keyword
https://read.qxmd.com/read/38352721/how-accurate-are-coordinate-systems-being-used-for-transcranial-magnetic-stimulation
#21
JOURNAL ARTICLE
Maria Anabel Uehara, Natasha Jacobson, Zahra Moussavi
When applying transcranial magnetic stimulation (TMS) to the brain, it is desired to be as precise as possible to reach a target area in the brain. For that, neuronavigational system using individuals' MRI scans were developed to guide TMS pulses delivery. All neuronavigational systems need coordinates of the target area to guide the TMS coil. Talairach coordinate system, which uses the Talairach-Tournoux atlas, is the most common system used with TMS pulses. In this study we investigated how an average Talairach coordinate from 50 healthy individuals is close to the actual location of the hand area of the primary motor cortex to investigate if that elicit a motor response in the hand; thus, investigating the fitness and accuracy of the Talairach coordinate system...
2024: Frontiers in Human Neuroscience
https://read.qxmd.com/read/38339559/two-stage-atomic-decomposition-of-multichannel-eeg-and-the-previously-undetectable-sleep-spindles
#22
JOURNAL ARTICLE
Piotr Durka, Marian Dovgialo, Anna Duszyk-Bogorodzka, Piotr Biegański
We propose a two-step procedure for atomic decomposition of multichannel EEGs, based upon multivariate matching pursuit and dipolar inverse solution, from which atoms representing relevant EEG structures are selected according to prior knowledge. We detect sleep spindles in 147 polysomnographic recordings from the Montreal Archive of Sleep Studies. Detection is compared with human scorers and two state-of-the-art algorithms, which find only about a third of the structures conforming to the definition of sleep spindles and detected by the proposed method...
January 28, 2024: Sensors
https://read.qxmd.com/read/38334651/postnatal-dynamic-ciliary-arl13b-and-adcy3-localization-in-the-mouse-brain
#23
JOURNAL ARTICLE
Katlyn K Brewer, Kathryn M Brewer, Tiffany T Terry, Tamara Caspary, Christian Vaisse, Nicolas F Berbari
Primary cilia are hair-like structures found on nearly all mammalian cell types, including cells in the developing and adult brain. A diverse set of receptors and signaling proteins localize within cilia to regulate many physiological and developmental pathways, including the Hedgehog (Hh) pathway. Defects in cilia structure, protein localization, and function lead to genetic disorders called ciliopathies, which present with various clinical features that include several neurodevelopmental phenotypes and hyperphagia-associated obesity...
January 30, 2024: Cells
https://read.qxmd.com/read/38318552/future-of-artificial-intelligence-in-surgery-a-narrative-review
#24
REVIEW
Aamir Amin, Swizel Ann Cardoso, Jenisha Suyambu, Hafiz Abdus Saboor, Rayner P Cardoso, Ali Husnain, Natasha Varghese Isaac, Haydee Backing, Dalia Mehmood, Maria Mehmood, Abdalkareem Nael Jameel Maslamani
Artificial intelligence (AI) is the capability of a machine to execute cognitive processes that are typically considered to be functions of the human brain. It is the study of algorithms that enable machines to reason and perform mental tasks, including problem-solving, object and word recognition, and decision-making. Once considered science fiction, AI today is a fact and an increasingly prevalent subject in both academic and popular literature. It is expected to reshape medicine, benefiting both healthcare professionals and patients...
January 2024: Curēus
https://read.qxmd.com/read/38286420/design-synthesis-and-in-vitro-evaluation-of-levodopa-stearic-acid-hydrazide-conjugate-for-the-management-of-parkinson-s-diseasenovel-conjugate-for-parkinson-s-disease
#25
JOURNAL ARTICLE
Vasanthi Chinraj, Ramakkamma Aishwarya Reddy, Jubie Selvaraj, Raman Sureshkumar
Parkinson's disease is the highest prevalent neurodegenerative disease in elderly individuals after Alzheimer's disease. The pathological identification for Parkinson's disease is loss of dopaminergic neurons in substantia nigra region of the brain that in turn leads to dopamine deficiency that affects the body's normal physiological and neurological disorder. The important drawback in the modality of treatment is levodopa is only supplying depleted dopamine in the brain, it does not affect neurodegeneration...
