Yuan Tao, Bronte Ficek, Zeyi Wang, Brenda Rapp, Kyrana Tsapkini
Objective: Transcranial direct current stimulation (tDCS) has shown promising results when used as an adjunct to behavioral training in neurodegenerative diseases. However, the underlying neural mechanisms are not understood and neuroimaging evidence from pre/post treatment has been sparse. In this study, we examined tDCS-induced neural changes in a language intervention study for primary progressive aphasia (PPA), a neurodegenerative syndrome with language impairment as the primary clinical presentation...
2021: Frontiers in Aging Neuroscience
Kristin M Schaffer, William S Evans, Christina D Dutcher, Christina Philburn, Maya L Henry
Purpose This study sought to determine the initial feasibility and benefit of a novel intervention that combines speech-language treatment with counseling treatment for an individual with the nonfluent/agrammatic variant of primary progressive aphasia (PPA). Method Using a single-case experimental design, we evaluated the utility of modified script training paired with aphasia-modified cognitive behavioral therapy. The study employed a multiple baseline design across scripts for the primary linguistic outcome measure and a mixed methods approach for analyzing counseling outcomes...
July 27, 2021: American Journal of Speech-language Pathology
Eun-Joo Kim, Seong-Ho Koh, Jungsoon Ha, Duk L Na, Sang Won Seo, Hee-Jin Kim, Kyung Won Park, Jae-Hong Lee, Jee Hoon Roh, Jay C Kwon, Soo Jin Yoon, Na-Yeon Jung, Jee H Jeong, Jae-Won Jang, Hee-Jin Kim, Kee Hyung Park, Seong Hye Choi, SangYun Kim, Young Ho Park, Byeong C Kim, Young-Eun Kim, Hyuk Sung Kwon, Hyun-Hee Park, Jeong-Hwa Jin
BACKGROUND: Telomeres are repetitive DNA sequences of TTAGGG at the ends of chromosomes. Many studies have shown that telomere shortening is associated with aging-related diseases, such as cardiovascular diseases, hypertension, diabetes, cancer, and various neurodegenerative diseases, including Alzheimer's disease, vascular dementia, Parkinson's disease, and dementia with Lewy bodies. However, changes in telomere length (TL) in patients with frontotemporal dementia (FTD) syndrome are unclear...
July 3, 2021: Journal of the Neurological Sciences
David Foxe, Muireann Irish, Mirelle D'Mello, Lucienne Barhon, James R Burrell, Roy P C Kessels, Olivier Piguet
OBJECTIVE: Differentiating the primary progressive aphasia (PPA) variants in clinical settings remains complex and challenging, especially for the logopenic (lv-PPA) and non-fluent variants (nfv-PPA). Recent studies suggest that visuospatial memory is more compromised in lv-PPA than in nfv-PPA and is relatively spared in the semantic variant (sv-PPA). Accordingly, assessment of visuospatial memory performance may assist in the differential diagnosis of PPA variants. Here, we investigated the utility of a novel computerised visuospatial working memory test-the Box Task-to differentiate the three PPA variants and typical Alzheimer's disease (AD)...
July 26, 2021: European Journal of Neurology
Nahuel Magrath Guimet, Bruce L Miller, Ricardo F Allegri, Katherine P Rankin
Behavioral variant frontotemporal dementia, unlike other forms of dementia, is primarily characterized by changes in behavior, personality, and language, with disinhibition being one of its core symptoms. However, because there is no single definition that captures the totality of behavioral symptoms observed in these patients, disinhibition is an umbrella term used to encompass socially disruptive or morally unacceptable behaviors that may arise from distinct neural etiologies. This paper aims to review the current knowledge about behavioral disinhibition in this syndrome, considering the cultural factors related to our perception of behavior, the importance of phenomenological interpretation, neuroanatomy, the brain networks involved and, finally, a new neuroscientific theory that offers a conceptual framework for understanding the diverse components of behavioral disinhibition in this neurodegenerative disorder...
