keyword
https://read.qxmd.com/read/36371137/aerodigestive-approach-to-pediatric-chronic-cough
#21
REVIEW
Zi Yang Jiang, Chelsea Gatcliffe, Tu Mai, Zhen Huang
Chronic cough is defined as cough lasting more than 4 weeks in children aged 14 years or older. Normal children, without pathophysiology, can cough up to more than 30 times a day. When cough occurs pathologically, it is often more often and can be divided into specific and nonspecific cough types. Inputs from otolaryngology, pulmonary medicine, and gastroenterology, along with other specialties in an aerodigestive team setting, allow a team approach to consider a wide variety of causes of cough and coordinate diagnostic procedures with treatment...
December 2022: Otolaryngologic Clinics of North America
https://read.qxmd.com/read/36283869/upper-airway-cough-syndrome
#22
REVIEW
Angela M Donaldson
Upper airway cough syndrome (UACS), formerly known as postnasal drip syndrome, is one of the most common causes of chronic cough. UACS, asthma, and gastroesophageal reflux make up 90% of the cause of chronic cough. UACS is a clinical diagnosis of exclusion with no diagnostic testing or objective findings. UACS can be present with or without associated rhinitis and chronic rhinosinusitis. Treatment includes dual therapy with H1 receptor antihistamines and decongestants. Diagnosis is confirmed when therapeutic intervention results in symptom resolution...
February 2023: Otolaryngologic Clinics of North America
https://read.qxmd.com/read/36276929/a-study-on-cough-sensitivity-and-airway-inflammation-in-patients-with-sinobronchial-syndrome
#23
JOURNAL ARTICLE
Shengyuan Wang, Shanshan Niu, Siwan Wen, Mengru Zhang, Cuiqin Shi, Zhongmin Qiu, Li Yu, Xianghuai Xu
OBJECTIVE: This study aimed to clarify the characteristics of cough-reflex sensitivity and airway inflammation in patients with sinobronchial syndrome (SBS). METHODS: 39 patients with SBS, 53 patients with upper airway cough syndrome (UACS) induced by rhinitis, 33 patients with chronic sinusitis without cough, and 39 healthy controls (HCs) were enrolled between January 2013 and December 2018. All participants underwent a capsaicin cough-sensitivity test and cytology of induced sputum...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36227349/narrative-review-of-the-mechanisms-and-treatment-of-cough-in-asthma-cough-variant-asthma-and-non-asthmatic-eosinophilic-bronchitis
#24
REVIEW
Nermin Diab, Matthew Patel, Paul O'Byrne, Imran Satia
Chronic cough is a debilitating condition affecting 10-12% of the general population and is one of the leading causes for referral to secondary care. Many conditions have been associated with chronic cough, including asthma, gastro-esophageal reflux disease and upper airways cough syndrome. Inflammatory airway conditions including cough variant asthma (CVA) and non-asthmatic eosinophilic bronchitis (NAEB) contribute to a significant proportion of presentations with chronic cough, with differing diagnostic criteria and different responses to commonly used asthma therapy for their respective diagnoses...
December 2022: Lung
https://read.qxmd.com/read/36198074/the-current-and-emerging-treatment-landscape-for-chronic-cough
#25
JOURNAL ARTICLE
Peter Dicpinigaitis
Cough serves a protective physiologic function as a vital defensive reflex preventing aspiration. However, exposure to viral infections or other triggers induces, in some individuals, a chronic cough (CC) that causes a significant symptomatic burden. Most cases of CC are due to conditions that respond to appropriate therapeutic trials (upper airway cough syndrome; asthma; reflux). Unfortunately, a significant subgroup of patients will have refractory CC, which does not respond to treatment of known underlying causes of CC...