January 29, 2024: Drug Research
https://read.qxmd.com/read/38279302/ubiquitin-carboxyl-terminal-hydrolase-l1-and-its-role-in-parkinson-s-disease
#26
REVIEW
Olga Buneeva, Alexei Medvedev
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1), also known as Parkinson's disease protein 5, is a highly expressed protein in the brain. It plays an important role in the ubiquitin-proteasome system (UPS), where it acts as a deubiquitinase (DUB) enzyme. Being the smallest member of the UCH family of DUBs, it catalyzes the reaction of ubiquitin precursor processing and the cleavage of ubiquitinated protein remnants, thus maintaining the level of ubiquitin monomers in the brain cells. UCHL1 mutants, containing amino acid substitutions, influence catalytic activity and its aggregability...
January 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38258064/systemic-and-brain-pharmacokinetics-of-milnacipran-in-mice-comparison-of-intraperitoneal-and-intravenous-administration
#27
JOURNAL ARTICLE
Sounak Bagchi, Ehsan Nozohouri, Yeseul Ahn, Dhavalkumar Patel, Ulrich Bickel, Vardan T Karamyan
Milnacipran is a dual serotonin and norepinephrine reuptake inhibitor, clinically used for the treatment of major depression or fibromyalgia. Currently, there are no studies reporting the pharmacokinetics (PK) of milnacipran after intraperitoneal (IP) injection, despite this being the primary administration route in numerous experimental studies using the drug. Therefore, the present study was designed to investigate the PK profile of IP-administered milnacipran in mice and compare it to the intravenous (IV) route...
December 29, 2023: Pharmaceutics
https://read.qxmd.com/read/38248864/thyroid-hormone-metabolites-quantified-in-pup-and-adult-rat-cerebellum-cortex-and-whole-brain-samples-using-an-automated-online-spe-lc-ms-ms-method
#28
JOURNAL ARTICLE
Christiane Hindrichs, Tilmann Walk, Robert Landsiedel, Hennicke Kamp, Steffen Schneider, Stephanie Melching-Kollmuss, Dorothee Funk-Weyer
Changes in thyroid hormone (TH) levels in rat brain at early developmental stages are correlated with adverse effects on offspring development. To characterize the ability of substances to interfere with the TH concentrations in, e.g., rat brain, it is essential to know the mean TH concentrations in this tissue under control conditions. In this publication, an online solid-phase extraction (SPE) liquid chromatography (LC) tandem mass spectrometry (MS/MS) method was validated and used to measure TH metabolites (T4, T3, rT3, T2 and T1) in the brains of untreated rats...
January 17, 2024: Metabolites
https://read.qxmd.com/read/38248288/artificial-intelligence-s-transformative-role-in-illuminating-brain-function-in-long-covid-patients-using-pet-fdg
#29
JOURNAL ARTICLE
Thorsten Rudroff
Cutting-edge brain imaging techniques, particularly positron emission tomography with Fluorodeoxyglucose (PET/FDG), are being used in conjunction with Artificial Intelligence (AI) to shed light on the neurological symptoms associated with Long COVID. AI, particularly deep learning algorithms such as convolutional neural networks (CNN) and generative adversarial networks (GAN), plays a transformative role in analyzing PET scans, identifying subtle metabolic changes, and offering a more comprehensive understanding of Long COVID's impact on the brain...
January 10, 2024: Brain Sciences
https://read.qxmd.com/read/38226128/fahr-syndrome-when-dysarthria-doesn-t-mean-a-stroke
#30
Daniela Casanova, Ana L Ferreira, Ana Sá, Isabel Trindade, Jorge Cotter
Fahr syndrome is a rare neurodegenerative disorder, characterized by calcium deposition in the brain. It is usually associated with phosphocalcium metabolism disorders, like hypoparathyroidism, or with genetical predisposition, as seen in Fahr disease. Given the wide array of differential diagnoses medical awareness should be emphasized to prompt diagnosis and management. In this case, we depict a classical presentation of Fahr syndrome, highlighting the differential diagnosis with stroke given the similar clinical signs and symptoms, although pointing out the distinct radiological presentation that raises clinical suspicion for this entity...
