Nour-El-Houda Mourksi, Cécile Dalban, Amélie Colombe-Vermorel, Laetitia Odeyer, Valentin Simioni, Jean-Sébastien Frenel, Michel Fabbro, Fernando Bazan, Sophie Abadie-Lacourtoisie, Elodie Coquan, Séverine Martinez, Gwenaelle Garin, Séverine Tabone-Eglinger, Isabelle Treilleux, Sylvie Chabaud, David Pérol, Isabelle Ray-Coquard, Pierre-Etienne Heudel, Jean-Jacques Diaz, Virginie Marcel
Resistance of advanced hormone-dependent endometrial carcinoma to endocrine therapy remains a worldwide clinical issue. We recently reported that the combination of Vistusertib (V, mTOR inhibitor) and Anastrozole (A, aromatase inhibitor) improves the progression-free rate compared to Anastrozole alone. However, a better patient selection based on biomarkers would improve patient outcome. We evaluate for the first time the usage of ribosome biogenesis (RiBi) factors as a source of innovative markers. Using 47 FFPE tumours (A n = 18; V + A n = 29), 32 blood samples (A n = 13; V + A n = 19) and 30 samples of total RNAs (A n = 12; V + A n = 18) from the VICTORIA clinical trial, we observed an association between RiBi-associated markers and drug activity or prediction of treatment response...
January 2023: Molecular Oncology