Dexamethasone asthma

Ning He, Liping Liu, Juan Ding, Yuemei Sun, Haiyan Xing, Shuyun Wang
GILZ expression is induced by glucocorticoids (GCs) and is involved in the mechanism of airway epithelial cell repair in patients with asthma. The present study aimed to investigate the role of miR-222-3p/GILZ pathway in treatment of airway epithelial cell repair by GCs. 9HTE cells were treated by 10 µmol/L dexamethasone (Dex) for 6, 12, and 24 hours (h). MiR-222-3p mimic and GILZ were used for cell transfection. Cell vitality, migration, and invasion were detected by methyl-thiazolyl tetrazolium (MTT), wound healing, and Transwell...
March 21, 2020: Journal of Receptor and Signal Transduction Research
Byung Gu Min, Sang Mi Park, Youn Woong Choi, Sae Kwang Ku, Il Je Cho, Young Woo Kim, Sung Hui Byun, Chung A Park, Sook Jahr Park, MinKyun Na, Sang Chan Kim
Pelargonium sidoides (PS) is traditionally used to treat respiratory and gastrointestinal infections, dysmenorrhea, and hepatic disorders in South Africa. Coptis Rhizoma (CR) is used to treat gastroenteric disorders, cardiovascular diseases, and cancer in East Asia. In the present study, we intended to observe the possible beneficial antiasthma effects of PS and CR on the ovalbumin- (OVA-) induced asthma C57BL/6J mice. Asthma in mice was induced by OVA sensitization and subsequent boosting. PS + CR (300 and 1,000 mg/kg; PO) or dexamethasone (IP) was administered once a day for 16 days...
2020: Evidence-based Complementary and Alternative Medicine: ECAM
Vahid Reza Askari, Vafa Baradaran Rahimi, Reza Zargarani, Razieh Ghodsi, Mostafa Boskabady, Mohammad Hossein Boskabady
BACKGROUND: Inflammation is characterized as a defensive response of our body against endogenous or exogenous stimuli. Chronic inflammation and oxidative stress play an important role in the pathogenesis of various disorders such as asthma, cancers, and multiple sclerosis. Recently, diverse pharmacological activities of auraptene, a natural prenyloxycoumarin, were reported. In the present study, we aimed to evaluate the anti-oxidative and anti-inflammatory effects of auraptene on human isolated lymphocytes...
March 12, 2020: Pharmacological Reports: PR
Tetsuya Homma, Yosuke Fukuda, Yoshitaka Uchida, Tomoki Uno, Megumi Jinno, Yasunari Kishino, Mayumi Yamamoto, Hiroki Sato, Kaho Akimoto, Keisuke Kaneko, Akiko Fujiwara, Haruna Sato, Kuniaki Hirai, Yoshito Miyata, Hideki Inoue, Shin Ohta, Yoshio Watanabe, Sojiro Kusumoto, Koichi Ando, Shintaro Suzuki, Toshimitsu Yamaoka, Akihiko Tanaka, Tohru Ohmori, Hironori Sagara
BACKGROUND: Viral infection is the main cause of asthma and COPD (chronic obstructive pulmonary disease) exacerbation and accumulate inflammatory cells to airway tissue. We have reported poly I:C, a mimic product of the virus and ligand of toll-like receptor 3 (TLR3), induced inflammatory chemokines from airway epithelial cells and found prior incubation with corticosteroids diminishes the effect of TLR3 activation. In clinical practice, mild asthma is recommended as-needed budesonide (BUD) when symptoms occur following a viral infection, etc...
February 27, 2020: Medicina
Pureun-Haneul Lee, Jisu Hong, An-Soo Jang
Background/Aims: N-acetylcysteine (NAC) affects signaling pathways involved in apoptosis, angiogenesis, cell growth and arrest, redox-regulated gene expression, and the inflammatory response. However, it is not known how the signal mechanism for tight junctional protein claudin (CLDN) 18 is regulated in asthma patients. Methods: To investigate the effects of NAC on CLDN18 expression in a mouse model of asthma, and to assess plasma levels of CLDN18 in asthma patients...
February 28, 2020: Korean Journal of Internal Medicine
Suidong Ouyang, Caini Liu, Jianxin Xiao, Xing Chen, Andy C Lui, Xiaoxia Li
IL-17A plays a critical role in the pathogenesis of steroid-resistant neutrophilic airway inflammation, which is a hallmark of severe asthma and chronic obstructive pulmonary disease (COPD). Through RNA sequencing analysis of transcriptomes of human airway smooth muscle cells treated with IL-17A, dexamethasone (DEX, a synthetic glucocorticoid drug), alone or in combination, we identified a group of genes that are synergistically induced by IL-17A and DEX, including the neutrophil-promoting cytokine CSF3. In type-17 (Th17/IL-17Ahi) preclinical models of neutrophilic severe asthma (acute and chronic) and COPD, although DEX treatment was able to reduce the expression of neutrophil-mobilizing CXCL1 and CXCL2 in lung tissue, CSF3 expression was upregulated by DEX treatment...