2021: Frontiers in Neurology
Lina Velilla, Jonathan Hernández, Margarita Giraldo-Chica, Edmarie Guzmán-Vélez, Yakeel Quiroz, Francisco Lopera
The differential diagnosis among the behavioral variant of frontotemporal dementia FTD (bvFTD) and the linguist one primary progressive aphasia (PPA) is challenging. Presentations of dementia type or variants dominated by personality change or aphasia are frequently misinterpreted as psychiatric illness, stroke, or other conditions. Therefore, it is important to identify cognitive tests that can distinguish the distinct FTD variants to reduce misdiagnosis and best tailor interventions. We aim to examine the discriminative capacity of the most frequently used cognitive tests in their Spanish version for the context of dementia evaluation as well as the qualitative aspects of the neuropsychological performance such as the frequency and type of errors, perseverations, and false positives that can best discriminate between bvFTD and PPA...
2021: Frontiers in Neurology
Angelina J Polsinelli, Mary M Machulda, Peter R Martin, Joseph R Duffy, Heather M Clark, Alissa M Butts, Hugo Botha, Val J Lowe, Jennifer L Whitwell, Keith A Josephs, Rene L Utianski
OBJECTIVE: To characterize and compare the neuropsychological profiles of patients with primary progressive apraxia of speech (PPAOS) and apraxia of speech with progressive agrammatic aphasia (AOS-PAA). METHOD: Thirty-nine patients with PPAOS and 49 patients with AOS-PAA underwent formal neurological, speech, language, and neuropsychological evaluations. Cognitive domains assessed included immediate and delayed episodic memory (Wechsler Memory Scale-Third edition; Logical Memory; Visual Reproduction; Rey Auditory Verbal Learning Test), processing speed (Trail Making Test A), executive functioning (Trail Making Test B; Delis-Kaplan Executive Functioning Scale - Sorting), and visuospatial ability (Rey-Osterrieth Complex Figure copy)...
July 22, 2021: Journal of the International Neuropsychological Society: JINS
Michael Guger, Stefan Raschbacher, Lukas Kellermair, Milan R Vosko, Christian Eggers, Thomas Forstner, Karin Leitner, Alexandra Fuchs, Franz Fellner, Gerhard Ransmayr
Studies on caregiver burden in patients with frontotemporal lobar degeneration are rare, differ methodologically and show variable results. Single center longitudinal pilot study on caregiver burden and potential risk factors in patients with behavioural variant frontotemporal dementia (bvFTD) and semantic (svPPA) and non-fluent variants (nfvPPA) primary progressive aphasia. Forty-six bvFTD, nine svPPA, and six nfvPPA patients and caring relatives were analysed for up to 2 years using the Mini-Mental State Examination as global measure for cognitive performance, Frontal Assessment Battery (frontal lobe functions), Frontal Behavioural Inventory (personality and behaviour), Neuropsychiatric Inventory (dementia-related neuropsychiatric symptoms), Barthel Index and Lawton IADL Scale (basic and instrumental activities of daily living), the Caregiver Strain Index (CSI), and in most participants also the Zarit Burden Interview (ZBI)...
July 19, 2021: Journal of Neural Transmission
Katerina A Tetzloff, Joseph R Duffy, Edythe A Strand, Mary M Machulda, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Keith A Josephs, Jennifer L Whitwell
BACKGROUND: Posterior cortical atrophy (PCA) is an atypical variant of Alzheimer's disease (AD) that presents with visuospatial/perceptual deficits. PCA is characterized by atrophy in posterior brain regions, which overlaps with atrophy occurring in logopenic variant of primary progressive aphasia (lvPPA), another atypical AD variant characterized by language difficulties, including phonological errors. Language abnormalities have been observed in PCA, although the prevalence of phonological errors is unknown...
