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JOURNAL ARTICLE
I Adachi, L Aggarwal, H Ahmed, H Aihara, N Akopov, A Aloisio, N Anh Ky, D M Asner, T Aushev, V Aushev, H Bae, P Bambade, Sw Banerjee, J Baudot, M Bauer, A Beaubien, J Becker, P K Behera, J V Bennett, E Bernieri, F U Bernlochner, V Bertacchi, M Bertemes, E Bertholet, M Bessner, S Bettarini, B Bhuyan, F Bianchi, T Bilka, D Biswas, D Bodrov, A Bolz, J Borah, A Bozek, M Bračko, P Branchini, T E Browder, A Budano, S Bussino, M Campajola, L Cao, G Casarosa, M-C Chang, P Cheema, V Chekelian, Y Q Chen, K Chilikin, K Chirapatpimol, H-E Cho, K Cho, S-J Cho, S-K Choi, S Choudhury, D Cinabro, L Corona, S Cunliffe, S Das, F Dattola, E De La Cruz-Burelo, S A De La Motte, G De Nardo, M De Nuccio, G De Pietro, R de Sangro, M Destefanis, S Dey, A De Yta-Hernandez, R Dhamija, A Di Canto, F Di Capua, Z Doležal, I Domínguez Jiménez, T V Dong, M Dorigo, K Dort, S Dreyer, S Dubey, G Dujany, M Eliachevitch, P Feichtinger, T Ferber, D Ferlewicz, T Fillinger, G Finocchiaro, A Fodor, F Forti, B G Fulsom, E Ganiev, V Gaur, A Gaz, A Gellrich, G Ghevondyan, R Giordano, A Giri, A Glazov, B Gobbo, R Godang, P Goldenzweig, S Granderath, E Graziani, D Greenwald, T Gu, Y Guan, K Gudkova, J Guilliams, T Hara, K Hayasaka, H Hayashii, S Hazra, C Hearty, I Heredia de la Cruz, M Hernández Villanueva, A Hershenhorn, T Higuchi, E C Hill, H Hirata, M Hohmann, C-L Hsu, T Iijima, K Inami, G Inguglia, N Ipsita, A Ishikawa, S Ito, M Iwasaki, P Jackson, W W Jacobs, D E Jaffe, E-J Jang, Q P Ji, S Jia, Y Jin, K K Joo, H Junkerkalefeld, A B Kaliyar, K H Kang, R Karl, G Karyan, C Ketter, C Kiesling, C-H Kim, D Y Kim, K-H Kim, Y-K Kim, H Kindo, P Kodyš, T Koga, S Kohani, K Kojima, T Konno, A Korobov, S Korpar, E Kovalenko, R Kowalewski, T M G Kraetzschmar, P Križan, P Krokovny, R Kumar, K Kumara, T Kunigo, A Kuzmin, Y-J Kwon, S Lacaprara, T Lam, L Lanceri, J S Lange, M Laurenza, K Lautenbach, R Leboucher, P M Lewis, C Li, L K Li, J Libby, K Lieret, Z Liptak, Q Y Liu, D Liventsev, S Longo, A Lozar, T Lueck, C Lyu, M Maggiora, R Maiti, R Manfredi, E Manoni, S Marcello, C Marinas, L Martel, A Martini, T Martinov, L Massaccesi, M Masuda, K Matsuoka, S K Maurya, J A McKenna, M Merola, F Metzner, M Milesi, C Miller, K Miyabayashi, R Mizuk, N Molina-Gonzalez, S Moneta, H-G Moser, M Mrvar, R Mussa, I Nakamura, M Nakao, Y Nakazawa, A Narimani Charan, M Naruki, Z Natkaniec, A Natochii, L Nayak, M Nayak, G Nazaryan, N K Nisar, S Ogawa, H Ono, Y Onuki, P Oskin, A Paladino, A Panta, E Paoloni, S Pardi, H Park, S-H Park, B Paschen, A Passeri, S Paul, T K Pedlar, I Peruzzi, R Peschke, R Pestotnik, M Piccolo, L E Piilonen, P L M Podesta-Lerma, T Podobnik, S Pokharel, L Polat, C Praz, S Prell, E Prencipe, M T Prim, H Purwar, N Rad, S Raiz, A Ramirez Morales, M Reif, S Reiter, M Remnev, I Ripp-Baudot, G Rizzo, S H Robertson, J M Roney, A Rostomyan, N Rout, G Russo, D A Sanders, S Sandilya, A Sangal, L Santelj, Y Sato, V Savinov, B Scavino, J Schueler, C Schwanda, Y Seino, A Selce, K Senyo, J Serrano, M E Sevior, C Sfienti, C P Shen, X D Shi, T Shillington, A Sibidanov, J B Singh, J Skorupa, R J Sobie, A Soffer, E Solovieva, S Spataro, M Starič, S Stefkova, Z S Stottler, R Stroili, Y Sue, M Sumihama, K Sumisawa, W Sutcliffe, S Y Suzuki, H Svidras, M Takizawa, K Tanida, H Tanigawa, F Tenchini, A Thaller, R Tiwary, D Tonelli, E Torassa, N Toutounji, K Trabelsi, M Uchida, I Ueda, Y Uematsu, T Uglov, K Unger, Y Unno, K Uno, S Uno, Y Ushiroda, S E Vahsen, R van Tonder, G S Varner, A Vinokurova, L Vitale, V Vobbilisetti, H M Wakeling, E Wang, M-Z Wang, A Warburton, S Watanuki, M Welsch, C Wessel, E Won, X P Xu, B D Yabsley, S Yamada, W Yan, S B Yang, H Ye, J Yelton, J H Yin, Y M Yook, K Yoshihara, C Z Yuan, L Zani, Y Zhang, X Y Zhou, V I Zhukova, R Žlebčík