February 13, 2020: JCI Insight
Mersine A Bryan, Annika M Hofstetter, Tamara D Simon, Chuan Zhou, Derek J Williams, Amy Tyler, Chén C Kenyon, Joyee G Vachani, Douglas J Opel, Rita Mangione-Smith
OBJECTIVES: To assess the relationship between vaccination status and clinician adherence to quality measures for children with acute respiratory tract illnesses. METHODS: We conducted a multicenter prospective cohort study of children aged 0 to 16 years who presented with 1 of 4 acute respiratory tract illness diagnoses (community-acquired pneumonia, croup, asthma, and bronchiolitis) between July 2014 and June 2016. The predictor variable was provider-documented up-to-date (UTD) vaccination status...
February 10, 2020: Hospital Pediatrics
Yongbin Yan, Lingling Liu, Ziying Dou, Yi Xu, Xiaoyu Yan
Airway remodeling is a key feature of asthma. Extracellular matrix synthesis and vascular remodeling respectively regulated by transforming growth factor (TGF-β1) and vascular endothelial growth factor (VEGF), are important for the airway remodeling. This study aimed to investigate the effect of Soufeng Yuchuan (SFYC) decoction, a Traditional Chinese Medicine, on airway remodeling and expression of VEGF and TGF-β1 in asthma model rats. A rat model of asthma was induced by ovalbumin (OVA) treatment. The results showed that SFYC decoction improved general conditions and reduced the damage in lung tissues in asthma model rats...
February 6, 2020: Biomedicine & Pharmacotherapy
Sung-Ho Kim, Qing-Mei Pei, Ping Jiang, Juan Liu, Rong-Fei Sun, Xue-Jiao Qian, Jiang-Bo Liu
Mucins are major macromolecular components of lung mucus that are mainly responsible for the viscoelastic property of mucus. MUC5AC is a major mucin glycoprotein that is hypersecreted in asthmatic individuals. Vascular endothelial growth factor (VEGF) has been implicated in inflammatory and airway blood vessel remodeling in asthmatics. Our previous studies indicate that VEGF upregulates MUC5AC expression by interacting with VEGF receptor 2 (VEGFR2). It has been shown that dexamethasone (Dex) downregulates MUC5AC expression; however, the underlying mechanisms have not been completely elucidated...
February 6, 2020: Experimental Cell Research
Hack Sun Choi, Su-Lim Kim, Ji-Hyang Kim, Dong-Sun Lee
Ciclesonide is an FDA-approved glucocorticoid (GC) used to treat asthma and allergic rhinitis. However, its effects on cancer and cancer stem cells (CSCs) are unknown. Our study focuses on investigating the inhibitory effect of ciclesonide on lung cancer and CSCs and its underlying mechanism. In this study, we showed that ciclesonide inhibits the proliferation of lung cancer cells and the growth of CSCs. Similar glucocorticoids, such as dexamethasone and prednisone, do not inhibit CSC formation. We show that ciclesonide is important for CSC formation through the Hedgehog signaling pathway...
February 4, 2020: International Journal of Molecular Sciences
Maria De Filippo, Evangéline Clark, Anouchka Fillard, Lucia Diaferio, Davide Caimmi
Corticosteroids (CS) are among the most prescribed drugs in pediatrics. In allergy, CS are prescribed for several different conditions. If CS show clear benefits when adequately prescribed, CS are also associated with several side effects, well known by pediatricians. As for asthma exacerbations, the oral route is always the preferred one in pediatrics. Several authors debated if the use of a single dose of dexamethasone is better in terms of efficacy, compared with a 3- to 5-day course of prednisone or prednisolone...
February 2020: Pediatric Allergy and Immunology
Hoang Kim Tu Trinh, Thuy Van Thao Nguyen, Seo-Hee Kim, Thi Bich Tra Cao, Quoc Quang Luu, Seung-Hyun Kim, Hae-Sim Park
Patients with late-onset asthma (LOA) have poor clinical outcomes. Osteopontin (OPN) is associated with airway inflammation and remodeling. To investigate the role of OPN in LOA compared to early-onset asthma (EOA), serum OPN levels were compared between 131 adult asthma patients (48 LOA and 83 EOA patients) and 226 healthy controls (HCs). BALB/c mice were sensitized with ovalbumin with/without polyinosinic-polycytidylic acid (poly(I:C)) from week 6 (A6 mice) or week 12 (A12 mice) after birth. Airway hyperresponsiveness (AHR), bronchoalveolar lavage fluid (BALF), cell counts, histology, and Spp1 expression were assessed...
February 3, 2020: Experimental & Molecular Medicine
Kapil K Soni, Deepak Meshram, Temitope O Lawal, Udeshi Patel, Gail B Mahady
BACKGROUND: Purified fractions from a Boswellia serrata Roxb. Ex. Colebr. (Burseraceae) extract (ETOH and DCM) contain biologically active compounds that are well known for having inflammation inhibitory properties. In this work, the purified fractions were tested in-vitro for LTC4, LTA4 and COX-2 activities using ELISA and qPCR was performed to determine gene regulation in human leukemia (HL-60) Cells. Two D-imaging tomography was performed to determine the anti-inflammatory activities of the fractions in BALB/c mouse model of lung inflammation...