July 16, 2021: Dementia and Geriatric Cognitive Disorders
Winson F Z Yang, Gianina Toller, Suzanne Shdo, Sonja A Kotz, Jesse Brown, William W Seeley, Joel H Kramer, Bruce L Miller, Katherine P Rankin
OBJECTIVE: Structural and task-based functional studies associate emotion reading with frontotemporal brain networks, though it remains unclear whether functional connectivity (FC) alone predicts emotion reading ability. The predominantly frontotemporal salience and semantic appraisal (SAN) networks are selectively impacted in neurodegenerative disease syndromes like behavioral-variant frontotemporal dementia (bvFTD) and semantic-variant primary progressive aphasia (svPPA). Accurate emotion identification diminishes in some of these patients, but studies investigating the source of this symptom in patients have predominantly examined structural rather than functional brain changes...
July 7, 2021: NeuroImage: Clinical
Harri Sivasathiaseelan, Charles R Marshall, Elia Benhamou, Janneke E P van Leeuwen, Rebecca L Bond, Lucy L Russell, Caroline Greaves, Katrina M Moore, Chris J D Hardy, Chris Frost, Jonathan D Rohrer, Sophie K Scott, Jason D Warren
Laughter is a fundamental communicative signal in our relations with other people and is used to convey a diverse repertoire of social and emotional information. It is therefore potentially a useful probe of impaired socio-emotional signal processing in neurodegenerative diseases. Here we investigated the cognitive and affective processing of laughter in forty-seven patients representing all major syndromes of frontotemporal dementia, a disease spectrum characterised by severe socio-emotional dysfunction (twenty-two with behavioural variant frontotemporal dementia, twelve with semantic variant primary progressive aphasia, thirteen with nonfluent-agrammatic variant primary progressive aphasia), in relation to fifteen patients with typical amnestic Alzheimer's disease and twenty healthy age-matched individuals...
June 23, 2021: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Ilaria Pagnoni, Elena Gobbi, Enrico Premi, Barbara Borroni, Giuliano Binetti, Maria Cotelli, Rosa Manenti
BACKGROUND: Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by a gradual, insidious and progressive loss of language abilities, with naming difficulties being an early and persistent impairment common to all three variants. In the absence of effective pharmacological treatments and given the progressive nature of the disorder, in the past few decades, many studies have investigated the effectiveness of language training to minimize the functional impact of word-finding difficulties in daily life...
July 16, 2021: Translational Neurodegeneration
Joseph R Duffy, Rene L Utianski, Keith A Josephs
Background: Apraxia of speech (AOS) can be caused by neurodegenerative disease and sometimes is its presenting sign (i.e., primary progressive apraxia of speech, PPAOS). During the last several decades our understanding of PPAOS has evolved from clinical recognition to a fuller understanding of its core and associated clinical features, its distinction from but relationship with primary progressive aphasia, its temporal course and eventual progression to include other neurological deficits, and its neuroimaging correlates and underlying pathology...
2021: Aphasiology
Natalia Parjane, Sunghye Cho, Sharon Ash, Katheryn A Q Cousins, Sanjana Shellikeri, Mark Liberman, Leslie M Shaw, David J Irwin, Murray Grossman, Naomi Nevler
BACKGROUND: Progressive supranuclear palsy syndrome (PSPS) and corticobasal syndrome (CBS) as well as non-fluent/agrammatic primary progressive aphasia (naPPA) are often associated with misfolded 4-repeat tau pathology, but the diversity of the associated speech features is poorly understood. OBJECTIVE: Investigate the full range of acoustic and lexical properties of speech to test the hypothesis that PSPS-CBS show a subset of speech impairments found in naPPA. METHODS: Acoustic and lexical measures, extracted from natural, digitized semi-structured speech samples using novel, automated methods, were compared in PSPS-CBS (n = 87), naPPA (n = 25), and healthy controls (HC, n = 41)...
