jinlong Huang, Yang Gao, Qiang Xie, Yong Yu, Fan Hu, Xiaobiao Zhang
BACKGROUND: Patients with pulvinar area lesions may develop hydrocephalus at any stage. The role of endoscopic third ventriculostomy (ETV) in this setting remains unclear. METHOD: We retrospectively enrolled 15 patients with a mean age of 43 years who underwent endoscopic resection of pulvinar area lesions using the supracerebellar infratentorial approach (SCITA). We compared the different modalities of hydrocephalus management and their outcomes. RESULTS: Nine of 15 patients (60...
September 27, 2023: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Junko Fujiyoshi, Hirosuke Inoue, Toru Sawano, Yuichi Mushimoto, Yoshitomo Motomura, Kei Nishiyama, Noriyuki Kaku, Hazumu Nagata, Kenichiro Yamamura, Masataka Ishimura, Yuhki Koga, Masayuki Ochiai, Yasunari Sakai, Tatsuro Tajiri, Shouichi Ohga
INTRODUCTION: To establish actionable neonatal screening during the first month of life, we investigated critical diseases in seemingly healthy newborns discharged from birth hospitals. METHODS: This retrospective study enrolled previously healthy full-term infants who visited our hospital, a tertiary hospital in Japan, from home between 5 and 28 days after birth from 2009 to 2018. Infants with known perinatal or congenital diseases, positive newborn screening results, or accidental injuries were excluded...
September 26, 2023: Early Human Development
Joep J J Ouwerkerk, Elaine P X van Ee, Tommy A Brown, Ander Dorken-Gallastegi, Anthony Gebran, Dias Argandykov, Jefferson A Proaño-Zamudio, John O Hwabejire, Haytham M A Kaafarani, George C Velmahos, Jonathan Parks
INTRODUCTION: Current guidelines for retained hemothorax (rHTX) in trauma patients recommend video-assisted thoracic surgery (VATS) within 4 days. However, this recommendation is currently based upon evidence from small observational studies. The aim of this study is to further evaluate the association between timing of VATS and clinical outcomes in rHTX following trauma. METHODS: Using the 2017-2019 Trauma Quality Improvement Program database, adult (≥15 years-old) trauma patients with rHTX who underwent evacuation of rHTX through VATS were included...
September 27, 2023: Journal of Surgical Research
Kian C Banks, Colin M Mooney, Nathan J Alcasid, Cynthia J Susai, Kirea Mazzolini, Timothy D Browder, Gregory P Victorino
INTRODUCTION: Concurrent colonic injury among patients with gunshot-related fractures presents a potential risk for infectious complications. We hypothesized that colon injuries are associated with more infectious orthopedic complications among gunshot victims with concurrent fractures. MATERIALS AND METHODS: We reviewed trauma patients arriving at our level 1 trauma center from January 1, 2019 to May 31, 2022 who suffered any gunshot-related fracture and also underwent an exploratory laparotomy...
September 27, 2023: Journal of Surgical Research
Qiuxia Zhang, Khuan Lee, Zawiah Mansor, Iskasymar Ismail, Yi Guo, Qiao Xiao, Poh Ying Lim
BACKGROUND: Despite the widespread adoption of the rapid response team (RRT) by many hospitals, questions remain regarding their effectiveness in improving several aspects of patient outcomes, such as hospital mortality, cardiopulmonary arrests, unplanned intensive care unit (ICU) admissions, and length of stay (LOS). OBJECTIVES: To conduct a systematic review to understand the rapid response team's (RRT) effect on patient outcomes. METHODS: A systematic search was conducted using PubMed, Cochrane, Embase, CINAHL, Web of Science, and two trial registers...
September 27, 2023: Heart & Lung: the Journal of Critical Care
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.