September 2022: American Journal of Managed Care
https://read.qxmd.com/read/36106228/bilateral-recurrent-laryngeal-nerve-paralysis-manifesting-as-long-covid
#26
Hiroshi Okuda, Chikako Kunieda, Hirofumi Shibata, Toshimitsu Ohashi, Takenori Ogawa
Management with ventilation is used for severe cases of coronavirus disease 2019 (COVID-19). After extubation, recurrent laryngeal nerve paralysis due to various factors may occur. Almost all cases of paralysis develop unilaterally; however, bilateral recurrent laryngeal nerve paralysis occurs rarely. Such cases may be fatal due to upper air obstruction, and patients are forced to adhere to restrictions after a tracheotomy. The present case illustrates bilateral recurrent laryngeal nerve paralysis that occurred 48 hours after withdrawal from the ventilator...
August 2022: Curēus
https://read.qxmd.com/read/36065149/subcutaneous-emphysema-following-open-tracheostomy-during-tracheostomy-mask-ventilation
#27
JOURNAL ARTICLE
Abdalhai Alshoubi, Archana Mathew
BACKGROUND Tracheostomy is a surgical procedure that is done by creating an ostomy in the anterior wall of the trachea to facilitate airway access and ventilation. It is indicated for acute respiratory failure after prolonged intubation, upper airway obstruction, difficult airway, and extensive secretions. Early perioperative complications include bleeding, pneumothorax/pneumomediastinum from a false tract, subcutaneous emphysema, esophageal perforation, and tracheal ring fractures. CASE REPORT We present the case of a 64-year-old woman with a past medical history of hypertension, asthma, alcohol and cocaine abuse, bipolar, and, right breast cancer that was treated by chemotherapy and total mastectomy...
September 6, 2022: American Journal of Case Reports
https://read.qxmd.com/read/35726145/two-case-reports-of-life-threatening-croup-caused-by-the-sars-cov-2-omicron-ba-2-variant-in-pediatric-patients
#28
Soyeon Park, Jihye You, Jaehyeon Lee, Esther Park
Croup is a common upper airway infection characterized by a barking cough, stridor, and hoarseness. It is usually caused by viral infection. A small number of croup caused by coronavirus disease 2019 (COVID-19) has been reported in children before the omicron variant surge. Previously reported cases indicated that croup caused by COVID-19 can be treated in the same manner as those with other viral causes. We describe two cases (9-month-old girl and 11-month-old boy) of previously healthy infants who presented with a barking cough and chest retraction and required endotracheal intubation and cardiopulmonary resuscitation...
June 20, 2022: Journal of Korean Medical Science
https://read.qxmd.com/read/35600836/wao-aria-consensus-on-chronic-cough-part-iii-management-strategies-in-primary-and-cough-specialty-care-updates-in-covid-19
#29
REVIEW
Philip W Rouadi, Samar A Idriss, Jean Bousquet, Tanya M Laidlaw, Cecilio R Azar, Mona S Al-Ahmad, Anahi Yañez, Maryam Ali Y Al-Nesf, Talal M Nsouli, Sami L Bahna, Eliane Abou-Jaoude, Fares H Zaitoun, Usamah M Hadi, Peter W Hellings, Glenis K Scadding, Peter K Smith, Mario Morais-Almeida, René Maximiliano Gómez, Sandra N Gonzalez Diaz, Ludger Klimek, Georges S Juvelekian, Moussa A Riachy, Giorgio Walter Canonica, David Peden, Gary W K Wong, James Sublett, Jonathan A Bernstein, Lianglu Wang, Luciana K Tanno, Manana Chikhladze, Michael Levin, Yoon-Seok Chang, Bryan L Martin, Luis Caraballo, Adnan Custovic, Jose Antonio Ortego-Martell, Olivia J Ly Lesslar, Erika Jensen-Jarolim, Motohiro Ebisawa, Alessandro Fiocchi, Ignacio J Ansotegui
Background: Chronic cough management necessitates a clear integrated care pathway approach. Primary care physicians initially encounter the majority of chronic cough patients, yet their role in proper management can prove challenging due to limited access to advanced diagnostic testing. A multidisciplinary approach involving otolaryngologists and chest physicians, allergists, and gastroenterologists, among others, is central to the optimal diagnosis and treatment of conditions which underly or worsen cough...
