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JOURNAL ARTICLE
Hye Suk Yoon, Christopher D Scharer, Parimal Majumder, Carl W Davis, Royce Butler, Wendy Zinzow-Kramer, Ioanna Skountzou, Dimitrios G Koutsonanos, Rafi Ahmed, Jeremy M Boss
CIITA and MHC class II expression is silenced during the differentiation of B cells to plasma cells. When B cell differentiation is carried out ex vivo, CIITA silencing occurs rapidly, but the factors contributing to this event are not known. ZBTB32, also known as repressor of GATA3, was identified as an early repressor of CIITA in an ex vivo plasma cell differentiation model. ZBTB32 activity occurred at a time when B lymphocyte-induced maturation protein-1 (Blimp-1), the regulator of plasma cell fate and suppressor of CIITA, was minimally induced...
September 1, 2012: Journal of Immunology
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