Calogero Calabrò, Eliana Di Tillo, Umberto Pensato, Corrado Zenesini, Valentina Favoni, Camilla Fontana, Sabina Cevoli, Eliana Tossani, Pietro Cortelli, Silvana Grandi, Giulia Pierangeli
OBJECTIVE: The underpinning biologics of migraine chronification are not well understood. We aim to investigate the role of the cumulative burden of stress, namely the allostatic load, in migraine chronification. METHODS: This was a cross-sectional study. The allostatic load was measured with a composite multi-system score (BALI: Bologna Allostatic Load Index), evaluating 20 biomarkers representing four physiological systems: immune, metabolic, cardiovascular, and neuroendocrinological systems...
January 23, 2024: Neurological Sciences