Alen Faiz, Rashad M Mahbub, Fia Sabrina Boedijono, Milan I Tomassen, Wierd Kooistra, Wim Timens, Martijn Nawijn, Philip M Hansbro, Matt D Johansen, Simon D Pouwels, Irene H Heijink, Florian Massip, Maria Stella de Biase, Roland F Schwarz, Ian M Adcock, Kian F Chung, Anne van der Does, Pieter S Hiemstra, Helene Goulaouic, Heming Xing, Raolat Abdulai, Emanuele de Rinaldis, Danen Cunoosamy, Sivan Harel, David Lederer, Michael C Nivens, Peter A Wark, Huib A M Kerstjens, Machteld N Hylkema, Corry-Anke Brandsma, Maarten van den Berge
INTRODUCTION: IL-33 is a pro-inflammatory cytokine thought to play a role in the pathogenesis of asthma and COPD. A recent clinical trial using the anti-IL33 antibody showed a reduction in exacerbation and improved lung function in ex-smokers but not current smokers with COPD. In this study, we aimed to understand the effects of smoking status on IL-33. METHODS: We investigated the association of smoking status with the level of gene expression of IL33 in the airways in eight independent transcriptomic studies of lung airways...
September 14, 2023: American Journal of Respiratory and Critical Care Medicine