We study the processes e^{+}e^{-}→ωχ_{bJ}(1P) (J=0, 1, or 2) using samples at center-of-mass energies sqrt[s]=10.701, 10.745, and 10.805 GeV, corresponding to 1.6, 9.8, and 4.7 fb^{-1} of integrated luminosity, respectively. These data were collected with the Belle II detector during special operations of the SuperKEKB collider above the ϒ(4S) resonance. We report the first observation of ωχ_{bJ}(1P) signals at sqrt[s]=10.745 GeV. By combining Belle II data with Belle results at sqrt[s]=10...
March 3, 2023: Physical Review Letters
#42
JOURNAL ARTICLE
F Abudinén, I Adachi, L Aggarwal, H Aihara, N Akopov, A Aloisio, N Anh Ky, D M Asner, H Atmacan, T Aushev, V Aushev, V Babu, S Bahinipati, P Bambade, Sw Banerjee, S Bansal, J Baudot, A Baur, A Beaubien, J Becker, P K Behera, J V Bennett, E Bernieri, F U Bernlochner, M Bertemes, E Bertholet, M Bessner, B Bhuyan, F Bianchi, T Bilka, D Biswas, A Bobrov, D Bodrov, A Bolz, A Bozek, M Bračko, P Branchini, T E Browder, A Budano, S Bussino, M Campajola, G Casarosa, C Cecchi, V Chekelian, C Chen, Y Q Chen, B G Cheon, K Chilikin, K Chirapatpimol, H-E Cho, K Cho, S-J Cho, S-K Choi, S Choudhury, D Cinabro, L Corona, S Cunliffe, F Dattola, G de Marino, G De Nardo, M De Nuccio, G De Pietro, R de Sangro, M Destefanis, S Dey, A De Yta-Hernandez, R Dhamija, A Di Canto, F Di Capua, J Dingfelder, Z Doležal, I Domínguez Jiménez, T V Dong, M Dorigo, K Dort, D Dossett, S Dreyer, S Dubey, G Dujany, M Eliachevitch, D Epifanov, P Feichtinger, T Ferber, D Ferlewicz, T Fillinger, C Finck, G Finocchiaro, K Flood, A Fodor, F Forti, A Frey, B G Fulsom, E Ganiev, M Garcia-Hernandez, V Gaur, A Gaz, A Gellrich, R Giordano, A Giri, B Gobbo, R Godang, P Goldenzweig, W Gradl, S Granderath, E Graziani, D Greenwald, T Gu, K Gudkova, J Guilliams, C Hadjivasiliou, K Hara, T Hara, K Hayasaka, H Hayashii, S Hazra, C Hearty, M T Hedges, I Heredia de la Cruz, M Hernández Villanueva, A Hershenhorn, T Higuchi, E C Hill, M Hoek, M Hohmann, C-L Hsu, T Iijima, K Inami, G Inguglia, N Ipsita, A Ishikawa, S Ito, R Itoh, M Iwasaki, P Jackson, W W Jacobs, D E Jaffe, E-J Jang, Q P Ji, S Jia, Y Jin, H Junkerkalefeld, H Kakuno, A B Kaliyar, J Kandra, K H Kang, R Karl, G Karyan, T Kawasaki, C Ketter, H Kichimi, C Kiesling, C-H Kim, D Y Kim, K-H Kim, Y-K Kim, K Kinoshita, P Kodyš, T Koga, S Kohani, K Kojima, T Konno, A Korobov, S Korpar, E Kovalenko, R Kowalewski, T M G Kraetzschmar, P Križan, P Krokovny, T Kuhr, R Kumar, K Kumara, T Kunigo, Y-J Kwon, S Lacaprara, Y-T Lai, T Lam, J S Lange, M Laurenza, R Leboucher, S C Lee, L K Li, Y B Li, J Libby, K Lieret, Q Y Liu, D Liventsev, S Longo, A Lozar, T Lueck, C Lyu, M Maggiora, R Maiti, S Maity, R Manfredi, E Manoni, S Marcello, C Marinas, L Martel, A Martini, L Massaccesi, M Masuda, K Matsuoka, J A McKenna, F Meier, M Merola, F Metzner, M Milesi, C Miller, K Miyabayashi, G B Mohanty, N Molina-Gonzalez, S