January 26, 2020: Current Drug Discovery Technologies
Simon Lea, Jian Li, Jonathan Plumb, Kate Gaffey, Sarah Mason, Rosie Gaskell, Chris Harbron, Dave Singh
p38 MAPK inhibition may have additive and synergistic anti-inflammatory effects when used with corticosteroids. We investigated crosstalk between p38 MAPK inhibitors and corticosteroids in bronchial epithelial cells to investigate synergistic effects on cytokine production and the molecular mechanisms involved. Effects of the p38 MAPK inhibitor BIRB-796 and dexamethasone alone and in combination on LPS, polyI:C or TNFα -induced IL-6, CXCL8 and RANTES were assessed in 16HBEs (human epithelial cell line) and on TNFα-induced IL-6 and CXCL8 in primary human epithelial cells from asthma patients and healthy controls...
January 23, 2020: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Stephanie L Bond, Persephone Greco-Otto, Jacqueline MacLeod, Angelica Galezowski, Warwick Bayly, Renaud Léguillette
BACKGROUND: Mild asthma in horses decreases racing performance and impairs gas exchange. The efficacy of treatment on performance is unknown. HYPOTHESIS: Treatment targeting lung inflammation improves <mml:math xmlns:mml=""> <mml:mover> <mml:mi>V</mml:mi> <mml:mo>˙</mml:mo> </mml:mover> </mml:math> O2 peak in horses with mild asthma. ANIMALS: Thoroughbred polo horses (n = 12) with smoke-induced mild asthma...
January 18, 2020: Journal of Veterinary Internal Medicine
Hye Jung Park, Eun-Yi Oh, Hee-Jae Han, Kyung Hee Park, Kyoung-Yong Jeong, Jung-Won Park, Jae-Hyun Lee
CD93 has been shown critical roles in inflammatory and immune diseases. However, in allergic asthma, the potential roles of soluble CD93 (sCD93) have not been well studied. We conducted house dust mite (HDM) stimulation with Der p 1 in BEAS-2B and U937 cells, followed by treatment with dexamethasone or small interfering RNA against CD93. A HDM-induced murine allergic asthma model was also established. We estimated the power of sCD93 to predict allergic asthma in a retrospective post-hoc analysis containing 96 human samples...
January 15, 2020: Scientific Reports
Yousra M Ezz El-Din, Ali A Aboseif, Marwa M Khalaf
BACKGROUND: Asthma is a complex inflammatory disease which affects multiple individuals worldwide especially pediatric ages. AIMS: This study aimed to assess the possible protective effect of carvacrol, as natural antioxidant anti-inflammatory drug, against bronchial asthma induced experimentally in rats. MAIN METHODS: Rats were randomly allocated into 5 groups; a normal control group, control drug group received only carvacrol, an asthma control group, a standard treatment group receiving dexamethasone (DEXA) and carvacrol treatment group...
December 24, 2019: Life Sciences
Nidhya Navanandan, Elizabeth Moran, Hana Smith, Heather Hoch, Rakesh D Mistry
<u>Objective</u>: Primary care providers (PCP) frequently care for children with acute asthma exacerbations in the outpatient setting. The objective of this study is to evaluate PCP preferences and perceptions regarding oral corticosteroids prescribed from both outpatient primary care and ED settings for the treatment of children with acute asthma exacerbations. <u>Methods</u>: PCPs belonging to the Colorado Chapter of the American Academy of Pediatrics were surveyed between February and May 2019...
December 26, 2019: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Martijn L Manson, Jesper Säfholm, Anna James, Anna-Karin Johnsson, Per Bergman, Mamdoh Al-Ameri, Ann-Charlotte Orre, Carina Kärrman Mårdh, Sven-Erik Dahlén, Mikael Adner
BACKGROUND: Specific inflammatory pathways are indicated to contribute to severe asthma but their individual involvement in the development of airway hyperresponsiveness remains unexplored. OBJECTIVE: This experimental study in human small bronchi aimed to provide insight into which of the Type-2 and Type-17 cytokines cause hyperresponsiveness of airway smooth muscle. METHODS: Explanted small bronchi isolated from human lung tissue and human airway smooth muscle cells (HASMC) were treated for 2 and 1 day(s) respectively with 100ng/mL of IL-4, IL-5, IL-13 or IL-17A, and contractile responses, Ca2+ -mobilization, and receptor expression were assessed...
December 2, 2019: Journal of Allergy and Clinical Immunology
Naima Eftekhar, Ali Moghimi, Nema Mohammadian Roshan, Saeideh Saadat, Mohammad Hossein Boskabady
BACKGROUND: Ocimum species (Lamiaceae) has been traditionally used for treatment of upper respiratory tract infections, bronchitis, coughs, sore throat, and wound healing. The Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of Ocimum basilicum (O. basilicum) leaves was examined in ovalbumin sensitized animals. METHODS: Wistar rats were divided to six groups; non-sensitized, sensitized to ovalbumin, sensitized and treated with dexamethasone (1...
December 4, 2019: BMC Complementary and Alternative Medicine
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