Paula Trujillo, Olivia C Roman, Kaitlyn R Hay, Meher R Juttukonda, Yan Yan, Hakmook Kang, Sachin Y Paranjape, Emily M Garland, Cyndya A Shibao, Italo Biaggioni, Manus J Donahue, Daniel O Claassen
PURPOSE: Pure autonomic failure (PAF) results from an impaired peripheral autonomic nervous system, and clinical symptoms present with orthostatic hypotension. While the impact on cardiovascular indices of orthostatic intolerance are well-characterized, more limited information is available regarding cerebral hemodynamic dysfunction in PAF. The objective of this study was to test the hypothesis that cerebral blood flow (CBF) is reduced in PAF, and to quantify the relationship between CBF and clinical indicators of disease severity, including peripheral supine arterial blood pressure...
March 7, 2021: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society