Arianna Polverino, Emahnuel Troisi Lopez, Roberta Minino, Marianna Liparoti, Antonella Romano, Francesca Trojsi, Fabio Lucidi, Leonardo Gollo, Viktor Jirsa, Giuseppe Sorrentino, Pierpaolo Sorrentino
BACKGROUND AND OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a multisystem disorder, as supported by clinical, molecular and neuroimaging evidence. As a consequence, predicting clinical features requires a description of large-scale neuronal dynamics. Normally, brain activity dynamically reconfigures over time, recruiting different brain areas. Brain pathologies induce stereotyped dynamics which, in turn, are linked to clinical impairment. Hence, based on recent evidence showing that brain functional networks become hyper-connected as ALS progresses, we hypothesized that the loss of flexible dynamics in ALS would predict the symptoms severity...
September 30, 2022: Neurology