Raiyan R Khan, Rafael F Guerrero, Ronald J Wapner, Matthew W Hahn, Anita Raja, Ansaf Salleb-Aouissi, William A Grobman, Hyagriv Simhan, Robert M Silver, Judith H Chung, Uma M Reddy, Predrag Radivojac, Itsik Pe'er, David M Haas
Adverse pregnancy outcomes (APOs) affect a large proportion of pregnancies and represent an important cause of morbidity and mortality worldwide. Yet the pathophysiology of APOs is poorly understood, limiting our ability to prevent and treat these conditions. To search for genetic markers of maternal risk for four APOs, we performed multi-ancestry genome-wide association studies (GWAS) for pregnancy loss, gestational length, gestational diabetes, and preeclampsia. We clustered participants by their genetic ancestry and focused our analyses on three sub-cohorts with the largest sample sizes: European, African, and Admixed American...
May 7, 2024: Scientific Reports