Moneta, H Moon, M Mrvar, I Nakamura, K R Nakamura, M Nakao, H Nakayama, A Narimani Charan, M Naruki, Z Natkaniec, A Natochii, L Nayak, M Nayak, N K Nisar, S Nishida, K Nishimura, S Ogawa, H Ono, P Oskin, G Pakhlova, A Paladino, A Panta, S Pardi, K Parham, H Park, S-H Park, A Passeri, S Patra, S Paul, T K Pedlar, M Piccolo, L E Piilonen, G Pinna Angioni, P L M Podesta-Lerma, T Podobnik, S Pokharel, L Polat, C Praz, S Prell, E Prencipe, M T Prim, H Purwar, N Rad, P Rados, S Raiz, A Ramirez Morales, M Reif, S Reiter, M Remnev, I Ripp-Baudot, G Rizzo, S H Robertson, D Rodríguez Pérez, J M Roney, A Rostomyan, N Rout, D Sahoo, D A Sanders, S Sandilya, L Santelj, Y Sato, B Scavino, J Schueler, C Schwanda, Y Seino, A Selce, K Senyo, J Serrano, M E Sevior, C Sfienti, T Shillington, J-G Shiu, A Sibidanov, F Simon, J B Singh, J Skorupa, A Soffer, A Sokolov, E Solovieva, S Spataro, B Spruck, M Starič, S Stefkova, Z S Stottler, R Stroili, M Sumihama, K Sumisawa, W Sutcliffe, S Y Suzuki, H Svidras, M Tabata, M Takizawa, U Tamponi, S Tanaka, K Tanida, H Tanigawa, F Tenchini, R Tiwary, D Tonelli, E Torassa, N Toutounji, K Trabelsi, M Uchida, I Ueda, Y Uematsu, T Uglov, K Unger, Y Unno, K Uno, S Uno, Y Ushiroda, S E Vahsen, R van Tonder, G S Varner, K E Varvell, A Vinokurova, L Vitale, V Vobbilisetti, E Waheed, H M Wakeling, E Wang, M-Z Wang, A Warburton, M Watanabe, S Watanuki, M Welsch, C Wessel, H Windel, E Won, X P Xu, B D Yabsley, S Yamada, W Yan, S B Yang, H Ye, J H Yin, K Yoshihara, C Z Yuan, Y Yusa, L Zani, Y Zhang, V Zhilich, Q D Zhou, X Y Zhou, V I Zhukova, R Žlebčík
The dark photon A^{'} and the dark Higgs boson h^{'} are hypothetical particles predicted in many dark sector models. We search for the simultaneous production of A^{'} and h^{'} in the dark Higgsstrahlung process e^{+}e^{-}→A^{'}h^{'} with A^{'}→μ^{+}μ^{-} and h^{'} invisible in electron-positron collisions at a center-of-mass energy of 10.58 GeV in data collected by the Belle II experiment in 2019. With an integrated luminosity of 8.34 fb^{-1}, we observe no evidence for signal...
February 17, 2023: Physical Review Letters
#43
JOURNAL ARTICLE
F Abudinén, L Aggarwal, H Ahmed, J K Ahn, H Aihara, N Akopov, A Aloisio, N Anh Ky, D M Asner, H Atmacan, T Aushev, V Aushev, V Babu, H Bae, P Bambade, Sw Banerjee, S Bansal, J Baudot, M Bauer, A Baur, A Beaubien, J Becker, J V Bennett, E Bernieri, F U Bernlochner, V Bertacchi, M Bertemes, E Bertholet, M Bessner, S Bettarini, V Bhardwaj, F Bianchi, T Bilka, D Biswas, D Bodrov, A Bolz, G Bonvicini, A Bozek, M Bračko, P Branchini, R A Briere, T E Browder, A Budano, S Bussino, M Campajola, L Cao, G Casarosa, C Cecchi, M-C Chang, P Chang, R Cheaib, P Cheema, C Chen, Y Q Chen, Y-T Chen, B G Cheon, K Chilikin, K Chirapatpimol, H-E Cho, K Cho, S-J Cho, S-K Choi, S Choudhury, D Cinabro, L Corona, L M Cremaldi, S Cunliffe, F Dattola, E De La Cruz-Burelo, S A De La Motte, G De Nardo, M De Nuccio, G De Pietro, R de Sangro, M Destefanis, A De Yta-Hernandez, R Dhamija, A Di Canto, F Di Capua, J Dingfelder, Z Doležal, I Domínguez Jiménez, T V Dong, M Dorigo, K Dort, D Dossett, S Dreyer, G Dujany, M Eliachevitch, D Epifanov, P Feichtinger, T Ferber, D Ferlewicz, T Fillinger, G Finocchiaro, K Flood, A Fodor, F Forti, A Frey, B G Fulsom, A Gabrielli, E Ganiev, M Garcia-Hernandez, A Gaz, A Gellrich, G Ghevondyan, R Giordano, A