Bhavjinder K Dhillon, Simone Kortbeek, Arjun Baghela, Mary Brindle, Dori-Ann Martin, Craig N Jenne, Hans J Vogel, Amy H Y Lee, Graham C Thompson, Robert E W Hancock
IMPORTANCE: Appendicitis is the most common indication for urgent surgery in the pediatric population, presenting across a range of severity and with variable complications. Differentiating simple appendicitis (SA) and perforated appendicitis (PA) on presentation may help direct further diagnostic workup and appropriate therapy selection, including antibiotic choice and timing of surgery. OBJECTIVE: To provide a mechanistic understanding of the differences in disease severity of appendicitis with the objective of developing improved diagnostics and treatments, specifically for the pediatric population...
February 19, 2024: JAMA Pediatrics