Nicole S Coverdale, Allen A Champagne, Matti Douglas Allen, Joshua C Tremblay, Tarrah S Ethier, Juan Fernandez-Ruiz, Rory A Marshall, Rebecca E K MacPherson, Kyra E Pyke, Douglas J Cook, T Dylan Olver
The aim of this study was to investigate how aging affects blood flow and structure of the brain. It was hypothesized older individuals would have lower grey matter volume (GMV), resting cerebral blood flow (CBF0 ), and depressed responses to iso-metabolic and neuro-metabolic stimuli. Additionally, increased carotid-femoral pulse wave velocity (PWV), carotid intima-media thickness (IMT), and decreased brachial flow-mediated dilation (FMD) would be associated with lower CBF0 , cerebrovascular reactivity (CVR) and GMV...
February 26, 2024: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology