Jing Xu, Wenli Shen, Xiaotao Zhang, Hongli Zhu, Yunduo Wu, Qizheng Wang, Changqiang Cui, Li Zha, Yan Jiao Lu, Rui Liu, Xiaofei Lin
Considering the significant impact of total cholesterol (TC) and vascular endothelin-1 (ET-1) on children sepsis outcomes, this research aimed to explore the association between the levels of plasma cholesterol and vascular endothelin-1 and the severity of sepsis and evaluated its clinical implications. In this study, we examined 250 pediatric patients diagnosed with sepsis between February 2019 and April 2021, collecting data on their plasma levels of TC and ET-1. Depending on the observed outcomes, the participants were divided into 2 categories: a group with a positive prognosis (control group, n = 100) and a group with a negative prognosis (n = 50)...
July 12, 2024: Medicine (Baltimore)
Alexandra Sebastiao, Haseeb Khawar, Russell Hawkins
Septic arthritis is a serious condition in children, with the hip and knee joints most typically affected. Patients typically present with pain, joint swelling, fever, and an inability to bear weight. Early recognition and treatment are crucial, as untreated septic arthritis can lead to serious complications, including sepsis, irreversible joint damage, growth problems, and early-onset arthritis. Clinical signs, inflammatory markers, and imaging are used for the diagnosis of septic arthritis. The mainstay of management includes antibiotic therapy and surgical washout...
June 2024: Curēus
Jing Fu, Ruipeng Zhang, Meixin Xu, Xin Wang, Yang Zhang, Xuanlin Feng, Li Chang
OBJECTIVE: To analyze the epidemiological characteristics of hospitalized patients diagnosed with sepsis in a large class III general hospital in Southwest China in a period of 2 years, and to explore the risk factors related to death in patients with sepsis. METHODS: A retrospective study was conducted to select patients with sepsis admitted to Sichuan Provincial People's Hospital from September 1, 2021 to August 31, 2023, and general characteristics such as gender, age, discharge diagnosis, discharge department, hospitalization cost, length of stay, and prognosis during hospitalization were collected...
June 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Huan Zhou
OBJECTIVE: The objective of this study was to investigate the association between total bilirubin and acute kidney injury (AKI) in neonates admitted to neonatal intensive care units (NICU). METHODS: All data utilized were extracted from Medical Information Mart for Intensive Care-III (MIMIC-III) in this retrospective cohort study. The primary outcome was the occurrence of AKI during hospitalization in the NICU, and the exposure was the initial measurement of total bilirubin levels within 24 h of neonatal admission to the NICU...
July 11, 2024: European Journal of Pediatrics
Birhanu Abie Mekonnen, Tilahun Dessie Alene, Yalemwork Anteneh Yimer, Ayenew Molla Lakew, Geta Bayu Genet
BACKGROUND: Infection is the most common complication of pediatric patients with nephrotic syndrome. The factors associated with infection in nephrotic syndrome are lacking. The objective of the study was to identify the prevalence and associated factors among children with nephrotic syndrome aged 2 to 18 years. METHODS: We conducted a hospital-based retrospective cross-sectional study. The data collector installed an Epi5 collector electronic data-collecting tool from Google Play...
July 10, 2024: BMC Public Health
Kathryn Wilson, Etimbuk Umana, David McCleary, Thomas Waterfield, Kerry Woolfall
BACKGROUND: Febrile infants under 3 months of age are at higher risk of invasive bacterial illness (IBI) when compared with older children. Increasingly sequential assessment based on age, clinical appearance and biomarkers is used to determine the risk of IBI, and appropriateness of invasive procedures such as lumbar puncture. The purpose of this qualitative study is to report parents and clinicians' opinions on communication of risks and benefits of sequential assessment and tailored treatment...
July 10, 2024: Archives of Disease in Childhood
Juan Tu, Tiantian Lin, Huarong Li, Chaoying Chen
Acute focal bacterial nephritis (AFBN) without pyuria is a subtype of urinary tract infection in children, often leading to diagnostic challenges. The clinical characteristics of 6 children diagnosed with AFBN, who exhibited an absence of pyuria, were retrospectively summarized and compared with the control group consisting of 49 hospitalized AFBN children with pyuria. The cases of AFBN without pyuria presented with more severe inflammatory responses and were predisposed to complications, such as sepsis and neurological abnormalities...
