Masanari Takami, Munehito Yoshida, Akihito Minamide, Hiroshi Hashizume, Yasutsugu Yukawa, Yukihiro Nakagawa, Hiroshi Iwasaki, Shunji Tsutsui, Keiji Nagata, Ryo Taiji, Hideto Nishi, Andrew J Schoenfeld, Andrew K Simpson, Hiroshi Yamada
BACKGROUND CONTEXT: Microendoscopic spinal surgery has demonstrated efficacy and is increasingly utilized as a minimally invasive approach to neural decompression, but there is a theoretical concern that bleeding and postoperative epidural hematoma (PEH) may occur with increased frequency in a contained small surgical field. Hemostatic agents, such as topical gelatin-thrombin matrix sealant (TGTMS), are routinely used in spine surgery procedures, yet there has been no data on whether PEH is suppressed by these agents when administered in microendoscopic spine surgery...
November 12, 2020: Spine Journal: Official Journal of the North American Spine Society
Rajalekshmi Resmi, Kaladevi Shaji Anusree, Roy Joseph, Anugya Bhatt
INTRODUCTION: Development of a tissue-engineered construct for hepatic regeneration remains a challenging task due to the lack of an optimum environment that support the growth of hepatocytes. Hydrogel systems possess many similarities with tissues and have the potential to provide the microenvironment essential for the cells to grow, proliferate, and remain functionally active. METHODS: In this work, fibrin (FIB) incorporated injectable alginate dialdehyde (ADA) - gelatin (G) hydrogel was explored as a matrix for liver tissue engineering...
November 6, 2020: International Journal of Biological Macromolecules
Adem Binnetoglu, Berat Demir, Yavuz Gundogdu
No abstract text is available yet for this article.
August 5, 2020: Ear, Nose, & Throat Journal
Ju-Eun Kim, Hyun-Seung Yoo, Dae-Jung Choi, Eugene J Park, Jin-Ho Hwang, Jeong-Duk Suh, Jun-Hyug Yoo
Background: Symptomatic postoperative spinal epidural hematoma (PSEH) is a devastating complication that could develop after lumbar decompression surgery. PSEH can also develop after biportal endoscopic spine surgery (BESS), one of the recently introduced minimally invasive spine surgery techniques. Gelatin-thrombin matrix sealant (GTMS) is commonly used to prevent PSEH. This study aimed at analyzing the clinical and radiological effects of GTMS use during BESS. Methods: A total of 206 patients with spinal stenosis who underwent decompression by BESS through a posterior interlaminar approach from October 2015 to September 2018 were enrolled in this study...
2020: BioMed Research International
Dai Kamamoto, Tokunori Kanazawa, Eriko Ishihara, Kaoru Yanagisawa, Hideyuki Tomita, Ryo Ueda, Masahiro Jinzaki, Kazunari Yoshida, Masahiro Toda
Background: Hemostasis plays an important role in safe brain tumor resection and also reduces the risk for surgical complications. This study aimed to evaluate the efficacy of FLOSEAL® , a topical hemostatic agent that contains thrombin and gelatin granules, in brain tumor resections. Methods: We evaluated the hemostatic effect of FLOSEAL by scoring the intensity of bleeding from 1 (mild) to 4 (life threatening). We assessed the rate of success of hemostasis with 100 patients who underwent intracranial tumor resection...
2020: Surgical Neurology International
Rita Bou Assaf, Kazem Zibara, Mohammad Fayyad-Kazan, Fatima Al-Nemer, Manal Cordahi, Saad Khairallah, Bassam Badran, Antoine Berbéri
Objective: Repairing bone defects, especially in older individuals with limited regenerative capacity, is still a big challenge. The use of biomimetic materials that can enhance the restoration of bone structure represents a promising clinical approach. In this study, we evaluated ectopic bone formation after the transplantation of human maxillary Schneiderian sinus membrane- (hMSSM-) derived cells embedded within various scaffolds in the femur of pigs. Methods: The scaffolds used were collagen, gelatin, and hydroxyapatite/tricalcium phosphate (HA/ β TCP) where fibrin/thrombin was used as a control...
2019: Stem Cells International
Erik D Hokenstad, John A Occhino
INTRODUCTION AND HYPOTHESIS: The objective of this video is to demonstrate a variety of available techniques that can be used in the management of acute presacral bleeding. METHODS: In this video, we demonstrate different methods for the management of presacral bleeding utilizing a fresh frozen cadaver. RESULTS: Presacral bleeding is a potentially catastrophic complication that can be encountered during pelvic surgery, particularly sacrocolpopexy...
