Jon Klein, Anderson Brito, Paul Trubin, Peiwen Lu, Patrick Wong, Tara Alpert, Mario Pena-Hernandez, Winston Haynes, Kathy Kamath, Feimei Liu, Chantal Vogels, Joseph Fauver, Carolina Lucas, Ji Eun Oh, Tianyang Mao, Julio Silva, Anne Wyllie, M Catherine Muenker, Arnau Casanovas-Massana, Adam Moore, Mary Petrone, Chaney Kalinich, Yale Impact Research Team, Charles Dela Cruz, Shelli Farhadian, Aaron Ring, John Shon, Albert Ko, Nathan Grubaugh, Benjamin Goldman-Israelow, Akiko Iwasaki, Marwan Azar
The underlying immunologic deficiencies enabling SARS-CoV-2 reinfections are currently unknown. Here we describe a renal-transplant recipient who developed recurrent, symptomatic SARS-CoV-2 infection 7 months after primary infection. To elucidate the immunological mechanisms responsible for reinfection, we performed longitudinal profiling of cellular and humoral responses during both primary and recurrent SARS-CoV-2 infection. We found that the patient responded to the primary infection with transient, poor-quality adaptive immune responses that was further compromised by intervening treatment for acute rejection of the renal allograft prior to reinfection...
May 5, 2021: Research Square