December 2023: Curēus
https://read.qxmd.com/read/38215500/is-simultaneous-occurrence-of-meningioma-and-glioblastoma-a-mere-coincidence
#31
REVIEW
Oday Atallah, Yasser F Almealawy, Wireko Andrew Awuah, Alfredo Conti, Bipin Chaurasia
BACKGROUND: It is extremely unusual for multiple tumors to arise from different cell types and occur at the same time inside the brain. It is still unknown whether or not the coexistence of meningioma and glioblastoma is connected in any way or if their simultaneous appearance is merely a coincidence. OBJECTIVE: We conduct a comprehensive literature review on cases of concurrent meningioma and glioblastoma occurrence to elucidate the underlying concepts that may constitute this coexistence...
January 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38206785/a-closed-formalism-for-anatomy-independent-projection-and-optimization-of-magnetic-stimulation-coils-on-arbitrarily-shaped-surfaces
#32
JOURNAL ARTICLE
Max Koehler, Stefan M Goetz
INTRODUCTION: Transcranial magnetic stimulation (TMS) is a popular method for the noninvasive stimulation of neurons in the brain. It has become a standard instrument in experimental brain research and has been approved for a range of diagnostic and therapeutic applications. These applications require appropriately shaped coils. Various applications have been established or approved for specific coil designs with their corresponding spatial electric field distributions. However, the specific coil implementation may no longer be appropriate from the perspective of available material and manufacturing opportunities or considering the latest understanding of how to achieve induced electric fields in the head most efficiently...
January 11, 2024: IEEE Transactions on Bio-medical Engineering
https://read.qxmd.com/read/38195076/case-report-durable-response-of-gliomatosis-cerebri-with-concurrent-tumor-treating-fields-ttfields-and-chemoradiotherapy-treatment
#33
Alex M DesJarlais, Ryan Miller, Ayesha S Ali, Muneeb Z Niazi, Louis Cappelli, Jon Glass, Christopher J Farrell, Wenyin Shi
BACKGROUND: Gliomatosis cerebri (GC) is a rare and aggressive form of widely disseminated glioma infiltrating at least 3 lobes of the brain. It is a diffuse pattern of growth seen in glioma rather than a distinct pathological diagnosis based on new Word Health Organization (WHO) classification. Despite this, it is associated with worse prognosis than equally graded gliomas. Tumor treating fields (TTFields) treatment is a more recent advancement in glioma treatment delivered through low energy, intermediate frequency (200 kHz) electromagnetic fields, with multi-modal mechanisms of action...
December 2023: Chinese Clinical Oncology
https://read.qxmd.com/read/38185093/a-study-on-the-possible-neurotoxic-effects-of-cumyl-4cn-binaca-in-sprague-dawley-rats
#34
JOURNAL ARTICLE
Ayşe Lafzi, Tuba Demirci, Neslihan Yüce, Ebru Annaç, Mustafa Çiçek, Turgay Şişman
Substances such as Δ9-tetrahydrocannabinol (THC) and cannabidiol cross the blood-brain barrier. Detecting the damage of these substances in the brain provides important data in drug abuse studies. The aim of the study is to define the neurotoxicity of a novel synthetic cannabinoid (CUMYL-4CN-BINACA) in the Sprague-Dawley rats. Histopathological, immunohistochemical, behavioral, and biochemical examinations were performed to determine the acute and subacute toxicity of the cannabinoid. Three cannabinoid doses were administered for 2 days in the acute exposure groups and 14 days in the subacute exposure groups...
December 29, 2023: Legal Medicine
https://read.qxmd.com/read/38176937/positron-emission-tomography-molecular-imaging-of-the-major-neurodegenerative-disorders-overview-and-pictorial-essay-from-a-nuclear-medicine-center-s-perspective
#35
REVIEW
Ferdinando Calabria, Mario Leporace, Andrea Cimini, Maria Ricci, Laura Travascio, Antonio Bagnato
Computed tomography (CT) and magnetic resonance imaging (MRI) provide key structural information on brain pathophysiology. Positron emission tomography (PET) measures metabolism in the living brain; it plays an important role in molecular neuroimaging and is rapidly expanding its field of application to the study of neurodegenerative diseases. Different PET radiopharmaceuticals allow in vivo characterization and quantization of biological processes at the molecular and cellular levels, from which many neurodegenerative diseases develop...