June 11, 2019: International Urogynecology Journal
Paul Slezak, Claudia Keibl, Heinz Redl, Dirk Labahn, Heinz Gulle
PURPOSE: Management of bleeding during surgery can be aided by the application of topical hemostatic agents. This study compared the hemostatic efficacy of a new powder agent containing collagen, chondroitin sulfate, and thrombin (PCCT) with a flowable gelatin-thrombin matrix with smooth particles (SmGM) in a porcine liver bleeding model. MATERIALS AND METHODS: Lesions 4-6 mm deep and ∼10 mm in diameter were created in porcine livers and treated with either SmGM or PCCT...
March 24, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Meng-Yin Ho, Shih-Hung Yang, Chien-Min Chen, Abel Po-Hao Huang
Local hemostatic agents has been used in neurosurgical field for many years; it is safe and efficient with no fatal complication reported in the literature. We routinely used gelatin-thrombin hemostatic agent (Floseal Hemostatic Matrix (Baxter Healthcare Corp, Fremont, CA, USA)) for hemostasis in minimally invasive endoscopic-assisted surgery for more than 500 intracerebral hemorrhage patients. However, two cases with sterile cyst formation were encountered. One received endoscopic hematoma evacuation, and the other had traditional craniotomy...
March 11, 2019: World Neurosurgery
Traci E Ito, Alexandra L Martin, Edith F Henderson, Jeremy T Gaskins, Vida M Vaughn, Shan M Biscette, Resad P Pasic
Background and Objectives: To perform a systematic review of articles evaluating hemostatic effectiveness and peri-operative outcomes when topical hemostatic agents (HA) are used in minimally invasive gynecologic surgeries (MIGS) for benign conditions. Methods: Studies published through March 31, 2017 were retrieved through PubMed, EMBASE, Cochrane, and to identify all eligible studies. No studies were excluded based on publish date. All comparative studies or case series with >10 participants reporting use of at least one topical HA in MIGS for benign conditions were included as long as full-text articles were available and written in English...
October 2018: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Chien-Chung Yang, Chih-Chung Lin, Li-Der Hsiao, Chuen-Mao Yang
Galangin, a member of the flavonol compounds of the flavonoids, could exert anti-inflammatory effects in various cell types. It has been used for the treatment of arthritis, airway inflammation, stroke, and cognitive impairment. Thrombin, one of the regulators of matrix metalloproteinase (MMPs), has been known as a vital factor of physiological and pathological processes, including cell migration, the blood⁻brain barrier breakdown, brain edema formation, neuroinflammation, and neuronal death. MMP-9 especially may contribute to neurodegenerative diseases...
December 17, 2018: International Journal of Molecular Sciences
Christopher Ito, Daniel Sharbel, Allison McMullen, Stilianos Kountakis
OBJECTIVE: Previous studies have not examined the potential role of endonasal hemostatic agents in facilitating growth of fungal species. We aim to determine the possibility of these to serve as a nutrient source for fungal growth. METHODS: Cultures of Aspergillus, Fusarium, and Mucor were harvested and placed in solution in sterile saline at standardized high and low concentrations. Thrombin gelatin matrix, carboxyl methylcelluose, and potato starch derivative agents were prepared following manufacturer instructions and applied to two separate Petri dishes per agent...
September 25, 2018: American Journal of Otolaryngology
Cristian de Quintana-Schmidt, Andreas Leidinger, Joan Molet Teixidó, Gerardo Conesa Bertrán
BACKGROUND: Few studies have been published about percutaneous techniques for the management of surgical bed hemorrhage during a stereotactic biopsy, a serious complication that may affect patient outcome. We describe the injection of a thrombin-gelatin matrix through the biopsy cannula as an effective method to arrest surgical bed bleeding that does not respond to conventional methods of hemostasis. METHODS: We prospectively documented image-guided stereotactic brain biopsy procedures on 30 awake patients between July 2014 and July 2017 at our center...
October 13, 2018: World Neurosurgery
Valentina Baro, Luca Denaro, Domenico d'Avella
PURPOSE: We report our preliminary experience concerning the use of thrombin-gelatin hemostatic matrix to strengthen the final hemostasis after posterior fossa low-grade tumor surgery in children. To our knowledge, this is the first report regarding the use of hemostatic matrix in pediatric neurosurgery. MATERIALS AND METHODS: Between 2012 and 2016, twenty-three patients underwent posterior fossa surgery for low-grade gliomas in our department. The mean age was 6...
