Jocellie E Marquez, Kailash Kapadia, Kanad Ghosh, Brittni Silvestri, Gurtej Singh, Tara L Huston
BACKGROUND: Fibrin sealant is a controversial method for reducing seroma formation. It is comprised of human proclotting factors, fibrinogen and thrombin. Fibrin sealants have been extensively studied for their efficacy in reducing the rates of seroma by sealing the dead space; however, in most studies, the sealants are used with surgical drains. According to the U.S. Food and Drug Administration, fibrin sealant carries the risk of life-threatening thromboembolic complications, gas emboli, and transmission of infectious agents...
March 19, 2020: Annals of Plastic Surgery
Dai Kamamoto, Tokunori Kanazawa, Eriko Ishihara, Kaoru Yanagisawa, Hideyuki Tomita, Ryo Ueda, Masahiro Jinzaki, Kazunari Yoshida, Masahiro Toda
Background: Hemostasis plays an important role in safe brain tumor resection and also reduces the risk for surgical complications. This study aimed to evaluate the efficacy of FLOSEAL® , a topical hemostatic agent that contains thrombin and gelatin granules, in brain tumor resections. Methods: We evaluated the hemostatic effect of FLOSEAL by scoring the intensity of bleeding from 1 (mild) to 4 (life threatening). We assessed the rate of success of hemostasis with 100 patients who underwent intracranial tumor resection...
2020: Surgical Neurology International
Camilo Partezani Helito, Marcelo Batista Bonadio, Marcel Faraco Sobrado, Pedro Nogueira Giglio, José Ricardo Pécora, Gilberto Luis Camanho, Marco Kawamura Demange
OBJECTIVE: Tranexamic acid (TXA) and the hemostatic agent Floseal® have already been used to minimize bleeding during total knee arthroplasty (TKA). METHODS: We conducted a prospective, randomized study of 90 patients with indications for TKA. Following inclusion, the participants were randomly allocated in blocks to the following 3 groups: control, Floseal® and TXA. Bleeding parameters, including decreases in hemoglobin (Hb), drain output, number of blood transfusions and complications, were assessed...
2019: Clinics
Nicholas C Dang, Abbas Ardehali, Brian A Bruckner, Patrick E Parrino, Daniel L Gillen, Rachel W Hoffman, Russell Spotnitz, Stephanie Cavoores, Ian J Shorn, Roberto J Manson, William D Spotnitz
AIM: This trial compared the hemostatic performance of a novel combination powder (CP) to a control hemostatic matrix (HM) in cardiothoracic operations. METHODS: Patients meeting eligibility criteria were enrolled after providing informed consent. Subjects were randomized intraoperatively to receive CP (HEMOBLAST Bellows; Biom'up, France) or HM (FLOSEAL Hemostatic Matrix; Baxter Healthcare Corporation, Hayward, CA). Bleeding was assessed using a clinically validated, quantitative bleeding severity scale...
February 2020: Journal of Cardiac Surgery
John M Lee, Vincent Wu, Marie E Faughnan, Andrea Lasso, Andrea Figol, Shaun J Kilty
BACKGROUND: Epistaxis is the most common symptom of hereditary hemorrhagic telangiectasia (HHT), affecting more than 98% of adults with HHT, with significant impact on quality of life. Floseal® has been shown to be effective for the management of anterior epistaxis, but has yet to be thoroughly evaluated in this population. Our goal was to evaluate the efficacy of Floseal® for managing acute anterior epistaxis in patients with HHT. METHODS: A pilot prospective clinical trial was conducted at two tertiary referral centres, St...
October 15, 2019: Journal of Otolaryngology—Head & Neck Surgery
Georgina Wellstead, Ananth Vijendren, Junaid Hanif, John Phillips
The jugular bulb is a confluence of the sigmoid and inferior petrosal sinuses within the posterolateral portion of the jugular fossa, continuing extracranially as the internal jugular vein. Its exact location within the temporal bone however is variable, and several jugular bulb abnormalities exist which can affect its position. Examples include a high-riding and/or dehiscent jugular bulb and a jugular bulb diverticulum. According to the literature, the prevalence of jugular bulb abnormalities is 10-15%, with dehiscence in 0...
September 27, 2019: Clinical Otolaryngology
Heemoon Lee, Jun Ho Lee, Chang-Seok Jeon, Jae Hyung Ko, Si-Nae Park, Young Tak Lee
Background: Flowable hemostatic agents may be more advantageous than nonflowable hemostats, as they have capability to cover irregular wound surfaces, fill deep lesions, and easily remove excess materials with irrigation. In this study, we evaluated the hemostatic efficacy of the collagen hemostatic matrix (CHM) compared to FloSeal® via incisions in the heart and cardiac vessels in a porcine model. Methods: In each of the two female pigs, a total of two incisions were made in seven locations: right atrium (RA), right ventricle (RV), and cardiac vessels, such as the innominate vein (IV), superior vena cava (SVC), pulmonary artery (PA), coronary artery (CA), and aorta...
