keyword
https://read.qxmd.com/read/38509094/pediatric-perforated-appendicitis-diagnosis-based-on-the-c-reactive-protein-prealbumin-ratio
#1
JOURNAL ARTICLE
Junshan Long, Jing Zhang, Gong Chen, Xiaoxia Su, Baowei Qiu, Qi Dong
Pediatric perforated appendicitis, prone to multiple complications, necessitates identifying potential serum biomarkers for early diagnosis and intervention. A cross-sectional study was conducted on patients under 16 with acute appendicitis, admitted to Hainan Women and Children's Medical Center from January 2019 to July 2023. The patients were categorized into perforated and non-perforated groups. Among the 313 included patients, 106 (33.87%, 95% CI 28.59-39.14%) developed perforation. The C-reactive protein to prealbumin ratio (CPA) showed a significant difference between the perforated and non-perforated groups [6...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38472526/radiological-biomarkers-reflecting-visceral-fat-distribution-help-distinguish-inflammatory-bowel-disease-subtypes-a-multicenter-cross-sectional-study
#2
JOURNAL ARTICLE
Ziman Xiong, Peili Wu, Yan Zhang, Jun Chen, Yaqi Shen, Ihab Kamel, Bing Wu, Xianying Zheng, Zhen Li
OBJECTIVES: To achieve automated quantification of visceral adipose tissue (VAT) distribution in CT images and screen out parameters with discriminative value for inflammatory bowel disease (IBD) subtypes. METHODS: This retrospective multicenter study included Crohn's disease (CD) and ulcerative colitis (UC) patients from three institutions between 2012 and 2021, with patients with acute appendicitis as controls. An automatic VAT segmentation algorithm was developed using abdominal CT scans...
March 13, 2024: Insights Into Imaging
https://read.qxmd.com/read/38372989/gene-expression-profiling-in-pediatric-appendicitis
#3
JOURNAL ARTICLE
Bhavjinder K Dhillon, Simone Kortbeek, Arjun Baghela, Mary Brindle, Dori-Ann Martin, Craig N Jenne, Hans J Vogel, Amy H Y Lee, Graham C Thompson, Robert E W Hancock
IMPORTANCE: Appendicitis is the most common indication for urgent surgery in the pediatric population, presenting across a range of severity and with variable complications. Differentiating simple appendicitis (SA) and perforated appendicitis (PA) on presentation may help direct further diagnostic workup and appropriate therapy selection, including antibiotic choice and timing of surgery. OBJECTIVE: To provide a mechanistic understanding of the differences in disease severity of appendicitis with the objective of developing improved diagnostics and treatments, specifically for the pediatric population...
February 19, 2024: JAMA Pediatrics
https://read.qxmd.com/read/38372987/new-genetic-biomarkers-to-diagnose-pediatric-appendicitis
#4
JOURNAL ARTICLE
Maurizio Pacilli, Rishikesan Kamaleswaran
No abstract text is available yet for this article.
February 19, 2024: JAMA Pediatrics
https://read.qxmd.com/read/38342139/usefulness-of-extended-inflammatory-parameters-related-to-neutrophil-activation-reported-by-sysmex-xn-1000-hematology-analyzer-for-predicting-complicated-acute-appendicitis-comparison-with-canonical-inflammatory-laboratory-tests
#5
JOURNAL ARTICLE
María Isabel Díaz López, Elena Crespo Álvarez, Álvaro Martínez Manzano, Eloísa Urrechaga, Manuel Tomás Orgaz Morales, Mercedes González Morales, Elena Martín García, Luis García de Guadiana-Romualdo
AIM: Accurate diagnosis of complicated appendicitis is of importance to ensure that patients receive early and effective treatment, minimizing the risk of postoperative complications to promote successful recovery. Biochemical markers are a promising tool to identify complicated appendicitis. We aimed to evaluate the potential role of novel parameters related with neutrophil activation, known as "Extended Inflammation Parameters" (EIP), included in blood cell count reported by Sysmex XN-Series analyzers, compared to other canonical biomarkers in identifying complicated appendicitis...