Giri, A Glazov, B Gobbo, R Godang, P Goldenzweig, W Gradl, S Granderath, D Greenwald, T Gu, Y Guan, K Gudkova, J Guilliams, S Halder, K Hara, O Hartbrich, K Hayasaka, H Hayashii, S Hazra, C Hearty, I Heredia de la Cruz, M Hernández Villanueva, A Hershenhorn, T Higuchi, M Hohmann, T Humair, T Iijima, K Inami, G Inguglia, N Ipsita, A Ishikawa, S Ito, R Itoh, M Iwasaki, Y Iwasaki, P Jackson, W W Jacobs, D E Jaffe, Q P Ji, Y Jin, H Junkerkalefeld, M Kaleta, J Kandra, K H Kang, R Karl, G Karyan, C Kiesling, C-H Kim, D Y Kim, K-H Kim, Y-K Kim, H Kindo, K Kinoshita, P Kodyš, T Koga, S Kohani, K Kojima, A Korobov, S Korpar, E Kovalenko, R Kowalewski, T M G Kraetzschmar, P Križan, P Krokovny, T Kuhr, J Kumar, R Kumar, K Kumara, T Kunigo, Y-J Kwon, S Lacaprara, T Lam, L Lanceri, J S Lange, M Laurenza, R Leboucher, S C Lee, P Leitl, D Levit, L K Li, S X Li, Y B Li, J Libby, Z Liptak, Q Y Liu, D Liventsev, S Longo, T Lueck, C Lyu, M Maggiora, R Maiti, S Maity, R Manfredi, E Manoni, S Marcello, C Marinas, L Martel, A Martini, L Massaccesi, M Masuda, K Matsuoka, D Matvienko, J A McKenna, F Meier, M Merola, M Milesi, C Miller, K Miyabayashi, G B Mohanty, N Molina-Gonzalez, S Moneta, H Moon, H-G Moser, M Mrvar, R Mussa, I Nakamura, M Nakao, H Nakayama, A Narimani Charan, M Naruki, Z Natkaniec, A Natochii, L Nayak, M Nayak, G Nazaryan, C Niebuhr, N K Nisar, S Nishida, K Nishimura, H Ono, P Oskin, E R Oxford, G Pakhlova, A Paladino, A Panta, E Paoloni, S Pardi, K Parham, H Park, S-H Park, A Passeri, T K Pedlar, I Peruzzi, R Peschke, R Pestotnik, F Pham, L E Piilonen, G Pinna Angioni, P L M Podesta-Lerma, T Podobnik, S Pokharel, L Polat, C Praz, S Prell, E Prencipe, M T Prim, H Purwar, N Rad, P Rados, S Raiz, M Reif, S Reiter, I Ripp-Baudot, G Rizzo, S H Robertson, J M Roney, A Rostomyan, N Rout, G Russo, D A Sanders, S Sandilya, A Sangal, L Santelj, Y Sato, V Savinov, B Scavino, C Schwanda, A J Schwartz, Y Seino, A Selce, K Senyo, J Serrano, C Sfienti, C P Shen, T Shillington, J-G Shiu, A Sibidanov, F Simon, R J Sobie, A Soffer, A Sokolov, E Solovieva, S Spataro, B Spruck, M Starič, S Stefkova, R Stroili, J Strube, M Sumihama, K Sumisawa, W Sutcliffe, S Y Suzuki, H Svidras, M Takahashi, M Takizawa, U Tamponi, S Tanaka, K Tanida, H Tanigawa, N Taniguchi, F Tenchini, R Tiwary, D Tonelli, E Torassa, N Toutounji, K Trabelsi, M Uchida, K Unger, Y Unno, K Uno, S Uno, P Urquijo, Y Ushiroda, S E Vahsen, R van Tonder, G S Varner, K E Varvell, A Vinokurova, L Vitale, V Vobbilisetti, E Waheed, H M Wakeling, E Wang, M-Z Wang, X L Wang, A Warburton, S Watanuki, M Welsch, C Wessel, J Wiechczynski, H Windel, E Won, X P Xu, B D Yabsley, S Yamada, S B Yang, H Ye, J Yelton, J H Yin, K Yoshihara, Y Yusa, Y Zhang, V Zhilich, Q D Zhou, V I Zhukova, R Žlebčík
An absolute measurement of the Λ_{c}^{+} lifetime is reported using Λ_{c}^{+}→pK^{-}π^{+} decays in events reconstructed from data collected by the Belle II experiment at the SuperKEKB asymmetric-energy electron-positron collider. The total integrated luminosity of the data sample, which was collected at center-of-mass energies at or near the ϒ(4S) resonance, is 207.2 fb^{-1}. The result, τ(Λ_{c}^{+})=203.20±0.89±0.77 fs, where the first uncertainty is statistical and the second systematic, is the most precise measurement to date and is consistent with previous determinations...