May 2022: World Allergy Organization Journal
https://read.qxmd.com/read/35569802/demographic-clinical-and-patient-reported-outcome-data-from-2-global-phase-3-trials-of-chronic-cough
#30
JOURNAL ARTICLE
Peter V Dicpinigaitis, Surinder S Birring, Michael Blaiss, Lorcan P McGarvey, Alyn H Morice, Ian D Pavord, Imran Satia, Jaclyn A Smith, Carmen La Rosa, Qing Li, Allison Martin Nguyen, Jonathan Schelfhout, Anjela Tzontcheva, David Muccino
BACKGROUND: The current characterization of patients with refractory or unexplained chronic cough (RCC and UCC, respectively) primarily stems from relatively small clinical studies. OBJECTIVE: To report the baseline medical history and clinical characteristics of individuals with RCC or UCC who were enrolled in COUGH-1 and COUGH-2, 2 large, global, phase 3 trials of gefapixant, a P2 × 3-receptor antagonist. METHODS: Adults with a chronic cough lasting for more than 1 year, diagnosis of RCC or UCC, and score greater than 40 mm on a 100-mm cough severity visual analog scale at both screening and baseline were eligible for enrollment...
January 2023: Annals of Allergy, Asthma & Immunology
https://read.qxmd.com/read/35483988/the-evolving-clinical-practice-of-chronic-cough
#31
REVIEW
Sumera R Ahmad, Vivek N Iyer
Chronic cough, defined as a cough lasting for greater than 8 weeks, accounts for a substantial number of primary care and specialist consultations in the United States. Although cough can arise from a myriad number of serious respiratory diseases, attention has traditionally focused on diagnosing and treating gastroesophageal reflux, upper airway cough syndrome, and eosinophilic airway inflammation (asthma and nonasthmatic eosinophilic bronchitis) in patients with normal chest imaging. The newly described paradigm and entity of cough hypersensitivity syndrome (CHS) becomes useful when the etiology of cough remains elusive or when the cough remains refractory despite appropriate therapy for underlying causes...
June 2022: Mayo Clinic Proceedings
https://read.qxmd.com/read/35037404/severe-acute-respiratory-syndrome-coronavirus-2-can-be-detected-in-exhaled-aerosol-sampled-during-a-few-minutes-of-breathing-or-coughing
#32
JOURNAL ARTICLE
Emilia Viklund, Spela Kokelj, Per Larsson, Rickard Nordén, Maria Andersson, Olof Beck, Johan Westin, Anna-Carin Olin
BACKGROUND: The knowledge on the concentration of viral particles in exhaled breath is limited. The aim of this study was to explore if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be detected in aerosol from subjects with the coronavirus disease 2019 (COVID-19) during various types of breathing and coughing and how infection with SARS-CoV-2 may influence the number and size of exhaled aerosol particles. METHODS: We counted and collected endogenous particles in exhaled breath in subjects with COVID-19 disease by two different impaction-based methods, during 20 normal breaths, 10 airway opening breaths, and three coughs, respectively...
May 2022: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/35001763/ferrets-are-valuable-models-for-sars-cov-2-research
#33
JOURNAL ARTICLE
Malgorzata Ciurkiewicz, Federico Armando, Tom Schreiner, Nicole de Buhr, Veronika Pilchová, Vanessa Krupp-Buzimikic, Gülşah Gabriel, Maren von Köckritz-Blickwede, Wolfgang Baumgärtner, Claudia Schulz, Ingo Gerhauser
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulted in an ongoing pandemic with millions of deaths worldwide. Infection of humans can be asymptomatic or result in fever, fatigue, dry cough, dyspnea, and acute respiratory distress syndrome with multiorgan failure in severe cases. The pathogenesis of COVID-19 is not fully understood, and various models employing different species are currently applied. Ferrets can be infected with SARS-CoV-2 and efficiently transmit the virus to contact animals...