2021: Journal of Alzheimer's Disease: JAD
Hulya Ulugut, Simone Stek, Lianne E E Wagemans, Roos J Jutten, Maria Antoinette Keulen, Femke H Bouwman, Niels D Prins, Afina W Lemstra, Welmoed Krudop, Charlotte E Teunissen, Bart N M van Berckel, Rik Ossenkoppele, Frederik Barkhof, Wiesje M van der Flier, Philip Scheltens, Yolande A L Pijnenburg
INTRODUCTION: Primary progressive aphasia (PPA) is divided into three prototypical subtypes that are all characterized by their single core symptom of aphasia. Although later in their course, other cognitive, behavioral, and motor domains may become involved, little is known about the progression profile of each subtype relative to the other subtypes. METHODS: In this longitudinal retrospective cohort study, based on the recent biomarker-supported diagnostic criteria, 24 subjects diagnosed with semantic variant (svPPA), 22 with non-fluent variant (nfvPPA), and 18 with logopenic variant (lvPPA) were collected and followed up for 1-6 years...
July 3, 2021: Journal of Neurology
Joanne T Douglas
Frontotemporal disorders are a group of rare young-onset dementias for which there is no cure, nor is there any way to slow the underlying progressive brain degeneration. To date those affected have typically received very little, if any, follow-up care after diagnosis, particularly in the early stages of their disease. I have received a clinical diagnosis, supported by imaging, of primary progressive aphasia, a form of frontotemporal degeneration characterized in the initial phase by progressive impairment of language ability...
July 2, 2021: Journal of Palliative Care
Joël Macoir, Annie Légaré, Monica Lavoie
Diagnosis of primary progressive aphasia (PPA) is essentially based on the identification of progressive impairment of language abilities while other cognitive functions are preserved. The three variants of PPA are characterized by core and supportive clinical features related to the presence or absence of language impairment in different linguistic domains. In this article, we review the cognitive neuropsychological approach to the assessment of PPA and its contribution to the differential diagnosis of the three variants...
June 19, 2021: Brain Sciences
Sladjana Lukic, Valentina Borghesani, Elizabeth Weis, Ariane Welch, Rian Bogley, John Neuhaus, Jessica Deleon, Zachary A Miller, Joel H Kramer, Bruce L Miller, Nina F Dronkers, Maria L Gorno-Tempini
Naming of nouns and verbs can be selectively impaired in neurological disorders, but the specificity of the neural and cognitive correlates of such dissociation remains unclear. Functional imaging and stroke research sought to identify cortical regions selectively recruited for nouns versus verbs, yet findings are inconsistent. The present study investigated this issue in neurodegenerative diseases known to selectively affect different brain networks, thus providing new critical evidence of network specificity...
June 2, 2021: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Talita Gallas Dos Reis, Thais Helena Machado, Paulo Caramelli, Francisco Scornavacca, Liana Lisboa Fernandez, Bárbara Costa Beber
Background: Primary Progressive Aphasia (PPA) is characterized by progressive language impairment due to focal degeneration of brain areas related to linguistic processing. The detection and differential diagnosis of PPA can be difficult with clinical features that may overlap with features of other neurological conditions, such as Alzheimer's disease (AD). The scientific production on PPA in Latin American patients is still scarce. This study investigated the first symptoms in a Brazilian sample of patients with PPA in comparison with AD patients...
2021: Frontiers in Neurology
Valentina Borghesani, Corby L Dale, Sladjana Lukic, Leighton Bn Hinkley, Michael Lauricella, Wendy Shwe, Danielle Mizuiri, Susanna Honma, Zachary Miller, Bruce L Miller, John F Houde, Maria Luisa Gorno-Tempini, Srikantan Nagarajan
Semantic representations are processed along a posterior-to-anterior gradient reflecting a shift from perceptual (e.g., it has eight legs ) to conceptual (e.g., venomous spiders are rare ) information. One critical region is the anterior temporal lobe (ATL): patients with semantic variant primary progressive aphasia (svPPA), a clinical syndrome associated with ATL neurodegeneration, manifest a deep loss of semantic knowledge. We test the hypothesis that svPPA patients perform semantic tasks by over-recruiting areas implicated in perceptual processing...
June 22, 2021: ELife
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"