February 17, 2023: Physical Review Letters
#44
JOURNAL ARTICLE
Anne-Marie Jacobsen, Nico C van de Merbel, Dorte K Ditlevsen, Ketil Tvermosegaard, Frank Schalk, Wietske Lambert, Christoffer Bundgaard, Jan T Pedersen, Nina Rosenqvist
Hyperphosphorylated tau protein is well-known to be involved in the formation of neurofibrillary tangles and the progression of age-related neurodegenerative diseases (tauopathies), including Alzheimer's Disease (AD). Tau protein phosphorylated at serine-396 (pS396-tau) is often linked to disease progression, and we therefore developed an analytical method to measure pS396-tau in cerebrospinal fluid (CSF) in humans and animal models of AD. In the S396-region, multiple phosphorylation sites are present, causing structural complexity and sensitivity challenges for conventional bottom-up mass spectrometry approaches...
January 31, 2023: Journal of the American Society for Mass Spectrometry
#45
JOURNAL ARTICLE
Melissa T Baysari, Bethany A Van Dort, Kristian Stanceski, Andrew Hargreaves, Wu Yi Zheng, Maria Moran, Richard Day, Ling Li, Johanna Westbrook, Sarah Hilmer
BACKGROUND: Limited research has focused on understanding if and how evidence of health information technology (HIT) effectiveness drives the selection and implementation of technologies in practice. This study aimed to explore the views of senior hospital staff on the role evidence plays in the selection and implementation of HIT, with a particular focus on clinical decision support (CDS) alerts in electronic medication management systems. METHODS: A qualitative descriptive design was used...
January 28, 2023: International Journal for Quality in Health Care
#46
Shalaila S Haas, Ruiyang Ge, Ingrid Agartz, G Paul Amminger, Ole A Andreassen, Peter Bachman, Inmaculada Baeza, Sunah Choi, Tiziano Colibazzi, Vanessa L Cropley, Camilo de la Fuente-Sandoval, Bjørn H Ebdrup, Adriana Fortea, Paolo Fusar-Poli, Birte Yding Glenthøj, Louise Birkedal Glenthøj, Kristen M Haut, Rebecca A Hayes, Karsten Heekeren, Christine I Hooker, Wu Jeong Hwang, Neda Jahanshad, Michael Kaess, Kiyoto Kasai, Naoyuki Katagiri, Minah Kim, Jochen Kindler, Shinsuke Koike, Tina D Kristensen, Jun Soo Kwon, Stephen M Lawrie, Jimmy Lee, Imke Lj Lemmers-Jansen, Ashleigh Lin, Xiaoqian Ma, Daniel H Mathalon, Philip McGuire, Chantal Michel, Romina Mizrahi, Masafumi Mizuno, Paul Møller, Ricardo Mora-Durán, Barnaby Nelson, Takahiro Nemoto, Merete Nordentoft, Dorte Nordholm, Maria A Omelchenko, Christos Pantelis, Jose C Pariente, Jayachandra M Raghava, Francisco Reyes-Madrigal, Jan I Røssberg, Wulf Rössler, Dean F Salisbury, Daiki Sasabayashi, Ulrich Schall, Lukasz Smigielski, Gisela Sugranyes, Michio Suzuki, Tsutomu Takahashi, Christian K Tamnes, Anastasia Theodoridou, Sophia I Thomopoulos, Paul M Thompson, Alexander S Tomyshev, Peter J Uhlhaas, Tor G Værnes, Therese Amj van Amelsvoort, Theo Gm van Erp, James A Waltz, Christina Wenneberg, Lars T Westlye, Stephen J Wood, Juan H Zhou, Dennis Hernaus, Maria Jalbrzikowski, René S Kahn, Cheryl M Corcoran, Sophia Frangou
IMPORTANCE: The lack of robust neuroanatomical markers of psychosis risk has been traditionally attributed to heterogeneity. A complementary hypothesis is that variation in neuroanatomical measures in the majority of individuals at psychosis risk may be nested within the range observed in healthy individuals. OBJECTIVE: To quantify deviations from the normative range of neuroanatomical variation in individuals at clinical high-risk for psychosis (CHR-P) and evaluate their overlap with healthy variation and their association with positive symptoms, cognition, and conversion to a psychotic disorder...