February 9, 2024: Cirugia española
https://read.qxmd.com/read/38336508/blood-biomarkers-to-distinguish-complicated-and-uncomplicated-appendicitis-in-pediatric-patients
#6
JOURNAL ARTICLE
Siu Chung Ha, Ya-Hui Tsai, Chee-Chee Koh, Shinn-Gwo Hong, Yun Chen, Chao-Ling Yao
BACKGROUND: /Purpose: Acute appendicitis (AA) stands as the most prevalent cause of acute abdominal pain among children. The potential for morbidity escalates significantly when uncomplicated appendicitis (UA) progresses to complicated appendicitis (CA), which can encompass gangrenous, necrotic, or perforated appendicitis. Consequently, establishing an early and accurate diagnosis of AA, and effectively differentiating CA from UA, becomes paramount. This study explores the diagnostic utility of various blood biomarkers for distinguishing CA from UA in pediatric patients...
February 8, 2024: Journal of the Formosan Medical Association
https://read.qxmd.com/read/38283485/the-role-of-neutrophil-to-lymphocyte-ratio-in-the-diagnosis-of-acute-appendicitis
#7
JOURNAL ARTICLE
Sundus A Khan, Raza Ashraf, Narmeen Hassaan, Mubashar Naseer, Muhammad Hassan Azad, Hamza Javed
BACKGROUND: Acute appendicitis (AA), a common reason for episodes of acute abdomen, is a surgical emergency. Its immediate diagnosis and management are of immense significance, as its diagnosis can become challenging at times, especially in resource-limited setups. The goal of this study was to ascertain the threshold value for the neutrophil-to-lymphocyte ratio (NLR) in diagnosing AA and to calculate the validity parameters for the NLR. METHODOLOGY:  A cross-sectional study was carried out involving 108 patients who were admitted to the surgical wards of Ayub Teaching Hospital, Abbottabad with suspicion of AA and subsequently underwent open appendectomy...
December 2023: Curēus
https://read.qxmd.com/read/38180096/usefulness-of-cell-ratios-and-the-derived-neutrophil-to-lymphocyte-ratio-in-the-diagnosis-of-pediatric-acute-appendicitis
#8
JOURNAL ARTICLE
J C Moreno-Alfonso, A Molina Caballero, A Pérez Martínez
OBJECTIVE: To analyze the accuracy of cell ratios in the diagnosis of pediatric acute appendicitis while introducing a new one -the derived neutrophil-to-lymphocyte ratio (dNLR). MATERIALS AND METHODS: An observational, retrospective study of patients aged 0-15 years old diagnosed with acute appendicitis (AA) and with non-surgical abdominal pain (AP) treated in our institution from 2021 to 2022 was carried out. The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and dNLR were compared between groups...
January 1, 2024: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://read.qxmd.com/read/38116728/diagnostic-performance-of-serum-biomarkers-in-acute-appendicitis-in-children
#9
JOURNAL ARTICLE
Juan Ventura Pernía, Teresa Cancho, Inés Segovia, Elena Granda, Roberto Velasco
No abstract text is available yet for this article.
February 1, 2024: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://read.qxmd.com/read/38104067/mean-platelet-volume-and-total-white-blood-cells-as-diagnostic-biomarkers-for-acute-appendicitis-at-omdurman-military-hospital-a-cross-sectional-study-%C3%A2-2021
#10
JOURNAL ARTICLE
Mohamed Osman Suliman Basher, Ahmed Abdelfattah Ahmed, Aamir Abdullahi Hamza
BACKGROUND: Acute appendicitis (AA) is among the most common nontraumatic indications for emergent abdominal surgical procedures. However, accurately diagnosing all cases can be challenging, physical examination, biochemical markers, and imaging techniques can sometimes be insufficient. This study aimed to (a) compare the mean platelet volume (MPV) and total white blood cell count (TWBCs) in patients with or without histological evidence of an inflamed appendix and (b) determine the positive predictive value, negative predictive value, sensitivity, and specificity of both MPV and TWBCs as diagnostic biomarkers in the diagnosis of AA...
December 16, 2023: BMC Gastroenterology
https://read.qxmd.com/read/38063001/alarmins-and-related-molecules-in-elective-surgery
#11
JOURNAL ARTICLE
Sabina Strohalmová, Kateřina Levová, Aleš Antonín Kuběna, David Hoskovec, Zdeněk Krška, Tomáš Zima, Marta Kalousová
Surgery is associated with alterations of alarmins' and related molecules' levels. The aim of this study was to investigate which biomarkers are most involved in surgery. The studied group consisted of 58 patients with inguinal or umbilical hernia or cholecystolithiasis and 21 healthy controls for compa-rison. We also added seven acute patients with appendicitis, cholecystitis and incarcerated hernia. Serum concentrations of soluble receptor of advanced glycation end-products (sRAGE), extracellular newly identified receptor for advanced glycation end-products binding protein (EN-RAGE), calprotectin, high mobility group box 1 (HMGB1) and interleukin 6 (IL-6) were analysed by ELISA before and after surgery...