July 2019: Journal of Thoracic Disease
Min Jhi Kim, Jung-Han Kim, Jee Soo Kim, Jun-Ho Choe
BACKGROUND: We evaluated the hemostatic efficacy and immunogenicity of CollaStat compared with FloSeal in a rabbit jejunal artery injury model. METHODS: A total of 27 experimental rabbits were used in the study. For each hemostatic agent, an injury was created in one of the right angles of the jejunal arteries originating from the vascular arcs. Time to hemostasis was determined after applying manual compression to the wound for 30 s, which was repeated a maximum of three times in cases of persistent bleeding...
November 2019: Journal of Surgical Research
Serdar Aykan, Mustafa Zafer Temiz, Ismail Ulus, Mehmet Yilmaz, Serkan Gonultas, Serhat Suzan, Atilla Semercioz, Ahmet Yaser Muslumanoglu
Objective: This study aimed to compare the effects of three different hemostatic agents on surgical and early renal functional outcomes after laparoscopic partial nephrectomy (LPN). Materials and Methods: A total of 126 cases of LPN performed between November 2008 and September 2016 were enrolled in this study. Spongostan™ Absorbable Hemostatic Gelatin Sponge (Ethicon, Somerville, NJ, USA) or Surgicel® Original Absorbable Hemostat (Ethicon, Somerville, NJ, USA), or a total of 5 mL of Floseal® Hemostatic Matrix (Baxter Healthcare, Deerfield, IL) was used for additional hemostasis...
June 2019: Eurasian Journal of Medicine
Hou-Tsung Chen, Chieh-Cheng Hsu, Meng-Lin Lu, Sung-Hsiung Chen, Jing-Miao Chen, Re-Wen Wu
How to decrease intraoperative bleeding, shorten surgical time, and increase safety in spinal surgery is an important issue. Ultrasonic bone removers and FloSeal have been proven to increase safety, reduce the surgical duration, and decrease intraoperative bleeding in skull base surgery. Therefore, we aimed to compare the surgical duration, blood loss, and complications during spinal surgery with or without the use of FloSeal and an ultrasonic bone scalpel. Therefore, we retrospectively reviewed 293 patients who underwent thoracolumbar spinal surgery with decompression and instrumented fusion performed by a single surgeon...
2019: BioMed Research International
Meng-Yin Ho, Shih-Hung Yang, Chien-Min Chen, Abel Po-Hao Huang
Local hemostatic agents has been used in neurosurgical field for many years; it is safe and efficient with no fatal complication reported in the literature. We routinely used gelatin-thrombin hemostatic agent (Floseal Hemostatic Matrix (Baxter Healthcare Corp, Fremont, CA, USA)) for hemostasis in minimally invasive endoscopic-assisted surgery for more than 500 intracerebral hemorrhage patients. However, two cases with sterile cyst formation were encountered. One received endoscopic hematoma evacuation, and the other had traditional craniotomy...
March 11, 2019: World Neurosurgery
Jung Jun Kim, Yoon Seok Suh, Deok Hyun Han
To investigate and compare surgical outcomes in totally tubeless percutaneous nephrolithotomy (ttPCNL) patients according to the type of sealant during nephrostomy tract closure, the records of 158 patients who underwent ttPCNL were retrospectively reviewed. Fibrin sealant [Tisseel® ; n = 107, fibrin-only sealant (FS)] or gelatin matrix hemostatic sealant [FloSeal® ; n = 51, gelatin matrix sealant (GS)] was applied during tract closure according to surgeon's preference. On the first postoperative day, computed tomography (CT) was scanned for all patients...
March 14, 2019: Urolithiasis
Rafał Watrowski
Acute hemoperitoneum (AHP) in early gestation is commonly treated via laparotomy. A ruptured corpus luteum (CL) cyst is a rare cause of AHP in pregnancy. This case report describes a 33-year-old, hemodynamically stable G2/P1 who presented at 5+5 gestational weeks with an acute abdomen due to ruptured CL cyst (7 cm). Emergent laparoscopy was performed. After evacuation of 1 L of hemoperitoneum, an atraumatic hemostasis was obtained without diathermy by use of hemostatic matrix (Floseal® ). The ovary was reformed with an absorbable suture under preservation of CL...