January 18, 2023: bioRxiv
#47
JOURNAL ARTICLE
Elisa J M Raineri, Sandra Maaß, Min Wang, Siobhan Brushett, Laura M Palma Medina, Neus Sampol Escandell, Dania Altulea, Erwin Raangs, Anne de Jong, Elias Vera Murguia, Edward J Feil, Alex W Friedrich, Girbe Buist, Dörte Becher, Silvia García-Cobos, Natacha Couto, Jan Maarten van Dijl
BACKGROUND: The opportunistic pathogen Staphylococcus aureus is an asymptomatically carried member of the microbiome of about one third of the human population at any given point in time. Body sites known to harbor S. aureus are the skin, nasopharynx, and gut. In particular, the mechanisms allowing S. aureus to pass the gut epithelial barrier and to invade the bloodstream were so far poorly understood. Therefore, the objective of our present study was to investigate the extent to which genetic differences between enteric S...
December 26, 2022: Microbiome
#48
JOURNAL ARTICLE
Yanyan Fu, Sandra Maaβ, Francis M Cavallo, Anne de Jong, Erwin Raangs, Johanna Westra, Girbe Buist, Dörte Becher, Jan Maarten van Dijl
Aggregatibacter actinomycetemcomitans ( Aa ) is a Gram-negative bacterial pathogen associated with periodontitis and nonoral diseases like rheumatoid arthritis and Alzheimer´s disease. Aa isolates with the serotypes a, b, and c are globally most prevalent. Importantly, isolates displaying these serotypes have different clinical presentations. While serotype b isolates are predominant in severe periodontitis, serotypes a and c are generally encountered in mild periodontitis or healthy individuals. It is currently unknown how these differences are reflected in the overall secretion of virulence factors...
December 21, 2022: Microbiology Spectrum
#49
JOURNAL ARTICLE
Thomas J McMorrow, Kristen Byrnes, Megan Gates, Tai Hairston, Aysha Jawed, Megan Keydash, Sonya Ulrike Steele, Dörte Thorndike, Liselotte van Londen, Benjamin E Bodnar
UNLABELLED: Despite the rising incidence of neonatal abstinence syndrome (NAS), there remains wide practice variation in its management. Many recent studies have focused on implementing new symptom scoring systems, typically as part of larger improvement interventions. Despite the continued use of the Finnegan Scoring System, we performed a quality improvement project to reduce the day of life at discharge and cumulative opioid exposure for newborns with NAS. METHODS: We developed a protocol for NAS treatment emphasizing early transfer to general pediatric units, maximization of non-pharmacologic care, and use of as-needed morphine whenever pharmacologic treatment is required...
2022: Pediatric Quality & Safety
#50
JOURNAL ARTICLE
Jürgen Harreiter, Lilian C Mendoza, David Simmons, Gernot Desoye, Roland Devlieger, Sander Galjaard, Peter Damm, Elisabeth R Mathiesen, Dorte M Jensen, Lise Lotte T Andersen, Fidelma Dunne, Annunziata Lapolla, Maria G Dalfra, Alessandra Bertolotto, Ewa Wender-Ozegowska, Agnieszka Zawiejska, David Hill, Judith G M Jelsma, Frank J Snoek, Christof Worda, Dagmar Bancher-Todesca, Mireille N M van Poppel, Rosa Corcoy, Alexandra Kautzky-Willer, On Behalf Of The Dali Core Investigator Group
Vitamin D deficiency is a common finding in overweight/obese pregnant women and is associated with increased risk for adverse pregnancy outcome. Both maternal vitamin D deficiency and maternal obesity contribute to metabolic derangements in pregnancy. We aimed to assess the effects of vitamin D3 supplementation in pregnancy versus placebo on maternal and fetal lipids. Main inclusion criteria were: women <20 weeks' gestation, BMI ≥ 29 kg/m2 . Eligible women ( n = 154) were randomized to receive vitamin D3 (1600 IU/day) or placebo...
September 14, 2022: Nutrients
#51
JOURNAL ARTICLE
Chee Lan Lau, Petrick Periyasamy, Muhd Nordin Saud, Sarah Anne Robert, Lay Yen Gan, Suet Yin Chin, Kiew Bing Pau, Shue Hong Kong, Farah Waheeda Tajurudin, Mei Kuen Yin, Sheah Lin Ghan, Nur Jannah Azman, Xin Yun Chua, Poy Kei Lye, Stephanie Wai Yee Tan, Dexter Van Dort, Ramliza Ramli, Toh Leong Tan, Aliza Mohamad Yusof, Saw Kian Cheah, Wan Rahiza Wan Mat, Isa Naina-Mohamed
Excessive antibiotic consumption is still common among critically ill patients admitted to intensive care units (ICU), especially during the coronavirus disease 2019 (COVID-19) period. Moreover, information regarding antimicrobial consumption among ICUs in South-East Asia remains scarce and limited. This study aims to determine antibiotics utilization in ICUs by measuring antibiotics consumption over the past six years (2016-2021) and specifically evaluating carbapenems prescribed in a COVID-19 ICU and a general intensive care unit (GICU) during the second year of the COVID-19 pandemic...