July 5, 2024: Pediatric Infectious Disease Journal
Yonatan Milman, Daniel Landau, Asaf Lebel, Yoel Levinsky, Nufar Marcus, Adi Chezana, Liat Ashkenazi-Hoffnung
BACKGROUND: The potential of hypophosphatemia (HP) to differentiate between febrile syndromes and its clinical significance in children without sepsis were not previously described. METHODS: Data were retrospectively collected of febrile children aged 3 months to 18 years, hospitalized at general pediatric wards during 2010-2019. Phosphate levels were compared between bacterial infection (BI), viral infection (VI), and Kawasaki disease (KD). Regression analyses were used to evaluate the relationship between HP and outcome...
July 3, 2024: Pediatric Infectious Disease Journal
Yanping Li, Ni Zhang, Tingting Jiang, Lanlan Gan, Hui Su, Yuanlin Wu, Xue Yang, Guiyuan Xiang, Rui Ni, Jing Xu, Chen Li, Yao Liu
BACKGROUND: Nusinersen is the first drug for precise targeted therapy of spinal muscular atrophy, a rare disease that occurs in one of 10,000 to 20,000 live births. Therefore, thorough and comprehensive reports on the safety of nusinersen in large, real-world populations are necessary. This study aimed to mine the adverse event (AE) signals related to nusinersen through the Food and Drug Administration Adverse Event Reporting System (FAERS) database. METHODS: We extracted reports of AEs with nusinersen as the primary suspect from FAERS between December 2016 and March 2023...
June 14, 2024: Pediatric Neurology
Stacey M Sears, Anisha K Coughlin, Kathryn Nelson, Terri Stillwell, Erin F Carlton, Heidi R Flori
INTRODUCTION: The Pediatric Surviving Sepsis Campaign supports the implementation of automated tools for early sepsis recognition. In 2019 the C.S. Mott Children's Hospital Pediatric Intensive Care Unit deployed an electronic medical record (EMR)-based screening for early recognition and treatment of sepsis. MATERIALS AND METHODS: We analyzed all automated primary sepsis alerts, secondary screens, and bedside huddles from November 2019 to January 2020 (Cohort 1) and from November 2020 to January 2021 (Cohort 2) to identify barriers and facilitators for the use of this tool...
October 2024: JAMIA Open
Dzulfikar Djalil Lukmanul Hakim, Ahmedz Widiasta, Chindy Arya Sari, Muhamad Rinaldhi Martiano
BACKGROUND: Hemodynamic monitoring is crucial for the comprehensive management of children with sepsis, particularly those involving the kidneys. Sepsis-associated acute kidney injury (S-AKI) is closely linked to poor outcomes. Recently, ultrasonography modalities have been widely accepted as a non-invasive, rapid, and reliable tool for assessing volume status. We conducted research to determine intravascular volume based on ultrasound examination in S-AKI patients. METHODS: A prospective cohort study was conducted between December 2023 and March 2024 in the Pediatric Intensive Care Unit (PICU) at Hasan Sadikin General Hospital...
July 8, 2024: Pediatric Nephrology
Piero Alberti, Christopher Westgarth-Taylor, Emanuele Trovalusci, Robyn Charlton, Giulia Brisighelli
PURPOSE: Acquired rectovaginal fistulae (RVF) are a complication of paediatric HIV infection. We report our experience with the surgical management of this condition. METHODS: We retrospectively reviewed the records of paediatric patients with HIV-associated RVF managed at Chris Hani Baragwanath Academic Hospital (2011-2023). Information about HIV management, surgical history, and long-term outcomes was collected. RESULTS: Ten patients with HIV-associated RVF were identified...
July 8, 2024: Pediatric Surgery International
Suzan Omar Mousa, Mohamed Farouk Afifi, Noha Anwar Hassuna, Michael Fekry Yassa, Hend Mohamed Moness
Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its tissues and organs. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme released in response to the drop in cholesterol level occurring in sepsis. Our study aimed to evaluate the prognostic role of serum Proprotein convertase subtilisin/kexin type 9 (PCSK9) level in children with sepsis and severe sepsis. Sixty children were included in this study. They were divided into two groups: 30 children in the sepsis group and 30 in the severe sepsis group...