July 2022: Veterinary Pathology
https://read.qxmd.com/read/34974350/inflammatory-but-not-respiratory-symptoms-are-associated-with-ongoing-upper-airway-viral-shedding-in-outpatients-with-uncomplicated-covid-19
#34
JOURNAL ARTICLE
Karen B Jacobson, Natasha Purington, Julie Parsonnet, Jason Andrews, Vidhya Balasubramanian, Hector Bonilla, Karlie Edwards, Manisha Desai, Upinder Singh, Haley Hedlin, Prasanna Jagannathan
Although the vast majority of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections are uncomplicated, our understanding of predictors of symptom resolution and viral shedding cessation remains limited. We characterized symptom trajectories and oropharyngeal viral shedding among 120 outpatients with uncomplicated Coronavirus Disease of 2019 (COVID-19) enrolled in a clinical trial of Peginterferon Lambda, which demonstrated no clinical or virologic benefit compared with placebo. In the combined trial cohort, objective fever was uncommon, inflammatory symptoms (myalgias, fatigue) peaked at 4 to 5 days postsymptom onset, and cough peaked at 9 days...
March 2022: Diagnostic Microbiology and Infectious Disease
https://read.qxmd.com/read/34963794/wao-aria-consensus-on-chronic-cough-part-ii-phenotypes-and-mechanisms-of-abnormal-cough-presentation-updates-in-covid-19
#35
REVIEW
Philip W Rouadi, Samar A Idriss, Jean Bousquet, Tanya M Laidlaw, Cecilio R Azar, Mona S Al-Ahmad, Anahi Yañez, Maryam Ali Y Al-Nesf, Talal M Nsouli, Sami L Bahna, Eliane Abou-Jaoude, Fares H Zaitoun, Usamah M Hadi, Peter W Hellings, Glenis K Scadding, Peter K Smith, Mario Morais-Almeida, René Maximiliano Gómez, Sandra N Gonzalez Diaz, Ludger Klimek, Georges S Juvelekian, Moussa A Riachy, Giorgio Walter Canonica, David Peden, Gary W K Wong, James Sublett, Jonathan A Bernstein, Lianglu Wang, Luciana K Tanno, Manana Chikhladze, Michael Levin, Yoon-Seok Chang, Bryan L Martin, Luis Caraballo, Adnan Custovic, Jose Antonio Ortega-Martell, Erika Jensen-Jarolim, Motohiro Ebisawa, Alessandro Fiocchi, Ignacio J Ansotegui
BACKGROUND: Chronic cough can be triggered by respiratory and non-respiratory tract illnesses originating mainly from the upper and lower airways, and the GI tract (ie, reflux). Recent findings suggest it can also be a prominent feature in obstructive sleep apnea (OSA), laryngeal hyperresponsiveness, and COVID-19. The classification of chronic cough is constantly updated but lacks clear definition. Epidemiological data on the prevalence of chronic cough are informative but highly variable...
December 2021: World Allergy Organization Journal
https://read.qxmd.com/read/34918623/chronic-cough
#36
JOURNAL ARTICLE
Karen Krüger, Felix Holzinger, Janina Trauth, Myriam Koch, Christoph Heintze, Sabine Gehrke-Beck
BACKGROUND: Chronic cough, i.e., cough lasting longer than eight weeks, affects approximately 10% of the population and is a common reason for outpatient medical consultation. Its differential diagnosis is extensive, and it is generally evaluated in poorly structured fashion with a variety of diagnostic techniques. The German Clinical Practice Guideline on Acute and Chronic Cough was updated in 2021 and contains a description of the recommended stepwise, patient-centered, and evidencebased procedure for the management of chronic cough...