August 30, 2022: Antibiotics
#52
JOURNAL ARTICLE
Lilian Cristina Mendoza, Jürgen Harreiter, Gernot Desoye, David Simmons, Juan M Adelantado, Alexandra Kautzky-Willer, Agnieszka Zawiejska, Ewa Wender-Ozegowska, Annunziata Lapolla, Maria G Dalfra, Alessandra Bertolotto, Roland Devlieger, Fidelma Dunne, Elisabeth R Mathiesen, Peter Damm, Lisse Lotte Andersen, Dorte Moller Jensen, David Hill, Mireille Nicoline Maria van Poppel, Rosa Corcoy
Studies on the relationship between vitamin D (VitD) and glucose homeostasis usually consider either total VitD or 25OHD3 but not 25OHD2 and epimers. We aimed to evaluate the cross-sectional association of VitD compounds with glucose homeostasis measurements in pregnant women with overweight/obesity participating in the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus Prevention study. METHODS: The analysis included 912 women. INCLUSION CRITERIA: <20 weeks gestation, body mass index ≥29 kg/m2 and information on exposure and outcome variables at baseline...
August 9, 2022: Nutrients
#53
JOURNAL ARTICLE
Marines du Teil Espina, Yanyan Fu, Demi van der Horst, Claudia Hirschfeld, Marina López-Álvarez, Lianne M Mulder, Costanza Gscheider, Anna Haider Rubio, Minke Huitema, Dörte Becher, Peter Heeringa, Jan Maarten van Dijl
Porphyromonas gingivalis is a keystone oral pathogen that successfully manipulates the human innate immune defenses, resulting in a chronic proinflammatory state of periodontal tissues and beyond. Here, we demonstrate that secreted outer membrane vesicles (OMVs) are deployed by P. gingivalis to selectively coat and activate human neutrophils, thereby provoking degranulation without neutrophil killing. Secreted granule components with antibacterial activity, especially LL-37 and myeloperoxidase (MPO), are subsequently degraded by potent OMV-bound proteases known as gingipains, thereby ensuring bacterial survival...
August 24, 2022: Microbiology Spectrum
#54
JOURNAL ARTICLE
Brian D Ross, Youngsoon Jang, Amanda Welton, Christopher A Bonham, Dilrukshika S W Palagama, Kevin Heist, Jagadish Boppisetti, Kasun P Imaduwage, Tanner Robison, Leah R King, Edward Z Zhang, Cyrus Amirfazli, Kathryn E Luker, Winston Y Lee, Gary D Luker, Thomas L Chenevert, Marcian E Van Dort
Activation of compensatory signaling nodes in cancer often requires combination therapies that are frequently plagued by dose-limiting toxicities. Intestinal lymphatic drug absorption is seldom explored, although reduced toxicity and sustained drug levels would be anticipated to improve systemic bioavailability. A potent orally bioavailable multi-functional kinase inhibitor (LP-182) is described with intrinsic lymphatic partitioning for the combined targeting of phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling pathways without observable toxicity...
August 17, 2022: Nature Communications
#55
JOURNAL ARTICLE
Bethany A Van Dort, Jane E Carland, Jonathan Penm, Angus Ritchie, Melissa T Baysari
OBJECTIVE: To understand and synthesize factors influencing user acceptance of digital interventions used for antimicrobial prescribing and monitoring in hospitals. MATERIALS AND METHODS: A meta-synthesis was conducted to identify qualitative studies that explored user acceptance of digital interventions for antimicrobial prescribing and/or monitoring in hospitals. Databases were searched and qualitative data were extracted and systematically classified using the unified theory of acceptance and use of technology (UTAUT) model...
September 12, 2022: Journal of the American Medical Informatics Association: JAMIA
#56
JOURNAL ARTICLE
Helen Baldwin, Joaquim Radua, Mathilde Antoniades, Shalaila S Haas, Sophia Frangou, Ingrid Agartz, Paul Allen, Ole A Andreassen, Kimberley Atkinson, Peter Bachman, Inmaculada Baeza, Cali F Bartholomeusz, Michael W L Chee, Tiziano Colibazzi, Rebecca E Cooper, Cheryl M Corcoran, Vanessa L Cropley, Bjørn H Ebdrup, Adriana Fortea, Louise Birkedal Glenthøj, Holly K Hamilton, Kristen M Haut, Rebecca A Hayes, Ying He, Karsten Heekeren, Michael Kaess, Kiyoto Kasai, Naoyuki Katagiri, Minah Kim, Jochen Kindler, Mallory J Klaunig, Shinsuke Koike, Alex Koppel, Tina D Kristensen, Yoo Bin Kwak, Jun Soo Kwon, Stephen M Lawrie, Irina Lebedeva, Jimmy Lee, Ashleigh Lin, Rachel L Loewy, Daniel H Mathalon, Chantal Michel, Romina Mizrahi, Paul Møller, Barnaby Nelson, Takahiro Nemoto, Dorte Nordholm, Maria A Omelchenko, Christos Pantelis, Jayachandra M Raghava, Jan I Røssberg, Wulf Rössler, Dean F Salisbury, Daiki Sasabayashi, Ulrich Schall, Lukasz Smigielski, Gisela Sugranyes, Michio Suzuki, Tsutomu Takahashi, Christian K Tamnes, Jinsong Tang, Anastasia Theodoridou, Sophia I Thomopoulos, Alexander S Tomyshev, Peter J Uhlhaas, Tor G Værnes, Therese A M J van Amelsvoort, Theo G M Van Erp, James A Waltz, Lars T Westlye, Stephen J Wood, Juan H Zhou, Philip McGuire, Paul M Thompson, Maria Jalbrzikowski, Dennis Hernaus, Paolo Fusar-Poli
Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface area (SA), cortical thickness (CT), subcortical volume (SV), and intracranial volume (ICV) in CHR-P individuals compared with healthy controls (HC), and in relation to subsequent transition to a first episode of psychosis...