2018: Pediatric Neurosurgery
Manuel G Ramirez, Xiaoli Niu, Josh Epstein, Dongyan Yang
BACKGROUND: A five-year retrospective database analysis comparing the use of Floseal 1 flowable topical hemostat alone (F) and in combination with gelatin/thrombin (F + G/T) to achieve hemostasis and control surgical bleeding showed higher resource utilization for F + G/T cases relative to F matched pairs during spinal surgery. Lower resource use in the F group was characterized by shorter hospital length of stay and surgical time as well as fewer blood transfusions and less hemostat agent used per surgery...
October 2018: Journal of Medical Economics
Paul Slezak, Philipp Heher, Xavier Monforte, Claudia Keibl, Heinz Redl, Daniel Spazierer, Heinz Gulle
PURPOSE: Topical hemostatic agents are an important means of controlling or preventing bleeding. This study was performed to compare gelatin-thrombin matrix with smooth particles (SmGM) versus gelatin-thrombin matrix with stellate particles (StGM) in a porcine kidney bleeding model. MATERIALS AND METHODS: In male pigs, reproducible lesions (diameter and depth ∼10 mm) were created in the renal cortex. Each lesion was treated topically using either SmGM or StGM...
March 21, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Giuseppe Cardillo, Francesco Carleo, Marco DI Martino, Bernardo Ciamberlano, Pasquale Ialongo, Giacomo Cusumano, Maria Denitza Tinti, Alberto Ricci, Stefano Cafarotti
BACKGROUND: Intraoperative pulmonary artery (PA) bleeding is common during thoracic surgery. We investigated the efficacy of the gelatin matrix-thrombin solution FloSeal (Baxter International, Deerfield, IL, USA) for control of major PA bleeding. METHODS: Retrospective data were collected on all intraoperative PA injuries during open or minimally invasive lobectomy or pneumonectomy between January 2000 and January 2014. Patients received either 4/0 prolene sutures (Standard) or the gelatin matrix-thrombin solution, plus sutures as needed (Matrix), with at least 6-month follow-up...
August 28, 2017: Journal of Cardiovascular Surgery
Roberto Gazzeri, Marcelo Galarza, Carlo Conti, Costanzo De Bonis
Association between the use of hemostatic agents made from collagen/gelatin mixed with thrombin and thromboembolic events in patients undergoing tumor resection has been suggested. This study evaluates the relationship between flowable hemostatic matrix and deep vein thrombosis in a large cohort of patients treated for brain tumor removal. The authors conducted a retrospective, multicenter, clinical review of all craniotomies for tumor removal performed between 2013 and 2014. Patients were classified in three groups: group I (flowable gelatin hemostatic matrix with thrombin), group II (gelatin hemostatic without thrombin), and group III (classical hemostatic)...
January 2018: Neurosurgical Review
Yun Hwan Kim, Hyun Joo Shin, Woong Ju, Seung Cheol Kim
OBJECTIVE: This prospective randomized controlled pilot study aimed to find whether gelatin-thrombin matrix used as a tissue sealant (FloSeal) can prevent the occurrence of pelvic lymphocele in patients with gynecologic cancer who has undergone pelvic lymphadenectomy. METHODS: Each patient, who undergo a laparotomic pelvic lymph node dissection on both sides, was randomly assigned for FloSeal application on 1 side of the pelvis. The other side of the pelvis without any product application being the control side...
May 2017: Journal of Gynecologic Oncology
Rafał Watrowski, Christoph Jäger, Johannes Forster
AIM: To assess the impact of the use of intraoperative hemostatic gelatin-thrombin matrix (HM) (Floseal®, Baxter Healthcare) on transfusion rates and short-term perioperative outcomes in gynecological surgery. PATIENTS AND METHODS: In this retrospective, single-center study, we evaluated data of 215 patients (83 cases and 132 controls) undergoing extensive gynecological surgery (e.g. oncological procedures) with and without intraoperative HM application. RESULTS: Cases and controls did not differ according to age, preoperative hemoglobin (Hb) concentration, and Hb or C-reactive protein (CRP) levels at discharge...
March 2017: In Vivo
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