February 4, 2022: Deutsches Ärzteblatt International
https://read.qxmd.com/read/34884187/supraglottic-botulinum-toxin-improves-symptoms-in-patients-with-laryngeal-sensory-dysfunction-manifesting-as-abnormal-throat-sensation-and-or-chronic-refractory-cough
#37
JOURNAL ARTICLE
Daniel Novakovic, Meet Sheth, Thomas Stewart, Katrina Sandham, Catherine Madill, Antonia Chacon, Duy Duong Nguyen
Laryngeal sensory dysfunction (LSD) encompasses disorders of the vagal sensory pathways. Common manifestations include chronic refractory cough (CRC) and abnormal throat sensation (ATS). This study examined clinical characteristics and treatment outcomes of LSD using a novel approach of laryngeal supraglottic Onabotulinum toxin Type A injection (BTX). This was a retrospective review of clinical data and treatment outcomes of supraglottic BTX in patients with LSD. Between November 2019 and May 2021, 14 patients underwent 25 injection cycles of supraglottic BTX for treatment of symptoms related to LSD, including ATS and CRC...
November 23, 2021: Journal of Clinical Medicine
https://read.qxmd.com/read/34849084/a-history-of-recurrent-episodes-of-prolonged-cough-as-a-predictive-value-for-determining-cough-variant-asthma-in-a-primary-care-setting
#38
JOURNAL ARTICLE
Masaaki Mikami, Katsuyuki Tomita, Akira Yamasaki
Background: Many patients visit primary care clinics with a complaint of cough. General practitioners (GPs) developed a list of the causative diseases of cough that can produce a patient's symptoms and signs. Then, the patients' medical histories were evaluated to determine whether the diagnosis of cough variant asthma (CVA) or post-infectious cough (PIC) could have been predicted. Methods: We retrospectively investigated 195 outpatients with a complaint of cough...
November 2021: Yonago Acta Medica
https://read.qxmd.com/read/34794590/acr-appropriateness-criteria%C3%A2-chronic-cough
#39
Christopher T Kuzniewski, Oskar Kizhner, Edwin F Donnelly, Travis S Henry, Alpesh N Amin, Asha Kandathil, Aine Marie Kelly, Archana T Laroia, Elizabeth Lee, Maria D Martin, Michael F Morris, Constantine A Raptis, Arlene Sirajuddin, Carol C Wu, Jeffrey P Kanne
Chronic cough is defined by a duration lasting at least 8 weeks. The most common causes of chronic cough include smoking-related lung disease, upper airway cough syndrome, asthma, gastroesophageal reflux disease, and nonasthmatic eosinophilic bronchitis. The etiology of chronic cough in some patients may be difficult to localize to an isolated source and is often multifactorial. The complex pathophysiology, clinical presentation, and variable manifestations of chronic cough underscore the challenges faced by clinicians in the evaluation and management of these patients...
November 2021: Journal of the American College of Radiology: JACR
https://read.qxmd.com/read/34734503/utility-of-cough-provocation-tests-in-chronic-cough-and-respiratory-diseases-a-comprehensive-review-and-introduction-of-new-reference-ranges-for-the-capsaicin-test
#40
REVIEW
Heikki Olavi Koskela, Hanna Maria Nurmi, Surinder Singh Birring
Cough provocation tests (CPTs) are an objective measurement of the sensitivity of the cough reflex arc. However, they are not established in clinical practice because a large variability of response in healthy subjects limits their diagnostic value. There is a paucity of studies that have investigated CPT reference ranges in healthy subjects. This systematic review describes the variability of the responses to CPTs in healthy subjects and factors that influence it. A new analysis of 134 healthy subjects was conducted to create reference ranges for single-breath capsaicin CPT by calculating the interquartile ranges for the provocative concentration of capsaicin to induce 2 and 5 coughs...
November 2021: Allergy, Asthma & Immunology Research
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