March 7, 2019: Zeitschrift Für Geburtshilfe und Neonatologie
Anha Afrin Shefa, Mirana Taz, Sun Young Lee, Byong-Taek Lee
To combat post-surgical and traumatic bleeding conditions effective hemostasis is of great importance. The study was designed to investigate the effect of thrombin (Th) loading on hemostatic performance of TEMPO-oxidized cellulose nanofiber (TOCN)-silk fibroin (SF) scaffolds. Addition of SF with TOCN significantly (***P < 0.001) increased blood absorption capacity and improved biocompatibility of TOCN. Thrombin loading potentiated platelet activation and hemostatic property of scaffolds (TOCN-SF-Th) compared to samples without thrombin (TOCN-SF)...
March 15, 2019: Carbohydrate Polymers
Mohammad Al-Saeedi, Hamidreza Fonouni, Arash Kashfi, Omid Ghamarnejad, Ali Majlesara, Negin Gharabaghi, Oliver Stahlheber, Thomas W Kraus, Arianeb Mehrabi, Yakup Kulu
BACKGROUND/OBJECTIVE: Biliary leakage is a potential complication of liver resection and is still a concern. The aim of the present study was to evaluate the effectiveness of four routinely used sealants in preventing bile leakage under pressure from an induced perforation of the gallbladder in a porcine model. METHODS: Forty Landrace pigs were randomly assigned to one of five groups. These included a control group (n = 8) and one group each for the sealants TachoSil®, TissuCol Duo®, Coseal®, and FloSeal® (n = 8 per group)...
July 2019: Asian Journal of Surgery
Ali H Aldoukhi, Kristian M Black, James Shields, Khurshid R Ghani
OBJECTIVE: To demonstrate the use of the Moses technology for holmium laser lithotripsy in conjunction with mini-percutaneous nephrolithotomy (PCNL) to treat a lower pole stone. The Moses technology is a pulse modulation method that can reduce stone retropulsion, which may have advantages when used during mini-PCNL. METHODS: A 63-year-old patient with a right-sided 1.5 cm lower pole stone (1300 Hounsfield Unit) underwent mini-PCNL using a 120W holmium laser (MosesP120, Lumenis)...
February 2019: Urology
Suat Canbay, Ali Erhan Kayalar, Gulce Gel, Hakan Sabuncuoğlu
Vertebral hemangiomas are relatively common, but those causing spinal cord compression are rare. A 19-year-old male presented with thoracic back pain. The neurologic examination was normal and radiological examinations demonstrated an aggressive vertebral hemangioma centered within the T11 vertebral body. Damaged vertebral bone and soft tissue components of the mass were observed in the epidural space. Surgery was performed using a new technique involving radiofrequency ablation, injection of a hemostatic agent (FLOSEAL, Baxter, USA), and bone autograft placement in the affected vertebral body...
September 25, 2018: Neurocirugía
Melissa Louise Acreman, Mahesh Sainani
A 34-year-old woman presented to hospital in shock 8 hours after a spontaneous home vaginal delivery. She is a known carrier of haemophilia A. Examination revealed a tender but firm, central and contracted uterus. There was a small second-degree perineal tear which was not actively bleeding and no other trauma or bleeding visualised in the vault or cervix. Bedside ultrasound showed a large 1 L blood clot anterior to the empty uterus. Exploratory laparotomy was performed which revealed a haematoma in the Retzius space with extension beneath the anterior serosa of the bladder, through the left broad ligament and into the retroperitoneal space...
August 29, 2018: BMJ Case Reports
Manuel G Ramirez, Xiaoli Niu, Josh Epstein, Dongyan Yang
BACKGROUND: A five-year retrospective database analysis comparing the use of Floseal 1 flowable topical hemostat alone (F) and in combination with gelatin/thrombin (F + G/T) to achieve hemostasis and control surgical bleeding showed higher resource utilization for F + G/T cases relative to F matched pairs during spinal surgery. Lower resource use in the F group was characterized by shorter hospital length of stay and surgical time as well as fewer blood transfusions and less hemostat agent used per surgery...
October 2018: Journal of Medical Economics
Manuel G Ramirez, Harel Deutsch, Nitin Khanna, Donald Cheatem, Dongyan Yang, Erik Kuntze
OBJECTIVE: Flowable agents such as Floseal® (F) are often reserved as adjuncts to non-flowable agents (i.e. gelatin (G) sponges and thrombin (T)) when bleeding is not sufficiently controlled. Based on their perceived positive impact, it is postulated that flowable agents alone may result in better clinical and resource utilization outcomes. Clinical and health-care utilization outcomes were compared in this retrospective analysis of spine surgery cases with charges for Floseal only (FO) and F + G/T...
October 2018: Hospital Practice (Minneapolis)
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