July 26, 2022: Translational Psychiatry
#57
JOURNAL ARTICLE
Elke S Schaeffner, Natalie Ebert, Martin K Kuhlmann, Peter Martus, Nina Mielke, Alice Schneider, Markus van der Giet, Dörte Huscher
BACKGROUND AND OBJECTIVES: In older adults, data on the age-related course of GFR are scarce, which might lead to misjudgment of the clinical relevance of reduced GFR in old age. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: To describe the course of eGFR in older adults and derive reference values in population-based individuals, we used the longitudinal design of the Berlin Initiative Study (BIS) with a repeated estimation of GFR over a median of 6.1 years of follow-up...
July 18, 2022: Clinical Journal of the American Society of Nephrology: CJASN
#58
JOURNAL ARTICLE
Ashley Hagaman, Damaris Lopez Mercado, Anubhuti Poudyal, Dörte Bemme, Clare Boone, Alastair van Heerden, Prabin Byanjankar, Sujen Man Maharjan, Ada Thapa, Brandon A Kohrt
The impacts of early pregnancy and young motherhood on everyday life, including interpersonal and individual behavior, are not well-known. Passive digital sensing on mobile technology including smartphones and passive Bluetooth beacons can yield information such as geographic movement, physical activity, and mother-infant proximity to illuminate behavioral patterns of a mother's everyday in Nepal. We contribute to mixed-methods research by triangulating passive sensing data (GPS, accelerometry, Bluetooth proximity) with multiple forms of qualitative data to characterize behavioral patterns and experiences of young motherhood in the first year postpartum...
2022: PloS One
#59
JOURNAL ARTICLE
Zeinab A El-Sayed, Dalia H El-Ghoneimy, José A Ortega-Martell, Nesrine Radwan, Juan C Aldave, Waleed Al-Herz, Maryam A Al-Nesf, Antonio Condino-Neto, Theresa Cole, Brian Eley, Nahla H H Erwa, Sara Espinosa-Padilla, Emilia Faria, Nelson A Rosario Filho, Ramsay Fuleihan, Nermeen Galal, Elizabeth Garabedian, Mary Hintermeyer, Kohsuke Imai, Carla Irani, Ebtihal Kamal, Nadia Kechout, Adam Klocperk, Michael Levin, Tomas Milota, Monia Ouederni, Roberto Paganelli, Claudio Pignata, Farah N Qamar, Isabella Quinti, Sonia Qureshi, Nita Radhakrishnan, Nima Rezaei, John Routes, Surjit Singh, Sangeetha Siniah, Intisar Abdel-Hakam Taha, Luciana K Tanno, Ben Van Dort, Alla Volokha, Kathleen Sullivan
Background: Allergies have long been observed in Inborn Errors of Immunity (IEI) and might even be the first presentation resulting in delayed diagnosis or misdiagnosis in some cases. However, data on the prevalence of allergic diseases among IEI patients are limited and contradictory. Objective: To provide a worldwide view of allergic diseases, across a broad spectrum of IEI, and their impact on the timely diagnosis of IEI. Methods: This is a worldwide study, conceived by the World Allergy Organization (WAO) Inborn Errors of Immunity Committee...
June 2022: World Allergy Organization Journal
#60
JOURNAL ARTICLE
Vladimir Loukachov, Karel A van Dort, Louis Jansen, Henk W Reesink, Neeltje A Kootstra
Hepatitis B Virus (HBV) encoded miRNAs were previously described and suggested to play a role in HBV replication and pathogenesis. In this study we aim to identify novel HBV encoded miRNAs in plasma and liver tissue samples from chronic hepatitis B (CHB) patients and determine their role in CHB pathogenesis and HBV replication. RNA next generation sequencing was performed on plasma and liver tissue samples from ten CHB patients and uninfected controls. The interaction of the potential miRNA-like structures with the RNA-induced silencing complex (RISC) was determined using RNA immunoprecipitation...
June 5, 2022: Viruses
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