2023: Folia Biologica (Praha)
https://read.qxmd.com/read/37982905/diagnostic-performance-of-urinary-5-hydroxyindoleacetic-acid-in-acute-appendicitis-a-systematic-review-and-diagnostic-test-accuracy-meta-analysis
#12
REVIEW
Javier Arredondo Montero, Oscar Emilio Bueso Asfura, Blanca Paola Pérez Riveros, Emilio López Burgos, María Rico Jiménez
OBJECTIVES: This study aimed to analyze the diagnostic performance of urinary 5-Hydroxyindoleacetic Acid (5-HIAA) in acute appendicitis (AA). METHODS: This review was registered in PROSPERO (CRD42023399541). We included prospective or retrospective original clinical studies evaluating the diagnostic performance of 5-HIAA in AA. A search was conducted in PubMed, Web of Science, Scopus and OVID. Search terms and keywords were: (appendicitis OR acute appendicitis) AND (5-HIAA OR 5-Hydroxyindoleacetic acid OR serotonin metabolite)...
November 20, 2023: International Journal of Colorectal Disease
https://read.qxmd.com/read/37729283/diagnosis-of-acute-appendicitis-and-appendicular-perforation-evaluation-of-platelet-indices-and-red-cell-distribution-width-as-emerging-biomarkers
#13
JOURNAL ARTICLE
Chetan Ag, Vijaya Patil
BACKGROUND: Acute appendicitis is a common surgical emergency worldwide. Recent studies on hematological inflammatory markers concerning acute appendicitis have shown variable results. AIMS: The aim of this study was to evaluate pre-operative values of platelet indices such as mean platelet volume (MPV) and platelet distribution width (PDW), and red cell distribution width (RDW) in relation to the diagnosis of acute appendicitis and their efficacy as predictors of appendicular perforation...
2023: Brazilian Archives of Digestive Surgery: ABCD
https://read.qxmd.com/read/37708143/pre-vaccination-monocyte-to-lymphocyte-ratio-as-a-biomarker-for-the-efficacy-of-malaria-candidate-vaccines-a-subgroup-analysis-of-pooled-clinical-trial-data
#14
JOURNAL ARTICLE
Jane Paula Nyandele, Ummi Abdul Kibondo, Fatuma Issa, Jean Pierre Van Geertruyden, George Warimwe, Said Jongo, Salim Abdulla, Ally Olotu
BACKGROUND: Pre-vaccination monocyte-to-lymphocyte ratio was previously suggested as a marker for malaria vaccine effectiveness. We investigated the potential of this cell ratio as a marker for malaria vaccine efficacy and effectiveness. Effectiveness was investigated by using clinical malaria endpoint, and efficacy was investigated by using surrogate endpoints of Plasmodium falciparum prepatent period, parasite density, and multiplication rates in a controlled human malaria infection trial (CHMI)...
2023: PloS One
https://read.qxmd.com/read/37695684/post-operative-increase-in-serum-interleukin-6-is-associated-with-longer-hospital-stay-in-children-operated-on-for-acute-appendicitis-a-pilot-study
#15
JOURNAL ARTICLE
Javier Arredondo Montero, Adriana Rivero Marcotegui, Carlos Bardají Pascual, Giuseppa Antona, Amaya Fernández-Celis, Natalia López-Andrés, Nerea Martín-Calvo
Background: Pediatric acute appendicitis (PAA) involves a substantial consumption of health and economic resources. The identification of serum biomarkers that may help predict the post-surgical evolution of these patients is a field of great interest. Patients and Methods: This was a prospective, observational substudy within the Biomarkers for the Diagnosis of Appendicitis in Pediatrics (BIDIAP) cohort aimed at evaluating the association between post-surgical increase in serum IL-6 and different outcomes related to the clinical evolution of children operated on for PAA...