July 7, 2024: Scientific Reports
Mansi Zied, Berriri Marouene, Romdhani Mokhtar, Tounsi Abdelkader, Chermiti Wajdi, Haggui Ali
INTRODUCTION AND IMPORTANCE: Epidural abscess is a rare but serious infection. Although more commonly seen in men over 50, our case is notable for its occurrence in a pediatric patient, highlighting the unusual nature of this abscess at such a young age, particularly in conjunction with septic arthritis of the hip. CASE PRESENTATION: A 10-year-old child was admitted to pediatrics for investigation of a prolonged fever. The child presented with back pain associated with left hip lameness...
July 4, 2024: International Journal of Surgery Case Reports
Diego Andrés Mazabanda López, Lourdes Urquia Martí, Desiderio Reyes Suárez, Marta Siguero Onrubia, Moreyba Borges Luján, Fermín García-Muñoz Rodrigo
No abstract text is available yet for this article.
July 2, 2024: Jornal de Pediatria
Zuhre Kadi Ozan, Erol Erduran, Serdar Ceylaner, Yakup Aslan, Aysenur Bahadir, Gokce P Reis, Mehmet Mutlu
OBJECTIVE: Neonatal sepsis and familial hemophagocytic lymphohistiocytosis (fHLH) have similar clinical and laboratory symptoms and the possibility of overlooking fHLH diagnosis is high in newborns with sepsis. History of consanguineous marriage and/or sibling death, hepatomegaly/splenomegaly, and hyperferritinemia (>500 ng/mL) are likely to support fHLH in newborns with sepsis. Therefore, in newborns with sepsis in whom at least 2 out of these 3 criteria were detected, genetic variants was investigated for the definitive diagnosed of fHLH...
July 2, 2024: Journal of Pediatric Hematology/oncology
Jami Wardati H, Mustafa Khadijah, Mustafa Nurul-Farhana, Wahit Karimmah, Yoon Kit Ivan Lai, Md Razali Syahmi, Fiona Lee Min Chew, Jamalia Rahmat, Norhafizah Hamzah, Ismail Shatriah
PURPOSE: This study aimed to evaluate the treatment efficacy, anatomical outcomes, and refractive outcomes of laser photocoagulation (LPC) and intravitreal ranibizumab (IVR) in the treatment of type I retinopathy of prematurity (ROP) at one-year follow-up. METHODS: This is a retrospective study on the treatment of type I ROP and aggressive ROP (A-ROP) using LPC or IVR in three Malaysian hospitals providing pediatric ophthalmology services from January 2019 to December 2021...
July 2024: Curēus
Peter E DeWitt, Seth Russell, Margaret N Rebull, L Nelson Sanchez-Pinto, Tellen D Bennett
OBJECTIVES: The publication of the Phoenix criteria for pediatric sepsis and septic shock initiates a new era in clinical care and research of pediatric sepsis. Tools to consistently and accurately apply the Phoenix criteria to electronic health records (EHRs) is one part of building a robust and internally consistent body of research across multiple research groups and datasets. MATERIALS AND METHODS: We developed the phoenix R package and Python module to provide researchers with intuitive and simple functions to apply the Phoenix criteria to EHR data...
October 2024: JAMIA Open
Vivian Giang, Brendan McMullan
Toxic shock syndrome (TSS) is a life-threatening complication of infection typically caused by one of two bacterial species: Staphylococcus aureus and Streptococcus pyogenes The outcomes in children with TSS can be devastating. Careful consideration of TSS is required as a potential differential diagnosis of children presenting with sepsis or severe illness associated with fever and rash.
July 3, 2024: Archives of Disease in Childhood. Education and Practice Edition
Elizabeth M Patt, Julie A Ribes, Lindsey M Long, Brian M Gardner, Joel I Howard, Aric Schadler, Katie B Olney
No abstract text is available yet for this article.
July 4, 2024: Journal of the Pediatric Infectious Diseases Society
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