December 13, 2023: Journal of Integrative Neuroscience
https://read.qxmd.com/read/38162471/-adansonia-digitata-l-stem-bark-attenuates-epileptic-seizure-depression-and-neurodegeneration-by-mediating-gaba-and-glutamate-in-pentylenetetrazol-kindled-rats
#36
JOURNAL ARTICLE
Adamu Muhammad, Luteino Lorna Hamman, Samaila Musa Chiroma, Martha Orendu Oche Attah, Nathan Isaac Dibal
OBJECTIVES: Epilepsy is a neurological condition characterized by repeated seizures attributable to synchronous neuronal activity in the brain. The study evaluated the effect of acetone extract of Adansonia digitata stem bark (ASBE) on seizure score, cognition, depression, and neurodegeneration as well as the level of Gamma-Aminobutyrate acid (GABA) and glutamate in Pentylenetetrazol-kindled rats. METHODS: Thirty-five rats were assigned into five groups (n = 7)...
December 31, 2023: Journal of Pharmacopuncture
https://read.qxmd.com/read/38156176/the-utility-of-artificial-intelligence-in-the-diagnosis-and-management-of-pancreatic-cancer
#37
REVIEW
Vikash Kumar, Mrunanjali Gaddam, Amr Moustafa, Rabia Iqbal, Dhir Gala, Mili Shah, Vijay Reddy Gayam, Praneeth Bandaru, Madhavi Reddy, Vinaya Gadaputi
Artificial intelligence (AI) has made significant advancements in the medical domain in recent years. AI, an expansive field comprising Machine Learning (ML) and, within it, Deep Learning (DL), seeks to emulate the intricate operations of the human brain. It examines vast amounts of data and plays a crucial role in decision-making, overcoming limitations related to human evaluation. DL utilizes complex algorithms to analyze data. ML and DL are subsets of AI that utilize hard statistical techniques that help machines consistently improve at tasks with experience...
November 2023: Curēus
https://read.qxmd.com/read/38151352/-neurovascular-coupling-responses-and-cognitive-function-the-impact-of-aging-and-the-interventional-effect-of-exercise
#38
JOURNAL ARTICLE
Yi-Min He, Chun-Li Wu, Yu-Mo Dong, Hua-Duo Wu, Qian Wang, Ning Jiang
Aging is a natural process accompanied with a progressive deterioration of cognitive functions. With an aging population, more and more elderly people are suffering from cognitive impairment. Previous studies have paid more attention to the impact of inflammation and oxidative stress on cognitive function during aging. Recently, it has been discovered that neurovascular coupling (NVC), a mechanism regulating cerebral blood flow, may play a significant role in aging-related cognitive impairment. NVC responses regulate the supply of energy substances and oxygen during brain activity, which in turn enhances cognitive function...
December 25, 2023: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://read.qxmd.com/read/38117395/unveiling-the-psychedelic-journey-an-appraisal-of-psilocybin-as-a-profound-antidepressant-therapy
#39
REVIEW
Fatima Iftikhar Shah, Somia Shehzadi, Fatima Akram, Ikram Ul Haq, Benish Javed, Sadeed Sabir, Yasha Kazim, Sehrish Ashfaq
Depression, a global health concern with significant implications for suicide rates, remains challenging to treat effectively with conventional pharmacological options. The existing pharmaceutical interventions for these illnesses need daily dosing, are accompanied by various adverse effects, and may exhibit limited efficacy in certain cases. However, hope emerges from an unlikely source-Psilocybin, a natural hallucinogen found in certain mushrooms. Recently, this enigmatic compound has garnered attention for its potential therapeutic benefits in addressing various mental health issues, including depression...
December 20, 2023: Molecular Biotechnology
https://read.qxmd.com/read/38108213/treatment-of-preterm-brain-injury-via-gut-microbiota-metabolite-brain-axis
#40
REVIEW
Ling Li, Tianjing Liu, Yongyan Shi
BACKGROUND: Brain injury in preterm infants potentially disrupts critical structural and functional connective networks in the brain. It is a major cause of neurological sequelae and developmental deficits in preterm infants. Interesting findings suggest that the gut microbiota (GM) and their metabolites contribute to the programming of the central nervous system (CNS) during developmental stages and may exert structural and functional effects throughout the lifespan. AIM: To summarize the existing knowledge of the potential mechanisms related to immune, endocrine, neural, and blood-brain barrier (BBB) mediated by GM and its metabolites in neural development and function...
December 18, 2023: CNS Neuroscience & Therapeutics
keyword
keyword
12087
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.