September 2023: Surgical Infections
https://read.qxmd.com/read/37685553/utility-of-ischemia-modified-albumin-as-a-biomarker-for-acute-appendicitis-a-systematic-review-and-meta-analysis
#16
REVIEW
Apoorv Singh, Zenon Pogorelić, Aniket Agrawal, Carlos Martin Llorente Muñoz, Deepika Kainth, Ajay Verma, Bibekanand Jindal, Sandeep Agarwala, Sachit Anand
BACKGROUND: Acute appendicitis is a frequently encountered surgical emergency. Despite several scoring systems, the possibility of delayed diagnosis persists. In addition, a delayed diagnosis leads to an increased risk of complicated appendicitis. Hence, there is a need to identify biological markers to help clinicians rapidly and accurately diagnose and prognosticate acute appendicitis with a high sensitivity and specificity. Although several markers have been evaluated, the pressing concern is still the low specificity of these markers...
August 24, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37680731/can-serum-soluble-urokinase-plasminogen-activator-receptor-be-an-effective-biomarker-in-comparing-the-inflammatory-response-between-laparoscopic-and-open-appendectomy
#17
JOURNAL ARTICLE
Basak Erginel, Meltem Savran Karadeniz, Secil Yuksel, Hayriye Senturk Ciftci, Demet Izgi, Cenk Ersavas, Erbug Keskin, Feryal Gun Soysal
INTRODUCTION: The inflammatory response after laparoscopy and laparotomy has been compared in studies in adults, but only a few studies have compared the immune response between laparoscopy and laparotomy in children. AIM: To compare open and laparoscopic appendectomies regarding a new biomarker, suPAR, to evaluate the inflammatory response. MATERIAL AND METHODS: Patients between 3 and 17 years of age who were admitted to the pediatric surgery department and scheduled for appendectomy due to appendicitis were enrolled in the investigation...
June 2023: Videosurgery and Other Miniinvasive Techniques
https://read.qxmd.com/read/37644670/the-role-of-blood-inflammatory-markers-in-the-preoperative-diagnosis-of-acute-appendicitis
#18
JOURNAL ARTICLE
Alper Adir, Andrei Braester, Perelstein Natalia, Dally Najib, Luiza Akria, Celia Suriu, Barhoum Masad, Waksman Igor
INTRODUCTION: Acute appendicitis (AA) requires a prompt diagnosis. According to postoperative pathological results, a significant number of appendectomies are performed on a normal appendix (NA). The aim of this study is to evaluate the role of preoperative inflammatory markers in supporting and improving the clinical diagnosis of AA, extracting more information from CBC parameters. METHODS: The study is a retrospective one. The histopathological results of operated appendix from 102 patients, who underwent appendectomy for clinically suspected AA, were extracted from the Galilee Medical Center systems...
August 29, 2023: International Journal of Laboratory Hematology
https://read.qxmd.com/read/37609538/the-value-of-complete-blood-count-parameters-in-predicting-complicated-acute-appendicitis-a-prognostic-accuracy-study
#19
JOURNAL ARTICLE
Natchanok Mekrugsakit, Thawatchai Tullavardhana
INTRODUCTION: Low accuracy of clinical variables can result in delayed diagnosis and increase the incidence of complicated appendicitis in some cases. This study aimed to determine the value of simple complete blood count (CBC) biomarkers in predicting complicated appendicitis. METHODS: This is a single-center retrospective cross-sectional study, which was conducted on cases referred to emergency department following acute appendicitis who underwent appendectomy, to evaluate the accuracy of some cell blood count variables (white blood cell count (WBC), neutrophil percent, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV)) in predicting complicated cases (gangrenous and ruptured appendicitis)...
2023: Archives of Academic Emergency Medicine
https://read.qxmd.com/read/37585982/diagnostic-value-of-serum-signal-peptide-cub-egf-like-domain-containing-protein-1-levels-in-patients-with-acute-appendicitis
#20
JOURNAL ARTICLE
Gürkan Altuntaş, Mehmet Altuntaş, Melih Imamoğlu, Muhammet Kadri Çolakoğlu, Hüseyin Avni Uydu, Recep Bedir
OBJECTIVE: Acute appendicitis is one of the most common surgical causes of an acute abdomen among patients admitted to the emergency room due to abdominal pain. The clinical diagnosis of acute appendicitis is usually difficult and is made by evaluating the clinical, laboratory, and radiological findings together. The aim of this study was to investigate the diagnostic potential of signal peptide-CUB-EGF-like domain-containing protein 1 as a biomarker for acute appendicitis. METHODS: A total of 67 adult patients without any comorbidities who presented to the emergency department with abdominal pain and were clinically diagnosed with acute appendicitis were included in the case group...
2023: Revista da Associação Médica Brasileira
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